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| 1 | Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells显示文摘Long-range communication between intestinal symbiotic bacteria and extra-intestinal organs can occur through circulating bacterial signal molecules, through neural circuits, or through cytokines or hormones from host cells. Here we report that Nod1 ligands derived from intestinal bacteria act as signal molecules and directly modulate insulin trafficking in pancreatic beta cells. The cytosolic peptidoglycan receptor Nod1 and its downstream adapter Rip2 are required for insulin trafficking in beta cells in a cell-autonomous manner. Mechanistically, upon recognizing cognate ligands, Nod1 and Rip2 localize to insulin vesicles, recruiting Rab1a to direct insulin trafficking through the cytoplasm. Importantly, intestinal lysozyme liberates Nod1 ligands into the circulation, thus enabling long-range communication between intestinal microbes and islets. The intestine-islet crosstalk bridged by Nod1 ligands modulates host glucose tolerance. Our study defines a new type of inter-organ communication based on circulating bacterial signal molecules, which has broad implications for understanding the mutualistic relationship between microbes and host. | Qin Zhang Ying Pan Benhua Zeng Xiaojiao Zheng Haifang Wang Xueying Shen Hui Li Qian Jiang Jiaxu Zhao Zhuo-Xian Meng Pingping Li Zhengjun Chen Hong Wei Zhihua Liu | 2019 | Cell Research2019，29，7： | 11 |
| 2 | Defect self-assembly of metal-organic framework triggers ferroptosis to overcome resistance显示文摘The emergence of multidrug treatment resistance presents a hurdle for the successful chemotherapy of tumours.Ferroptosis,resulting from the iron-dependent accumulation of lipid peroxides,has the potential to reverse multidrug resistance.However,simultaneous delivery of the iron sources,ferroptosis inducers,drugs,and enhanced circulation carriers within matrices remains a significant challenge.Herein,we designed and fabricated a defect self-assembly of metal-organic framework(MOF)-red blood cell(RBC)membrane-camouflaged multi-drug-delivery nanoplatform for combined ferroptosis-apoptosis treatment of multidrug-resistant cancer.Ferroptosis and chemotherapeutic drugs are embedded in the centre of the iron(III)-based MOF at defect sites by coordination with metal clusters during a one-pot solvothermal synthesis process.The RBC membrane could camouflage the nanoplatform for longer circulation.Our results demonstrate that this defect self-assembly-enabled MOF-membrane-camouflaged nanoplatform could deplete the glutathione,amplify the reactive oxidative species oxidative stress,and enable remarkable anticancer properties.Our work provides an alternative strategy for overcoming multidrug resistance,which could regulate the fluidity and permeability of the cell membrane by ferroptosis to downregulate of P-glycoprotein protein expression by ferroptosis.This defect self-assembly-enabled MOF-membrane-camouflaged multi-drug-delivery nanoplatform has great therapeutic potential. | Haibao Peng Xingcai Zhang Peng Yang Jiaxu Zhao Wei Zhang Nianping Feng Wuli Yang Jing Tang | 2023 | Bioactive Materials2023，，1： | 2 |
| 3 | RNF114 suppresses metastasis through regulation of PARP10 in cervical cancer cells显示文摘Dear editor,ADP-ribosylation is a post-translational modification catalysed by poly(ADP-ribose)polymerases(PARPs)and plays important roles in diverse biological processes,such as DNA repair,chromatin remodelling,telomere homeostasis,transcription,chromosome segregation,cell proliferation,and cell death[1,2].While much is known about the cellular roles of PARPs that catalyse polyADP ribosylation,the function of the PARPs that catalyse monoADP ribosylation is substantially less understood. | Yahui Zhao Xiao Liang Li Wei Yao Liu Juan Liu Huan Feng Fen Zheng Ying Wang Haijie Ma Jiaxue Wu | 2021 | Cancer Communications2021，41，2： | 1 |
