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| 1 | 南海西部越南岸外晚第四纪黏土矿物记录:物源分析与东亚季风演化显示文摘南海西部越南岸外MD05-2901孔晚第四纪450ka以来黏土矿物和氧同位素的高分辨率分析表明,伊利石、绿泥石和高岭石含量表现出明显的冰期-间冰期旋回变化,而蒙脱石含量呈现频率更高的周期性变化.物源分析表明,MD05-2901孔黏土矿物中的蒙脱石主要由巽他陆架及其主要源区印度尼西亚岛弧提供,伊利石和绿泥石主要由湄公河和红河提供,而高岭石则主要由珠江提供.高岭石/(伊利石+绿泥石)比值的变化显示强烈的100ka偏心率周期,指示了冰盖驱动的冬季风演化;而蒙脱石含量的高频变化除了具有冰盖驱动的41ka斜率周期以外,还具有23和19ka岁差周期、以及13ka半岁差周期,指示了热带驱动的夏季风演化.东亚冬季风的演化基本上与冰期-间冰期旋回一致,冰期时强盛,间冰期时明显减弱;而夏季风的演化则与北半球低纬夏季日射量吻合较好,日射量高时强盛,低时减弱.研究认为,高纬冰盖和低纬热带分别驱动了晚第四纪东亚冬季风和夏季风的演化,反映了东亚季风演化的双重和独立的驱动机制. | 刘志飞 赵玉龙 李建如 Christophe Colin | 2007 | 中国科学(D辑)2007，37，9： | 40 |
| 2 | Clay minerals in surface sediments of the Pearl River drainage basin and their contribution to the South China Sea显示文摘Clay minerals have played a significant role in the study of the East Asian monsoon evolution in the South China Sea by being able to track oceanic current variations and to reveal contemporaneous pa- leoclimatic changes prevailing in continental source areas.As one of the most important rivers input- ting terrigenous matters to the northern South China Sea,the Pearl River was not previously paid at- tention to from the viewpoint of clay mineralogy.This paper presents a detailed study on clay minerals in surface sediments collected from the Pearl River drainage basin(including all three main channels, various branches,and the Lingdingyang in the estuary)by using the X-ray diffraction(XRD)method. The results indicate that the clay mineral assemblage consists dominantly of kaolinite(35%-65%), lesser abundance of chlorite(20%-35%)and illite(12%-42%),and very scare smectite occurrences (generally<5%).Their respective distribution does not present any obvious difference throughout the Pearl River drainage basin.However,downstream the Pearl River to the northern South China Sea,the clay mineral assemblage varies significantly:kaolinite decreases gradually,smectite and illite increase gradually.Additionally,illite chemistry index steps down and illite crystallinity steps up.These varia- tions indicate the contribution of major kaolinite,lesser illite and chlorite,and very scarce smectite to the northern South China Sea from the Pearl River drainage basin.The maximum contribution of clay minerals from the Pearl River is 72%to the northern margin and only 15%to the northern slope of the South China Sea.In both glacials and interglacials,kaolinite indicates that the ability of mechanical erosion occurred in the Pearl River drainage basin. | LIU ZhiFei Christophe COLIN HUANG Wei CHEN Zhong Alain TRENTESAUX CHEN JianFang | 2007 | Chinese Science Bulletin2007，52，8： | 33 |
| 3 | 粘土矿物在气候环境变化研究中的应用进展显示文摘在古环境和古气候的重建中,粘土矿物和碳-氧同位素、孢粉、树轮、冰芯等代用指标一样具有同等重要的地位。在没有地质构造运动影响时,气候是影响粘土矿物形成的主要因素,沉积物中的粘土矿物可用来分析古气候和古环境。粘土矿物及其组合可以独立或作为主要指标反映气候和环境变化,并已应用于高分辨率的晚第四纪地层的气候环境研究中。粘土矿物在很短的时间内也会发生明显地变化,不仅可以反映千年-百年尺度的气候环境变化,而且也可以反映几十年尺度的古气候环境变化过程。粘土矿物与其它指标对同一气候环境响应的相位差有待深入研究。不同的半定量分析方法测量出的同一剖面中粘土矿物的含量变化趋势和特征具有一致性。 | 孙庆峰 陈发虎 Christophe Colin 张家武 | 2011 | 矿物学报2011，31，1： | 31 |
| 4 | 气候环境变化研究中影响粘土矿物形成及其丰度因素的讨论显示文摘粘土矿物在形成过程中受构造运动、气候、盆地规模、地表母岩、土壤、植被、地貌、介质环境、风以及成岩作用等多种因素的影响,这些因素对地层中粘土矿物的类型和含量的影响程度不一。构造运动和气候是影响粘土矿物形成的两个主要因素,对沉积物中的粘土矿物形成和含量以及影响粘土矿物形成的其他次要影响因素有着控制作用。在构造活动稳定的状态下,气候则成为影响粘土矿物形成和含量的决定性因素,其他因素尽管也有不同程度的影响,但可以看成是相对稳定不变的,粘土矿物携带的主要是气候环境变化的信息。地表水系的复杂程度引起的沉积物的混合程度影响粘土矿物信号的清晰度,沉积埋藏成岩作用对粘土矿物的影响也不容忽视。 | 孙庆峰 Christophe Colin 陈发虎 张家武 | 2011 | 岩石矿物学杂志2011，30，2： | 32 |
