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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | L_(1/2) regularization显示文摘In this paper we propose an L1 /2 regularizer which has a nonconvex penalty.The L 1/2 regularizer is shown to have many promising properties such as unbiasedness, sparsity and oracle properties.A reweighed iterative algorithm is proposed so that the solution of the L 1/2 regularizer can be solved through transforming it into the solution of a series of L 1 regularizers.The solution of the L 1/2 regularizer is more sparse than that of the L 1 regularizer, while solving the L 1/2 regularizer is much simpler than solving the L 0 regularizer.The experiments show that the L 1/2 regularizer is very useful and efficient, and can be taken as a representative of the Lp(0 < p < 1) regularizer. | XU ZongBen ZHANG Hai WANG Yao CHANG XiangYu LIANG Yong | 2010 | Science China(Information Sciences)2010，53，6： | 32 |
| 3 | Therapeutic potential of siRNA-mediated combined knockdown of the lAP genes (Livin, XIAP, and Survivin) on human bladder cancer T24 cells显示文摘Livin, apoptosis (XIAP ) 的 X 连接禁止者,和 Survivin 几乎是 apoptosis 的三个著名禁止者在癌症房间只过去表示并且为癌症治疗被认为有势力目标。在现在的学习,我们发现 Livin, XIAP,和 Survivin 同时在膀胱癌症房间被表示。我们推测了那 Livin, XIAP,和 Survivin 可能在房间生长和 apoptosis 上有 synergistic 效果。我们的结果证实了联合那所有这三基因击倒能 synergistically 禁止增长和高级膀胱癌症 T24 房间的转变能力并且把房间 apoptotic 敏感提升到化疗。而且,联合了 Livin, XIAP,和 Survivin 罐头击倒显著地增加许多活跃 caspase-3,活跃 caspase-7,活跃 caspase-9,和 cytosolic Smac。我们的调查结果暗示 Livin, XIAP,和 Survivin 的那联合 silencing 可以是一个有势力为膀胱癌症的多指向的基因治疗。 | Deyong Yang Xishuang Song Jianing Zhang Lin Ye Shujing Wang Xiangyu Che Jianbo Wang Zhiwei Zhang Lina Wang Wei Shi | 2010 | Acta Biochimica et Biophysica Sinica2010，42，2： | 29 |
| 4 | Interactions between cancer cells and bone microenvironment promote bone metastasis in prostate cancer显示文摘Bone metastasis is the leading cause of death in prostate cancer patients,for which there is currently no effective treatment.Since the bone microenvironment plays an important role in this process,attentions have been directed to the interactions between cancer cells and the bone microenvironment,including osteoclasts,osteoblasts,and bone stromal cells.Here,we explained the mechanism of interactions between prostate cancer cells and metastasis-associated cells within the bone microenvironment and further discussed the recent advances in targeted therapy of prostate cancer bone metastasis.This review also summarized the effects of bone microenvironment on prostate cancer metastasis and the related mechanisms,and provides insights for future prostate cancer metastasis studies. | Xiangyu Zhang | 2019 | Cancer Communications2019，39，1： | 22 |
| 5 | Towards 10 Gb/s orthogonal frequency division multiplexing-based visible light communication using a GaN violet micro-LED显示文摘Visible light communication(VLC)is a promising solution to the increasing demands for wireless connectivity.Gallium nitride micro-sized light emitting diodes(micro-LEDs)are strong candidates for VLC due to their high bandwidths.Segmented violet micro-LEDs are reported in this work with electrical-to-optical bandwidths up to 655 MHz.An orthogonal frequency division multiplexing-based VLC system with adaptive bit and energy loading is demonstrated,and a data transmission rate of 11.95 Gb/s is achieved with a violet micro-LED,when the nonlinear distortion of the micro-LED is the dominant noise source of the VLC system.A record 7.91 Gb/s data transmission rate is reported below the forward error correction threshold using a single pixel of the segmented array when all the noise sources of the VLC system are present. | MOHAMED SUFYAN ISLIM RICARDO X.FERREIRA XIANGYU HE ENYUAN XIE STEFAN VIDEV SHAUN VIOLA SCOTT WATSON NIKOLAOS BAMIEDAKIS RICHARD V.PENTY IAN H.WHITE ANTHONY E.KELLY ERDAN GU HARALD HAAS MARTIN D.DAWSON | 2017 | Photonics Research2017，5，2： | 23 |