| 4 | The applications of induced pluripotent stem(iPS)cells in drug development显示文摘The introduction of induced pluripotent stem(iPS)cells has been a milestone in the field of regenerative medicine and drug discovery.iPS cells can provide a continuous and individualized source of stem cells and are considered to hold great potential for economically feasible personalized stem cell therapy.Various diseases might potentially be cured by iPS cell-based therapy including Parkinson’s disease,Alzheimer’s disease,Huntington disease,ischemic heart disease,diabetes and so on.Moreover,iPS cells derived from patients suffering from unique incurable diseases can be developed into patient-and disease-specific cell lines.These cells can be used as an effective approach to study the mechanisms of diseases,providing useful tools for drug discovery,development and evaluation.The development of suitable methods for the culture and expansion of iPS cells and their differentiated progenies make feasible modern drug discovery techniques such as high-throughput screening.Furthermore,iPS cells can be applied in the field of toxicological and pharmacokinetics tests.This review focuses on the applications of iPS cells in the field of pharmaceutical industry. | Shulong YANG Xuelian WANG Jinmiao LIU Zhao LIU Jiaxue HUANG | 2011 | Frontiers in Biology2011，6，1： | 1 |
| 5 | Biological indicators of sub-optimal health status显示文摘OBJECTIVE:To investigate biological indicators of sub-optimal health status and provide means of objective assessment of sub-optimal health status.METHODS:We set the unified standards for diagnosing a SHS.We tested various laboratory indicators in 407 cases that we selected randomly from2807 subjects and collected 15 mL of fasting venous blood from each case.We measured serum immunoglobulin A(IgA)and immunoglobulin G(IgG)concentrations,serum beta endorphins(β-EP),cortisol(C),testosterone(T),plasma adrenocorticotropic hormone(ACTH)and serum T lymphocyte subsets CD3+and CD4+.RESULTS:Mean serum testosterone concentrations and their ratio to cortisol(C)concentrations weresignificantly higher in the healthy group than in those with sub-optimal health status(P<0.01).Mean serum CD3+concentrations were significantly higher in those with sub-optimal health status than in the healthy group(P<0.05).CONCLUSION:Decreased serum testosterone/cortisol ratio may be an objective indication of sub-optimal health status.Changes in neuroendocrine and immunological indicators may explain some of the symptoms,including malaise and poor work performance,attributable to persistent or relapsing fatigue in subjects with sub-optimal health status. | Limin Wang Xin Zhao Jiaxu Chen Xiaoling Guo Xin Liang Danhui Yi Huating Cui Yueyun Liu | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 1 |
| 6 | Somatic mutation contributing to clonal haematopoiesis is a risk factor of recurrent stroke in first-ever acute ischaemic stroke:a prospective cohort study显示文摘Background Somatic mutation contributes to clonal haematopoiesis of indeterminate potential(CHIP)is related to age and associated with a higher risk of stroke and atherosclerotic cardiovascular disease.Here,we investigated the prognostic significance of CHIP in a large first-ever acute ischaemic stroke(AIS)cohort and explored the underlying mechanisms.Methods We studied a prospective cohort of 6016 patients who had a first-ever AIS in China.Whole-genome sequencing was performed to identify CHIP.High-sensitivity C reactive protein(hs-CRP)levels above 3 mg/L at baseline were defined as hyperinflammation.Recurrent stroke during the 3-month follow-up was the primary outcome.Results Among the 6016 patients who had a first-ever AIS,with a median age was 62 years(IQR,54.0‒70.0),3.70%were identified as CHIP carriers.The most common mutations occurred in the DNMT3A(30.0%)and TET2(11.4%)genes.During a follow-up of 3 months,the presence of CHIP was associated with recurrent stroke(HR 1.62,95%CI 1.04 to 2.51,p=0.03),recurrent ischaemic stroke(HR 1.64,95%CI 1.04 to 2.58,p=0.03)and combined vascular events(HR 1.58,95%CI 1.02 to 2.44,p=0.04)after adjusting for hsCRP levels at baseline in patients who had a first-ever AIS.Subgroup analysis demonstrated that CHIP was only associated with recurrent stroke when patients under hyperinflammation(OR 3.10,95%CI 1.92 to 5.00,p<0.001)but not in those without hyperinflammation(OR 0.18,95%CI 0.03 to 1.04,p=0.06,Pinteraction=0.002).Conclusion Our results suggest that somatic mutations contributing to CHIP increase the risk of short-term recurrent stroke in patients who had a first-ever AIS.Hyperinflammation may be important in the relationship between CHIP and recurrent stroke. | Xin Qiu Yalun Dai Si Cheng Hong-Qiu Gu Yong Jiang Xia Meng Yilong Wang Xingquan Zhao Yingyu Jiang Zhe Xu Xinying Huang Meng Wang Tian Jie Lyu Yubo Wang Jiaxu Weng Lingyun Cui Yi Shangguan Hao Li Yongjun Wang Zixiao Li | 2023 | Stroke & Vascular Neurology2023，8，2： | 1 |
