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| 1 | 北京PM_(2.5)化学物种的质量平衡特征显示文摘以北京 2个采样点连续采集的样品对PM2 5中的元素、水溶性离子和含碳组分进行分析 .车公庄和清华园PM2 5中有机物的含量分别为 2 7 8%和 30 9% ,是含量最丰富的物种 ,其次是二次无机粒子、土壤尘、元素碳和微量元素 .PM2 5中约有 2 4 %的质量未能鉴别成分 ,相关性分析表明 ,含碳物种的估算所引起的偏差可能是主要的原因 .采暖期重污染周和春季沙尘周PM2 5的化学物种构成悬殊 ,反映了季节性变化的源排放和特殊气象条件的综合作用 . | 杨复沫 贺克斌 马永亮 张强 Cadle S H Chan T Mulawa P A | 2004 | 环境化学2004，23，3： | 63 |
| 2 | 延胡索酸水合酶缺陷型肾细胞癌32例临床病理和分子分析显示文摘延胡索酸水合酶缺陷型肾细胞癌属于罕见的、新近发现的与遗传性平滑肌瘤病和肾细胞癌综合征相关的肿瘤实体。延胡索酸水合酶缺陷型肾细胞癌可表现出多种临床和病理学表现,但通常表现为局部进展和转移性疾病,预后较差。作者通过延胡索酸水合酶免疫组化和(或)延胡索酸水合酶突变分析确定32例延胡索酸水合酶缺陷型肾细胞癌,并对其临床和病理特征进行回顾性分析。 | Lau H D Chan E Fan A C 魏建国(摘译) 方三高(审校) | 2020 | 临床与实验病理学杂志2020，36，3： | 19 |
| 3 | 基于矩量法的移动荷载识别显示文摘从桥梁响应识别桥面移动荷载往往出现逆问题的病态(不适定性)等共性问题。本文基于移动荷载识别理论,借助矩量法求解积分方程理论并采用整域基函数——正交勒让德多项式表达桥面移动荷载,提出了一种移动荷载识别的时域改进算法。两轴车辆多种组合工况下的常载和时变荷载数值仿真研究表明:与时域法比较,改进时域法识别桥面移动荷载时,其识别精度高、抗噪能力强,识别结果不适定性有显著改善。 | 余岭 朱军华 陈敏中 Chan T H T | 2006 | 振动工程学报2006，19，4： | 9 |
| 4 | Targeting c-Myc as a novel approach for hepatocellular carcinoma显示文摘Hepatocelluar carcinoma(HCC) is the most lethal cancer in the world.Most HCC over-express c-Myc,which plays a critical role in regulating cellular growth,differentiation and apoptosis in both normal and neoplastic cells. c-Myc is among the most frequently overexpressed genes in human cancers.Overexpression of c-Myc in hepatic cells leads to development of hepatocellular carcinoma.Here,we review the current progress in understanding physiologic function and regulation of c-Myc as well as its role in hepatic carcinogenesis and discuss the association of c-Myc activation in chronic hepatitis B infection and the upregulation of HIF-1/VEGF.We also explore the possibility of treating HCC by inhibiting c-Myc and examine the pros and cons of such an approach.Although this strategy is currently not available in clinics,with recent advances in better drug design,pharmacokinetics and pharmacogenetics,inhibition of c-Myc might become a novel therapy for HCC in the future. | Chien-Ru Liu Chun-Nin Lee Tze-Sian Chan H Eugene Liu | 2010 | World Journal of Hepatology2010，2，1： | 9 |
| 5 | 桥梁时变移动车载的间接识别显示文摘针对桥梁上时变移动车载 ,提出了两种桥梁模型、四种移动车载间接识别方法和两种不同解决方案 ,并通过模型实验对上述不同桥梁移动车载解决方案进行验证。仿真和试验结果表明 :虽然各种车桥参数对识别结果都有不同程度的影响 ,但每种解决方案都能有效识别桥梁移动车载且以“时域法”和“频时域法”识别精度较高、实用性较强 ,可推荐用于现场桥梁移动车载识别。 | 余岭 Chan T H T | 2005 | 振动工程学报2005，18，1： | 8 |
| 6 | 膳食中钠(盐)与血压的关系及其他膳食因素可能的调节作用显示文摘现有资料表明,膳食钠(盐)与血压直接相关。以往大多数研究结果来自缺乏膳食数据的研究;因此,这种钠-血压关系是否受其他膳食因素调节尚不清楚。国际宏量/微量营养素和血压研究(international study on macro/micronutrients and blood pressure,INTERMAP)结果显示,在控制多种非膳食因素情况下,年龄40~59岁的男性和女性4680人(中国、日本、英国和美国的17个人口样本)的血压与24h尿钠排泄和尿钠/钾直接相关。 | 刘莉 叶鹏 Stamler J Chan Q Daviglus ML Dyer AR Van Horn L Garside DB Miura K Wu Y Ueshima H Zhao L Elliott P INTERMAP Research Group | 2018 | 中华高血压杂志2018，26，4： | 8 |
| 7 | 基于矩量法的桥梁移动车载识别试验研究显示文摘基于矩量法和移动荷载识别理论,采用整域基函数———正交勒让德多项式表达桥面移动车载,从车致桥梁弯矩响应识别桥面移动车载,提出了一种时域移动荷载识别改进方法(ITDM)。利用试验测量的车致桥梁弯矩响应时程数据重点研究了几个主要参数对ITDM的影响,这些参数包括:基函数数量、模态数、测点数及测点位置和运行时间等,同时与时域法(TDM)进行了对比研究。试验研究结果表明:ITDM性能与TDM相若,但ITDM更以适应性强和省时而优于TDM,这对于桥梁移动荷载的现场在线准确识别非常有利。 | 余岭 朱军华 陈敏中 Chan T H T | 2007 | 振动与冲击2007，26，1： | 8 |
| 8 | Response to endoscopic therapy for biliary anastomotic strictures in deceased versus living donor liver transplantation显示文摘BACKGROUND:Endoscopic therapy has been successful in the management of biliary complications after both deceased donor liver transplantation(DDLT) and living donor liver transplantation(LDLT).LDLT is thought to be associated with higher rates of biliary complications,but there are few studies comparing the success of endoscopic management of anastomotic strictures between the two groups.This study aims to compare our experience