| 5 | Petawatt and exawatt class lasers worldwide显示文摘In the 2015 review paper‘Petawatt Class Lasers Worldwide’a comprehensive overview of the current status of highpower facilities of>200 TW was presented.This was largely based on facility specifications,with some description of their uses,for instance in fundamental ultra-high-intensity interactions,secondary source generation,and inertial confinement fusion(ICF).With the 2018 Nobel Prize in Physics being awarded to Professors Donna Strickland and Gerard Mourou for the development of the technique of chirped pulse amplification(CPA),which made these lasers possible,we celebrate by providing a comprehensive update of the current status of ultra-high-power lasers and demonstrate how the technology has developed.We are now in the era of multi-petawatt facilities coming online,with 100 PW lasers being proposed and even under construction.In addition to this there is a pull towards development of industrial and multi-disciplinary applications,which demands much higher repetition rates,delivering high-average powers with higher efficiencies and the use of alternative wavelengths:mid-IR facilities.So apart from a comprehensive update of the current global status,we want to look at what technologies are to be deployed to get to these new regimes,and some of the critical issues facing their development. | Colin N.Danson Constantin Haefner Jake Bromage Thomas Butcher Jean-Christophe FChanteloup Enam A.Chowdhury Almantas Galvanauskas Leonida A.Gizzi Joachim Hein David I.Hillier Nicholas W.Hopps Yoshiaki Kato Efim A.Khazanov Ryosuke Kodama Georg Korn Ruxin Li Yutong Li Jens Limpert Jingui Ma Chang Hee Nam David Neely Dimitrios Papadopoulos Rory R.Penman Liejia Qian Jorge J.Rocca andrey A.Shaykin Craig W.Siders Christopher Spindloe Sándor Szatmári Raoul M.G.M.Trines Jianqiang Zhu Ping Zhu Jonathan D.Zuegel | 2019 | High Power Laser Science and Engineering2019，7，3： | 33 |
| 6 | SDN在IP网络演进中的作用显示文摘Web已经改变了一切。新的服务每天都在出现,并且有些服务一夜之间就能够获得巨大的用户量,导致网络中的使用方式和流量模式完全难以预测。过去所建立的基础设施难以适应这些新变化,为了满足这些需求,网络必须能够快速、自动、经济地适应新的变化。软件定义网络(SDN)和网络功能虚拟化(NFV)就是其中两个能灵活地使能上述需求的技术。本文描述了SDN在IP网络领域中所起的作用(包括在实现NFV方面的关键作用),并介绍了关于网络如何引入SDN和NFV的场景和多个使用案例,用于说明SDN和NFV如何使得网络更加敏捷、可编程、优化地支持业务和用户的特殊需求。 | Mark M.Clougherty Christopher A.White Harish Viswanathan Colin L.Kahn | 2014 | 电信科学2014，30，5： | 25 |
| 7 | Late Quaternary clay minerals off Middle Vietnam in the western South China Sea: Implications for source analysis and East Asian monsoon evolution显示文摘High-resolution clay mineral records combined with oxygen isotopic stratigraphy over the past 450 ka during late Quaternary from Core MD05-2901 off Middle Vietnam in the western South China Sea are re-ported to reconstruct a history of East Asian monsoon evolution. Variations in Illite, chlorite, and kaolinite contents indicate a strong glacial-interglacial cyclicity, while changes in smectite content present a higher frequency cyclicity. The provenance analysis indicates a mixture of individual clay minerals from various sources surrounding the South China Sea. Smectite derived mainly from the Sunda shelf and its major source area of the Indonesian islands. Illite and chlorite originated mainly from the Mekong and Red rivers. Kaolinite was provided mainly by the Pearl River. Spectral analysis of the kaolin-ite/(illite+chlorite) ratio displays a strong eccentricity period of 100 ka, implying the ice sheet-forced win-ter monsoon evolution; whereas higher frequency changes in the smectite content show an ice sheet-forced obliquity period of 41 ka, and precession periods of 23 and 19 