| 7 | A Trade-off between Solvation and Collision Activation in Steering Competing E2 and S_(N)2 Dynamics显示文摘The prototypical E2 elimination and SN2 sub-stitution reactions between microsolvated fluoride and ethyl bromide show unexpected dynamic behaviors in mechanistic evolution driven by solvation and collision activation.Considering the steric effects,the gas-phase selectivity favors an E2 pathway barely dependent on collision energies.Remarkably,base solvation steers the reaction in an effective way toward substitution at a near-thermal energy,whereas the governing high-energy events retain elimination.Chemical dynamics simulations reproduce exper-imental findings and uncover a crucial solute-solvent coupling in determining such competing processes.Interestingly,collision activation can tune the underlying atomistic dynamics essentially in the reactant entrance channel and cause a mechanism shift.These features for the ubiquitous competing E2/SN2 dynamics remain quite unknown,providing unique insight into reaction selectivity for complex chemical networks. | Hongyi Wang Xu Liu Siwei Zhao Gang Fu Wenqing Zhen Li Yang Jiaxu Zhang | 2024 | Precision Chemistry2024，2，1： | 0 |
| 8 | Characteristics and modeling of UAV-vehicle MIMO wideband channels显示文摘A geometry-based stochastic model(GBSM) for unmanned aerial vehicle to vehicle(UAV-V) multiple-input multiple-output(MIMO) wideband channel is proposed to investigate the characteristics of UAV-V channel. Based on the proposed model, a three-dimensional(3D) wideband channel matrix regarding channel numbers, time and delay is constructed. And some important channel characteristics parameters, such as power delay profile(PDP), root mean square(RMS) delay spread, RMS Doppler spread, channel gain and Doppler power spectral density(PSD) are investigated with different vehicle velocities. It is much simpler and clearer compared with the complex analytical derivations. The results are compared with validated analysis to confirm the theoretical analysis. | Liang Xiaolin Ma Jiaxu Cao Wangbin Xu Jianpeng Liu Shuaiqi Zhao Xiongwen | 2023 | The Journal of China Universities of Posts and Telecommunications2023，30，6： | 0 |
| 9 | Study on Prevention and Treatment of Autophagy and Cervical HPV Infection by Traditional Chinese Medicine Based on Pathogenesis of 'Syndrome of Dampness-heat Diffusing Downward'显示文摘Autophagy is a self-protection mechanism of the body,and also an important physiological process for cells to maintain internal environment stability.Studies have shown that the degree of autophagy damage is positively correlated with the expression of oncogenes,and the expression of oncogenes is closely related to cervical HPV infection,so the control of autophagy ability can interfere with cervical HPV virus infection.Traditional Chinese medicine believes that dampness-heat evil down,can damage and Chong Ren cell.The author believes that autophagy damage and the theory of dampness-heat injection in cervical HPV infection have similar pathogenic mechanism,and explores the prevention and treatment of autophagy and cervical HPV infection based on the theory of traditional Chinese medicine dampness-heat injection,in attempt to provide a new treatment for clinical prevention and treatment. | Anqi Liu Mei Chen Nan Li Hongli Zhu Jun Bai Xin Zhao Jiaxue Yang | 2021 | Journal of Clinical and Nursing Research2021，5，3： | 0 |
| 10 | Toward Establishing a Low-cost UAV Coordinated Carbon Observation Network(LUCCN):First Integrated Campaign in China显示文摘In this study,we introduce our newly developed measurement-fed-perception self-adaption Low-cost UAV Coordinated Carbon Observation Network(LUCCN)prototype.The LUCCN primarily consists of two categories of instruments,including ground-based and UAV-based in-situ measurement.We use the GMP343,a low-cost non-dispersive infrared sensor,in both ground-based and UAV-based instruments.The first integrated measurement campaign took place in Shenzhen,China,4 May 2023.During the campaign,we found that LUCCN’s UAV component presented significant data-collecting advantages over its ground-based counterpart owing to