| 6 | The outlook of blockchain technology for construction engineering management显示文摘Current construction engineering management suffers numerous challenges in terms of the trust,information sharing, and process automation. Blockchain which is a decentralised transaction and data management technology, has attracted increasing interests from both academic and industrial aspects since 2008. However,most of the existing research and practices are focused on the blockchain itself(i.e. technical challenges and limitations) or its applications in the finance service sector(i.e.Bitcoin). This paper aims to investigate the potential of applying blockchain technology in the construction sector.Three types of blockchain-enabled applications are proposed to improve the current processes of contract management, supply chain management, and equipment leasing, respectively. Challenges of blockchain implementation are also discussed in this paper. | Jun WANG Peng WU Xiangyu WANG Wenchi SHOU | 2017 | Frontiers of Engineering Management2017，4，1： | 20 |
| 7 | PCNN Model Analysis and Its Automatic Parameters Determination in Image Segmentation and Edge Detection显示文摘The Pulse coupled neural network(PCNN)has been widely used in digital image processing, but the automatic parameters determination is still a difficult aspect, which becomes the focus of PCNN research. In this paper, by the classical solution to difference equations and the time-domain analysis of PCNN model, we provide the expressions of the firing time and the firing period of neurons, and reveal the 'mathematics firing' phenomenon of PCNN. Based on this, we propose a new method of automatic parameters determination based on both eliminating the 'mathematics firing' and getting the highest efficiency of PCNN. We also present an edge detection model on the basis of image segmentation of PCNN and a method to determine automatically the parameters of the model. Experimental results prove the validity and efficiency of our proposed algorithm for the segmentation and the edge detection of the test images. | DENG Xiangyu MA Yide | 2014 | Chinese Journal of Electronics2014，23，1： | 20 |
| 8 | Poxue Huayu and Tianjing Busui Decoction for cerebral hemorrhage Upregulation of neurotrophic factor expression显示文摘This study established a rat model of cerebral hemorrhage by injecting autologous anticoagulated blood.Rat models were intragastrically administered 5,10,20 g/kg Poxue Huayu and Tianjing Busui Decoction,supplemented with Hirudo,raw rhubarb,raw Pollen Typhae,gadfly,Fructrs Trichosanthis,Radix Notoginseng,Rhizoma Acori Talarinowii,and glue of tortoise plastron,once a day,for 14 consecutive days.Results demonstrated that brain water content significantly reduced in rats with cerebral hemorrhage,and intracerebral hematoma volume markedly reduced after treatment.Immunohistochemical staining revealed that brain-derived neurotrophic factor,tyrosine kinase B and vascular endothelial growth factor expression noticeably increased around the surrounding hematoma.Reverse transcription-PCR revealed that brain-derived neurotrophic factor and tyrosine kinase B mRNA expression significantly increased around the surrounding hematoma.Neurologic impairment obviously reduced.These results indicated that Poxue Huayu and Tianjing Busui Decoction exert therapeutic effects on cerebral hemorrhage by upregulating the expression of brain-derived neurotrophic factor. | Jixiang Ren Xiangyu Zhou Jian Wang Jianjun Zhao Pengguo Zhang | 2013 | Neural Regeneration Research2013，8，22： | 19 |
| 9 | A Deep Adaptive Learning Method for Rolling Bearing Fault Diagnosis Using Immunity显示文摘The extraction of rolling bearing fault features using traditional diagnostic methods is not sufficiently comprehensive and the features are often chosen subjectively and depend on human experience. In this paper, an improved deep convolutional process is used to extract a set of features adaptively. The hidden multi-layer feature of deep convolutional neural networks is also exploited to improve the extraction features. A deterministic detection of low-confidence samples is performed to ensure the reliability of the recognition results and to decrease the rate of false positives by evaluating the diagnosis of the deep convolutional neural network. To improve the efficiency of the continuous learning elements of the rolling bearing fault diagnosis, a clone learning strategy based on cloning and mutation operations is proposed. The experimental results show that the proposed deep convolutional neural network model can extract multiple rolling bearing fault features, improve classification and detection accuracy by reducing the false positive rate when diagnosing rolling bearing faults, and accelerate learning efficiency when using low-confidence rolling bearing fault samples. | Yuling Tian Xiangyu Liu | 2019 | Tsinghua Science and Technology2019，24，6： | 18 |
