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| 1 | Mapping wetland changes in China between 1978 and 2008显示文摘Four wetland maps for all China have been produced,based on Landsat and CBERS-02B remote sensing data between 1978 and 2008 (1978,1990,2000 and 2008).These maps were mainly developed by manual interpretation and validated by substantial field investigation in 2009.Based on these maps,we analyzed the 2008 wetland distribution in China and discussed wetland changes and their drivers over the past 30 years.(i) There were about 324097 km 2 of wetlands in 2008,for which inland marshes or swamps were the most common wetland type (35%),with lakes (26%) second.Most of the wetlands were in Heilongjiang,Inner Mongolia,Qinghai and Tibet,occupying about 55% of the national wetland area.(ii) From 1978 to 2008,China's wetland area continually and significantly decreased,by about 33% based on changes in the wetland map.This was in sharp contrast to the increase in artificial wetlands,which increased by about 122%.Inland marshes accounted for the main loss of total wetlands from 1978 to 2000.From 2000 through 2008,riverine and lacustrine wetlands constituted the main wetland loss.Fortunately however,the rate of wetland loss decreased from 5523 to 831 km 2 /a.(iii) The change ratio of lost natural wetlands (including inland and coastal wetlands) to non-wetlands has decreased slightly over the past 30 years.From 1978 to 1990,nearly all natural wetlands (98%) lost were transformed into non-wetlands.However,the ratio declined to 86% from 1990 to 2000,and to 77% from 2000 to 2008.(iv) All Chinese provinces were divided into three groups according to patterns of wetland changes,which could relate to the driving forces of such changes.Tibet was completely different from other provinces,as it was one representative example in which there was a net wetland increase,because of global warming and decreased human activity since 1990.Increased economic development caused considerable wetland loss in most eastern provinces,and artificial wetlands increased. | NIU ZhenGuo ZHANG HaiYing WANG XianWei YAO WenBo ZHOU DeMin ZHAO KuiYi ZHAO Hui LI NaNa HUANG HuaBing LI CongCong YANG Jun LIU CaiXia LIU Shuang WANG Lin LI Zhan YANG ZhenZhong QIAO Fei ZHENG YaoMin CHEN YanLei SHENG YongWei GAO XiaoHong ZHU WeiHong WANG WenQing WANG Hong WENG YongLing ZHUANG DaFang LIU JiYuan LUO ZhiCai CHENG Xiao GUO ZiQi GONG Peng | 2012 | Chinese Science Bulletin2012，57，22： | 51 |
| 2 | Identification of long-range transport pathways and potential sources of PM2.5 and PM10 in Beijing from 2014 to 2015显示文摘Trajectory clustering, potential source contribution function(PSCF) and concentration-weighted trajectory(CWT) methods were applied to investigate the transport pathways and identify potential sources of PM_(2.5)and PM_(10) in different seasons from June 2014 to May 2015 in Beijing.The cluster analyses showed that Beijing was affected by trajectories from the south and southeast in summer and autumn. In winter and spring, Beijing was not only affected by the trajectories from the south and southeast, but was also affected by trajectories from the north and northwest. In addition, the analyses of the pressure profile of backward trajectories showed that backward trajectories, which have important influence on Beijing, were mainly distributed above 970 h Pa in summer and autumn and below 950 h Pa in spring and winter. This indicates that PM_(2.5)and PM_(10) were strongly affected by the near surface air masses in summer and autumn and by high altitude air masses in winter and spring. Results of PSCF and CWT analyses showed that the largest potential source areas were identified in spring, followed by winter and autumn,then summer. In addition, potential source regions of PM_(10) were similar to those of PM_(2.5). There were a clear seasonal and spatial variation of the potential source areas of Beijing and the airflow in the horizontal and vertical directions. Therefore, more effective regional emission reduction measures in Beijing's surrounding provinces should be implemented to reduce emissions of regional sources in different seasons. | Deping Li Jianguo Liu Jiaoshi Zhang Huaqiao Gui Peng Du Tongzhu Yu Jie Wang Yihuai Lu Wenqing Liu Yin Cheng | 2017 | Journal of Environmental Sciences2017，29，6： | 22 |