ka and a semi-precession period of 13 ka as well, implying the tropical-forced summer monsoon evolution. The winter monsoon evolution is generally in coherence with the glacial-interglacial cyclicity, with intensified winter monsoon winds during glacials and weakened winter monsoon winds during interglacials; whereas the summer monsoon evolution provides an almost linear response to the summer insolation of low latitude in the Northern Hemisphere, with strengthened summer monsoon during higher insolation and weakened summer monsoon during lower insolation. The result suggests that the high-latitude ice sheet and low-latitude tropical factor could drive the late Quaternary evolution of East Asian winter and summer monsoons, respectively, implying their diplex and self-contained forcing mechanism. | Christophe COLIN | 2007 | Science China Earth Sciences2007，50，11： | 24 |
| 8 | A high-resolution clay mineralogical record in the northern South China Sea since the Last Glacial Maximum,and its time series provenance analysis显示文摘High-resolution clay mineralogical analysis of Core MD05-2904 in the northern South China Sea(SCS) covering the period since the Last Glacial Maximum shows that illite(29%-48%),smectite(14%-45%),chlorite(17%-28%),and minor kaolinite(6%-14%) comprise the clay mineral assemblage,and that time series variation does not present glacial-interglacial cyclicity.Provenance analysis indicates three end-member sources:almost all smectite derives from Luzon,all kaolinite is sourced from the Pearl River,and illite and chlorite originate from both the Pearl River and Taiwan.By comparing clay mineral compositions in surface sediments from the three major source areas and of the SCS,we reconstructed a time series of clay mineral contribution from the major provenances to the northern slope of the SCS using the linear separation method for illite crystallinity.There were three stages of provenance change.(1) During 24.1-17.5 ka BP,contributions from Taiwan and Luzon were similar(30%-40%),while that from the Pearl River was only 25%.(2) During 17.5-14.0 ka BP,the contribution from Luzon decreased rapidly to 20%-25%,while that from Taiwan increased to 35% from an average of 25% at 18 ka BP,and that from the Pearl River increased largely to 40%.(3) During the Holocene,differences in contributions from the three major provenances increased:the contribution from Luzon increased slightly and then remained at 27%-35%,that from Taiwan increased rapidly and then remained at 55%-60%,and that from the Pearl River decreased to 15%.The change in clay mineral contributions from different provenances is influenced mainly by clay mineral production,monsoon rainfall denudation,oceanic current transport,and sea-level change. | LIU ZhiFei LI XiaJing COLIN Christophe GE HuangMin | 2010 | Chinese Science Bulletin2010，55，35： | 20 |
| 9 | 南海北部末次冰盛期以来高分辨率黏土矿物记录及其时间序列物源区分析显示文摘南海北部MD05-2904孔末次冰盛期以来黏土矿物学的高分辨率分析表明,伊利石(29%~48%)、蒙脱石(14%~45%)、绿泥石(17%~28%)和少量高岭石(6%~14%)构成了该孔的黏土矿物组合,其时间序列变化不具冰期-间冰期的旋回特征.物源区分析显示,MD05-2904孔的蒙脱石几乎全部都是源自吕宋岛,全部高岭石都是源自珠江,而伊利石和绿泥石分别由珠江和台湾岛提供.根据同这3个主要物源区和南海表层现代沉积物中黏土矿物成分的对比,采用伊利石结晶度的线性剥离方法,建立了各主要物源区对南海北部陆坡黏土矿物相对贡献量的时间序列变化.研究结果发现,吕宋岛和台湾岛的贡献在24.1~17.5kaBP都维持在30%~40%,而珠江的贡献平均仅有25%;在进入17.5~14.0kaBP后,吕宋岛的贡献快速降为20%~25%,台湾岛的贡献从18kaBP的平均25%上升至平均35%,而珠江的贡献上升为平均40%;在进入全新世后,这3个主要物源区的贡献显著差异化,吕宋岛的贡献小幅上升并维持在27%~35%,台湾岛的贡献快速上升并维持在55%~60%,而珠江的贡献逐渐回落至全新世中晚期的平均15%.各物源区的黏土矿物贡献可能受黏土矿物形成、季风降雨剥蚀、洋流搬运能力、以及海平面变化等多种因素影响. | 刘志飞 李夏晶 COLIN Christophe 葛黄敏 | 2010 | 科学通报2010，55，29： | 17 |
