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| 1 | The protean manifestations of central nervous system IgG4-related hypertrophic pachymeningitis:a report of two cases显示文摘Background:IgG4-related hypertrophic pachymeningitis is a relative newly recognized and rare manifestation of IgG4-related disease,an immune-mediated fibroinflammatory tumefactive disorder.Fewer than 80 patients have been reported in the literature,and it can mimic common neurosurgical conditions.We describe the clinical presentation of two patients that were initially considered to have a subdural collection,tuberculous meningitis,and a cervical spinal meningioma,but were eventually diagnosed with this disease.Case presentation:Two ethnic Chinese men,86 and 62 years old,experienced a 4-week history of headache.Both patients had a history of autoimmune disease,namely glomerulonephritis and Grave’s disease,respectively.Magnetic resonance brain imaging revealed diffuse dural thickening with the latter patient exhibiting homogeneous and intense gadolinium-contrast enhancement.Since the 86-year-old patient also had progressive bilateral visual loss,giant cell arteritis was suspected and a 2-week course of glucocorticoid therapy was prescribed,but his symptoms failed to improve.The 62-year-old patient also had accompanying low-grade fever and was treated empirically as having tuberculous meningitis although there were no confirmatory microbiological findings.This patient further developed right hemiparesis,and additional imaging revealed a C4/5 intradural-extramedullary contrast-enhancing lesion resembling a meningioma causing cord compression.Both patients underwent neurosurgical intervention with the former undergoing a dural biopsy and the latter having the cervical lesion resected.The final diagnosis was IgG4-related hypertrophic pachymeningitis with the hallmark histological features of lymphoplasmacytic infiltration of IgG4+plasma cells,storiform fibrosis,and obliterative phlebitis.In addition,their serum IgG4 levels were elevated(i.e.,>135 mg/dL).Both patients received at least 6 months of glucocorticoid therapy while the latter also had azathioprine.Their symptoms improved significantly and recurrent lesions were not detected on follow-up imaging.Conclusions:A high index of suspicion for this condition is suggested when a male patient with a history of autoimmune disease and compatible radiological findings,experiences subacute headache that is disproportionate to the degree of dural involvement.Neurosurgeons should consider early meningeal biopsy to establish a definitive histological diagnosis in order for early effective immunosuppressive treatment to be initiated and to avoid unnecessary morbidity. | Peter Y.M.Woo Ben C.F.Ng June H.M.Wong Oliver K.S.Ng Timothy S.K.Chan Ngai-Fung Kwok Kwong-Yau Chan | 2021 | Chinese Neurosurgical Journal2021，7，4： | 2 |
| 2 | Pancreatic cancer, animal protein and dietary fat in a population-based study, San Francisco Bay Area, California显示文摘 | June M. Chan Furong Wang Elizabeth A. Holly | 2007 | Cancer Causes & Control2007，，10： | 1 |
| 3 | Physical activity and prostate gene expression in men with low-risk prostate cancer显示文摘 | Mark Jesus M. Magbanua Erin L. Richman Eduardo V. Sosa Lee W. Jones Jeff Simko Katsuto Shinohara Christopher M. Haqq Peter R. Carroll June M. Chan | 2014 | Cancer Causes & Control2014，，： | 1 |
| 4 | Impact of obesity on prostate cancer recurrence after radical prostatectomy: Data from CaPSURE显示文摘 | William W. Bassett Matthew R. Cooperberg Natalia Sadetsky Stefanie Silva Janeen DuChane David J. Pasta June M. Chan Jason W. Anast Peter R. Carroll Christopher J. Kane | 2005 | Urology2005，，5： | 1 |
| 5 | Rapid and transient induction of calmodulin-encoding gene(s) of Brassica napus by a touch stimulus显示文摘 | Sung-Aeong Oh June Myoung Kwak Il Chan Kwun Hong Gil Nam | 1996 | Plant Cell Reports1996，，8： | 1 |
| 6 | A study on effect of lithium ion battery design variables upon features of thermal-runaway using mathematical model and simulation显示文摘 | Chan H L Sang June B Minyoung J | 2015 | Journal of Power Sources2015，293，： | 1 |
| 7 | Management of the neck after chemoradiotherapy for head and neck cancers in Asia: consensus statement from the Asian Oncology Summit 2009显示文摘 | Joseph T Wee Benjamin O Anderson June Corry Anil D’Cruz Khee C Soo Chao-Nan Qian Daniel T Chua Rodney J Hicks Christopher HK Goh James B Khoo Seng C Ong Arlene A Forastiere Anthony T Chan | 2009 | Lancet Oncology2009，，11： | 1 |
| 8 | Electron microscopic dual labeling of high-affinity neurotensin and dopamine D2 receptors in the rat nucleus accumbens shell 显示文摘 | Delle Donne KT Chan June Boudin H | 2004 | Synapse2004，52，3： | 1 |
| 9 | Diet After Diagnosis and the Risk of Prostate Cancer Progression, Recurrence, and Death (United States)显示文摘 | June M. Chan Crystal N. Holick Michael F. Leitzmann Eric B. Rimm Walter C. Willett Meir J. Stampfer Edward L. Giovannucci | 2006 | Cancer Causes & Control2006，，2： | 1 |
| 10 | 孔子的T恤显示文摘如果白T恤在孔子时代已经发明了,那它的袖子一定是宽长的,因为这是当时的社会风尚。 | June Ritchie Chan | 2010 | 中华手工2010，，10： | 0 |
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