| 3 | A structural view of the antibiotic degradation enzyme NDM-1 from a superbug显示文摘Gram-negative Enterobacteriaceae with resistance to carbapenem conferred by New Delhi metallo-β-lactamase 1(NDM-1)are a type of newly discovered antibioticresistant bacteria.The rapid pandemic spread of NDM-1 bacteria worldwide(spreading to India,Pakistan,Europe,America,and Chinese Taiwan)in less than 2 months characterizes these microbes as a potentially major global health problem.The drug resistance of NDM-1 bacteria is largely due to plasmids containing the blaNDM-1 gene shuttling through bacterial populations.The NDM-1 enzyme encoded by the blaNDM-1 gene hydrolyzes β-lactam antibiotics,allowing the bacteria to escape the action of antibiotics.Although the biological functions and structural features of NDM-1 have been proposed according to results from functional and structural investigation of its homologues,the precise molecular characteristics and mechanism of action of NDM-1 have not been clarified.Here,we report the threedimensional structure of NDM-1 with two catalytic zinc ions in its active site.Biological and mass spectroscopy results revealed that D-captopril can effectively inhibit the enzymatic activity of NDM-1 by binding to its active site with high binding affinity.The unique features concerning the primary sequence and structural conformation of the active site distinguish NDM-1 from other reported metallo-β-lactamases(MBLs)and implicate its role in wide spectrum drug resistance.We also discuss the molecular mechanism of NDM-1 action and its essential role in the pandemic of drug-resistant NDM-1 bacteria.Our results will provide helpful information for future drug discovery targeting drug resistance caused by NDM-1 and related metallo-β-lactamases. | Yu Guo Jing Wang Guojun Niu Wenqing Shui Yuna Sun Honggang Zhou Yaozhou Zhang Cheng Yang Zhiyong Lou Zihe Rao | 2011 | Protein & Cell2011，2，5： | 16 |
| 4 | Insect flight speed estimation analysis based on a full-polarization radar显示文摘Dear editor,As most migratory insects are nocturnal, the entomological radar with the advantage of all-time and all-weather application is the most effective technique for insect migration observation [1]. Generally, the current entomological radar could be categorized into the scanning radar and verticallooking radar (VLR). The aerial density of migration could be measured by the scanning radar,while the flight speed, displacement direction, | Cheng HU Wenqing LI Rui WANG Yuanhao LI Weidong LI Tianran ZHANG | 2018 | Science China(Information Sciences)2018，61，10： | 9 |
| 5 | Vertical Distribution Characteristics of PM2.5 Observed by a Mobile Vehicle Lidar in Tianjin, China in 2016显示文摘We present mobile vehicle lidar observations in Tianjin, China during the spring, summer, and winter of 2016. Mobile observations were carried out along the city border road of Tianjin to obtain the vertical distribution characteristics of PM_(2.5). Hygroscopic growth was not considered since relative humidity was less than 60% during the observation experiments. PM_(2.5) profile was obtained with the linear regression equation between the particle extinction coefficient and PM_(2.5) mass concentration. In spring, the vertical distribution of PM_(2.5) exhibited a hierarchical structure. In addition to a layer of particles that gathered near the ground, a portion of particles floated at 0.6–2.5-km height. In summer and winter, the fine particles basically gathered below 1 km near the ground. In spring and summer, the concentration of fine particles in the south was higher than that in the north because of the influence of south wind. In winter, the distribution of fine particles was opposite to that measured during spring and summer. High concentrations of PM_(2.5) were observed in the rural areas of North Tianjin with a maximum of 350 μg m–3 on 13 December2016. It is shown that industrial and ship emissions in spring and summer and coal combustion in winter were the major sources of fine particles that polluted Tianjin. The results provide insights into the mechanisms of haze formation and the effects of meteorological conditions during haze–fog pollution episodes in the Tianjin area. | Lihui LYU Yunsheng DONG Tianshu ZHANG Cheng LIU Wenqing LIU Zhouqing XIE Yan XIANG Yi ZHANG Zhenyi CHEN Guangqiang FAN Leibo ZHANG Yang LIU Yuchen SHI Xiaowen SHU | 2018 | Journal of Meteorological Research2018，32，1： | 5 |
