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| 1 | Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases显示文摘在各种各样的纸巾的 microRNAs (miRNAs ) 的 Dysregulated 表示与许多疾病被联系了,包括癌症。这里,我们证明 miRNAs 在象老鼠,老鼠,牛的胎儿,小牛,和马那样的人和另外的动物的浆液和血浆是在场的。在浆液的 miRNAs 的层次在一样的种类的个人之中稳定、可再现、一致。采用 Solexa,我们定序健康中国题目的所有浆液 miRNAs 并且分别地在男、女的题目发现超过 100 和 91 浆液 miRNAs。我们也为肺癌症, colorectal 癌症,和糖尿病识别了浆液 miRNAs 的特定的表示模式,提供证据那浆液 miRNAs 为各种各样的疾病包含指纹。癌症特定的浆液 miRNAs 由 Solexa 获得了的二个非小的房间肺进一步在 75 个健康施主和 152 个癌症病人的独立审判被验证,用量的反向的抄写聚合酶链反应试金。通过这些分析,我们断定浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。 | Xi Chen Yi Ba Lijia Ma Xing Cai Yuan Yin Kehui Wang Jig ang Guo Yujing Zhang Jiangning Chen Xing Guo Qibin Li Xiaoying Li Wenjing Wang Yan Zhang Jin Wang Xueyuan Jiang Yang Xiang Chen Xu Pingping Zheng Juanbin Zhang Ruiqiang Li Hongjie Zhang Xiaobin Shang Ting Gong Guang Ning Jun Wang Ke Zen Junfeng Zhang Chen-Yu Zhang | 2008 | Cell Research2008，18，10： | 975 |
| 2 | Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules显示文摘由病毒的 transduction 的四抄写因素 Oct4, Klf4, Sox2 和 c-Myc 的介绍能导致体的房间的 reprogramming 进导致的 pluripotent 干细胞(iPSCs ) ,但是 iPSCs 的使用被病毒的交货系统的使用妨碍。导致化学药品的 reprogramming 把一条新奇途径提供给没有任何病毒的基于向量的基因修正,产生 iPSCs。尽管,以前的报告证明几个小分子能代替一些 reprogramming 因素至少二个抄写因素, Oct4 和 Klf4,仍然被要求从老鼠产生 iPSCs 胚胎的成纤维细胞。这里,我们识别特定的化学联合,它是足够的面对一个单个抄写因素从胚胎的老鼠和成年成纤维细胞允许 reprogramming, Oct4 在 20 天以内,代替 Sox2, Klf4 和 c-Myc。用这个处理产生的 iPSCs 类似于胚胎的干细胞以全球基因表示介绍的老鼠,在 vitro 并且在 vivo 的 epigenetic 地位和 pluripotency。我们也发现那 8 天 Oct4 正式就职是足够的面对小分子启用导致 Oct4 的 reprogramming,它建议 reprogramming 在开始的 8 天以内被开始并且独立于连续外长的 Oct4 表示。没有基因修正,这些发现将帮助 iPSCs 的未来产生,以及阐明位于 reprogramming 过程下面的分子的机制。 | Yanqin Li Qiang Zhang Xiaolei Yin Weifeng Yang Yuanyuan Du Pingping Hou Jian Ge Chun Liu Weiqi Zhang Xu Zhang Yetao Wu Honggang Li Kang Liu Chen Wu Zhihua Song Yang Zhao Yan Shi Hongkui Deng | 2011 | Cell Research2011，21，1： | 51 |
| 3 | Two stages of immiscible liquid separation in the formation of Panzhihua-type Fe-Ti-V oxide deposits,SW China显示文摘在 260 妈 Emeishan 大火的省(ELIP ) 的 Magmatic 氧化物沉积物, SW 中国和北越南,是 Fe, Ti 和 V 的重要来源。一些巨大的 magmatic Fe-Ti-V 氧化物沉积物例如 Panzhihua, Hongge,和 Baima 沉积物,很好在文学被描述并且在 Panxi 区域在分层的 mafic-ultramafic 侵入被招待,中央 ELIP。ELIP 相关的沉积物的一样的类型也远发生到南方并且在红河差错地区包括 Anyi 沉积物, Panzhihua 的大约 130 km 南方,和 Mianhuadi 沉积物。Anyi 沉积物是相对小的,但是同样在分层的 mafic 侵入被招待。Mianhuadi 沉积物有 260 妈的锆石 U-Pb 年龄并且与 ELIP 因此是同时期的。这存款易变地在指责的 Indosinian 造山运动和红河期间被变形。组合地, Mianhuadi 存款的磁铁矿比另外的存款的包含 Ti 和 V 的更小的数量,对以后的变态可能可归因。氧化物矿石存款的分发不与 ELIP 的 domal 结构有关。在 ELIP 的所有氧化物存款的一个主要特征是忍受氧化物的 gabbroic 侵入,黑花岗石 plutons 和 high-Ti 洪水暗岩的空间协会。因此,我们建议从一根披风羽毛的岩浆是进他们被发展进液体 immiscibility 的域形成二硅酸盐液体的一个浅岩浆房间的 emplaced,与一极其 Fe-Ti-rich gabbroic 作文和另外的黑花岗石。不能混合的 Fe-Ti-(P) 氧化物融化然后可以与 mafic 岩浆分开形成氧化物存款。这些存款从形成了的父母岩浆是在作文的可能的 Fe-Ti-rich picritic 并且比生产了 ELIP 的忍受硫化物的侵入的岩浆在更大的深度从充实的 asthenospheric 披风被导出。 | Mei-Fu Zhou Wei Terry Chen Christina Yan Wang Stephen A.Prevec Patricia Pingping Liu Geoffrey H.Howarth | 2013 | Geoscience Frontiers2013，4，5： | 35 |
| 4 | Joint Inversion of the 3D P Wave Velocity Structure of the Crust and Upper Mantle under the Southeastern Margin of the Tibetan Plateau Using Regional Earthquake and Teleseismic Data显示文摘The special seismic tectonic environment and frequent seismicity in the southeastern margin of the Qinghai–Tibet Plateau show that this area is an ideal location to study the present tectonic movement and background of strong earthquakes in China's Mainland and to predict future strong earthquake risk zones. Studies of the structural environment and physical characteristics of the deep structure in this area are helpful to explore deep dynamic effects and deformation field characteristics, to strengthen our understanding of the roles of anisotropy and tectonic deformation and to study the deep tectonic background of the seismic origin of the block's interior. In this paper, the three-dimensional(3D) P-wave velocity structure of the crust and upper mantle under the southeastern margin