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| 1 | Carbon nanotube-polypyrrole core-shell sponge and its application as highly compressible supercapacitor electrode显示文摘 | Peixu Li Enzheng Shi Yanbing Yang Yuanyuan Shang Qingyu Peng Shiting Wu Jinquan Wei Kunlin Wang Hongwei Zhu Quan Yuan Anyuan Cao Dehai Wu | 2014 | Nano Research2014，7，2： | 10 |
| 2 | Control measures during the COVID-19 outbreak reduced the transmission of hand,foot,and mouth disease显示文摘Control measures during the coronavirus disease 2019(COVID-19)outbreak may have limited the spread of infectious diseases.This study aimed to analyze the impact of COVID-19 on the spread of hand,foot,and mouth disease(HFMD)in China.A mathematical model was established to fit the reported data of HFMD in six selected cities in China's Mainland from 2015 to 2020.The absolute difference(AD)and relative difference(RD)between the reported incidence in 2020,and simulated maximum,minimum,or median incidence of HFMD in 2015-2019 were calculated.The incidence and R effof HFMD have decreased in six selected cities since the outbreak of COVID-19,and in the second half of 2020,the incidence and R effof HFMD have rebounded.The results show that the total attack rate(TAR)in 2020 was lower than the maximum,minimum,and median TAR fitted in previous years in six selected cities(except Changsha City).For the maximum,median,minimum fitted TAR,the range of RD(%)is 42·20-99·20%,36·35-98·41%48·35-96·23%(except Changsha City)respectively.The preventive and control measures of COVID-19 have significantly contributed to the containment of HFMD transmission. | Yan Niu Li Luo Jia Rui Shiting Yang Bin Deng Zeyu Zhao Shengnan Lin Jingwen Xu Yuanzhao Zhu Yao Wang Meng Yang Xingchun Liu Tianlong Yang Weikang Liu Peihua Li Zhuoyang Li Chan Liu Jiefeng Huang Tianmu Chen | 2021 | Journal of Safety Science and Resilience2021，2，2： | 3 |
| 3 | Electromyographic evaluation of functional electrical stimulation to injured oculomotor nerve显示文摘Functional electrical stimulation delivered early after injury to the proximal nerve stump has been proposed as a therapeutic approach for enhancing the speed and specificity of axonal regeneration following nerve injury. In this study, the injured oculomotor nerve was stimulated functionally by an implantable electrode. Electromyographic monitoring of the motor unit potential of the inferior oblique muscle was conducted for 12 weeks in two injury groups, one with and one without electric stimulation. The results revealed that, at 2, 4, 6, 8 weeks after functional electric stimulation of the injured oculomotor nerve, motor unit potentials significantly increased, such that amplitude was longer and spike duration gradually shortened. These findings indicate that the injured oculomotor nerve has the potential for regeneration and repair, but this ability is not sufficient for full functional recovery to occur. Importantly, the current results indicated that recovery and regeneration of the injured oculomotor nerve can be promoted with functional electrical stimulation. | Min Yang Youqiang Meng Ningxi Zhu Xuhui Wang Liang Wan Wenchuan Zhang JunZhong Shugan Zhu Massimiliano Visocchi Shiting Li | 2011 | Neural Regeneration Research2011，6，11： | 2 |
| 4 | Direct fabrication of carbon nanotube-graphene hybrid films by a blown bubble method显示文摘有 graphene 的碳 nanotubes (CNT ) 的杂交提供集成两材料的属性的一个有希望的工具,从而创新的普遍申请。这里,我们在场直接由一个吹的水泡方法装配混合 CNT-graphene 电影的一个方法与选择底层退火结合了。我们把 polymethylmethacrylate (PMMA ) 用作聚合矩阵吹包含自我装配的多围的 CNT 数组的水泡,然后由在 Cu 底层上的热退火把水泡电影转变成一部 CNT-graphene 混合电影;PMMA 为在 CNT 网络之中对很少层 graphene 变得单个直到担任碳来源一连续地, hybridized 结构被形成。比作赤裸(non-hybridized ) CNT 联网,混合电影展览改进了电的电导率和结构的完整。我们的方法也启用一节多围的 CNT-Si 太阳能电池的制造,它有高力量变换效率,通过混合 CNT-graphene 结构的集会。 | Shiting Wu Enzheng Shi Yanbing Yang Wenjing Xu Xinyang Li Anyuan Cao | 2015 | Nano Research2015，8，5： | 2 |