| 6 | Crustal Motion Characteristics in the Eastern Margin of the Tibetan Plateau and Adjacent Regions after the Wenchuan Earthquake显示文摘The Wenchuan earthquake has altered the crustal motion characteristics in the eastern margin of the Tibetan Plateau and adjacent regions.Using discontinuous GPS survey data for 2008–2012, the velocity field for the Eurasia reference framework has been obtained, and the general trend of contemporary crustal motion after the occurrence of the Wenchuan earthquake has been studied.In addition, using the velocity field, the block movement velocity has been estimated by least-squares fitting.Furthermore, the properties and displacement rates of main faults have been obtained from the differences in velocity vectors of the blocks on both sides of the faults.The results reveal that there are no obvious changes in the general characteristics of crustal motion in this area after the Wenchuan earthquake.The earthquake mainly changed the rate of the movement of the Chuan-Qing block and caused variation in the movement direction of the South China block.The effect of the earthquake on faults is mainly reflected in variations in fault displacement velocity; there is no fundamental change in the properties of fault activity.The displacement rates of the Xianshuihe fault decreased by 3–4 mm/a, the Longmenshan fault increased by 9–10 mm/a, and the northern segment of the Anninghe fault increased by approximately 9 mm/a.Furthermore, the displacement rates of the Minjiang, Xueshan, Huya, Longquanshan, and Xinjin faults increased by 2–3 mm/a.This implies that the effects of the Wenchuan earthquake on crustal movement can mainly be observed in the Chuan-Qing, South China, and N-Chuan-Dian blocks and their internal faults, as well as the Xianshuihe and Longmenshan faults and the northern section of the Anninghe fault.The reason for this is that the Wenchuan earthquake disturbed the kinematic and dynamic balance in the region. | TANG Wenqing ZHANG Qingzhi PAN Zhongxi LI Jun YANG Cheng | 2015 | Acta Geologica Sinica(English Edition)2015，89，5： | 5 |
| 7 | Combined detection and subclass characteristics analysis of CTCs and CTECs by SE-iFISH in ovarian cancer显示文摘Objective:Hematogenous metastasis is essential for the progression of ovarian cancer(OC),and circulating tumor cells(CTCs)are part of the metastatic cascade.However,the detection rate of CTC is low due to the use of less sensitive detection methods.Therefore,this study aimed to detect CTCs and circulating tumorigenic endothelial cells(CTECs)in patients with OC using subtraction enrichment and immunostaining and fluorescence in situ hybridization(SE-iFISH).Methods:We enrolled a total of 56 subjects,including 20 OC patients and 36 ovarian benign tumor patients.CTCs and CTECs were captured by subtraction enrichment(SE)and counted and classified according to immunofluorescence staining of tumor markers(TMs)carbohydrate antigen 125(CA125)and human epididymis protein 4(HE4)combined with fluorescence in situ hybridization(iFISH)of chromosome 8(Chr8)aneuploidy.The diagnostic value and subtype characteristics of CTCs and CTECs were investigated.Results:The detection rate of CTCs by SE-iFISH was high.Compared with CA125 and HE4,Chr8 aneuploidy was the major identification feature of CTC.CTC counts in OC were statistically higher than those in benign groups.CTC and CTEC with≥pentaploidy were detected in both groups,illustrating the poor diagnostic value of CTC or CTEC.Distributions of triploid and tetraploid CTC subtypes were significantly different,and combined detection of triploid and tetraploid CTCs showed the best diagnostic value.In contrast,the distribution of CTECs in the OC and benign groups had no statistically significant difference.Small CTCs accounted for over 1/3 of the total CTC count.We also found that small CTCs and CTECs primarily comprised triploid cells,while large CTCs and CTECs mainly comprised pentaploidy and beyond.Conclusions:The application of SE-iFISH offered a more comprehensive understanding of heterogeneous CTCs and CTECs in OC.Analysis of subclass characteristics of the CTCs and CTECs according to Chr8 aneuploidy and cell size may broaden their potential clinical utility and deepen mechanistic studies in OC. | Hongyan Cheng Shang Wang Wenqing Luan Xue Ye Sha Dou Zhijian Tang Honglan Zhu Peter Ping Lin Yi Li Heng Cui Xiaohong Chang | 2021 | Chinese Journal of Cancer Research2021，33，2： | 3 |