of the Qinghai–Tibet Plateau is obtained via observational data from 224 permanent seismic stations in the regional digital seismic network of Yunnan and Sichuan Provinces and from 356 mobile China seismic arrays in the southern section of the north–south seismic belt using a joint inversion method of the regional earthquake and teleseismic data. The results indicate that the spatial distribution of the P-wave velocity anomalies in the shallow upper crust is closely related to the surface geological structure, terrain and lithology. Baoxing and Kangding, with their basic volcanic rocks and volcanic clastic rocks, present obvious high-velocity anomalies. The Chengdu Basin shows low-velocity anomalies associated with the Quaternary sediments. The Xichang Mesozoic Basin and the Butuo Basin are characterised by lowvelocity anomalies related to very thick sedimentary layers. The upper and middle crust beneath the Chuan–Dian and Songpan–Ganzi Blocks has apparent lateral heterogeneities, including low-velocity zones of different sizes. There is a large range of low-velocity layers in the Songpan–Ganzi Block and the sub–block northwest of Sichuan Province, showing that the middle and lower crust is relatively weak. The Sichuan Basin, which is located in the western margin of the Yangtze platform, shows high-velocity characteristics. The results also reveal that there are continuous low-velocity layer distributions in the middle and lower crust of the Daliangshan Block and that the distribution direction of the low-velocity anomaly is nearly SN, which is consistent with the trend of the Daliangshan fault. The existence of the low-velocity layer in the crust also provides a deep source for the deep dynamic deformation and seismic activity of the Daliangshan Block and its boundary faults. The results of the 3D P-wave velocity structure show that an anomalous distribution of high-density, strong-magnetic and high-wave velocity exists inside the crust in the Panxi region. This is likely related to late Paleozoic mantle plume activity that led to a large number of mafic and ultra-mafic intrusions into the crust. In the crustal doming process, the massive intrusion of mantle-derived material enhanced the mechanical strength of the crustal medium. The P-wave velocity structure also revealed that the upper mantle contains a low-velocity layer at a depth of 80–120 km in the Panxi region. The existence of deep faults in the Panxi region, which provide conditions for transporting mantle thermal material into the crust, is the deep tectonic background forthe area's strong earthquake activity. | LI Dahu LIAO Hua DING Zhifeng ZHAN Yan WU Pingping XU Xiaoming ZHENG Chen | 2018 | Acta Geologica Sinica(English Edition)2018，92，1： | 12 |
| 5 | Influence of coupled boundary layer suction and bowed blade on flow field and performance of a diffusion cascade显示文摘Based on the investigation of mid-span local boundary layer suction and positive bowed cascade, a coupled local tailored boundary layer suction and positive bowed blade method is developed to improve the performance of a highly loaded diffusion cascade with less suction slot. The effectiveness of the coupled method under different inlet boundary layers is also investigated.Results show that mid-span local boundary layer suction can effectively remove trailing edge separation, but deteriorate the flow fields near the endwall. The positive bowed cascade is beneficial for reducing open corner separation, but is detrimental to mid-span flow fields. The coupled method can further improve the performance and flow field of the cascade. The mid-span trailing edge separation and open corner separation are eliminated. Compared with linear cascade with suction, the coupled method reduces overall loss of the cascade by 31.4% at most. The mid-span loss of the cascade decreases as the suction coefficient increases, but increases as bow angle increases. The endwall loss increases as the suction coefficient increases. By contrast, the endwall loss decreases significantly as the bow angle increases. The endwall loss of coupled controlled cascade is higher than that of bowed cascade with the same bow angle because of the spanwise inverse ‘‘C' shaped static pressure distribution. Under different inlet boundary layer conditions, the coupled method can also improve the cascade effectively. | Cao Zhiyuan Liu Bo Zhang Ting Yang Xiqiong Chen Pingping | 2017 | Chinese Journal of Aeronautics2017，30，1： | 12 |