in the endoscopic management of anastomotic strictures in DDLT versus LDLT.METHODS:This is a retrospective database review of all liver transplant patients undergoing endoscopic retrograde cholangiopancreatography(ERCP) after liver transplantation.The frequency of anastomotic stricture and the time to develop and to resolve anastomotic stricture were compared between DDLT and LDLT.The response of anastomotic stricture to endoscopic therapy was also analyzed.RESULTS:A total of 362 patients underwent liver transplantation between 2003 and 2011,with 125 requiring ERCP to manage biliary complications.Thirty-three(9.9%) cases of DDLT and 8(27.6%) of LDLT(P=0.01) were found to have anastomotic stricture.When comparing DDLT and LDLT,there was no difference in the mean time to the development of anastomotic strictures(98±17 vs 172±65 days,P=0.11),likelihood of response to ERCP [22(66.7%) vs 6(75.0%),P=0.69],mean time to the resolution of anastomotic strictures(268±77 vs 125±37 days,P=0.34),and the number of ERCPs required to achieve resolution(3.9±0.4 vs 4.7±0.9,P=0.38).CONCLUSIONS:Endoscopic therapy is effective in the majority of biliary complications relating to liver transplantation.Anastomotic strictures occur more frequently in LDLT compared with DDLT,with equivalent endoscopic treatment response and outcomes for both groups. | Calvin HY Chan Fergal Donnellan Michael F Byrne Alan Coss Mazhar Haque Holly Wiesenger Charles H Scudamore Urs P Steinbrecher Alan A Weiss Eric M Yoshida | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，5： | 7 |
| 9 | 基于LabVIEW的桥梁健康监测数据采集系统显示文摘桥梁健康监测的第一步是如何实现现场桥梁结构输入输出数据和环境音像资料的精确采集和存储.针对香港新界西青衣南桥的特点,基于LabVIEW软件平台,开发桥梁健康监测数据采集系统,采集并存储桥面运行重车车型、轴数、车速和车辆视频音像资料以及运行重车作用下桥梁的应变和加速度响应时程数据,为桥梁健康监测提供高精度实时原始数据.五昼夜的现场监测结果表明该系统运行正常、桥梁响应数据采集精度高、运行车辆音像资料全面,不失为大型桥梁健康监测采集系统的有益尝试. | 余岭 朱军华 CHAN T H T | 2009 | 暨南大学学报(自然科学与医学版)2009，30，5： | 5 |
| 10 | Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts显示文摘The accumulation and aggregation of alpha-synuclein(α-syn)in several tissue including the brain is a major pathological hallmark in Parkinson’s disease(PD).In this study,we show that α-syn can be taken up by primary human cortical neurons,astrocytes and skin-derived fibroblasts in vitro.Our findings that brain and peripheral cells exposed to α-syn can lead to impaired mitochondrial function,leading to cellular degeneration and cell death,provides additional evidence for the involvement of mitochondrial dysfunction as a mechanism of toxicity of α-syn in human cells. | Nady Braidy Wei-Ping Gai Ying Hua Xu Perminder Sachdev Gilles J Guillemin Xing-Mai Jiang J William O Ballard Martin P Horan Zhi Ming Fang Beng H Chong Daniel Kam Yin Chan | 2013 | Translational Neurodegeneration2013，2，1： | 4 |
| 11 | Moving Force Identification - Time Domain Method显示文摘 | Law S S Chan T H T Zeng Q H | 1997 | Journal of Sound and Vibration1997，201，1： | 4 |
| 12 | Consolidation and dynamics of 3D unsaturated porous seabed under rigid caisson breakwater loaded by hydrostatic pressure and wave显示文摘In this study,based on the dynamic Biot's theory 'u-p' approximation,a 3D finite element method(FEM) numerical soil model is developed,in which the Generalized Newmark-β method is adopted to determine the time integration.The developed 3D FEM soil model is a part of the coupled model PORO-WSSI 3D for 3D wave-seabed-marine structures interaction problem,and is validated by the analytical solution proposed by Wang(2000) for a laterally infinite seabed loaded by a uniform force.By adopting the developed 3D soil model,the consolidation of seabed under a caisson breakwater and hydrostatic pressure is investigated.The