|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The Inhibitory Effect of Oridonin on the Growth of Fifteen Human Cancer Cell Lines显示文摘OBJECTIVE To study the inhibitory effect of oridonin on the growth of cancer cells. METHODS Fifteen human cancer cell lines were subjected to various concentrations of oridonin in culture medium. The inhibitory rate of cell growth was measured by the MTT assay, and compared with a negative con- trol and 5-Fu-positive control. RESULTS The 50% inhibiting concentration (IC50) and maximal inhibition (Imax) of oridonin shown by studying the growth of the cancer cell lines were as follows: leukemias (HL60 cells: 3.9 μg/ml and 73.8%, K562 cells: 4.3 μg/ml and 76.2%); esophageal cancers(SHEEC cells: 15.4 μg/ml and 99.2%, Eca109 cells: 15.1 μg/ml and 84.6%, TE1 cells: 4.0 μg/ml and 70.2%); gastric cancers (BGC823 cells: 7.6 μg/ml and 98.7%, SGC7901 cells: 12.3 μg/ml and 85.7%); colon cancers (HT29 cells: 13.6 μg/ml and 97.2%, HCT cells: 14.5 μg/ml and 96.5%); liver cancers (Bel7402 cells: 15.2 μg/ml and 89.2%, HepG2 cells: 7.1 μg/ml and 88.3%); pancreatic cancer (PC3 cells: 11.3 μg/ml and 68.4%); lung cancer (A549 cells: 18.6 μg/ml and 98.0% ); breast cancer (MCF7 cells: 18.4 μg/ml and 84.7%); uterine cervix cancer (Hela cells: 13.7 μg/ml and 98.5%). CONCLUSION Oridonin had a relatively wide anti-tumor spectrum, and a relatively strong inhibitory effect on the growth of the 15 human cancer cells. Inhibitory effects were concentration dependent. | Junhui Chen Shaobin Wang Dongyang Chen Guisheng Chang Qingfeng Xin Shoujun Yuan Zhongying Shen | 2007 | Chinese Journal of Clinical Oncology2007，4，1： | 32 |
| 2 | α-Asarone suppresses the proliferation and migration of ASMCs through targeting the IncRNA-PVT1/miR-203a/E2F3 signal pathway in RSV-infected rats显示文摘气喘是长期的煽动性的肺的疾病,呼吸 syncytial 病毒(RSV ) 感染是在婴儿和小孩子的更低的呼吸的道病的一个普通原因。-Asarone 介绍许多药理学效果并且被表明了在对待气喘有用。然而,在感染 RSV 的气喘的 -asarone 的功能的机制没被调查。长非编码的 RNA (lncRNAs ) 被报导了在许多生物过程起关键作用。尽管许多 lncRNAs 被描绘了,很少在气喘被报导,特别在导致 RSV 的气喘。当前,一条新奇 post-transcriptional 规定在哪个 lncRNAs 作为竞争内长的 RNA (ceRNAs ) 工作竞争地擦掉 miRNAs 被建议了,从而调整目标基因。在现在的学习,我们建立了一个感染 RSV 的 Sprague-Dawley 老鼠模型并且证明 lncRNA-PVT1 在对待导致 RSV 的气喘,和 lncRNA-PVT1 涉及 -asarone 的机制由作为竞争地擦掉 miR-203a 的 ceRNA 工作调整 E2F3 的表示。 | Xiao Yu Zhe Zhe Binqing Tang Shaobin Li Ling Tang Yingen Wu Xiaorong Chen Hong Fang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，7： | 14 |
| 3 | Boride-based electrocatalysts:Emerging candidates for water splitting显示文摘Electrocatalytic water splitting(EWS)is a promising route to produce hydrogen in a sustainable and environment-benign manner.To realize the large-scale hydrogen production,it is paramount to develop desirable electrocatalysts with engineered structure,high catalytic activity,facile accessibility,low cost,and good durability.Of late,boride-based materials,especially transition-metal borides(TMBs),are emerging as promising candidates for the EWS process.However,so far,ittle attempt has been made to provide a comprehensive summary on these findings.Herein,this review provides the up-to-date status on upgrading the catalytic performance of TMB-based nanomaterials by regulating the internal and external characteristics.The conventional synthetic techniques are first presented for the preparation of TMB-based catalysts.Afterwards,the advanced strategies are summarized to enhance the catalytic performance of TMBs,including morphology control,component regulation,phase