| 8 | G protein-coupled receptors: structure- and function-based drug discovery显示文摘As one of the most successful therapeutic target families,G protein-coupled receptors(GPCRs)have experienced a transformation from random ligand screening to knowledge-driven drug design.We are eye-witnessing tremendous progresses made recently in the understanding of their structure-function relationships that facilitated drug development at an unprecedented pace.This article intends to provide a comprehensive overview of this important field to a broader readership that shares some common interests in drug discovery. | Dehua Yang Qingtong Zhou Viktorija Labroska Shanshan Qin Sanaz Darbalaei Yiran Wu Elita Yuliantie Linshan Xie Houchao Tao Jianjun Cheng Qing Liu Suwen Zhao Wenqing Shui Yi Jjiang Ming-Wei Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 3 |
| 9 | Structural basis of the Norrin-Frizzled 4 interaction显示文摘 | Guobo Shen Jiyuan Ke Zhizhi Wang Zhihong Cheng Xin Gu Yuquan Wei Karsten Melcher H Eric Xu Wenqing Xu | 2015 | Cell Research2015，25，9： | 3 |
| 10 | Oxygen vacancies enable the visible light photoactivity of chromium-implanted TiO2 nanowires显示文摘Although computational studies have demonstrated that metal ion doping can effectively narrow the bandgap of TiO_(2),the visible-light photoactivity of metal-doped TiO_(2) photoanodes is still far from satisfactory.Herein,we report an effective strategy to activate the visible-light photoactivity of chromiumimplanted TiO_(2) via the incorporation of oxygen vacancies.The chromium-doped TiO_(2) activated by oxygen vacancies(Cr-TiO_(2)-vac)exhibited an incident photon-to-electron conversion efficiency(IPCE)of~6.8%at450 nm,which is one of the best values reported for metal-doped TiO_(2).Moreover,Cr-TiO_(2)-vac showed no obvious photocurrent decay after 100 h under visible-light illumination. | Xianyin Song Wenqing Li Xiaojing Liu Yishang Wu Dong He Zunjian Ke Li Cheng Changzhong Jiang Gongming Wang Xiangheng Xiao Yat Li | 2021 | Journal of Energy Chemistry2021，30，4： | 2 |
| 11 | Present-day Block Movement and Fault Activity on the Eastern Margin of the Tibetan Plateau显示文摘The geology and tectonics in the eastern margin of Tibetan Plateau are complex. The main tectonic framework is composed of blocks and faults. Using discontinuous global positioning system survey data for 2008–2014, the velocity field for the Eurasia reference framework was obtained. Based on the velocity field, the present-day velocities of the blocks and boundary faults were estimated. The results reveal that the movement rates of the Chuan-Qing, South China, Chuan-Dian and Indo-China blocks are(17.02±0.60) mm/a,(8.77±1.51) mm/a,(13.85±1.31) mm/a and(6.84 ± 0.74) mm/a, respectively, and their movement directions are 99.5°, 120.3°, 142.9° and 153.3°, respectively. All blocks exhibit clockwise rotation. The displacement rates of the Xianshuihe, Longmenshan, Anninghe, Zemuhe, Xiaojiang and Red River faults are(7.30±1.25–8.30±1.26) mm/a,(10.07±0.97–11.79±0.89) mm/a,(0.96±0.74–2.98±1.73) mm/a,(2.03±0.49–3.20±0.73) mm/a,(3.45±0.40–6.02±0.50) mm/a and(6.23±0.56) mm/a, respectively. The Xianshuihe, Anninghe, Zemuhe and Xiaojiang faults show leftlateral strike-slip movement, while the Longmenshan and Red River faults show right-lateral strikeslip. These characteristics of the blocks and faults are related to the particular tectonic location and dynamic mechanism. | TANG Wenqing ZHANG Yongshuang ZHANG Qingzhi ZHOU Hongfu PAN Zhongxi LI Jun YANG Cheng | 2016 | Acta Geologica Sinica(English Edition)2016，90，2： | 2 |
| 12 | An Energy-efficient V-BLAST Based Cooperative MIMO Transmission Scheme for Wreless Sensor Networks显示文摘 | XU Kanru YUAN Wei CHENG Wenqing | 2008 | IEEE WCNC Conference2008，，： | 1 |
| 13 | An Efficient Authentication Scheme based on One-Way Key Chain for Sensor Network显示文摘 | Lang Weimin Cheng Wenqing Yang Zongkai Tan Yunmeng | 2004 | Journal of Harbin Institute of Technology2004，11，4： | 1 |
| 14 | A new π-conjugated star-shaped polymer comprising of full fluorene units: An efficient blue emitter without reduction of color purity undergoing an annealing显示文摘 | Shijie Ren Jiangong Cheng Danli Zeng Wenqing Zhu Jing Sun Junping Du Erjian Xu Hongliang Zhong Yingchun Liu Qiang Fang | 2008 | Synthetic Metals2008，，1： | 1 |
