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| 1 | Antimony(V) removal from water by iron-zirconium bimetal oxide: Performance and mechanism显示文摘A Fe-Zr binary oxide adsorbent has been successfully synthesized using a co-precipitation method. It showed a better performance for antimonate (Sb(V)) removal than zirconium oxide or amorphous ferric oxide. The experimental results showed that the Fe-Zr adsorbent has a capacity of 51 mg/g at an initial Sb(V) concentration of 10 mg/L at pH 7.0. Sb(V) adsorption on the Fe-Zr bimetal oxide is normally an endothermic reaction. Most of the Sb(V) adsorption took place within 3 hr and followed a pseudo second-order rate law. Co-existing anions such as SO42- , NO3- and Cl- had no considerable effects on the Sb(V) removal; PO34 had an inhibitory effect to some extent at high concentration; while CO32- and SiO44- showed significant inhibitory effects when they existed in high concentrations. The mechanism of Sb(V) adsorption on the adsorbent was investigated using a combination of zeta potential measurements, XPS, Raman, FT-IR observations and SO42- release determination. The ionic strength dependence and zeta potential measurements indicated that inner-sphere surface complexes were formed after Sb(V) adsorption. Raman and XPS observations demonstrated that both Fe-OH and Zr-OH sites at the surface of the Fe-Zr adsorbent play important roles in the Sb(V) adsorption. FT-IR characterization and SO42- release determination further demonstrated that the exchange of SO42- with Sb(V) also could promote the adsorption process. In conclusion, this adsorbent showed high potential for future application in Sb(V) removal from contaminated water. | Xuehua Li Xiaomin Dout Junqing Li | 2012 | Journal of Environmental Sciences2012，24，7： | 21 |
| 2 | Effect of different concentrations of surfactant on the wettability of coal by molecular dynamics simulation显示文摘Anionic surfactant sodium dodecyl benzene sulfonate(SDBS)at varying concentrations was selected to investigate the influence on the wettability of Zhaozhuang Coal by molecular dynamics simulation.Six groups of water/surfactant/coal systems with different concentrations were constructed.The influence of surfactant with different concentrations on the wettability of coal was concluded by analyzing various properties from the energetic behaviors to the dynamic characteristics.The results show that the interfacial tension decreases sharply and then rises slowly with the increase of SDBS surfactant concentration,obtaining that surfactants can obviously reduce the interfacial tension.The surfactant molecules could be detected at the water/coal interface through analyzing the system’s relative concentration distribution.In addition,the difference in the wettability of surfactants on coal surfaces is caused by the spatial distribution differences of alkyl chains and the benzene ring of the surfactant molecules.And the negative interaction energy between SDBS and the coal surface indicates that adsorption process is spontaneous.Furthermore,it is of great practical significance for improving the dust reduction effect and reducing the disaster of coal dust by exploring the effects of surfactant molecules on the wettability of coal. | Junqing Meng Feifei Yin Shichao Li Ruquan Zhong Zeyuan Sheng Baisheng Nie | 2019 | International Journal of Mining Science and Technology2019，29，4： | 20 |
| 3 | Pluripotent stem cells induced from mouse neural stem cells and small intestinal epithelial cells by small molecule compounds显示文摘最近,我们报导了一条化学途径从老鼠成纤维细胞产生 pluripotent 干细胞。然而,是否化学上导致了 pluripotent 干细胞(CiPSCs ) ,能从要示威的另外的房间类型遗体被导出。用系跟踪,这里,我们首先从成纤维细胞验证 CiPSCs 的产生。下次,我们证明从外胚层的神经干细胞(NSC ) 和从内胚叶的小肠的上皮的房间(IEC ) 能是化学上 reprogrammed 进 pluripotent 干细胞。CiPSCs 源于 NSC 和 IEC 类似于老鼠处于增长率,全球基因表示侧面, epigenetic 地位,自强和区别能力的胚胎的干细胞,和 germline 传播才能。有趣地, pluripotency 基因 Sall4 从不同房间类型,和一样的核心在化学 reprogramming 过程在起始的阶段被表示小分子为 reprogramming 被要求,在从这些多样的房间类型位于化学 reprogramming 下面的分子的机制建议保存。我们的分析也证明这些小分子的使用应该被调整从不同房间类型满足 reprogramming 的要求。一起,这些调查结果证明那条完整的化学 reprogramming 途径能在不同织物起源的房间被使用并且建议化学 reprogramming 是有要延长到更起始的类型的潜力的有希望的策略。 | Junqing Ye Jian Ge Xu Zhang Lin Cheng Zhengyuan Zhang Shan He Yuping Wang Hua Lin Weifeng Yang Junfang Liu Yang Zhao Hongkui Deng | 2016 | Cell Research2016，26，1： | 19 |