| 6 | Toxicity of graphene oxide and multi-walled carbon nanotubes against human cells and zebrafish显示文摘Graphene possesses unique physical and chemical properties, which have inspired a wide range of potential biomedical applications. However, little is known about the adverse effects of graphene on the human body and ecological environment. The purpose of our work is to make assessment on the toxicity of graphene oxide (GO) against human cell line (human bone marrow neuroblastoma cell line and human epithelial carcinoma cell line) and zebrafish (Danio rerio) by comparing the toxic effects of GO with its sister, multi-walled carbon nanotubes (MWNTs). The results show that GO has a moderate toxicity to organisms since it can induce minor (about 20%) cell growth inhibition and slight hatching delay of zebrafish embryos at a dosage of 50 mg/L, but did not result in significant increase of apoptosis in embryo, while MWNTs exhibit acute toxicity leading to a strong inhibition of cell proliferation and serious morphological defects in developing embryos even at relatively low concentration of 25 mg/L. The distinctive toxicity of GO and MWNTs should be ascribed to the different models of interaction between nanomaterials and organisms, which arises from the different geometric structures of nanomaterials. Collectively, our work suggests that GO does actual toxicity to organisms posing potential environmental risks and the result is also shedding light on the geometrical structure-dependent toxicity of graphitic nanomaterials. | CHEN LiQiang HU PingPing ZHANG Li HUANG SiZhou LUO LingFei HUANG ChengZhi | 2012 | Science China Chemistry2012，55，10： | 12 |
| 7 | Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells显示文摘Long-range communication between intestinal symbiotic bacteria and extra-intestinal organs can occur through circulating bacterial signal molecules, through neural circuits, or through cytokines or hormones from host cells. Here we report that Nod1 ligands derived from intestinal bacteria act as signal molecules and directly modulate insulin trafficking in pancreatic beta cells. The cytosolic peptidoglycan receptor Nod1 and its downstream adapter Rip2 are required for insulin trafficking in beta cells in a cell-autonomous manner. Mechanistically, upon recognizing cognate ligands, Nod1 and Rip2 localize to insulin vesicles, recruiting Rab1a to direct insulin trafficking through the cytoplasm. Importantly, intestinal lysozyme liberates Nod1 ligands into the circulation, thus enabling long-range communication between intestinal microbes and islets. The intestine-islet crosstalk bridged by Nod1 ligands modulates host glucose tolerance. Our study defines a new type of inter-organ communication based on circulating bacterial signal molecules, which has broad implications for understanding the mutualistic relationship between microbes and host. | Qin Zhang Ying Pan Benhua Zeng Xiaojiao Zheng Haifang Wang Xueying Shen Hui Li Qian Jiang Jiaxu Zhao Zhuo-Xian Meng Pingping Li Zhengjun Chen Hong Wei Zhihua Liu | 2019 | Cell Research2019，29，7： | 11 |