the relatively high altitudes of the point emission sources,which was especially obvious at a gas power plant in Shenzhen.The emission flux was calculated by a crosssectional flux(CSF)method,the results of which differed from the Open-Data Inventory for Anthropogenic Carbon dioxide(ODIAC).The CSF result was slightly larger than others because of the low sampling rate of the whole emission cross section.The LUCCN system will be applied in future carbon monitoring campaigns to increase the spatiotemporal coverage of carbon emission information,especially in scenarios involving the detection of smaller-scale,rapidly varying sources and sinks. | Dongxu YANG Tonghui ZHAO Lu YAO Dong GUO Meng FAN Xiaoyu REN Mingge LI Kai WU Jing WANG Zhaonan CAI Sisi WANG Jiaxu GUO Liangfu CHEN Yi LIU | 2024 | Advances in Atmospheric Sciences2024，41，1： | 0 |
| 11 | Artificial intelligence-based medical image segmentation for 3D printing and naked eye 3D visualization显示文摘Image segmentation for 3D printing and 3D visualization has become an essential component in many fields of medical research,teaching,and clinical practice.Medical image segmentation requires sophisticated computerized quantifications and visualization tools.Recently,with the development of artificial intelligence(AI)technology,tumors or organs can be quickly and accurately detected and automatically contoured from medical images.This paper introduces a platform-independent,multi-modality image registration,segmentation,and 3D visualization program,named artificial intelligence-based medical image segmentation for 3D printing and naked eye 3D visualization(AIMIS3D).YOLOV3 algorithm was used to recognize prostate organ from T2-weighted MRI images with proper training.Prostate cancer and bladder cancer were segmented based on U-net from MRI images.CT images of osteosarcoma were loaded into the platform for the segmentation of lumbar spine,osteosarcoma,vessels,and local nerves for 3D printing.Breast displacement during each radiation therapy was quantitatively evaluated by automatically identifying the position of the 3D printed plastic breast bra.Brain vessel from multimodality MRI images was segmented by using model-based transfer learning for 3D printing and naked eye 3D visualization in AIMIS3D platform. | Guang Jia Xunan Huang Sen Tao Xianghuai Zhang Yue Zhao Hongcai Wang Jie He Jiaxue Hao Bo Liu Jiejing Zhou Tanping Li Xiaoling Zhang Jinglong Gao | 2022 | Intelligent Medicine2022，2，1： | 0 |
| 12 | Coupling effect of bifunctional ZnCe@SBA-15 catalyst in 1,3-butadiene production from bioethanol显示文摘A series of bifunctional Zn Ce@SBA-15 catalysts with different Zn/Ce ratios were prepared by a solid-state grinding strategy and used in the conversion of ethanol to 1,3-butadiene(ETB).For the supported metal oxides,Zn O serves as the active sites for the dehydrogenation of ethanol,and CeO_(2) promotes the aldolcondensation reaction.Based on the results of Py-FTIR and NH_(3)-TPD,it suggests that the yield of 1,3-butadiene is positively correlated with the number of weak Lewis acid sites on the catalyst surface,given their benefit for aldol-condensation reactions.The catalyst with an optimal Zn/Ce ratio of about 1:5 has the highest concentration of weak Lewis acid.Coupling with the Zn O sites,it contributes to a 98.4%conversion of ethanol and a 45.2%selective of 1,3-butadiene under relatively mild reaction conditions(375°C,101.325 k Pa,and 0.54 h^(-1)). | Zheng Wang Sijia Li Shengping Wang Jiaxu Liu Yujun Zhao Xinbin Ma | 2022 | Chinese Journal of Chemical Engineering2022，35，5： | 0 |
| 13 | Selective deletion of zinc transporter 3 in amacrine cells promotes retinal ganglion cell survival and optic nerve regeneration after injury显示文摘Vision depends on accurate signal conduction from the retina to the brain through the optic nerve,an important part of the central nervous system that consists of bundles of axons originating from retinal ganglion cells.The mammalian optic nerve,an important part of the central nervous system,cannot regenerate once it is injured,leading to permanent vision loss.To date,there is no clinical treatment that can regenerate the optic nerve and restore vision.Our previous study found that the mobile zinc(Zn^(2+))level increased rapidly after optic nerve injury in the retina,specifically in the vesicles of the inner