| 5 | Feasibility of Booster Vaccination in High-Risk Populations for Controlling Coronavirus Variants—China,2021显示文摘Introduction:Vaccination booster shots are completely necessary for controlling breakthrough infections of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in China.The study aims to estimate effectiveness of booster vaccines for high-risk populations(HRPs).Methods:A vaccinated Susceptible-Exposed-Symptomatic-Asymptomatic-Recovered/Removed(SEIAR)model was developed to simulate scenarios of effective reproduction number(Reff)from 4 to 6.Total number of infectious and asymptomatic cases were used to evaluated vaccination effectiveness.Results:Our model showed that we could not prevent outbreaks when covering 80%of HRPs with booster unless Reff=4.0 or the booster vaccine had efficacy against infectivity and susceptibility of more than 90%.The results were consistent when the outcome index was confirmed cases or asymptomatic cases.Conclusions:An ideal coronavirus disease 2019(COVID-19)booster vaccination strategy for HRPs would be expected to reach the initial goal to control the transmission of the Delta variant in China.Accordingly,the recommendation for the COVID-19 booster vaccine should be implemented in HRPs who are already vaccinated and could prevent transmission to other groups. | Kangguo Li Zeyu Zhao Hongjie Wei Jia Rui Jiefeng Huang Xiaohao Guo Yichao Guo Shiting Yang Guzainuer Abudurusuli Li Luo Xingchun Liu Yao Wang Jingwen Xu Yuanzhao Zhu Meng Yang TianlongYang Weikang Liu Bin Deng Chan Liu Zhuoyang Li Peihua Li Shanshan Yu Zimei Yang Yanhua Su Benhua Zhao Yan Niu Tianmu Chen | 2021 | China CDC weekly2021，3，50： | 2 |
| 6 | Dorsomorphin induces cancer cell apoptosis and sensitizes cancer cells to HSP90 and proteasome inhibitors by reducing nuclear heat shock factor 1 levels显示文摘Objective: Heat shock factor 1(HSF1), a transcriptional regulator of heat shock proteins(HSPs), is an attractive therapeutic target for cancer. However, only a few HSF1 inhibitors have been identified so far.Methods: The mRNA and protein levels of HSF1, HSPs, cleaved PARP, and phosphorylated HSF1 were examined by real-time PCR and Western blot. Forced expression, RNA interference, and immunofluorescence assay were used for mechanistic studies.Cell viability and apoptosis were measured by WST-8 assay and flow cytometry, respectively. Xenograft studies were performed in nude mice to evaluate the effect of dorsomorphin and an HSP90 inhibitor on tumor growth.Results: Dorsomorphin suppressed multiple stimuli-induced and constitutive HSPs expression in cancer cells. Mechanistic studies revealed that dorsomorphin reduced heat-induced HSP expression independent of adenosine monophosphate activated protein kinase. Dorsomorphin reduced heat-stimulated HSF1 Ser320 phosphorylation and nuclear translocation, as well as resting nuclear HSF1 levels in cancer cells. Dorsomorphin induced cancer cell apoptosis by inhibiting HSF1 expression. A structure-activity study revealed that the 4-pyridyl at the 3-site of the pyrazolo [1, 5-a]pyrimidine ring is critical for the anti-HSF1 activities of dorsomorphin. Dorsomorphin sensitized cancer cells to HSP90 and proteasome inhibitors and inhibited HSP70 expression induced by these inhibitors in vitro. In tumor-bearing nude mice, dorsomorphin enhanced HSP90 inhibitor-induced cancer cell apoptosis, tumor growth inhibition, and HSP70 expression.Conclusions: Dorsomorphin is an HSF1 inhibitor. It induces cancer cell apoptosis, sensitizes cancer cells to both HSP90 and proteasome inhibitors, and suppresses HSP upregulation by these drugs, which may prevent the development of drug resistance.Hence, dorsomorphin and its derivates may serve as potential precursors for developing drugs against cancer. | Na Li Ting Wang Zongmeng Li Xiaoli Ye Bo Deng Shu Zhuo Pengle Yao Mengmei Yang Hong Mei Xiaofang Chen Tengfei Zhu Shiting Chen Hui Wang Jiming Wang Yingying Le | 2019 | Cancer Biology & Medicine2019，16，2： | 1 |