| 10 | 南海南部末次冰期浊流沉积的高分辨率沉积学和地球化学研究显示文摘通过对南海南部巽他陆坡底部MD05-2895孔末次冰期发育的浊流沉积物进行激光粒度和XRF岩芯元素扫描分析,试图揭示其沉积学和地球化学特性,进而对理解浊流形成过程提供帮助.研究结果显示,浊流沉积层中的碎屑颗粒粒径比正常深海沉积物有大幅度增加,在地球化学成分上表现为Si,K,Ti,Fe等元素异常富集,表明浊流发生时有大量粗颗粒陆源碎屑物质输入.显微观察发现,这些粗颗粒碎屑物质主要由石英、长石、火山玻璃、以及少量含铁含钛重矿物组成,推断应来源于巽他陆架上部的残留沉积,可能与末次冰期时古巽他河输送的陆源物质有关.分析认为这些浊流活动的发生可能与末次冰期时海平面快速变化造成的海岸线大幅移动及沉积物供给不稳定有关,而在单次浊流活动中浊流沉积物的形成主要是受重力(对不同比重、粒级颗粒的)分选的控制. | 赵玉龙 刘志飞 COLIN Christophe 谢昕 吴琼 | 2011 | 科学通报2011，56，31： | 9 |
| 11 | 傅里叶变换红外光谱(FTIR)方法在南海定量矿物学研究中的应用:以MD01-2393孔为例显示文摘傅里叶变换红外光谱 (FTIR)方法以其测量多种矿物绝对含量的能力在古环境研究中有很大的优势 .运用FTIR方法分析了南海南部湄公河口MD0 1 - 2 393孔的矿物成分含量 ,对比运用X射线衍射 (XRD)的半定量分析方法 ,研究了青藏高原东部和湄公河盆地晚第四纪 1 90ka以来风化剥蚀演化历史 .结果显示 ,全岩高岭石 /石英和粘土粒级 ( <2 μm)高岭石 /蒙脱石比率可用作陆源区风化侵蚀的矿物学标志 .晚第四纪 190ka以来 ,青藏高原东部和湄公河盆地机械侵蚀作用在冰期比间冰期强 ,化学风化作用在间冰期比冰期强 ,揭示出亚洲季风气候驱动的风化剥蚀演化历史 .全新世期间 ,虽然全岩高岭石 /石英与粘土粒级 ( <2 μm)蒙脱石 /高岭石比率指示相同趋势的风化剥蚀作用 ,但全岩高岭石 /石英比率显示更强的机械侵蚀能力 。 | 刘志飞 Christophe Colin Alain Trentesaux | 2005 | 地球科学(中国地质大学学报)2005，30，1： | 8 |
| 12 | Turbidite deposition in the southern South China Sea during the last glacial: Evidence from grain-size and major elements records显示文摘High-resolution grain size and major element geochemical measurements were performed on the marine sediments of Core MD05-2895 to help understand the formation of turbidite sequences. Grain-size results show that these turbidite sediments contain more coarse sediment grains than normal marls. The coarse sediment grains are mostly derived from relict sediments on the Sunda Shelf. Relict sediments are composed mainly of quartz, feldspar, tephra and a few titaniferous or ferruginous heavy minerals. Corresponding to the concentration of these minerals, increases in Si/Al, K/Al, Ti/Al and Fe/Al ratios are observed in the turbidite layers. As all the observed turbidite sequences were deposited during the last glacial, the occurrence of these turbidity events is implied to be closely related to instabilities in sea-level-induced sediment supply. We suggest that deposition of sediment particles from a single turbidity current is usually controlled by a counterbalance between gravity and buoyancy, with the interaction of individual grains being of minor importance. | ZHAO YuLong LIU ZhiFei COLIN Christophe XIE Xin WU Qiong | 2011 | Chinese Science Bulletin2011，56，33： | 7 |
| 13 | Paleoclimate and Paleoenvironment of Gonghe Basin, Qinghai-Tibet Plateau, During the Lastdeglacial: Weathering, Erosion and Vegetation Cover Affect Clay Mineral Formation显示文摘With the analysis of the sources and formation mechanism of the clay minerals in the sediment core from the Dalianhai lake in the Gonghe Basin, northeastern Tibet-Qinghai Plateau, clay mineral composition proxies, grain-size and carbonate contents have been employed for highresolution study in order to reconstruct East Asian Summer Monsoon(EASM) over the northeastern Tibet-Qinghai Plateau during the lastdeglacial. The study also extended to establish a relationship between vegetation cover changes and erosion during the last 14.5 ka with pollen record and clay mineral proxies. Smectite/kaolinite and smectite/(illite+chlorite) ratios allow us to assess hydrolysis conditions in lowlands and/or physical erosion process in highlands of the Gonghe Basin. Before 12.9 Cal ka BP, both mineralogical ratios show low values indicative of strong physical erosion in the basin with a dominant cold and dry phase. After 12.9 Cal ka BP, an increase in both mineralogical ratios indicates enhanced