| 4 | Dynamic Field Division of Hydrocarbon Migration,Accumulation and Hydrocarbon Enrichment Rules in Sedimentary Basins显示文摘Hydrocarbon distribution rules in the deep and shallow parts of sedimentary basins are considerably different, particularly in the following four aspects. First, the critical porosity for hydrocarbon migration is much lower in the deep parts of basins: at a depth of 7000 m, hydrocarbons can accumulate only in rocks with porosity less than 5%. However, in the shallow parts of basins (i.e., depths of around 1000 m), hydrocarbon can accumulate in rocks only when porosity is over 20%. Second, hydrocarbon reservoirs tend to exhibit negative pressures after hydrocarbon accumulation at depth, with a pressure coefficient less than 0.7. However, hydrocarbon reservoirs at shallow depths tend to exhibit high pressure after hydrocarbon accumulation. Third, deep reservoirs tend to exhibit characteristics of oil (-gas)-water inversion, indicating that the oil (gas) accumulated under the water. However, the oil (gas) tends to accumulate over water in shallow reservoirs. Fourth, continuous unconventional tight hydrocarbon reservoirs are distributed widely in deep reservoirs, where the buoyancy force is not the primary dynamic force and the caprock is not involved during the process of hydrocarbon accumulation. Conversely, the majority of hydrocarbons in shallow regions accumulate in traps with complex structures. The results of this study indicate that two dynamic boundary conditions are primarily responsible for the above phenomena: a lower limit to the buoyancy force and the lower limit of hydrocarbon accumulation overall, corresponding to about 10%-12% porosity and irreducible water saturation of 100%, respectively. These two dynamic boundary conditions were used to divide sedimentary basins into three different dynamic fields of hydrocarbon accumulation: the free fluid dynamic field, limit fluid dynamic field, and restrain fluid dynamic field. The free fluid dynamic field is located between the surface and the lower limit of the buoyancy force, such that hydrocarbons in this field migrate and accumulate under the influence of, for example, the buoyancy force, pressure, hydrodynamic force, and capillary force. The hydrocarbon reservoirs formed are characterized as 'four high,' indicating that they accumulate in high structures, are sealed in high locations, migrate into areas of high porosity, and are stored in reservoirs at high pressure. The basic features of distribution and accumulation in this case include hydrocarbon migration as a result of the buoyancy force and formation of a reservoir by a caprock. The limit fluid dynamic field is located between the lower limit of the buoyancy force and the lower limit of hydrocarbon accumulation overall; the hydrocarbon migrates and accumulates as a result of, for example, the molecular expansion force and the capillary force. The hydrocarbon reservoirs formed are characterized as 'four low,' indicating that hydrocarbons accumulate in low structures, migrate into areas of low porosity, and accumulate in reservoirs with low pressure, and that oil(-gas)-water inversion occurs at low locations. Continuous hydrocarbon accumulation over a large area is a basic feature of this field. The restrain fluid dynamic field is located under the bottom of hydrocarbon accumulation, such that the entire pore space is filled with water. Hydrocarbons migrate as a result of the molecular diffusion force only. This field lacks many of the basic conditions required for formation of hydrocarbon reservoirs: there is no effective porosity, movable fluid, or hydrocarbon accumulation, and potential for hydrocarbon exploration is low. Many conventional hydrocarbon resources have been discovered and exploited in the free fluid dynamic field of shallow reservoirs, where exploration potential was previously considered to be low. Continuous unconventional tight hydrocarbon resources have been discovered in the limit fluid dynamic field of deep reservoirs; the exploration potential of this setting is thought to be tremendous, indicating that future exploration should be focused primarily in this direction. | PANG Xiongqi LIU Keyu MA Zhongzhen JIANG Zhenxue XIANG Caifu HUO Zhipeng PANG Hong CHEN Junqing | 2012 | Acta Geologica Sinica(English Edition)2012，86，6： | 13 |
