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| 1 | The PCA3 test for guiding repeat biopsy of prostate cancer and its cut-off score: a systematic review and meta-analysis显示文摘为在重复活体检视的早干预的前列腺特定的抗原(PSA ) 的特性是不能令人满意的。(PCA3 ) 前列腺癌症抗原 3 可能比为前列腺癌症(PCa ) 的早察觉的另外的方法在结果预言是更精确的。然而,结果在重复活体检视是不一致的。因此,我们执行了系统的评论和元分析在结果预言评估 PCA3 的角色。系统的文献的搜索为在 2013 年 4 月前出版的文章被进行,用从健康技术评价机构的 PubMed, Medline,科学的网, Embase 和另外的数据库。研究的质量根据 QUADAS 标准被估计。诊断测试与的十一研究对高质量中等被选择。元分析被执行综合结果。元分析的结果在研究之中是异构的。我们执行了亚群分析(与或没有高级 prostatic intraepithelial 瘤形成(HGPIN ) 和不正常的小 acinar 增长的包括(尽快)) 。用 20 或 35 的 PCA3 截止,在二亚群,全球敏感价值是 0.93 或 0.80 和 0.79 或 0.75 ,特性是 0.65 或 0.44 和 0.78 或 0.70 ,积极可能性的比率是 1.86 或 1.58 和 2.49 或 1.78 ,否定可能性的比率是 0.81 或 0.43 和 0.91 或 0.82 ,诊断奇怪的比率( ORs )分别地是 5.73 或 3.45 和 7.13 或 4.11 。在操作典型曲线的概括接收装置的曲线(AUC ) 下面的区域分别地是 0.85 或 0.72 和 0.81 或 0.69。PCA3 能被用于前列腺的重复活体检视改进 PCa 察觉的精确性。不必要的活体检视能被使用 20 的一个 PCa 截止分数避免。 | Yong Luo Xin Gou Peng Huang Chan Mou | 2014 | Asian Journal of Andrology2014，16，3： | 13 |
| 2 | Serological diagnosis of nasopharyngeal carcinoma by enzyme linked immunosorbant assay:optimization,standardization and diagnostic criteria显示文摘Serologicaldiagnosisofnasopharyngealcarcinomabyenzymelinkedimmunosorbantasay:optimization,standardizationanddiagnosticcriteri... | M.H. Ng, H.L. Chen, R.X. Luo, K.H. Chan, P.C.Y. Woo, J.S.T. Sham, J. Huang, W.H.Seto P. Smith and B.E. Griffin | 1998 | Chinese Medical Journal1998，，6： | 8 |
| 3 | A Model of Hydrothermal Dolomite Reservoir Facies in Precambrian Dolomite, Central Sichuan Basin, SW China and its Geochemical Characteristics显示文摘Hydrothermal mineral assemblages and related hydrothermally enhanced fracturing are common in the Precambrian Dengying Formation of Central Sichuan Basin. Petrographic and geochemical analyses of core samples show that the hydrothermal dolomite reservoirs of Dengying Formation consist of four main types of pores in the reservoir facies. These include: 1) hydrothermal dissolution vug(or pore), 2) intercrystalline pore, 3) residual inter-breccia vug(or pore), and 4) enlarged dissolved-fracture. There are three different fabrics dolomite in hydrothermal dolomite reservoirs, namely, saddle dolomite, fine-medium dolomite and micritic dolomite. Micritic dolomite is the original lithology of host rock. Saddle dolomite with curved or irregular crystal faces was directly crystallized from hydrothermal fluids(average temperature 192°C). Fine-medium dolomites are the products of recrystallization of micritic dolomite, resulting in abnormal geochemical characteristics, such as slight depletion of δ^(18)O, significant enrichment of Mn-Fe and ^(87)Sr/^(86)Sr, and positive Eu anomaly. A model for the distribution of various hydrothermal dolomite reservoir facies is proposed here, which incorporates three fundamental geological controls: 1) extensional tectonics and tectono-hydrothermal events(i.e., the Xingkai Taphrogenesis of Late Sinian-Early Cambrian, and Emei Taphrogenesis of Late Permian), 2) hydrothermal fluid storage in clastic rocks with large thickness(e.g., Nanhua System of Chengjiang Formation and part of Doushantuo Formation), and 3) confining bed for hydrothermal fluids(such as, the shale in Qiongzhusi Formation). The supply of hydrothermal fluid is critical. Large basement-rooted faults and associated grid-like fracture system may function as the channels for upward migration of hydrothermal fluid flow. The intersection of the above-mentioned faults(including the conversion fault), especially transtensional sags above negative flower structures on wrench faults can serve as a key target for future hydrocarbon exploration. | GU Yifan ZHOU Lu JIANG Yuqiang JIANG Chan LUO Mingsheng ZHU Xun | 2019 | Acta Geologica Sinica(English Edition)2019，93，1： | 5 |