| 8 | Tip-leakage flow loss reduction in a two-stage turbine using axisymmetric-casing contouring显示文摘In order to reduce the losses caused by tip-leakage flow, axisymmetric contouring is applied to the casing of a two-stage unshrouded high pressure turbine(HPT) of aero-engine in this paper. This investigation focuses on the effects of contoured axisymmetric-casing on the blade tipleakage flow. While the size of tip clearance remains the same as the original design, the rotor casing and the blade tip are obtained with the same contoured arc shape. Numerical calculation results show that a promotion of 0.14% to the overall efficiency is achieved. Detailed analysis indicates that it reduces the entropy generation rate caused by the complex vortex structure in the rotor tip region, especially in the tip-leakage vortex. The low velocity region in the leading edge(LE) part of the tip gap is enlarged and the pressure side/tip junction separation bubble extends much further away from the leading edge in the clearance. So the blocking effect of pressure side/tip junction separation bubble on clearance flow prevents more flow on the tip pressure side from leaking to the suction side, which results in weaker leakage vortex and less associated losses. | Wei Zuojun Qiao Weiyang Shi Peijie Chen Pingping Zhao Lei | 2014 | Chinese Journal of Aeronautics2014，27，5： | 9 |
| 9 | Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease显示文摘 | Pingping Song Shanshan Li Hao Wu Ruize Gao Guanhua Rao Dongmei Wang Ziheng Chen Biao Ma Hongxia Wang Nan Sui Haiteng Deng Zhuohua Zhang Tieshan Tang Zheng Tan Zehan Han Tieyuan Lu Yushan Zhu Quan Chen | 2016 | Protein & Cell2016，7，2： | 8 |
| 10 | Wogonoside inhibits tumor growth and metastasis in endometrial cancer via ER stress-Hippo signaling axis显示文摘Wogonoside,a bioactive flavonoid component derived from Scutellaria baicalensis Georgi,has been reported to inhibit tumor growth in mice bearing various types of cancer cells such as breast cancer,lung cancer,and leukemia cells.However,whether wogonoside could inhibit tumor growth of endometrial cancer has not been elucidated.In this study,we explored the function of wogonoside on tumor growth and the underlying mechanism on endometrial cancer.Firstly,we investigated the effect of wogonoside on endometrial cancer cells and found that wogonoside could significantly decrease cell proliferation and metastasis.Mechanistically,wogonoside could aggravate the extent of ER stress and upregulate the phosphorylation level of Mammalian Ste20-like kinase 1,leading to the activation of the Hippo signaling pathway.Taken together,in vitro and in vivo data demonstrated that wogonoside could be a potent inducer of ER stress and could be further developed into a promising therapy for endometrial cancer. | Shaorong Chen Zhuna Wu Yumin Ke Pingping Shu Caihong Chen Ruying Lin Qirong Shi | 2019 | Acta Biochimica et Biophysica Sinica2019，51，11： | 8 |
| 11 | Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy显示文摘Although PD-L1/PD-1 blockade therapy has been approved to treat many types of cancers,the majority of patients with solid tumors do not respond well,but the underlying reason remains unclear.Here,we studied ovarian cancer(OvCa),a tumor type generally resistant to current immunotherapies,to investigate PD-1-independent immunosuppression.We found that PD-L1 was not highly expressed in the tumor microenvironment(TME)of human OvCa.Instead,B7-H3,another checkpoint molecule,was highly expressed by both tumor cells and tumor-infiltrating antigen-presenting cells(APCs),which correlated with T-cell exhaustion in patients.Using ID8 OvCa mouse models,we found that B7-H3 expressed on tumor cells,but not host cells,had a dominant role in suppressing antitumor immunity.Therapeutically,B7-H3 blockade,but not PD-1 blockade,prolonged the survival of ID8 tumorbearing mice.Collectively,our results demonstrate that tumor-expressed B7-H3 inhibits the function of CD8^(+)T cells and suggest that B7-H3 may be a target in patients who are not responsive to PD-L1/PD-1 inhibition,particularly OvCa patients. | Dongli Cai Jiaming Li Dingfeng Liu Shanjuan Hong Qin Qiao Qinli Sun Pingping Li Nanan Lyu Tiantian Sun Shan Xie Li Guo Ling Ni Liping Jin Chen Dong | 2020 | Cellular & Molecular Immunology2020，17，3： | 8 |