| 10 | Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor显示文摘According to the World Health Organization(WHO)newly updated situation report on March 18th,2020,the coronavirus disease 2019(COVID-19)pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide.1 The etiological agent of COVID-19 has been identified as a novel coronavirus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belonging to Sarbecovirus subgenus(genus Betacoronavirus,family Coronaviridae)and showing 79.6 and 96.2%sequence identity in nucleotide to SARS-CoV and a bat coronavirus(BatCoV RaTG13),respectively.2–4 Like SARS-CoV infection,a substantial fraction of COVID-19 patients exhibits severe respiratory symptoms and has to be hospitalized in intensive care unit.5–8 Although the mortality rate of COVID-19 is significantly lower than that of SARS-CoV infection,SARS-CoV-2 shows much higher human-to-human transmission rate,rapidly leading to a global pandemic declared by WHO on March 11th,2020. | Xiangyu Chen Ren Li Zhiwei Pan Chunfang Qian Yang Yang Renrong You Jing Zhao Pinghuang Liu Leiqiong Gao Zhirong Li Qizhao Huang Lifan Xu Jianfang Tang Qin Tian Wei Yao Li Hu Xiaofeng Yan Xinyuan Zhou Yuzhang Wu Kai Deng Zheng Zhang Zhaohui Qian Yaokai Chen Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，6： | 17 |
| 11 | Stability control of surrounding rocks for a coal roadway in a deep tectonic region显示文摘In order to effectively control the deformation and failure of surrounding rocks in a coal roadway in a deep tectonic region, the deformation and failure mechanism and stability control mechanism were studied. With such methods as numerical simulation and field testing, the distribution law of the displacement, stress and plastic zone in the surrounding rocks was analyzed. The deformation and failure mechanisms of coal roadways in deep tectonic areas were revealed: under high tectonic stress, two sides will slide along the roof or floor; while the plastic zone of the two sides will extend along the roof or floor,leading to more serious deformation and failure in the corner of two sides and the bolt supporting the corners is readily cut off by the shear force or tension force. Aimed at controlling the large slippage deformation of the two sides, serious deformation and failure in the corners of the two sides and massive bolt breakage, a ‘‘controlling and yielding coupling support'' control technology is proposed. Firstly, bolts which do not pass through the bedding plane should be used in the corners of the roadway, allowing the two sides to have some degree of sliding to achieve the purpose of ‘‘yielding'' support, and which avoid breakage of the bolts in the corner. After yielding support, bolts in the corner of the roadway and which pass through the bedding plane should be used to control the deformation and failure of the coal in the corner. ‘‘Controlling and yielding coupling support'' technology has been successfully applied in engineering practice, and the stability of deep coal roadway has been greatly improved. | Xiao Tongqiang Wang Xiangyu Zhang Zhigao | 2014 | International Journal of Mining Science and Technology2014，24，2： | 16 |