| 5 | Scaling all-fiber mid-infrared supercontinuum up to 10 W-level based on thermal-spliced silica fiber and ZBLAN fiber显示文摘We demonstrate an integrated all-fiber mid-infrared(mid-IR)supercontinuum(SC)source generated by a 1.95μm master oscillator power amplifier system and a single-mode ZBLAN(ZrF_4–BaF_2–LaF_3–AlF_3–NaF)fiber.The maximum average output power is 10.67 W with spectral bandwidth covering from~1.9 to 4.1μm.The single-mode ZBLAN fiber and silica fiber are thermal-spliced to enhance the robustness and practicability of the system.It is,to the best of our knowledge,the first high-power integrated compacted all-fiber mid-IR SC source based on thermal-spliced silica fiber and ZBLAN fiber. | Zhijian Zheng Deqin Ouyang Junqing Zhao Minqiu Liu Shuangchen Ruan Peiguang Yan Jinzhang Wang | 2016 | Photonics Research2016，4，4： | 13 |
| 6 | The role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint control显示文摘真核细胞的房间的染色体在由环境代理人和内长的新陈代谢的副产品的连续袭击下面。在 DNA 导致的损坏通常导致细胞的事件的串联, DNA 损坏反应。DNA 损坏反应的失败能由减少 DNA 修理的效率和忠实导致恶意的开发。NBS1 蛋白质是在对 DNA 损坏和 chromosomal 正直的维护的细胞的反应起一个关键作用的 MRE11/RAD50/NBS1 建筑群(MRN ) 的一个部件。在 NBS1 基因的变化为 Nijmegen 破裂症候群(NBS ) 负责,给予增加的倾向到恶意的开发的世袭混乱。从病人们在 DNA 双海滨裂缝的修理指向缺乏的 NBS 孤立的房间的 phenotypic 特征。这里,我们在 DNA 损坏反应考察 NBS1 的角色的当前的知识。强调在 DNA 双海滨修理,察觉到并且发信号的 DNA 损坏的调整,房间周期检查点控制和 telomere 稳定性的维护被放在 NBS1 的角色上。 | Ying Zhang Junqing Zhou Chang UK Lim | 2006 | Cell Research2006，16，1： | 13 |
| 7 | Quantitative analysis of E-cadherin expression and clinicopathologic evaluation in gastric cancer显示文摘QuantitativeanalysisofEcadherinexpresionandclinicopathologicevaluationingastriccancer.DaiDongqiu,ChehJunqing,XuLei,etal.Canc... | Dai Dongqiu, Cheh Junqing, Xu Lei, et al. Cancer Institute, China Medical University, Shenyang 10001, China. | 1998 | Chinese Medical Journal1998，，1： | 11 |
| 8 | A unified model for the formation and distribution of both conventional and unconventional hydrocarbon reservoirs显示文摘The discovery and large-scale exploration of unconventional oil/gas resources since 1980s have been considered as the most important advancement in the history of petroleum geology;that has not only changed the balance of supply and demand in the global energy market,but also improved our understanding of the formation mechanisms and distribution characteristics of oil/gas reservoirs.However,what is the difference of conventional and unconventional resources and why they always related to each other in petroliferous basins is not clear.As the differences and correlations between unconventional and conventional resources are complex challenging issues and very critical for resources assessment and hydrocarbon exploration,this paper focused on studying the relationship of formations and distributions among different oil/gas reservoirs.Drilling results of 12,237 exploratory wells in 6 representative petroliferous basins of China and distribution characteristics for 52,926 oil/gas accumulations over the world were applied to clarify the formation conditions and genetic relations of different oil/gas reservoirs in a petroliferous basin,and then to establish a unified model to address the differences and correlations of conventional and unconventional reservoirs.In this model,conventional reservoirs formed in free hydrocarbon dynamic field with high porosity and permeability located above the boundary of hydrocarbon buoyancy-driven accumulation depth limit.Unconventional tight reservoirs formed in confined hydrocarbon dynamic field with low porosity and permeability located between hydrocarbon buoyancy-driven accumulation depth limit and hydrocarbon accumulation depth limit.Shale oil/gas reservoirs formed in the bound hydrocarbon dynamic field with low porosity and ultra-low permeability within the source rock layers.More than 75%of proved reserves around the world are discovered in the free hydrocarbon dynamic field,which is estimated to contain only 10%of originally generated hydrocarbons.Most of