engineering,surface oxidation and hybridization.Then,the design principles of TMB-based electrocatalysts for high-performance EWS are outined.Lastly,the current challenges and future directions in the development of TMB-based materials are proposed.This review article is expected to envisage insights into the TMBs-based water splitting and to provide strategies for design of the next-generation TMB-based electrocatalysts. | ZhiJie Chen Xiaoguang Duan Wei Wei Shaobin Wang Zejie Zhang Bing-Jie Ni | 2020 | Nano Research2020，13，2： | 5 |
| 4 | Neofusicoccum parvum causing canker of seedlings of Juglans regia in China显示文摘Cankered, dying seedlings of Juglans regia were observed in Shaanxi province in the northwest region of China. Neofusicoccum parvum was isolated from these cankered tissues, with the identification based on morphology and an ITS-nr DNA sequence. In order to demonstrate how cultures of N. parvum could cause the expected symptoms, artificial infection, using these isolates and re-isolation of the pathogen, was used. This is the first report on this taxon as a walnut canker pathogen in China. | Zhongdong Yu Guanghui Tang Shaobin Peng Hui Chen Meizhi Zhai | 2015 | Journal of Forestry Research2015，26，4： | 4 |
| 5 | In situ synthesis of graphene oxide/gold nanorods theranostic hybrids for efficient tumor computed tomography imaging and photothermal therapy显示文摘Graphene 氧化物 / 黄金 nanorod (GO/GNR ) nanohybrids 被混合聚苯乙烯 sulfonate (PSS ) 在房间温度在 situ 生长方法与 GO-seed-mediated 和 gold-seed-mediated 综合 functionalized 去,第二等的生长答案,和金种子。与 GO/GNRs 或 graphene (G)/GNRs 的前 situ 准备方法相比,在里面 GO/GNRs 的 situ 合成在他们的附件前处理了 GNR 的聚集的问题到 GO 上。方法直接、环境友好。GO/GNRs 在 vitro 显示出显著 photothermal 效果。GO/GNR nanohybrids 的温度在女人上从 25 ~ 49.9 增加了光谱为宽事件角度的范围(365 ~ 1,100 nm )(0io 是超过 6.00 ~ 10 个病人和 35 age-/gender-matched 控制(吝啬的 s 吗?? | Bingmei Sun Jinrui Wu Shaobin Cui Huanhuan Zhu Wei An Qingge Fu Chengwei Shao Aihua Yao Bingdi Chen Donglu Shi | 2017 | Nano Research2017，10，1： | 4 |
| 6 | Geochronological and geochemical constraints on the petrogenesis of late Mesoproterozoic mafic and granitic rocks in the southwestern Yangtze Block显示文摘Late Mesoproterozoic igneous rocks in the SW Yangtze Block are important for understanding the role of it in reconstruction of the Rodinia supercontinent.In the present study,we report new geochronological,geochemical,and Nd-Hf isotopic data for the Cuoke plagioclase amphibolites and granites in the SW Yangtze Block.Geochronological results show that the plagioclase amphibolites and granites have similar late Mesoproterozoic zircon U-Pb ages of 1168-1162 Ma,constituting a bimodal igneous assemblage.The plagioclase amphibolites have high and variable TiO2 contents(1.15-4.30 wt.%)and Mg#(34-66)values,similar to the tholeiitic series.They are characterized by enrichment in LREEs and LILEs,and have OIB-like affinities with positive Nb and Ta anomalies.The plagioclase amphibolites have positive whole-rockεNd(t)(+3.2 to+4.3)and zirconεHf(t)(+4.3 to+10.7)values,indicating that they were derived from an OIB-like asthenospheric mantle source.The granites belong to the reduced peralkaline A-type series and have negativeεNd(t)value of-6.0 andεHf(t)values of-5.8 to-13.8,indicating a derivation from the partial melting of ancient mafic lower crust.In combination with the~1.05-1.02 Ga bimodal igneous assemblage in the SW Yangtze Block,we propose that the Cuoke 1168-1162 Ma igneous rocks were likely formed in a continental rift basin and argue against the existance of Grenvillian Orogen in the SW Yangtze Block during the late Mesoproterozoic. | Guichun Liu Jing Li Xin Qian Qinglai Feng Wei Wang Guangyan Chen Shaobin Hu | 2021 | Geoscience Frontiers2021，12，1： | 3 |