| 7 | Establishment of a beagle dog model of oculomotor nerve injury显示文摘The oculomotor nerves of beagle dogs received electrical stimulation at 0.3-2.0 V. After recording compound muscle action potentials of the inferior oblique muscle, the oculomotor nerve was quickly cut off and a direct end-to-end anastomosis was then performed. As a result, the stimulating elec-trode was smoothly inserted and placed, and ideal bioelectrical signals of the interior oblique muscle were acquired. After oculomotor nerve injury, compound muscle action potentials of the inferior oblique muscle were significantly decreased in beagle dogs. These findings suggest that an animal model of oculomotor nerve injury was successfully established for electrophysiological studies. | Wenxiang Zhong Xuhui Wang Wenchuan Zhang Shiting Li Min Yang | 2011 | Neural Regeneration Research2011，6，21： | 1 |
| 8 | Impact of elevated ozone concentration on yield of four Chinese rice cultivars under fully open-air field conditions显示文摘 | Guangyao Shi Lianxin Yang Yunxia Wang Kazuhiko Kobayashi Jianguo Zhu Haoye Tang Shiting Pan Tao Chen Gang Liu Yulong Wang | 2009 | Agriculture Ecosystems and Environment2009，，3： | 1 |
| 9 | Transmissibility of tuberculosis among students and non-students:an occupational-specific mathematical modelling显示文摘Background: Recently, despite the steady decline in the tuberculosis (TB) epidemic globally, school TB outbreaks have been frequently reported in China. This study aimed to quantify the transmissibility ofMycobacterium tuberculosis (MTB) among students and non-students using a mathematical model to determine characteristics of TB transmission.Methods: We constructed a dataset of reported TB cases from four regions (Jilin Province, Xiamen City, Chuxiong Prefecture, and Wuhan City) in China from 2005 to 2019. We classified the population and the reported cases under student and non-student groups, and developed two mathematical models [nonseasonal model (Model A) and seasonal model (Model B)] based on the natural history and transmission features of TB. The effective reproduction number (R(eff)) of TB between groups were calculated using the collected data.Results: During the study period, data on 456,423 TB cases were collected from four regions: students accounted for 6.1% of cases. The goodness-of-fit analysis showed that Model A had a better fitting effect (P < 0.001). The average R_(eff) of TB estimated from Model A was 1.68 [interquartile range (IQR): 1.20–1.96] in Chuxiong Prefecture, 1.67 (IQR: 1.40–1.93) in Xiamen City, 1.75 (IQR: 1.37–2.02) in Jilin Province, and 1.79 (IQR: 1.56–2.02) in Wuhan City. The average R_(eff) of TB in the non-student population was 23.30 times (1.65/0.07) higher than that in the student population.Conclusions: The transmissibility of MTB remains high in the non-student population of the areas studied, which is still dominant in the spread of TB. TB transmissibility from the non-student-to-student-population had a strong influence on students. Specific interventions, such as TB screening, should be applied rigorously to control and to prevent TB transmission among students. | Qiuping Chen Shanshan Yu Jia Rui Yichao Guo Shiting Yang Guzainuer Abudurusuli Zimei Yang Chan Liu Li Luo Mingzhai Wang Zhao Lei Qinglong Zhao Laurent Gavotte Yan Niu Roger Frutos Tianmu Chen | 2022 | Infectious Diseases of Poverty2022，11，6： | 0 |