undiscovered resources distributed in the confined hydrocarbon dynamic field and the bound hydrocarbon dynamic field,which contains 90%of original generated hydrocarbons,implying a reasonable and promising area for future hydrocarbon explorations.The buried depths of hydrocarbon dynamic fields become shallow with the increase of heat flow,and the remaining oil/gas resources mainly exist in the deep area of“cold basin”with low geothermal gradient.Lithology changing in the hydrocarbon dynamic field causes local anomalies in the oil/gas dynamic mechanism,leading to the local formation of unconventional hydrocarbon reservoirs in the free hydrocarbon dynamic field or the occurrence of oil/gas enrichment sweet points with high porosity and permeability in the confined hydrocarbon dynamic field.The tectonic movements destroy the medium conditions and oil/gas components,which leads to the transformation of conventional oil/gas reservoirs formed in free hydrocarbon dynamic field to unconventional ones or unconventional ones formed in confined and bound hydrocarbon dynamic fields to conventional ones. | Xiongqi Pang Chengzao Jia Junqing Chen Maowen Li Wenyang Wang Qinhong Hu Yingchun Guo Zhangxin Chen Junwen Peng Keyu Liu Keliu Wu | 2021 | Geoscience Frontiers2021，12，2： | 8 |
| 9 | Research and development of drug delivery systems based on drug transporter and nano-formulation显示文摘In recent years,the continuous occurrence of multi-drug resistance in the clinic has made people pay more attention to the transporter.Changes in the expression and activity of transporters can cause corresponding changes in drug pharmacokinetics and pharmacodynamics.The drug-drug interactions(DDI)caused by transporters can seriously affect drug effectiveness and toxicity.In the development of pharmaceutical preparations,people have increasingly concerned about the effects and regulation of transporters in drug effects.To improve the targeting and physicochemical properties of drugs,the development of targeted agents is very rapid.Among them,novel nano-formulations are the best.With the continuous innovation and development of nano-formulation,its application has become more and more extensive.Nano-formulation has exerted certain advantages in the drug development based on transporters,and is also involved in the combination of targeted transporters.This review focuses on the application of novel nano-agents targeting transporters and the introduction of drug-transporter-based nano-formulations. | Yi Peng Lu Chen Sheng Ye Yu Kang Junqing Liu Su Zeng Lushan Yu | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，2： | 8 |
| 10 | Study on law of raw coal seepage during loading process at different gas pressures显示文摘In order to reveal the law of raw coal seepage at different gas pressures, the gravity constant load seepage experimental system was developed and used. The law of raw coal seepage at different gas pressures with He, N2 and CO2was investigated. The results show that, in a given state of stress during the experiment, with the increase of gas pressure, the permeability of raw coal sample prone to outburst exhibits a significantly decrease, and then exhibits an increasing trend when reaching the extreme point.The law of Klingberg coefficient related to the stress state and the gas adsorption properties was also obtained. Under the same experimental conditions, the Klingberg coefficient of He is greater than that of N2; and the Klingberg coefficient of CO2 has minimum value; so the stronger the gas adsorption is,the smaller the Klingberg coefficient of gas goes. Klinkenberg coefficient decreases with the increase of effective stress. Under the same conditions, the permeability of He is greater than that of N2; the permeability of CO2 has minimum value; so the stronger the gas adsorption is, the lower the permeability of the coal sample goes. The results have important significance in revealing the mechanism of gas seepage, predicting coal mine gas disaster, and gas drainage and safety production. | Meng Junqing Nie Baisheng Zhao Bi Ma Yechao | 2015 | International Journal of Mining Science and Technology2015，25，1： | 8 |