| 12 | Upregulation of CD81 in trophoblasts induces an imbalance of Treg/Th17 cells by promoting IL-6 expression in preeclampsia显示文摘The disturbance of maternal immune tolerance to a semiallogeneic fetus is recognized as one of the key pathologies of preeclampsia(PE),in which an imbalance between the inflammation-limiting regulatory T cells(Tregs)and the inflammationmediating Th17 cells plays an essential role.Previously,we reported that the abnormal upregulation of tetraspannin CD81 in trophoblast cells(fetal component)participated in the pathogenesis of PE.However,as one of the potential immune regulatory molecules,whether CD81 induces PE by interfering with the balance of the maternal immune system has not yet been clarified.Thus,we investigated the relationship between the upregulation of CD81 in trophoblast cells and the imbalance of Treg and Th17 cells in mothers.Here,we demonstrated that upregulation of CD81 in trophoblast cells was accompanied by a decrease in Treg cells and an increase in Th17 cells in both the basal plate(placental maternal side)and peripheral blood of patients with PE.In vitro culture of naïve T cells with medium from the CD81-overexpressing trophoblast cell line HTR-8 resulted in enhanced differentiation of T cells into Th17 cells and decreased the formation of Tregs,which was dependent on the paracrine signaling of IL-6 in trophocytes,induced by CD81.In a CD81-induced PE rat model,we found a significant shift of T cell differentiation towards Th17 cells,and administration of IL-6 antibody mitigated the PE phenotype and the imbalance of the Treg/Th17 cells.These results define a vital regulatory cascade involving trophocyte-derived CD81,IL-6,and maternal Treg/Th17 cells in the pathogenesis of PE and suggests new therapeutic approaches based on CD81 and IL-6 downregulation to prevent human PE. | Hailin Ding Yimin Dai Yi Lei Zhiyin Wang Dan Liu Ruotian Li Li Shen Ning Gu Mingming Zheng Xiangyu Zhu Guangfeng Zhao Yali Hu | 2019 | Cellular & Molecular Immunology2019，16，3： | 15 |
| 13 | The microbiome in inflammatory bowel diseases:from pathogenesis to therapy显示文摘Inflammatory bowel disease(IBD)has become a global disease with accelerating incidence worldwide in the 21st century while its accurate etiology remains unclear.In the past decade,gut microbiota dysbiosis has consistently been associated with IBD.Although many IBDassociated dysbiosis have not been proven to be a cause or an effect of IBD,it is often hypothesized that at least some of alteration in microbiome is protective or causative.In this article,we selectively reviewed the hypothesis supported by both association studies in human and pathogenesis studies in biological models.Specifically,we reviewed the potential protective bacterial pathways and species against IBD,as well as the potential causative bacterial pathways and species of IBD.We also reviewed the potential roles of some members of mycobiome and virome in IBD.Lastly,we covered the current status of therapeutic approaches targeting microbiome,which is a promising strategy to alleviate and cure this inflammatory disease. | Sheng Liu Wenjing Zhao Ping Lan Xiangyu Mou | 2021 | Protein & Cell2021，12，5： | 15 |
| 14 | Catalytic fast pyrolysis of Kraft lignin with HZSM-5 zeolite for producing aromatic hydrocarbons显示文摘 | Xiangyu LI Lu SU Yujue WANG Yanqing YU Chengwen WANG Xiaoliang LI Zhihua WANG | 2012 | Frontiers of Environmental Science & Engineering2012，6，3： | 14 |
| 15 | Three-dimensional analytical solution for a transversely isotropic functionally graded piezoelectric circular plate subject to a uniform electric potential difference显示文摘This paper studies the problem of a functionally graded piezoelectric circular plate subjected to a uniform electric potential difference between the upper and lower surfaces. By assuming the generalized displacements in appropriate forms,five differential equations governing the generalized displacement functions are derived from the equilibrium equations. These displacement functions are then obtained in an explicit form,which still involve four undetermined integral constants,through a step-by-step integration which properly incorporates the boundary conditions at the upper and lower surfaces. The boundary conditions at the cylindrical surface are then used to determine the integral constants. Hence,three-dimen sional analytical solutions for electrically loaded functionally graded piezoelectric circular plates with free or simply-supported edge are completely determined. These solutions can account for an arbitrary material variation along the thickness,and thus can be readily degenerated into those for a homogenous plate. A numerical example is finally given to show the validity of the analysis,and the effect of material inhomogeneity on the elastic and electric fields is discussed. | LI XiangYu DING HaoJiang CHEN WeiQiu | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，8： | 13 |