chemical weathering in the basin associated with a warm and humid climate. The beginning of Holocene is characterized by high smectite/(illite+chlorite) and smectite/kaolinite ratios that is synchronous as with deposition of many peat laminae, implying the best warm and humid conditions specifically between 8.0 to 5.5 Cal ka BP. The time interval after 5.0 Cal ka BP is characterized by a return to high physical erosion and low chemical weathering with dry climate conditions in the basin. Comparing variations of clay mineral assemblages with previous pollen results, we observe a rapid response in terms of chemical weathering and physical erosion intensity to a modification of the vegetation cover in the basin. | SUN Qingfeng Christophe COLIN | 2014 | Acta Geologica Sinica(English Edition)2014，88，2： | 6 |
| 14 | A history of high-power laser research and development in the United Kingdom显示文摘The first demonstration of laser action in ruby was made in 1960 by T.H.Maiman of Hughes Research Laboratories,USA.Many laboratories worldwide began the search for lasers using different materials,operating at different wavelengths.In the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications.This historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years. | Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone | 2021 | High Power Laser Science and Engineering2021，9，2： | 5 |
| 15 | 马来半岛和婆罗洲北部的化学风化作用:来自河流表层沉积物的黏土矿物和元素地球化学记录显示文摘硅酸盐岩的风化产物通常可以有效地用于研究陆地表面发生的化学风化作用及其控制因素.选择位于东南亚热带地区的马来半岛和婆罗洲北部,通过分析其主要流域表层沉积物的黏土矿物和主要元素地球化学组成,开展热带地区化学风化及其控制因素的现代过程研究.结果显示,马来半岛的黏土矿物组合以高岭石(平均80%)为主,其次为伊利石(17%),基本不含绿泥石和蒙脱石;而婆罗洲北部则是以伊利石和绿泥石为主,两者之和在西北和东北婆罗洲平均分别为84%和87%,其次为高岭石(14%),不含蒙脱石.通过全岩和黏土粒级颗粒主要元素地球化学分析发现,这两个地区的化学风化作用都呈现强烈状态.相对而言,从东北婆罗洲、西北婆罗洲到马来半岛,化学风化强度依次持续加强,马来半岛已达到非常强烈的化学风化状态.研究认为,以马来半岛和婆罗洲为代表的东南亚热带地区,热带温暖如一的气温和东亚季风降雨等气候条件是控制化学风化作用的一级因素,形成遍布热带地区的强烈化学风化作用;构造活动和母岩性质是影响化学风化作用的次级因素,但仍然对风化产物的产生重要影响,形成马来半岛和婆罗洲完全不同的黏土矿物组合. | 王浩 刘志飞 Edlic SATHIAMURTHY Christophe COLIN 李建如 赵玉龙 | 2011 | 中国科学:地球科学2011，41，2： | 4 |
| 16 | INTEGRABILITY VIA INVARIANT ALGEBRAIC CURVES FOR PLANAR POLYNOMIALDIFFERENTIAL SYSTEMS显示文摘We present an introduction to the Darboux integrability theory of planar complex and real polynomial differential systems containing some improvements to the classical theory. | Colin Christopher (School of Mathematics and Statistics, University of Plymouth, Plymouth, Devon PL4 SAA, UNITED KINGDOM) Jaume Llibre (Dopartament de Matematiques, Universitat Autonoma de Barcelona, 08193-Bellaterra, Barcelona, SPAIN) | 2000 | Annals of Differential Equations2000，16，1： | 4 |
| 17 | Chemical weathering in Malay Peninsula and North Borneo:Clay mineralogy and element geochemistry of river surface sediments显示文摘Weathering products of silicate rocks are particularly useful for evaluating the continental chemical weathering on the Earth's surface and its mechanism.Clay mineralogy and major-element geochemistry of surface sediment samples collected in major rivers of Malay Peninsula and North Borneo in the tropical Southeast Asian region are used to study the present chemical weathering process and its controlling factors of tropical regions.The results indicate that the clay mineral assemblage in Malay Peninsula consists dominantly of kaolinite(average 80%) and minor illite(average 17%),almost without chlorite and smectite,whereas in North Borneo it consists mainly of illite and chlorite,with minor amounts of kaolinite(average 14%) and no smectite.Total contents of illite