| 7 | Target-triggered inhibiting oxidase-mimicking activity of platinum nanoparticles for ultrasensitive colorimetric detection of silver ion显示文摘The development of efficient methods for the detection of hazardous and toxic elements is extremely important for environmental security and public health. In this work, we developed a facile colorimetric assaying system for Ag+ detection in aqueous solution. Chitosan-stabilized platinum nanoparticles(ChPtNPs) were synthesized and severed as an artificial oxidase to catalyze the oxidation of the substrate3,30,5,50-tetramethylbenzidine(TMB) and generate color signal. In the presence of Ag+, due to the strong metallophilic interactions between Ag+ and Pt2+ on the surface of Ch-PtNPs, Ag+ can weaken the affinity to the substrates and inactivate the catalytic activity of Ch-PtNPs, leading to decreased absorbance signal to varying degrees depending on Ag+ amount. Combing the specific binding between Ch-PtNPs and Ag+ with signal amplification procedure based on the Ch-PtNPs-catalyzed TMB oxidation, a sensitive,selective, simple, cost-effective, and rapid detection method for Ag+ can be realized. Ag+ ions in tap and lake waters have been successfully detected. We ensured that the proposed method can be a potential alternative for Ag+ determination in environmental samples. | Haohua Deng Shaobin He Xiuling Lin Lu Yang Zhen Lin Ruiting Chen Huaping Peng Wei Chen | 2019 | Chinese Chemical Letters2019，30，9： | 3 |
| 8 | Geochronological and Geochemical Constraints on the Petrogenesis of Early Paleoproterozoic(2.40–2.32 Ga) Nb-Enriched Mafic Rocks in Southwestern Yangtze Block and Its Tectonic Implications显示文摘Recent geological survey has identified the Early Paleoproterozoic meta-mafic intrusions in the southwestern Yangtze Block.We present geochronological,whole-rock geochemical and Nd isotopic data for these meta-mafic rocks to better address the tectonic evolution of the Yangtze Block during the Early Paleoproterozoic Period.Geochronological data show that the meta-mafic rocks have zircon ages of 2 395-2 316 Ma.They have high TiO_2 contents of 1.40 wt.%-3.66 wt.% and Nb concentrations of 13.7 ppm-45.5 ppm,thus aregrouped as Nb-enriched mafic rocks.These mafic rocks are characterized by tholeiitic compositions with enrichment of LREEs and LILEs,and can be divided into two groups.Group 1 samples display E-MORB-like geochemical characteristics.Group 2 samples have positive ENd(t) values of 4.0-5.0.Geochemical data indicate that all meta-mafic rocks were likely derived from a depleted asthenospheric mantle.REE modeling indicates lower degree of partial melting for Group 2 samples(3%-10%) relative to Group 1 samples(15%-20%).Taking into account contemporaneous post-collisional granitoids in southwestern Yangtze Block,we propose that these meta-mafic rocks were formed in a post-collisional extension setting.These meta-mafic rocks can be compared with those in Africa,South America and Europe,and might be linked with the Arrowsmith orogenic belt. | Guichun Liu Xin Qian Jing Li Jian-Wei Zi Tianyu Zhao Qinglai Feng Guangyan Chen Shaobin Hu | 2020 | Journal of Earth Science2020，31，1： | 3 |