| 11 | Estimated cancer incidence and mortality in Hebei province,2012显示文摘Objective: This study estimates the numbers of new cancer cases and cancer deaths in Hebei province using incidence and mortality data from 9 population-based cancer registries in 2012.Methods: The data of new diagnosed cancer cases and cancer deaths in 2012 were collected from 9 population-based cancer registries of Hebei province in 2015. All the data met the National Central Cancer Registry of China(NCCR) criteria of data quality. The pooled data analysis was stratified by areas(urban/rural), gender, age group(0, 1-4, 5-9, 10-14, …, 85+) and cancer type. New cancer cases and deaths in Hebei province were estimated using age-specific rates and corresponding provincial population in 2012. The 10 most common cancers in different groups and the cumulative rates were calculated. Chinese population census in 2000 and Segi's population were used for age-standardized incidence/mortality rates. Results: All cancer registries covered 4,986,847 populations, 6.84% of Hebei provincial population(2,098,547 in urban and 2,888,300 in rural areas). The percentage of cases morphologically verified(MV%) and death certificate-only cases(DCO%) were 76.40% and 4.72%, respectively. The mortality to incidence rate ratio(M/I) was 0.64. In 2012, it is estimated that there were about 187,900 new diagnosed cancer cases and 119,800 cancer deaths in Hebei province. The incidence rate of cancer was 258.12/100,000(275.75/100,000 in males, 239.78/100,000 in females), and the age-standardized incidence rates by Chinese standard population(ASIRC) and by world standard population(ASIRW) were 210.65/100,000 and 208.50/100,000, with the cumulative incidence rates(0-74 years old) of 24.46%. The cancer incidence and ASIRC were 256.99/100,000 and 211.32/100,000 in urban areas and 258.94/100,000 and 209.99/100,000 in rural areas, respectively. The cancer mortality rate was 164.63/100,000(201.85/100,000 in males, 125.92/100,000 in females). Agestandardized mortality rates by Chinese standard population(ASMRC) and by world standard population(ASMRW) were 137.30/100,000 and 137.39/100,000 with the cumulative mortality rate(0-74 years old) of 14.58%, respectively. The cancer mortality rate in rural areas(167.16/100,000) was higher than that in urban areas(161.16/100,000). The most common cancers were lung cancer, stomach cancer, breast cancer, esophageal cancer, liver cancer and colorectal cancer, which accounted for 72.31% of all cancer cases. Lung cancer, stomach cancer, liver cancer, esophageal cancer and colorectal cancer were the major causes of cancer death in Hebei province, which accounted for 75.24% of all cancer deaths. The cancer spectrum differs between urban and rural, males and females in both incidence and mortality rates.Conclusions: The most common cancers were lung cancer, stomach cancer, esophageal cancer, breast cancer, liver cancer and colorectal cancer in Hebei province. | Yutong He Di Liang Daojuan Li Jingbo Zhai Junqing Zhu Jing Jin Denggui Wen Baoen Shan | 2016 | Chinese Journal of Cancer Research2016，28，3： | 8 |
| 12 | Hepatocyte growth factor improves right ventricular remodeling in pulmonary arterial hypertensive rats via decreasing neurohormonal activation and inhibiting apoptosis显示文摘 | Wang Xiaolin Wang Yongjin Rong Shuling Ma Hongbiao Ma Qing Zhao Junqing | 2014 | Chinese Medical Journal2014，，10： | 7 |
| 13 | Design and field tests of a deck-extension bridge with small box girder显示文摘A jointless bridge could fundamentally eliminate vulnerable deck joints, thereby meeting the need for sustainable development of bridges, especially for an expressway with highspeed traffic. In this paper, one jointless bridge(deck-extension bridge) with a small box girder in an expressway was chosen as a case study to examine the structural design,construction and field test. The field tests of the bridge indicated that the designed and constructed structures can satisfy the requirement for service performance of the deckextension bridge. Some key technologies, such as the position of longitudinal reinforcements in the superstructure-approach slab connections and the arrangement of the sliding material layers, were introduced. The longitudinal