plexiform layer.Furthermore,chelating Zn^(2+)significantly promoted axonal regeneration with a long-term effect.In this study,we conditionally knocked out zinc transporter 3(ZnT3)in amacrine cells or retinal ganglion cells to construct two transgenic mouse lines(VGAT^(Cre)ZnT3^(fl/fl)and VGLUT2^(Cre)ZnT3^(fl/fl),respectively).We obtained direct evidence that the rapidly increased mobile Zn^(2+)in response to injury was from amacrine cells.We also found that selective deletion of ZnT3 in amacrine cells promoted retinal ganglion cell survival and axonal regeneration after optic nerve crush injury,improved retinal ganglion cell function,and promoted vision recovery.Sequencing analysis of reginal ganglion cells revealed that inhibiting the release of presynaptic Zn^(2+)affected the transcription of key genes related to the survival of retinal ganglion cells in postsynaptic neurons,regulated the synaptic connection between amacrine cells and retinal ganglion cells,and affected the fate of retinal ganglion cells.These results suggest that amacrine cells release Zn^(2+)to trigger transcriptomic changes related to neuronal growth and survival in reginal ganglion cells,thereby influencing the synaptic plasticity of retinal networks.These results make the theory of zinc-dependent retinal ganglion cell death more accurate and complete and provide new insights into the complex interactions between retinal cell networks. | Zhe Liu Jingfei Xue Canying Liu Jiahui Tang Siting Wu Jicheng Lin Jiaxu Han Qi Zhang Caiqing Wu Haishun Huang Ling Zhao Yehong Zhuo Yiqing Li | 2023 | Neural Regeneration Research2023，18，12： | 0 |
| 14 | E2/S_(N)2 Selectivity Driven by Reaction Dynamics. Insight into Halogen Bonding显示文摘Ubiquitous competition of stereospecific E2 elimination versus SN2 substitution is of central importance in chemical synthesis.Herein,we uncover how the nature of the leaving group affects the intrinsic competing dynamics that remains largely unknown as opposed to its role in reactivity.Results are presented for a prototype case of fluoride anion reacting with ethyl chloride,compared to reacting with ethyl iodide.Chemical dynamics simulations reproduce scattering signatures observed in experiments and reveal that the direct stripping/rebound mechanisms characterize the E2/S_(N)2 reactions,in line with their dynamic fingerprints identified.Quite similar structures and energetics are found for the Cl^(−)and I^(−)leaving halides,whereas the competing dynamics show markedly distinct features.A halogen-bonding attraction is found to be crucial that modifies the interaction potential in the entrance channel and essentially tunes the underlying atomistic behaviors causing a mechanistic shift.This work highlights the dynamical effects induced by a leaving group on the proceedings of baseinduced elimination and nucleophilic substitution,providing a unique insight into the reaction selectivity for complex chemical networks and environments. | Siwei Zhao Hongyi Wang Gang Fu Wenqing Zhen Meiling Liu Li Yang Jiaxu Zhang | 2023 | Precision Chemistry2023，1，8： | 0 |
| 15 | A robust membrane with dual superlyophobicity for solving water-caused lubricant deterioration and water contamination显示文摘Lubricants are often contaminated by water in different ways. Water-polluted lubricants extremely accelerate wear corrosion, leading to the deterioration of lubricity performance. Recently, multiphase media superwettability has been developed to endow one surface with compatible functions, such as on-demand separation of oily wastewater. However, realizing the robustness of the dual superlyophobic surface to solve water-caused lubricant deterioration and water contamination as needed remains challenges. Herein, a robust dual superlyophobic membrane is presented to realize on-demand separation for various lubricant–water emulsions. Compared to pure lubricants, the purified lubricants have equivalent tribology performance, which are much better than that of water-polluted lubricants. The as-prepared membrane maintains dual superlyophobicity, high-efficient for water or lubricant purification, and excellent tribology performance of the purified lubricant, even after immersion in hot liquids for 24 h, multicycle separation, and sandpaper abrasion for 50 cycles. Water-polluted lubricant extremely accelerates wear corrosion to promote catalytic dehydrogenation of lubricants, generating too much harmful carbon-based debris. This work shows great guiding significance for recovering the tribology performance of water-polluted lubricants and purifying water by the dual superlyophobic membrane. | Siyang ZHAO Chenggong XU Jiaxu ZHANG Yongmin LIANG Weimin LIU Jinxia HUANG Zhiguang GUO | 2023 | Friction2023，11，8： | 0 |