| 4 | Cirrhotic patients at increased risk of peptic ulcer bleeding: a nationwide population‐based cohort study显示文摘 | J.‐C. Luo H.‐B. Leu M.‐C. Hou C.‐C. Huang H.‐C. Lin F.‐Y. Lee F.‐Y. Chang W.‐L. Chan S.‐J. Lin J.‐W. Chen | 2012 | Aliment Pharmacol Ther2012，，6： | 3 |
| 5 | Magnetoelectric and converse magnetoelectric responses in Tb_xDy_(1-x)Fe_(2-y) alloy & Pb(Mg_(1/3)Nb_(2/3))_(1-x)Ti_xO_3 crystal laminated composites显示文摘Measured results of magnetoelectric (ME) and converse magnetoelectric (CME) effects of TbxDy1-xFe2-y/ Pb(Mg1/3Nb2/3)(1-x)TixO3/TbxDy1-xFe2-y (TD/PMNT/TD) and PMNT/TD/PMNT laminated composites are pre- sented. ME effect was determined by measuring laminate voltage output under a Helmholtz-gener- ated AC field biased by a DC field (0―1 kOe) (1 Oe = 79.58 A/m). The CME effect was measured by re- cording the voltage induced in a solenoid encompassing the ME sample while exposed to a DC bias field and PMNT layer driven by a 10 V AC source. The ME and CME responses in the two laminated structure are linear. The highest values of ME coefficients in TD/PMNT/TD and PMNT/TD/PMNT com- posites are 384 mV/Oe and 158 mV/Oe, respectively, while the highest values of CME coefficients in the two composites are 118 mG/V and 162 mG/V (1 G=10-4 T), respectively. | JIA YanMin LUO HaoSu OR Siu Wing WANG YaoJin CHAN Helen L W | 2008 | Chinese Science Bulletin2008，53，14： | 3 |
| 6 | Chinese herbal medicine for chronic heart failure:a multicenter,randomized,double-blind,placebo-controlled trial显示文摘Objective:The purpose of this study was to assess the efficacy and safety of Chinese herbal medicine(CHM)in the treatment of chronic heart failure(CHF)patients according to syndrome differentiation.Methods:In this multicenter,randomized,double-blind,placebo-controlled clinical trial,a total of 220 CHF patients were assigned to receive CHM or placebo granules without decoction according to syndrome differentiation in addition to their standard western treatment for 4 weeks.The change in the left ventricular ejection fraction(LVEF)was the primary outcome,and the changes in the TCM syndrome scores(TCM-SS)and New York Heart Association functional classification(NYHA-FC)were the secondary outcomes. | Liangtao Luo Juan Wang Aiqing Han Peng Zhang Shuzhen Guo Chan Chen Xuegong Xu Qian Lin Huihui Zhao Wei Wang | 2014 | Journal of Traditional Chinese Medical Sciences2014，1，2： | 3 |
| 7 | Understanding divergent domestication traits from the whole-genome sequencing of swamp-and river-buffalo populations显示文摘Domesticated buffaloes have been integral to rice-paddy agro-ecosystems formillennia,yet relatively little is known about the buffalo genomics.Here,we sequenced and assembled reference genomes for both swamp and river buffaloes and we re-sequenced 230 individuals(132 swamp buffaloes and 98 river buffaloes)sampled from across Asia and Europe.Beyond the many actionable insights that our study revealed about the domestication,basic physiology and breeding of buffalo,we made the striking discovery that the divergent domestication traits between swamp and river buffaloes can be explained with recent selections of genes on social behavior,digestion metabolism,strengths and milk production. | Xier Luo Yu Zhou Bing Zhang Yi Zhang Xiaobo Wang Tong Feng Zhipeng Li Kuiqing Cui Zhiqiang Wang Chan Luo Hui Li Yanfei Deng Fenghua Lu Jianlin Han Yongwang Miao Huaming Mao Xiaoyan Yi Cheng Ai Shigang Wu Alun Li Zhichao Wu Zijun Zhuo Do Da Giang Bikash Mitra Mohammad Farhad Vahidi Shahid Mansoor Sahar Ahmed Al-Bayatti Eka Meutia Sari Neena Amatya Gorkhali Sigit Prastowo Laiba Shafique Guoyou Ye Qian Qian Baoshan Chen Deshun Shi Jue Ruan Qingyou Liu | 2020 | National Science Review2020，7，3： | 3 |