| 12 | Effect of monovalent anions on cationic Gemini micro-emulsion显示文摘Micro-emulsion usually consists of water, oil, surfactants and co-surfactants, and each component has an effect on the phase behavior and solubilization of the micro-emulsion. When the surfactant in the micro-emulsion system is quaternary ammonium cationic Gemini surfactant, the surfactant mainly combines with the anions in the salt. With the increase of salt concentration, the phase transformation of Winsor I → Winsor III → Winsor II occurred, but the optimum salinity and salt width are different because of the type of salt. The effects of 5 different kinds of monovalent anions, including C_6H_5SO_3^-, I-, Br-, NO_3^- and Cl-, on the phase behavior and solubilization of quaternary ammonium cationic Gemini micro-emulsion are researched by Winsor phase diagram. It is found that the effects of organic anions C_6H_5SO_3-and I-on the phase behavior and solubilization of quaternary ammonium cationic Gemini micro-emulsion are most significant, and the effects of Br-, NO_3^- and Cl-are less significant. Meanwhile, when the optimum solubilization is achieved, the amount of sodium benzoate is the least, indicating that the organic anion has stronger self-organization behavior with quaternary ammonium cationic Gemini surfactants. | Yinglu Gu Shuang Chen Hui'e Liu Yubin Wang Pingping Zhou | 2018 | Chinese Journal of Chemical Engineering2018，26，12： | 6 |
| 13 | Efficient Image Transmission Schemes over Zigbee-Based Image Sensor Networks显示文摘Image transmission is one of the biggest challenges in wireless sensor networks because of the limited resource on sensor nodes. We proposed two image transmission schemes driven by reliability and real time considerations in order to transfer JPEG images over Zigbee-based sensor networks. By adding two bytes counter in the header of data packet, we can easily solve the repeated data reception problem caused by retransmission mechanism in traditional Zigbees network layer. We proposed an efficient retransmission and acknowledgment mechanism in Zigbees application layer. By classifying different data reception response events, we can provide data packets with differential responses and ensure that image packets can be transferred quickly even with large maximum number of retransmission. Practical results show the effectiveness of our solutions to make image transmission over Zigbee-based sensor networks efficient. | TAO Dan YANG Guangwei CHEN Houjin WU Hao LIU Pingping | 2016 | Chinese Journal of Electronics2016，25，2： | 5 |
| 14 | Nano-hydroxyapatite accelerates vascular calcification via lysosome impairment and autophagy dysfunction in smooth muscle cells显示文摘Vascular calcification(VC)is a common characteristic of aging,diabetes,chronic renal failure,and atherosclerosis.The basic component of VC is hydroxyapatite(HAp).Nano-sized HAp(nHAp)has been identified to play an essential role in the development of pathological calcification of vasculature.However,whether nHAp can induce calcification in vivo and the mechanism of nHAp in the progression of VC remains unclear.We discovered that nHAp existed both in vascular smooth muscle cells(VSMCs)and their extracellular matrix(ECM)in the calcified arteries from patients.Synthetic nHAp had similar morphological and chemical properties as natural nHAp recovered from calcified artery.nHAp stimulated osteogenic differentiation and accelerated mineralization of VSMCs in vitro.Synthetic nHAp could also directly induce VC in vivo.Mechanistically,nHAp was internalized into lysosome,which impaired lysosome vacuolar H+-ATPase for its acidification,therefore blocked autophagic flux in VSMCs.Lysosomal re-acidification by cyclic-3′,5′-adenosine monophosphate(cAMP)significantly enhanced autophagic