| 16 | A review of rapid transport of pesticides from sloping farmland to surface waters: Processes and mitigation strategies显示文摘Pesticides applied to sloping farmland may lead to surface water contamination through rapid transport processes as influenced by the complex topography and high spatial variability of soil properties and land use in hilly or mountainous regions. However, the fate of pesticides applied to sloping farmland has not been sufficiently elucidated. This article reviews the current understanding of pesticide transport from sloping farmland to surface water. It examines overland flow and subsurface lateral flow in areas where surface soil is underlain by impervious subsoil or rocks and tile drains. It stresses the importance of quantifying and modeling the contributions of various pathways to rapid pesticide loss at catchment and regional scales. Such models could be used in scenario studies for evaluating the effectiveness of possible mitigation strategies such as constructing vegetated strips, depressions, wetlands and drainage ditches, and implementing good agricultural practices. Field monitoring studies should also be conducted to calibrate and validate the transport models as well as biophysical-economic models, to optimize mitigation measures in areas dominated by sloping farmland. | Xiangyu Tang Bo Zhu Hidetaka Katou | 2012 | Journal of Environmental Sciences2012，24，3： | 13 |
| 17 | A Review of Colloid Transport in Fractured Rocks显示文摘Recent recognition of colloid and colloidassociated transport of strongly sorbing contaminants in fractured rocks highlights the importance of exploring the transport behavior of colloids under conditions prevailing in the field.The rapid transport of colloids through fractured rocks-as affected by the hydraulic properties of the flow system,the properties of fracture surface and the geochemical conditionshas not been sufficiently elucidated,and predictions of colloid transport through fractures have encountered difficulties,particularly at the field scale.This article reviews the current understanding of the mechanisms and modeling of colloid transport and retention in fractured rocks.Commonly used experimental techniques and approaches for conducting colloid transport experiments at different scales,ranging from the laboratory to the field scale,are summarized and commented upon.The importance of various interactions(e.g.,dissolution,colloid deposition,generation,mobilization and deposition of filling materials within fractures) between the flowing solution and the fracture walls(in many cases,with skin or coating on the host rock at the liquid-solid interface) has been stressed.Colloid transport through fractures of high heterogeneity has not yet been well understood and modeled at the field scale.Here,we summarize the current knowledge and understanding accumulated in the last two decades in regard to colloid and colloidassociated transport through fractures.Future research needs are also discussed. | ZHANG Wei TANG Xiangyu WEISBROD Noam GUAN Zhuo | 2012 | Journal of Mountain Science2012，9，6： | 12 |