| 9 | Autophagy of cancer stem cells is involved with chemoresistance of colon cancer cells显示文摘 | Shaobin Wu Xianwei Wang Jinxiang Chen Yuxiang Chen | 2013 | Biochemical and Biophysical Research Communications2013，，4： | 2 |
| 10 | A Clinicopathological Study on the Expression of Cadherin-17 and Caudal-related Homeobox Transcription Factor (CDX2) in Human Gastric Carcinoma显示文摘 | Jie Ge Zhikang Chen Shaobin Wu Weijie Yuan Bin Hu Zihua Chen | 2008 | Clinical Oncology2008，，4： | 2 |
| 11 | Overexpression of EphA2 correlates with epithelial–mesenchymal transition-related proteins in gastric cancer and their prognostic importance for postoperative patients显示文摘 | Futao Hou Weijie Yuan Jin Huang Liyuan Qian Zhikang Chen Jie Ge Shaobin Wu Jinxiang Chen Jixu Wang Zihua Chen | 2012 | Medical Oncology2012，，4： | 2 |
| 12 | Experimental Study of Bowed-twisted Stators in an Axial Transonic Fan Stage显示文摘Bowed-twisted stators with large camber angles have been developed to replace the conventional tandem stators in an axial transonic fan stage working at high subsonic speeds.Experimental study is carried out on both stages with tandem stators and with bowed-twisted stators.Compared to the tandem stators,the bowed-twisted stators change the distribution of the low-energy fluid and the potential high-energy fluid at the compressor outlets,reduce the endwall loss significantly,improve the aerody-namic matching of rotors and stators,and eventually increase the fan stage performances.The aerodynamic performances of the fan stage at different operating points are compared and contrasted.The results show that the transonic fan stage with bowed-twisted stators has better aerodynamic performances.It is thus suggested that the bowed-twisted stators with large camber angles be popularized into the high-loaded transonic fan designs. | Chen Fu,Li Shaobin,Su Jiexian,Wang Zhongqi School of Energy Science and Engineering,Harbin Institute of Technology,Harbin 150001,China | 2009 | Chinese Journal of Aeronautics2009，22，4： | 2 |
| 13 | Nitrogen-doped Carbon Nanospheres-Modified Graphitic Carbon Nitride with Outstanding Photocatalytic Activity显示文摘Metals and metal oxides are widely used as photo/electro-catalysts for environmental remediation.However,there are many issues related to these metal-based catalysts for practical applications,such as high cost and detrimental environmental impact due to metal leaching.Carbon-based catalysts have the potential to overcome these limitations.In this study,monodisperse nitrogen-doped carbon nanospheres(NCs)were synthesized and loaded onto graphitic carbon nitride(g-C3N4,GCN)via a facile hydrothermal method for photocatalytic removal of sulfachloropyridazine(SCP).The prepared metal-free GCN-NC exhibited remarkably enhanced efficiency in SCP degradation.The nitrogen content in NC critically influences the physicochemical properties and performances of the resultant hybrids.The optimum nitrogen doping concentration was identified at 6.0 wt%.The SCP removal rates can be improved by a factor of 4.7 and 3.2,under UV and visible lights,by the GCN-NC composite due to the enhanced charge mobility and visible light harvesting.The mechanism of the improved photocatalytic performance and band structure alternation were further investigated by density functional theory(DFT)calculations.The DFT results confirm the high capability of the GCN-NC hybrids to activate the electron–hole pairs by reducing the band gap energy and efficiently separating electron/hole pairs.Superoxide and hydroxyl radicals are subsequently produced,leading to the efficient SCP removal. | Qiaoran Liu Hao Tian Zhenghua Dai Hongqi Sun Jian Liu Zhimin Ao Shaobin Wang Chen Han Shaomin Liu | 2020 | Nano-Micro Letters2020，12，2： | 2 |