| 16 | Cloning and Characterization of EuGID1 in Eucommia ulmoides Oliver显示文摘Gibberellic acid controlled the key developmental processes of the life cycle of landing plants,and regulated the growth and development of plants.In this study,a novel gibberellin receptor gene EuGID1 was obtained from Eucommia ulmoides Oliver.The cDNA of EuGID1 was 1556 bp,and the open reading frame was 1029 bp,which encoded 343 amino acids.EuGID1 had the homology sequence with the hormone-sensitive lipase family.Amino acid sequence alignment confirmed EuGID1 protein had the highest homology with the GID1 protein of Manihot esculenta.EuGID1 was located in the nucleus and cell membrane and had expression in four plant organs.Overexpression of EuGID1 in transgenic Arabidopsis plants promoted plant elongation and increased siliques yield. | Yulu Chen Fen Zhang Ju Cai Yichen Zhao Jiaxue Cui Yan Li | 2022 | Phyton-International Journal of Experimental Botany2022，91，5： | 0 |
| 17 | Breathable Kirigami‑Shaped Ionotronic e‑Textile with Touch/Strain Sensing for Friendly Epidermal Electronics显示文摘Flexible ionotronic devices have great potential to revolutionize epidermal electronics.However,the lack of breathability in most ionotronic devices is a significance barrier to practical application.Herein,a breathable kirigami-shaped ionotronic e-textile with two functions of sensing(touch and strain)is designed,by integrating silk fabric and kirigami-shaped ionic hydrogel.The kirigami-shaped ionic hydrogel,combined with fluffy silk fabric,allows the ionotronic e-textile to achieve excellent breathability and comfortability.Furthermore,the fabricated ionotronic e-textile can precisely perform the function of touch sensing and strain perception.For touch-sensing,the ionotronic e-textile can detect the position of finger touching point with a fast response time(3 ms)based on the interruption of the ion field.For strain sensing,large workable strain range(>100%),inconspicuous drift(<0.78%)and long-term stability(>10,000 cycles)is demonstrated.On the proof of concept,a fabric keyboard and game controlling sleeve have been designed to display touch and strain sensing functions.The ionotronic e-textile break through the bottlenecks of traditional wearable ionotronic devices,suggesting a great promising application in future wearable epidermal electronics. | Ruidong Xu Minghua She Jiaxu Liu Shikang Zhao Hong Liu Lijun Qu Mingwei Tian | 2022 | Advanced Fiber Materials2022，4，6： | 0 |
| 18 | Injectable Fiber Electronics for Tumor Treatment显示文摘Electrochemical therapy emerged as a low-cost and efective method for tumor ablation.However,it has challenges such as the production of toxic byproducts and the use of rigid electrodes that damage soft tissues.Here,we report a new injectable and tissue-compatible fber therapeutic electronics for safe and efcient tumor treatment.The design of aligned carbon nanotube(CNT)fber as electrodes endowed the device with high softness and enabled mini-invasive implantation through injection.Under a mild voltage(1.2 V),the fber device released hydroxyl ions to alter the local chemical environment of the tissues without additional toxic products/gases,leading to immediate death of tumor cells.The fexible fber device could form stable interface with tissues and showed good biocompatibility after implantation for 30 days.The in vitro experimental results showed the fber device could efciently kill 90.9%of QGY-7703 cancer cells after a single treatment in a few minutes.The tumor-bearing animal models proved that the fber therapeutic device could efectively inhibit the growth of tumor tissues,indicating it is a safe,efective,controllable and low-cost method for tumor therapy. | Yang Zhao Chuanrui Chen Yangyang Qiu Tenglong Mei Lei Ye Huan Feng Ye Zhang Liyuan Wang Yue Guo Xuemei Sun Jiaxue Wu Huisheng Peng | 2022 | Advanced Fiber Materials2022，4，2： | 0 |
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