| 18 | CRISPR/Cas9-mediated PINK1 deletion leads to neurodegeneration in rhesus monkeys显示文摘Dear Editor,PINK1 mutations cause autosomal recessive and early-onset Parkinson’s disease(PD)with selective neurodegeneration.Unfortunately,current PINK1 knockout(KO)mouse1,2 and pig models3,4 are unable to recapitulate the selective and overt neurodegeneration seen in PD patients.Furthermore,endogenous Pink1 in the mouse brain is expressed at very low levels and can only be detected via immunoprecipitation,5 meaning that PINK1’s function in the mammalian brain needs to be assessed using larger animals that are closer to humans.We previously used CRISPR/Cas9 to target the monkey gene in one-cell stage embryos.6 Using the same approach,we designed two gRNAs to target exon 2(T1)and exon 4(T2),which encode a kinase domain in the PINK1 gene of rhesus monkeys(Fig.1a).CRISPR/Cas9 and PINK1 gRNAs were injected into one-cell stage rhesus monkey embryos.A T7E1 assay and sequencing of PCR products from the injected embryos showed high efficiency(61.5%)in targeting PINK1(Fig.1b and Supplementary information,Fig.S1).Transfer of 87 embryos to 28 surrogate rhesus monkeys resulted in 11 pregnancies(39.2%)(Fig.1b).Eleven fetuses developed to term and were born naturally.Of these live monkeys,eight carried PINK1 mutations(M),and three were wild type(WT).However,three mutant monkeys(M1,M3 and M4)were newborn triplets that struggled to survive and died 3-4 days after birth.One WT newborn monkey also died after a difficult labor.Another mutant monkey(M2)died 7 days after birth without noticeable warning signs or symptoms.The other three mutant monkeys(M6,M7 and M8)have lived for three years;M5,however,reduced its food intake and showed weakness at the age of 1.5 years,and died 30 days after anesthesia for MRI examination. | Weili Yang Yunbo Liu Zhuchi Tu Chong Xiao Sen Yan Xishan Ma Xiangyu Guo Xiusheng Chen Peng Yin Zhengyi Yang Su Yang Tianzi Jiang Shihua Li Chuan Qin Xiao-Jiang Li | 2019 | Cell Research2019，29，4： | 12 |
| 19 | Pretreatment with scutellaria baicalensis stem-leaf total flavonoid prevents cerebral ischemia-reperfusion injury显示文摘Pretreatment with scutellaria baicalensis stem-leaf total flavonoid has protective effects against ischemia and attenuates myocardial ischemia-reperfusion injury.In this study,rats were given scutellaria baicalensis stem-leaf total flavonoid intragastrically at 50,100,and 200 mg/kg per day for7 days before focal cerebral ischemia-reperfusion injury models were established using the suture method.We then determined the protective effects of scutellaria baicalensis stem-leaf tota flavonoid pretreatment on focal cerebral ischemia-reperfusion injury.Results showed that neurological deficit scores increased,infarct volumes enlarged,apoptosis increased and Bcl-2 and Bax protein expression were upregulated at 24 hours after reperfusion.Pretreatment with scutellaria baicalensis stem-leaf total flavonoid at any dose lowered the neurological deficit scores reduced the infarct volume,prevented apoptosis in hippocampal cells,attenuated neuronal and blood-brain barrier damage and upregulated Bcl-2 protein expression but inhibited Bax protein expression.Doses of 100 and 200 mg/kg were the most efficacious.Our findings indicate that pretreatment with scutellaria baicalensis stem-leaf total flavonoid at 100 and 200 mg/kg can improve the neurological functions and have preventive and protective roles after focal cerebra ischemia-reperfusion injury. | Shumin Zhao Wei Kong Shufeng Zhang Meng Chen Xiaoying Zheng Xiangyu Kong | 2013 | Neural Regeneration Research2013，8，34： | 11 |
| 20 | Numerical simulation of low pressure die-casting aluminum wheel显示文摘The FDM numerical simulation software,ViewCast system,was employed to simulate the low pressure die casting(LPDC)of an aluminum wheel.By analyzing the mold-filling and solidification stage of the LPDC process,the distribution of liquid fraction,temperature field and solidification pattern of castings were studied.The potential shrinkage defects were predicted to be formed at the rim/spoke junctions,which is in consistence with the X-ray detection result.The distribution pattern of the defects has also been studied.A solution towards reducing such defects has been presented.The cooling capacity of the mold was improved by installing water pipes both in the side mold and the top mold.Analysis on the shrinkage defects under forced cooling mode proved that adding the cooling system in the mold is an effective method for reduction of shrinkage defects. | Mi Guofa Liu Xiangyu Wang Kuangfei Fu Hengzhi | 2009 | China Foundry2009，6，1： | 11 |
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