| 10 | Monocular Depth Estimation with Sharp Boundary显示文摘Monocular depth estimation is the basic task in computer vision.Its accuracy has tremendous improvement in the decade with the development of deep learning.However,the blurry boundary in the depth map is a serious problem.Researchers find that the blurry boundary is mainly caused by two factors.First,the low-level features,containing boundary and structure information,may be lost in deep networks during the convolution process.Second,themodel ignores the errors introduced by the boundary area due to the few portions of the boundary area in the whole area,during the backpropagation.Focusing on the factors mentioned above.Two countermeasures are proposed to mitigate the boundary blur problem.Firstly,we design a scene understanding module and scale transformmodule to build a lightweight fuse feature pyramid,which can deal with low-level feature loss effectively.Secondly,we propose a boundary-aware depth loss function to pay attention to the effects of the boundary’s depth value.Extensive experiments show that our method can predict the depth maps with clearer boundaries,and the performance of the depth accuracy based on NYU-Depth V2,SUN RGB-D,and iBims-1 are competitive. | Xin Yang Qingling Chang Shiting Xu Xinlin Liu Yan Cui | 2023 | Computer Modeling in Engineering & Sciences2023，，7： | 0 |
| 11 | Modeling Cross-Regional Transmission and Assessing the Effectiveness of Restricting Inter-Regional Population Movements in Controlling COVID-19-Xi’an City,Shaanxi Province,China,2021显示文摘Introduction:The aim of this study was to construct an assessment method for cross-regional transmission of coronavirus disease 2019(COVID-19)and to provide recommendations for optimizing measures such as interregional population movements.Methods:Taking Xi’an City as the example subject of this study’s analysis,a Cross-Regional-Gravitational-Dynamic model was constructed to simulate the epidemic in each district of Xi’an under three scenarios of controlled population movement(Scenario 1:no intensive intervention;Scenario 2:blocking Yanta District on December 18 and blocking the whole region on December 23;and Scenario 3:blocking the whole region on December 23).This study then evaluated the effects of such simulated population control measures.Results:The cumulative number of cases for the three scenarios was 8,901,425,178,and 474,respectively,and the duration of the epidemic was 175,18,and 22 days,respectively.The real world prevention and control measures in Xi’an reduced the cumulative number of cases for its outbreak by 99.98%in comparison to the simulated response in Scenario 1;in contrast,the simulated prevention and control strategies set in Scenarios 2(91.26%)and 3(76.73%)reduced cases even further than the real world measures used in Xi’an.Discussion:The constructed model can effectively simulate an outbreak across regions.Timely implementation of two-way containment and control measures in areas where spillover is likely to occur is key to stopping cross-regional transmission. | Tianlong Yang Yao Wang Nankun Liu Guzainuer Abudurusuli Shiting Yang Shanshan Yu Weikang Liu Xuecheng Yin Tianmu Chen | 2022 | China CDC weekly2022，4，31： | 0 |
| 12 | 放牧对青藏高原高寒草地种子萌发性状选择的影响显示文摘以前的研究表明放牧能够引起草地生物与非生物环境的显著变化,但这种变化影响草地群落对种子萌发特征的选择机制尚不清楚。因此,我们旨在回答:放牧是否对草地群落中萌发特征的组成和多样性产生显著影响。我们在实验室检测了研究草地群落内主要物种种子的萌发特性,并比较了这些植物在放牧和非放牧草地上的表现。在此基础上,比较了放牧草地和非放牧草地的各萌发性状的群落加权平均值和萌发性状多样性,从而了解放牧草地和非放牧草地是否存在不同的萌发性状结构。研究结果表明,在物种水平上,放牧和非放牧草地各物种的多度变化与物种的萌发性状无显著关系。但在群落水平上,与非放牧草地相比,放牧草地的物种普遍具有较高的种子萌发率;放牧草地种子萌发对变温的正响应显著大于非放牧草地,而且放牧草地种子萌发温度生态位宽度小于非放牧草地。与非放牧草地相比,放牧草地种子萌发性状多样性增加,萌发性状均匀度降低。放牧可以改变微生境,从而通过环境过滤改变草地群落对萌发性状的选择,导致草地群落的萌发性状于放牧前后在群落水平上存 在显著差异。 | Yang Liu Kun Liu Zhilong Zhang Shiting Zhang Carol C.Baskin Jerry M.Baskin Ting Liang Haiyan Bu Shuxia Li Tingting Zhang Xianliang Cui Sa Xiao | 2022 | Journal of Plant Ecology2022，15，4： | 0 |