degradation and attenuated nHAp-induced calcification.The accumulated autophagosomes and autolysosomes were converted into calcium-containing exosomes which were secreted into ECM and accelerated vascular calcium deposit.Inhibition of exosome release in VSMCs decreased calcium deposition.Altogether,our results demonstrated a repressive effect of nHAp on lysosomal acidification,which inhibited autophagic degradation and promoted a conversion of the accumulated autophagic vacuoles into exosomes that were loaded with undissolved nHAp,Ca^(2+),Pi and ALP.These exosomes bud off the plasma membrane,deposit within ECM,and form calcium nodules.Vascular calcification was thus accelerated by nHAP through blockage of autophagic flux in VSMCs. | Qi Liu Yi Luo Yun Zhao Pingping Xiang Jinyun Zhu Wangwei Jing Wenjing Jin Mingyao Chen Ruikang Tang Hong Yu | 2022 | Bioactive Materials2022，7，2： | 5 |
| 15 | Structure and quality controlled growth of InAs nanowires through catalyst engineering显示文摘在这研究,结构和用在一个分子的横梁取向附生反应堆的 Au 催化剂的 InAs nanowires 的 quality controlled 生长被介绍。由在催化剂调节铟集中,没有缺点的 wurtzite 结构和没有缺点的锌闪锌矿结构 InAs nanowires 能被导致。这些没有缺点的锌闪锌矿结构 InAs nanowires 沿着\成长,这被发现( \left\langle { \bar 1 \bar 10 } \right\rangle \)方向与四低精力{ 111 }并且二{ 110 }方面墙方面并且采用\( \left ({ \bar 1 \bar 1 \bar 1 } \right )\) catalyst/nanowire 接口。我们的结构、化学的描述和计算为 InAs nanowire 生长识别催化剂过度饱和阀值的存在。什么时候在里面在催化剂的集中足够地高,没有缺点的锌闪锌矿结构 InAs nanowires 能被导致。这研究通过催化剂工程提供卓见进晶体结构的操作和 IIIV 半导体 nanowires 的结构质量。 | ZhiZhang Zhenyu Lu Hongyi Xu Pingping Chen Wei Lu Jin Zou | 2014 | Nano Research2014，7，11： | 4 |
| 16 | Spacecraft angular velocity estimation method using optical flow of stars显示文摘Angular velocity is a crucial parameter for spacecraft navigation, which, at present, is mainly obtained by using gyroscopes. Several studies have been performed on angular velocity estimation using star sensors when data from gyroscopes are not available. Most of the previous angular velocity estimation methods using star sensors are based on information on the attitude or star vector measurements. In this paper,an angular velocity estimation method using the optical flow(OF) directly from the star images is proposed,which, unlike the previous methods, requires star coordinates in two consecutive images only. Because the procedure of star identification is eliminated, the corresponding high computation requirement is reduced.Simulations demonstrate that the proposed method has a robust performance in terms of computational cost and the number of stars in the field of view(FOV) compared with the previous methods. Finally, certain affecting factors are analyzed, including lens distortion, star senor instantaneous FOV(IFOV), star number,and accuracy of the star sensor. | Xiaolin NING Zonghe DING Pingping CHEN Weiren WU Jiancheng FANG Gang LIU | 2018 | Science China(Information Sciences)2018，61，11： | 3 |
| 17 | Experimental investigations on the fluid flow mechanism in porous media of enhanced oil recovery by alkli/surfactant/polymer flooding显示文摘The fluid flow mechanism in porous media of enhanced oil recovery by Alkli/ Surfactant/ Polymer (ASP) flooding is investigated by measuring production performance, pressure distribution and saturation distribution through installing differential pressure transducers and saturation measuring probes in a physical model of vertical heterogeneous reservoir. The fluid flow variation in porous media is the main reason of enhanced oil recovery of ASP flooding. The pressure field and saturation field are nonlinearly coupled together and the interaction between them results in the fluid flow variation in the reservoir. In a vertical heterogeneous reservoir, the ASP agents initially flow in the high permeability layer, and fluid changes the flow direction toward the low and the middle permeability layers because the resistance in the high permeability layer is increased under the physical and chemical action of adsorption, retention and emulsion. ASP flooding displaces out not only the residual oil in the high permeability layer, but also the remaining oil in the low and the middle permeability layers by increasing swept volume and displacing efficiency. | WANG Jialu SHEN Pingping CHEN Yongzhong ZHANG Zubo JIA Xu TIAN Yuling | 2005 | Science China(Technological Sciences)2005，48，4： | 3 |