thermal movement of the superstructure in the deck-extension bridge with a small box girder could be predicted accurately by using the average temperature of the cross section of a small box girder. The finite element model, built by using the MIDAS program, was used to analyze the temperature distribution on the cross section of a small box girder, the accuracy of which could be verified by comparing with the measured values. The maximum longitudinal thermal movement of the superstructure in deck-extension bridges with a small box girder under historically extreme temperature conditions was predicted. | Junqing Xue Bruno Briseghella Jianhui Lin Fuyun Huang Baochun Chen | 2018 | Journal of Traffic and Transportation Engineering(English Edition)2018，5，6： | 7 |
| 14 | Hydrophilic bismuth sulfur nanoflower superstructures with an improved photothermal efficiency for ablation of cancer cells显示文摘Nanomaterials 与强烈在红外线附近(NIR ) 吸收展览有效 photon-to-thermal 精力转移能力和罐头产生热切除癌症房间,因此在 photothermal 癌症治疗学起一个枢轴的作用。此处,吸水的象花的铋硫(双性人 2 有一致尺寸的 S 3) 上层建筑和改进 NIR 吸收 controllably 经由 polyvinylpyrrolidone (PVP ) 帮助的一个灵巧的 solvothermal 过程被综合,它能调整产品形态学。由 808-nm 激光导致了,同样准备的双性人 2 S 3 nanoflowers 比双性人 2 当 PVP 不在时准备的 S 3 nanobelts (36.5%) 。这能被归因于双性人 2 与一个更低的乐队一起与 NIR 光而且到非结晶的结构的改进反射率和吸收用作许多激光洞镜子的 3-dimensional crumpled-paper-like nanosheets 装配的 S 3 nanoflower 上层建筑豁开。因此,当使用双性人 2 与相比的 S 3 nanoflowers 用双性人 2 S 3 nanobelts,它由于减少的毒性在治疗为使用使他们更有利。而且,这些双性人 2 S 3 nanoflowers 有效地在 vitro 并且在 vivo 完成了癌症房间的 photothermal 脱离。这些结果不仅支持了双性人 2 是的 S 3 nanoflowers 为癌症治疗的一个有希望的 photothermal 代理人而且铺了一条途径与改进 photothermal 效率利用新代理人。 | Zhiyin Xiao Chaoting Xu Xiaohong Jiang Wenlong Zhang Yuxuan Peng Rujia Zou Xiaojuan Huang Qian Liu Zongyi Qin Junqing Hu | 2016 | Nano Research2016，9，7： | 7 |
| 15 | Comparison of the Surface and Underground Natural Gas Occurrences in the Tazhong Uplift of the Tarim Basin显示文摘体积由探索的井的生产率揭示了的油,气体和水不反映实际地下的状况。在地质的条件下面,溶解天然气的某个数量在油或水被存储。在 Tazhong 基于探索的井的生产测试数据 Tarim 盆高举,这篇论文详细在在表面和地下的天然气之间的出现和分发 featrues 讨论差别;在不同温度,压力和中等条件下面根据天然气的可溶性介绍表面气体出现的恢复给实际地下的地质的条件;并且分类天然气进三个状态,即 oversaturated,浸透并且 undersaturated,根据它的相对内容地下。通过在表面和天然气的地下的出现的差别的比较分析,它讨论烃水库形成机制和分发规则,从而在学习区域为潜在的天然气水库分发的预言作为新方法和技术提供指导。 | TIAN Jun CHEN Junqing JIAO Jiao PANG Xiongqi | 2010 | Acta Geologica Sinica(English Edition)2010，84，5： | 6 |
| 16 | Simulation of electro-slag re-melting process of 120t large ingot for nuclear power station and its application显示文摘Further research on metallic materials for the super critical rotator and the main pipe line of a nuclear power station is very important for developing the nuclear power industry. In this study, the mathematical model for 120 t large ingot was established, and the computer program ESR3D was developed to simulate the whole electro-slag re-melting (ESR) process. This includes the electrode melting, metallic droplet falling, metal pool forming, metal pool and slag pool rising and moving, installation of top crystallizer, ingot solidifying, etc. The simulated average melting rate of the electrode was in good agreement with that in practical production. The optimized parameters were used to produce 80-120 t large ingots, and the quality of the ingots satisfied the specifications of nuclear power and the super critical generating unit. | Liu Xihai Wang Junqing Jia Weiguo Gao Jianjun Zhao Lin Tang Zuobin | 2011 | China Foundry2011，8，4： | 6 |
| 17 | Climate background of the evolution from Paleolithic to Neolithic cultural transition during the last deglaciation in the middle reaches of the Yellow River显示文摘Shizitan in Jixian County, Shanxi Province, is a site of transitional period from Paleolithic to Neolithic. The dating and the sporopollen analysis show that the middle reaches of the Yellow River where the site is located had been maintaining a steppe environment during 35.1-9.4 kaBP, in which, 35.1-17 kaBP belonged to the last glacial. With cold and dry climate, this period featured a desert steppe environment. In the late of this period, the area had a cold and half-humid steppe environment. The 17.0-11.9 kaBP belonged to the early- and mid-period of the last deglaciation. Mild and half-arid steppe alternates with mild and half-arid steppe, with a small amount of deciduous broadleaf species. During the period of 11.9-10.5 kaBP, cold and dry glacial climate appeared once more, featuring a desert steppe environment. During 10.5-9.4 kaBP, it is mild and half-arid, and later transited toward warm and half-humid. The early phase of this period featured a steppe environment and the later transited into a | Zhengkai Xia Ge Chen Gongwang Zheng Fuyou Chen Junqing Han | 2002 | Chinese Science Bulletin2002，47，1： | 6 |