| 13 | Computing R_(0) of dynamic models by a definition-based method显示文摘Objectives:Computing the basic reproduction number(R0)in deterministic dynamical models is a hot topic and is frequently demanded by researchers in public health.The nextgeneration methods(NGM)are widely used for such computation,however,the results of NGM are usually not to be the true R0 but only a threshold quantity with little interpretation.In this paper,a definition-based method(DBM)is proposed to solve such a problem.Methods:Start with the definition of R0,consider different states that one infected individual may develop into,and take expectations.A comparison with NGM has proceeded.Numerical verification is performed using parameters fitted by data of COVID-19 in Hunan Province.Results:DBM and NGM give identical expressions for single-host models with single-group and interactive Rij of single-host models with multi-groups,while difference arises for models partitioned into subgroups.Numerical verification showed the consistencies and differences between DBM and NGM,which supports the conclusion that R0 derived by DBM with true epidemiological interpretations are better.Conclusions:DBM is more suitable for single-host models,especially for models partitioned into subgroups.However,for multi-host dynamic models where the true R0 is failed to define,we may turn to the NGM for the threshold R0. | Xiaohao Guo Yichao Guo Zeyu Zhao Shiting Yang Yanhua Su Benhua Zhao Tianmu Chen | 2022 | Infectious Disease Modelling2022，7，2： | 0 |
| 14 | A standardized method to create peripheral nerve injury in dogs using an automatic non-serrated forceps显示文摘This study describes a method that not only generates an automatic and standardized crush injury in the skull base, but also provides investigators with the option to choose from a range of varying pressure levels. We designed an automatic, non-serrated forceps that exerts a varying force of 0 to 100 g and lasts for a defined period of 0 to 60 seconds. This device was then used to generate a crush injury to the right oculomotor nerve of dogs with a force of 10 g for 15 seconds, resulting in a deficit in the pupil-light reflex and ptosis. Further testing of our model with Toluidine-blue staining demonstrated that, at 2 weeks post-surgery disordered oculomotor nerve fibers, axonal loss, and a thinner than normal myelin sheath were visible. Electrophysiological examination showed occasional spontaneous potentials. Together, these data verified that the model for oculomotor nerve injury was successful, and that the forceps we designed can be used to establish standard mechanical injury models of peripheral nerves. | Xuhui Wang Liang Wan Xinyuan Li Youqiang MenG Ningxi Zhu Min Yang Baohui Feng Wenchuan Zhang Shugan Zhu Shiting Li | 2012 | Neural Regeneration Research2012，7，32： | 0 |
| 15 | Contact pattern,current immune barrier,and pathogen virulence determines the optimal strategy of further vaccination显示文摘Background:The current outbreak of novel coronavirus disease 2019 has caused a seriousdisease burden worldwide.Vaccines are an important factor to sustain the epidemic.Although with a relatively high-vaccination worldwide,the decay of vaccine efficacy andthe arising of new variants lead us to the challenge of maintaining a sufficient immunebarrier to protect the population.Method:A case-contact tracking data in Hunan,China,is used to estimate the contactpattern of cases