and chlorite in both Northwest and Northeast Borneo are 84% and 87%,respectively.Major-element geochemical results of both bulk and clay-fraction sediments show intensive chemical weathering degree for both areas.Relatively,the chemical weathering degree is gradually strengthened from Northeast Borneo,Northwest Borneo,to Malay Peninsula,and it is extremely intensive in Malay Peninsula.Our results indicate that,in the tropical Southeast Asian region exampled by Malay Peninsula and Borneo,climatic condition of tropical warm temperature and East Asian monsoon rainfall is the first-order controlling factor on the chemical weathering,resulting in intensive chemical weathering throughout tropical areas,and tectonic activity and lithology of parent rocks are subordinate factors,which still have an important impact on the weathering products,forming completely different clay mineral assemblages between Malay Peninsula and Borneo. | WANG Hao LIU ZhiFei Edlic SATHIAMURTHY Christophe COLIN LI JianRu ZHAO YuLong | 2011 | Science China Earth Sciences2011，54，2： | 4 |
| 18 | Guidelines for the Management of Aneurysmal Subarachnoid Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association显示文摘 | E. Sander Connolly Alejandro A. Rabinstein J. Ricardo Carhuapoma Colin P. Derdeyn Jacques Dion Randall T. Higashida Brian L. Hoh Catherine J. Kirkness Andrew M. Naidech Christopher S. Ogilvy Aman B. Patel B. Gregory Thompson Paul Vespa | 2012 | Stroke2012，，6： | 3 |
| 19 | Expression of Transforming Growth Factor-β1 by Pancreatic Stellate Cells and Its Implications for Matrix Secretion and Turnover in Chronic Pancreatitis显示文摘 | Fanny Wai-Tsing Shek Robert Christopher Benyon Fiona Mairi Walker Peter Raymond McCrudden Sylvia Lin Foon Pender Elizabeth Jean Williams Penelope Ann Johnson Colin David Johnson Adrian Calvin Bateman David Roger Fine John Peter Iredale | 2002 | The American Journal of Pathology2002，，5： | 2 |
| 20 | Targeting inflammation in pancreatic cancer: Clinical translation显示文摘Preclinical modelling studies are beginning to aid development of therapies targeted against key regulators of pancreatic cancer progression. Pancreatic cancer is an aggressive, stromally-rich tumor, from which few people survive. Within the tumor microenvironment cellular and extracellular components exist, shielding tumor cells from immune cell clearance, and chemotherapy, enhancing progression of the disease. The cellular component of this microenvironment consists mainly of stellate cells and inflammatory cells. New findings suggest that manipulation of the cellular component of the tumor microenvironment is possible to promote immune cell killing of tumor cells. Here we explore possible immunogenic therapeutic strategies. Additionally extracellular stromal elements play a key role in protecting tumor cells from chemotherapies targeted at the pancreas. We describe the experimental findings and the pitfalls associated with translation of stromally targeted therapies to clinical trial. Finally, we discuss the key inflammatory signal transducers activated subsequent to driver mutations in oncogenic Kras in pancreatic cancer. We present the preclinical findings that have led to successful early trials of STAT3 inhibitors in pancreatic adenocarcinoma. | Colin William Steele Nina Angharad Kaur Gill Nigel Balfour Jamieson Christopher Ross Carter | 2016 | World Journal of Gastrointestinal Oncology2016，8，4： | 2 |
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