| 18 | In vitro testicular organogenesis from human fetal gonads produces fertilization-competent spermatids显示文摘Unlike most organs that mature during the fetal period,the male reproductive system reaches maturity only at puberty with the commencement of spermatogenesis.Robust modelling of human testicular organogenesis in vitro would facilitate research into mechanisms of and factors affecting human spermatogenic failure and male fertility preservation in prepubertal tumor patients.Here,we report successful recapitulation of human testicular organogenesis in vitro from fetal gonadal ridge.Our model displayed the formation of mature seminiferous epithelium and self-renewing spermatogonia.Remarkably,in vitro-derived haploid spermatids have undergone meiotic recombination,and showed increased genetic diversity as indicated by genetic analysis.Moreover,these spermatids were able to fertilize oocytes and support subsequent blastocyst formation.The in vitro testicular organogenesis system described here will play an important role in elucidating the regulation of human testis development and maintaining male fertility in prepubertal cancer patients. | Yan Yuan Laihua Li Qing Cheng Feiyang Diao Qiao Zeng Xiaoyu Yang Yibo Wu Hao Zhang Mingqian Huang Junqing Chen Quan Zhou Yunfei Zhu Rong Hua Jianyu Tian Xin Wang Zuomin Zhou Jie Hao Jinjin Yu Dong Hua Jiayin Liu Xuejiang Guo Qi Zhou Jiahao Sha | 2020 | Cell Research2020，30，3： | 6 |
| 19 | Effect of calycosin on left ventricular ejection fraction and angiogenesis in rat models with myocardial infarction显示文摘OBJECTIVE:To evaluated the effect of calycosin on left ventricular ejection fraction and angiogenesis.METHODS:Adult male Sprague-Dawley rats were randomly assigned into calycosin-treated groups(0.5,1,2,and 4 mg/kg qd),a dimethyl sulfoxide(DMSO),or a sham-operated control group.The myocardial ischaemia(Ml) model was intraperitoneally administered calycosin for 28 days.The survival rates and left ventricular ejection fractions(LVEF)were compared between groups.The expression levels of vascular endothelial growth factor(VEGF)and cluster of differentiation 31(CD31) in ischaemic myocardium were also measured and compared.RESULTS:The construction of MI model resulted in a LVEF reduction of 50% compared with the sham-control.After 28 days,the LVEF value was 10% higher when calycosin(4 mg/kg) was administered compared with the DMSO group.The expression of VEGF and CD31 showed a dose-dependent manner when calycosin was administrated.The calycosin-treated(4 mg/kg) group displayed a twofold increase in VEGF expression at both the mRNA and protein levels compared with the DMSO group.In addition,CD31 expression in the microvascular increased 1.5-fold in the 4 mg/kg calycosin-treated group.CONCLUSION:Calycosin improved left ventricular ejection fraction in the MI rat models,induced VEGF expression in the ischaemic myocardium,increased CD31 expression and promoted angiogenesis. | Gao Junqing Chen Tao Jin Huigen Liu Zongjun Zhao Deqiang | 2015 | Journal of Traditional Chinese Medicine2015，35，2： | 6 |
| 20 | Numerical simulation and processoptimization for producing large-sized castings显示文摘3-Dvelocity and temperature fields of mold filling and solidification processes of large-sized castingswere calculated,and the efficiency and accuracy of numerical calculation were studied.The mold filling andsolidification processes of large-sized stainless steel,iron and aluminum alloy castings were simulated by using ofnew scheme;their casting processes were optimized,and then applied to produce castings. | Wang Junqing Sun Xun Guan Yang Wang Penghua Li Hailan Bai Limei Sun Xinzhi | 2008 | China Foundry2008，5，3： | 6 |
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