| 14 | A New Clustering Model Based on Word2vec Mining on Sina Weibo Users' Tags显示文摘 | Bai Xue Chen Fu Zhan Shaobin | 2014 | International Journal of Grid Distribution Computing2014，7，3： | 1 |
| 15 | Twisted toroidal Lie algebras and Moody-Rao-Yokonuma presentation显示文摘Let g be a(twisted or untwisted)affine Kac-Moody algebra,and μ be a diagram automorphism of g.In this paper,we give an explicit realization for the universal central extensionˆg[μ]of the twisted loop algebra of g with respect toμ,which provides a Moody-Rao-Yokonuma presentation for the algebraˆg[μ]whenμis non-transitive,and the presentation is indeed related to the quantization of twisted toroidal Lie algebras. | Fulin Chen Naihuan Jing Fei Kong Shaobin Tan | 2021 | Science China Mathematics2021，64，6： | 1 |
| 16 | Detection of methylated tissue factor pathway inhibitor 2 and human long DNA in fecal samples of patients with colorectal cancer in China显示文摘 | JinPing Zhang ShaoBin Yang YuanYuan Xie XiangYu Chen Ye Zhao DeZhi He JianSheng Li | 2011 | Cancer Epidemiology2011，，1： | 1 |
| 17 | Acidification and bubble template derived porous g-C_(3)N_(4) for efficient photodegradation and hydrogen evolution显示文摘Graphitic carbon nitride(g-C_(3)N_(4))as a metal-free candidate of photocatalyst has received worldwide attention because of its great potentials in solar light-induced degradation and hydrogen evolution,yet the industrial application is seriously hindered by the small specific surface area and rapid recombination rate of carriers.Herein,we demonstrate that porous g-C_(3)N_(4)(HCl-CNU-X)can be prepared via the copolymerization of acidified melamine and a green bubble template(urea).Transmission electron microscopy and nitrogen sorption characterization results show that the prepared HCl-CNU-X possesses an in-plane porous structure and large specific surface area,enabling the exposure of more accessible active sites.As a result,HCl-CNU-X exhibits both enhanced photocatalytic tetracycline hydrochloride degradation and higher hydrogen evolution than bulk g-C_(3)N_(4).The boosted photocatalytic performance was ascribed to the formation of the porous structure,which dramatically promotes the separation of charge-carriers and facilitates the electron transfer.This work demonstrates that the acidification of nitrogen-rich precursors combined with a bubble-template can develop a new paradigm of highly porous photocatalysts for environmental remediation and water splitting. | Yixuan Wang Fengting He Lin Chen Jie Shang Jiajia Wang Shuaijun Wang Huimin Song Jinqiang Zhang Chaocheng Zhao Shaobin Wang Hongqi Sun | 2020 | Chinese Chemical Letters2020，31，10： | 1 |
| 18 | Characterizing the interaction between oridonin and bovine serum albumin by a hybrid spectroscopic approach显示文摘 | Zhen Wang Junhui Chen Shaobin Wang Zhanguang Chen | 2013 | Journal of Luminescence2013，，： | 1 |
| 19 | Atomic Decomposition by Basis Pursuit显示文摘 | Chen Shaobin Donoho D L Saunders M A | 2001 | SIAM Journal on Scientific Computing2001，43，1： | 1 |
| 20 | Primary Mucoepidermoid Carcinoma of the Esophagus显示文摘 | Shaobin Chen Yuping Chen Jiesheng Yang Weiping Yang Hongrui Weng Hua Li Ditian Liu | 2011 | Journal of Thoracic Oncology2011，，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员