| 8 | Control measures during the COVID-19 outbreak reduced the transmission of hand,foot,and mouth disease显示文摘Control measures during the coronavirus disease 2019(COVID-19)outbreak may have limited the spread of infectious diseases.This study aimed to analyze the impact of COVID-19 on the spread of hand,foot,and mouth disease(HFMD)in China.A mathematical model was established to fit the reported data of HFMD in six selected cities in China's Mainland from 2015 to 2020.The absolute difference(AD)and relative difference(RD)between the reported incidence in 2020,and simulated maximum,minimum,or median incidence of HFMD in 2015-2019 were calculated.The incidence and R effof HFMD have decreased in six selected cities since the outbreak of COVID-19,and in the second half of 2020,the incidence and R effof HFMD have rebounded.The results show that the total attack rate(TAR)in 2020 was lower than the maximum,minimum,and median TAR fitted in previous years in six selected cities(except Changsha City).For the maximum,median,minimum fitted TAR,the range of RD(%)is 42·20-99·20%,36·35-98·41%48·35-96·23%(except Changsha City)respectively.The preventive and control measures of COVID-19 have significantly contributed to the containment of HFMD transmission. | Yan Niu Li Luo Jia Rui Shiting Yang Bin Deng Zeyu Zhao Shengnan Lin Jingwen Xu Yuanzhao Zhu Yao Wang Meng Yang Xingchun Liu Tianlong Yang Weikang Liu Peihua Li Zhuoyang Li Chan Liu Jiefeng Huang Tianmu Chen | 2021 | Journal of Safety Science and Resilience2021，2，2： | 3 |
| 9 | FTIR Spectroscopy in Cultural Heritage Studies: Non-destructive Analysis of Chinese Handmade Papers显示文摘Chinese handmade papers have been the carriers of paper-based documents, paintings and calligraphies, which are of great importance for historical and cultural heritage studies. This research developed the attenuated total reflectance-Fourier transform infrared(ATR-FTIR) spectroscopic technique for the analysis of Chinese handmade papers. The test was applied to Chinese handmade papers taken from bark, hemp and bamboo groups, followed by papers from ancient books and arts collected in library and museum. Our study indicated tliat FTIR was an efficient analytical method to identify fiber types of library/museum papers of unknown origin. Moreover, information about degree of crystallinity and state of deterioration of cellulosic fibers was learned from FTIR spectra. This research provides a non-destnictive method to study the molecular structure of cellulosic fibers, and guides tlie selection of appropriate Chinese handmade papers for the restoration of cultural heritage objects. | YAN Yueer WEN Chenqing JIN Ming DUAN Lian ZHANG Ruohong LUO Chan XIAO Jianfang YE Zhaoqi GAO Boxu LIU Peng TANG Yi | 2019 | Chemical Research in Chinese Universities2019，35，4： | 2 |