| 18 | Statin therapy improves response to interferon alfa and ribavirin in chronic hepatitis C: A systematic review and meta-analysis显示文摘 | Qianqian Zhu Na Li Qunying Han Pingping Zhang Cuiling Yang Xiaoyan Zeng Yanping Chen Yi Lv Xi Liu Zhengwen Liu | 2013 | Antiviral Research2013，，3： | 3 |
| 19 | Composition and Distribution of Planktonic Ciliates in the Southern South China Sea During Late Summer: Comparison Between Surface and 75 m Deep Layer显示文摘Ciliates are very important components in most marine ecosystem.They are trophic link between the microbial food web and grazing food chain.In this study,ciliates were collected from 11 sites in the southern South China Sea(SCS) during August 25 to September 28,2011.Their composition and distribution at the surface and 75 m deep depth of the ocean were studied.A total of 30 species belonging to 22 genera were identified,and 22 species of 15 genera were Tintinnids.Eutintinnus fraknoii and E.stramentus were the most common species.The other dominants were strombidiids ciliates including Strombidium conicum and S.globosaneum,which were followed by the tide form,Mesodinium pulex.Ciliates abundance ranged from 46 ind L^(-1) to 368 ind L^(-1) in the open sites,46–368 ind L^(-1) at surface and 73–198 ind L^(-1) at 75 m deep layer.In the Yongshu reef,ciliates abundance ranged from 167 ind L^(-1) to 365 ind L^(-1) in the water column,similar to that in Sanya coral reef waters.Ciliates composition showed obvious difference between surface and 75 m deep layer at station S2(P < 0.05),while no similar result was observed at other sites.At 75 m deep layer,salinity was negatively related to mixed layer depth(P < 0.05),but positively to chlorophyll a concentration(P < 0.05),indicating that the change of vertical mixing in water column influenced vertical distribution of ciliates in the southern SCS. | LIU Huaxue SHEN Pingping LI Chunhou CHEN Zuozhi QI Zhanhui HUANG Honghui | 2016 | Journal of Ocean University of China2016，15，1： | 3 |
| 20 | New Fractal Evidence of Pacific Plate Subduction in the Late Mesozoic, Great Xing’an Range, Northeast China显示文摘Late Mesozoic granitoids are widespread in the Great Xing’an Range(GXR), which is part of a large igneous province in eastern China. The geodynamic setting of the Late Mesozoic granitoids is still debated, and there have been two dominant models proposed, subduction and thermal erosion. This study discusses the geodynamic mechanisms from a new perspective on ages of the granitoids and fractal dimensions of their shape. Our results show that granitoids become gradually older from South GXR to North GXR to Erguna Block(EB) in the Jurassic, and opposite in the Cretaceous. The fractal dimensions of the Perimeter-area model(DAP) exhibit the same features. The values of DAP are smaller from South GXR(0.673 1) to North GXR(0.628 0) to EB(0.607 9) in the Jurassic, and larger from South GXR(0.609 6) to North GXR(0.630 2) to EB(0.639 9) in the Cretaceous. This implies that the geometrical irregularities of the granitoids are shaped by subduction rather than thermal erosion. These spatial variations could be best explained by the subduction of the Pacific Plate and consequent granitoid magmatism in the Late Mesozoic, thus providing a new fractal evidence for Pacific Plate subduction mechanism and opening a new possibility method for studing plate movement. | Pingping Zhu Qiuming Cheng Guoxiong Chen | 2019 | Journal of Earth Science2019，30，5： | 2 |
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