for scenarios including school,workspace,etc,rather than ordinary susceptible population.Based on the estimated vaccine coverage and efficacy,a multi-groupvaccinated-exposed-presymptomatic-symptomatic-asymptomatic-removed model(VEFIAR)with 8 age groups,with each partitioned into 4 vaccination status groups isdeveloped.The optimal dose-wise vaccinating strategy is optimized based on the currentlyestimated immunity barrier of coverage and efficacy,using the greedy algorithm thatminimizes the cumulative cases,population size of hospitalization and fatality respectivelyin a certain future interval.Parameters of Delta and Omicron variants are used respectivelyin the optimization.Results:The estimated contact matrices of cases showed a concentration on middle ages,and has compatible magnitudes compared to estimations from contact surveys in otherstudies.The VEFIAR model is numerically stable.The optimal controled vaccination strategy requires immediate vaccination on the un-vaccinated high-contact population of age30e39 to reduce the cumulative cases,and is stable with different basic reproductionnumbers(R_(0)).As for minimizing hospitalization and fatality,the optimized strategy requires vaccination on the un-vaccinated of both aged 30e39 of high contact frequencyand the vulnerable older.Conclusion:The objective of reducing transmission requires vaccination in age groups ofthe highest contact frequency,with more priority for un-vaccinated than un-fully or fullyvaccinated.The objective of reducing total hospitalization and fatality requires not only toreduce transmission but also to protect the vulnerable older.The priority changes byvaccination progress.For any region,if the local contact pattern is available,then with thevaccination coverage,efficacy,and disease characteristics of relative risks in heterogeneouspopulations,the optimal dose-wise vaccinating process will be obtained and gives hintsfor decision-making. | Xiaohao Guo Ziyan Liu Shiting Yang Zeyu Zhao Yichao Guo Guzainuer Abudurusuli Shanlu Zhao Ge Zeng Shixiong Hu Kaiwei Luo Tianmu Chen | 2023 | Infectious Disease Modelling2023，8，1： | 0 |
| 16 | A follow up study of cycle threshold values of SARS-CoV-2 in Hunan Province,China显示文摘Since the epidemic of the severe acute respiratory syndrome coronavirus 2(SARS-COV-2),many governments have used reverse transcription polymerase chain reaction(RT-PCR)to detect the virus.However,there are fewer measures of CT values information based on RT-PCR results,and the relationship between CT values and factors from consecutive tests is not clear enough.So in this study,we analyzed the connection between CT values and the factors based on cohort data from Delta variant of SARS-CoV-2 in Hunan Province.Previous studies have showed that the mean age of the cases was 33.34 years(±18.72 years),with a female predominance(55.03%,n=71),and the greatest proportion of clinical symptoms were of the common type(60.47%,n=78).There were statistical differences between the N and ORF1ab genes in the CT values for the cases.Based on the analysis of the association between CT values and the factors,the lowest CT values were obtained for the unvaccinated,older and clinically symptomatic group at 3e10 days,the maximum peak of viral load occurred.Therefore,it is recommended to use patient information to focus on older,clinically symptomatic,unvaccinated patients and to intervene promptly upon admission. | Guzainuer Abudurusuli Kaiwei Luo Xiaohao Guo Zeyu Zhao Yichao Guo Buasiyamu Abudunaibi Shiting Yang Hongjie Wei Shanlu zhao Zhihui Dai Qianlai Sun Hao Yang Shixiong Hu Tianmu Chen | 2023 | Infectious Disease Modelling2023，8，1： | 0 |
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