| 10 | Plasma metabolomics combined with personalized diagnosis guided by Chinese medicine reveals subtypes of chronic heart failure显示文摘Background:Chronic heart failure(CHF)is characterized by insufficient blood supply from heart to meet the body’s metabolic demands.Integrating Western and traditional Chinese medicine to treat CHF has proved a validated therapeutic approach.In recent years,metabolomics has been regarded as a potential platform to provide biomarkers for diseasesubtypes.Objective:To examine 38 patients,combined NMR plasma metabolomics and traditional Chinese medicine diagnosis in order to identify diagnostic biomarkers for two CHF syndrome subtypes.Methods:After processing the spectra,orthogonal partial least square discriminant analysis was performed,and the contributing NMR signals were analyzed using Y-scrambling statistical validation with good reliability.Results:Plasma metabolic patterns of yin deficiency and yang deficiency patients were clearly discriminated.The yin-deficiency group had increased level of lactate,glycoprotein,lipoprotein and lower levels of glucose,valine and proline.The yang-deficiency group had higher levels of lactate,glycoprotein and pyruvic acid,and lower levels of glucose and lipoprotein.Potential biomarkers of CHF based on the two traditional Chinese medicine syndromes indicated alternative modes of metabolites and metabolic pathways in the disease,e.g.dysfunction of energy utilization and disturbance in fatty acids,amino acids.Conclusion:This study suggests that combining metabolomics with traditional Chinese medicine diagnosis can reveal metabolic signatures for CHF syndrome subtypes.The plasma metabolites identified might be of special clinical relevance for subtypes of CHF,which could lead to further understanding of mechanisms involved and an improvement in personalized treatment for CHF. | Juan Wang Shuzhen Guo Kuo Gao Qi Shi Bangze Fu Chan Chen Liangtao Luo Dong Deng Huihui Zhao Wei Wang | 2015 | Journal of Traditional Chinese Medical Sciences2015，2，2： | 2 |
| 11 | Design,synthesis and characterization of novel biodegradable macrodiols based on poly(DL-lactic acid) and poly(p-dioxanone)显示文摘poly 集成(乳的酸)(PLA ) ,乙醇酸(GA ) 和乙烯乙二醇(例如) 将希望导致联合系住的如此的优点和可控制的版本的新奇共聚物和好简历相容性的率和改进灵活性。在这研究, p-dioxanone (PDO ) 被采用经由戒指洞与 dl 减水乳酸(LA ) 异分子聚合作为一个合作开始者作为一个开始者和乙烯乙二醇用 Sn (10 月)2 融化聚合。获得的可能减解的 macrodiols (跳跃( LA-co-PDO )-OH)只是由 PLA 组成的如此的共聚物, GA 并且例如 1 H NMR 被采用描绘共聚物,并且在分子的重量上的化工物品的 PDO/LA 臼齿的比率的效果跳跃( LA-co-PDO )哦借助于结束氢氧根分析被调查, 1 H NMR 或GPC广场。结果证实了成功的合成跳跃(LA-co-PDO ) 哦并且表明 micarodiols 的一结束氢氧根被合作开始者被 LA 或 PDO 和另一个另外例如捐赠,分子的重量跳跃(LA-co-PDO ) 哦与减少的 PDO/LA 比率增加了。 | Chan Yu Zhang Yan Feng Luo Su Jun Wang Zhao Liu Yuan Liang Wang Zhi Qing Liang | 2009 | Chinese Chemical Letters2009，20，6： | 2 |
| 12 | Prostate cancer antigen 3 test for prostate biopsy decision: a systematic review and meta analysis显示文摘 | Luo Yong Gou Xin Huang Peng Mou Chan | 2014 | Chinese Medical Journal2014，，9： | 2 |
| 13 | Feasibility of Booster Vaccination in High-Risk Populations for Controlling Coronavirus Variants—China,2021显示文摘Introduction:Vaccination booster shots are completely necessary for controlling breakthrough infections of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in China.The study aims to estimate effectiveness of booster vaccines for high-risk populations(HRPs).Methods:A vaccinated Susceptible-Exposed-Symptomatic-Asymptomatic-Recovered/Removed(SEIAR)model was developed to simulate scenarios of effective reproduction number(Reff)from 4 to 6.Total number of infectious and asymptomatic cases were used to evaluated vaccination effectiveness.Results:Our model showed that we could not prevent outbreaks when covering 80%of HRPs with booster unless Reff=4.0 or the booster vaccine had efficacy against infectivity and susceptibility of more than 90%.The results were consistent when the outcome index was confirmed cases or asymptomatic cases.Conclusions:An ideal coronavirus disease 2019(COVID-19)booster vaccination strategy for HRPs