| 15 | Bilateral Collaborative Optimization for Cloud Manufacturing Service显示文摘Manufacturing service composition of the supply side and scheduling of the demand side are two important components of Cloud Manufacturing,which directly affect the quality of Cloud Manufacturing services.However,the previous studies on the two components are carried out independently and thus ignoring the internal relations and mutual constraints.Considering the two components on both sides of the supply and the demand of Cloud Manufacturing services at the same time,a Bilateral Collaborative Optimization Model of Cloud Manufacturing(BCOM-CMfg)is constructed in this paper.In BCOM-CMfg,to solve the manufacturing service scheduling problem on the supply side,a new efficient manufacturing service scheduling strategy is proposed.Then,as the input of the service composition problem on the demand side,the scheduling strategy is used to build the BCOM-CMfg.Furthermore,the Cooperation Level(CPL)between services is added as an evaluation index in BCOM-CMfg,which reveals the importance of the relationship between services.To improve the quality of manufacturing services more comprehensively.Finally,a Self-adaptive Multi-objective Pigeon-inspired Optimization algorithm(S-MOPIO)is proposed to solve the BCOM-CMfg.Simulation results show that the BCOM-CMfg model has advantages in reliability and cost and S-MOPIO can solve BCOM-CMfg effectively. | Bin Xu Yong Tang Yi Zhu Wenqing Yan Cheng He Jin Qi | 2020 | Computers, Materials & Continua2020，，9： | 1 |
| 16 | Classification of two species of Bidens based on discrete stationary wavelet transform extraction of FTIR spectra combined with probability neural network显示文摘 | Cungui Cheng Jia Liu Wenqing Cao Renwei Zheng Hong Wang Changjiang Zhang | 2010 | Vibrational Spectroscopy2010，，1： | 1 |
| 17 | Tubulointerstitial nephritis antigen-like 1 is a novel matricellular protein that promotes gastric bacterial colonization and gastritis in the setting of Helicobacter pylori infection显示文摘The interaction between the gastric epithelium and immune cells plays key roles in H. pylori-associated pathology. Here, we demonstrate a procolonization and proinflammatory role of tubulointerstitial nephritis antigen-like 1 (TINAGL1), a newly discovered matricellular protein, in H. pylori infection. Increased TINAGL1 production by gastric epithelial cells (GECs) in the infected gastric mucosa was synergistically induced by H. pylori and IL-1β via the ERK-SP1 pathway in a cagA-dependent manner. Elevated human gastric TINAGL1 correlated with H. pylori colonization and the severity of gastritis, and mouse TINAGL1 derived from non-bone marrow-derived cells promoted bacterial colonization and inflammation. Importantly, H. pylori colonization and inflammation were attenuated in Tinagl1−/− and Tinagl1ΔGEC mice and were increased in mice injected with mouse TINAGL1. Mechanistically, TINAGL1 suppressed CCL21 expression and promoted CCL2 production in GECs by directly binding to integrin α5β1 to inhibit ERK and activate the NF-κB pathway, respectively, which not only led to decreased gastric influx of moDCs via CCL21-CCR7-dependent migration and, as a direct consequence, reduced the bacterial clearance capacity of the H. pylori-specific Th1 response, thereby promoting H. pylori colonization, but also resulted in increased gastric influx of Ly6Chigh monocytes via CCL2-CCR2-dependent migration. In turn, TINAGL1 induced the production of the proinflammatory protein S100A11 by Ly6Chigh monocytes, promoting H. pylori-associated gastritis. In summary, we identified a model in which TINAGL1 collectively ensures H. pylori persistence and promotes gastritis. | Yongsheng Teng Rui Xie Jingyu Xu Pan Wang Wanyan Chen Zhiguo Shan Zongbao Yan Fangyuan Mao Ping Cheng Liusheng Peng Jinyu Zhang Wenqing Tian Shiming Yang Yongliang Zhao Weisan Chen Quanming Zou Yuan Zhuang | 2023 | Cellular & Molecular Immunology2023，20，8： | 1 |
| 18 | Preparation and characterization of targeted DOX–PLGA–PEG micelles decorated with bivalent fragment HAb18 F(ab′) 2 for treatment of hepatocellular carcinoma显示文摘 | Cheng Jin Wenqing Yang Ling Bai Junqing Wang Kefeng Dou | 2011 | Journal of Controlled Release2011，，： | 1 |
| 19 | Direct observation of hydrogen-trapping sites in newly developed high-strength mooring chain steel by atom probe tomography显示文摘Hydrogen-trapping sites were directly observed by using a three-dimensional atom probe(3DAP) in high-strength mooring chain steel.Three typical 3DAP datasets show that trapping hydrogen is mainly enriched in retained austenite,and secondarily in carbides.In addition,these interfaces between ferrite and carbide are segregated by phosphorus,but do not admit hydrogen. | Xiaoying Cheng Zhijuan Zhang Wenqing Liu Xiaojiao Wang | 2013 | Progress in Natural Science:Materials International2013，23，4： | 1 |
| 20 | DsMTOPVIB Promotes Meiotic DNA Double-Strand Break Formation in Rice显示文摘 | Zhihui Xue Yafei Li LeiZhang Wenqing Shi Chao Zhang Mengshi Feng Fanfan Zhang Ding Tang Hengxiu Yu Minghong Gu Zhukuan Cheng | 2016 | Molecular Plant2016，9，11： | 0 |
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