would be expected to reach the initial goal to control the transmission of the Delta variant in China.Accordingly,the recommendation for the COVID-19 booster vaccine should be implemented in HRPs who are already vaccinated and could prevent transmission to other groups. | Kangguo Li Zeyu Zhao Hongjie Wei Jia Rui Jiefeng Huang Xiaohao Guo Yichao Guo Shiting Yang Guzainuer Abudurusuli Li Luo Xingchun Liu Yao Wang Jingwen Xu Yuanzhao Zhu Meng Yang TianlongYang Weikang Liu Bin Deng Chan Liu Zhuoyang Li Peihua Li Shanshan Yu Zimei Yang Yanhua Su Benhua Zhao Yan Niu Tianmu Chen | 2021 | China CDC weekly2021，3，50： | 2 |
| 14 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 15 | Cancer stem cell markers are associated with adverse biomarker profiles and molecular subtypes of breast cancer显示文摘 | Julia Y. S. Tsang Yu-Hua Huang Ming-Hua Luo Yun-Bi Ni Siu-Ki Chan Philip C. W. Lui Alex M. C. Yu Puay Hoon Tan Gary M. Tse | 2012 | Breast Cancer Research and Treatment2012，，2： | 1 |
| 16 | Effect of high temperature and cooling regimes on the compressive strength and pore properties of high performance concrete显示文摘 | CHAN Y N LUO X SUN W | 2000 | Construction and Build- ing Materials2000，14，5： | 1 |
| 17 | Effect of heating and cooling refines on residual strength and microstructure of normal strength and high-performance concrete显示文摘 | LUO X SUN W CHAN Y N | 2000 | Cement and Con crete Research2000，30，3： | 1 |
| 18 | Compressvie strength and pore structure of high-performance concrete after exposure to high temperature up to 800 ℃ 显示文摘 | CHAN Y N LUO X SUN W | 2000 | Cement and Concrete Research2000，30，2： | 1 |
| 19 | The cell surface marker CD36 selectively identifies matured, mitochondria-rich hPSC-cardiomyocytes显示文摘Dear Editor,Human pluripotent stem cell(hPSC)-derived cardiomyocytes(CMs)are of significant translational value to in vitro studies of human cardiac development,drug and cardiotoxicity testing and cardiac disease modelling.Differentiation of hPSCs to CMs,however,yields mixed cultures of atrial-,ventricular-,and pacemaker-like cells as well as non-CMs in variable proportions.1 Strategies to enrich CMs from non-CMs and to generate ventricular versus atrial cells have been successful;however,enriched hPSC-CMs are developmentally immature and fail to recapitulate key functional traits that are fundamental to the(patho)physiology of adult CMs.1,2 Moreover,these strategies do not adequately address experimental variabilities caused by differences in the genomes and differentiation capabilities of diverse hPSC lines.One validated approach that overcomes issues of cell heterogeneity and experimental variability is immunophenotyping;however,accessible markers suitable for defining mature,live CMs are lacking.Although cell surface markers such as SIRPA(CD172a)and VCAM1(CD106)3,4 have been used to sort for hPSC-CMs,they do not distinguish between maturation states.Here,we report the identification of CD36 as a cell surface marker of maturation,which can be used to reduce experimental variability and improve drug screens. | Ellen Ngar-Yun Poon Xiao-ling Luo Sarah EWebb Bin Yan Rui Zhao Stanley Chun Ming Wu Yong Yang Peng Zhang Huajun Bai Jiaofang Shao Ching Man Chan Godfrey Chi-Fung Chan Suk Ying Tsang Rebekah LGundry Huang-Tian Yang Kenneth RBoheler | 2020 | Cell Research2020，30，7： | 1 |
| 20 | Compressive strength and pore structure of high-performance concrete after exposure to high temperature up to 800 C显示文摘 | CHAN Y N LUO X SUN W | 2000 | Cem Concr Res2000，30，： | 1 |
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