numerical results show that the caisson breakwater built on seabed has very significant effect on the stresses/displacements fields in the seabed foundation after the transient deformation and primary consolidation are completed.The parametric study indicates that the Young's modulus E of seabed is the most important parameter to affect the settlement of breakwater,and the displacement fields in seabed foundation.Taking the consolidation status as the initial condition,the interaction between ocean wave,caisson breakwater and seabed foundation is briefly investigated.The 3D ocean wave is determined by solving the Navier-Stokes equations with finite volume method(FVM).The numerical results indicate that there is intensive interaction between | YE JianHong JENG DongSheng CHAN A H C | 2012 | Science China(Technological Sciences)2012，55，8： | 4 |
| 13 | Evolution of hepatitis B management in kidney transplantation显示文摘Chronic hepatitis B virus(HBV)infection adversely influences the clinical outcomes of renal transplant recipients owing to increased hepatic complications.Management of HBV infection in kidney transplant recipients presents a challenge to clinicians,especially in endemic regions.Interferon precipitates renal allograft dysfunction.Treatment with lamivudine,the first oral nucleoside analogue available,resulted in effective viral suppression,reduced liver-related complications,and improved patient survival so that medium-term data showed comparable patient survival rates between hepatitis B surface antigen-positive and HBsAg-negative kidney transplant recipients in the era of effective antiviral therapies.Entecavir has replaced lamivudine as first-line therapy for treatment-na?ve subjects in view of the propensity for drug resistance with the latter.Management of HBV infection in kidney transplant patients needs to take into consideration the nephrotoxicity of nucleoside/tide analogues such as adefovir and tenofovir.Prevention of HBV-related complications in kidney transplant recipients starts much earlier prior to transplantation,with vaccination of patients with chronic kidney disease and donor-recipient matching with regard to HBV status.In addition to anti-viral treatment,patients with chronic HBV infection must have regular surveillance for liver cancer and assessment for the development of cirrhosis. | Desmond Y H Yap Tak Mao Chan | 2014 | World Journal of Gastroenterology2014，20，2： | 3 |
| 14 | Long-term evaluation of biliary reconstruction after partial resection of segments IV and V in iatrogenic injuries显示文摘 | Miguel ángel Mercado M.D. Carlos Chan M.D. Héctor Orozco M.D. José M. Villalta M.D. Alexandra Barajas-Olivas M.D. Javier Era?a M.D. Ismael Domínguez M.D | 2006 | Journal of Gastrointestinal Surgery2006，，1： | 3 |
| 15 | 伴有浆细胞分化的套细胞淋巴瘤显示文摘 | Young K H Chan W C Fu K 黄文斌(摘译) | 2006 | 临床与实验病理学杂志2006，22，5： | 2 |
| 16 | 一种模拟堆石料的二维多边形离散单元法及程序显示文摘在考虑堆石料真实颗粒形状的基础上,将每个颗粒用一个多边形离散单元表示,基于一种线性搜索算法对多边形-多边形之间的接触详情进行检索计算,引入基于势能原理的法向多边形-多边形接触模型及切向库仑摩擦模型,形成了一种多边形离散元计算方法,并开发了相应的PDEM程序。可以从颗粒尺度层面展示颗粒之间的相互作用以及每个颗粒的位移和转动,帮助进一步揭示颗粒的细观特性(形状、大小、材料特性等)对堆石料的宏观强度和变形的影响。最后采用PDEM程序对某粗粒料的二维模型试验进行了数值模拟,得到了与室内试验一致的应力变形规律,展现了其方法和程序用于研究堆石料的有效性。 | 罗滔 OOI E T CHAN A H C 傅少君 | 2017 | 岩土力学2017，38，3： | 2 |
| 17 | Widespread use of gastric acid inhibitors in infants:Are they needed? Are they safe?显示文摘Gastroesophageal reflux is a common phenomenon in infants,but the differentiation between gastro-esophageal reflux and gastroesophageal reflux disease can be difficult.Symptoms are non-specific and there is increasing evidence that the majority of symptoms may not be acid-related.Despite this,gastric acid inhibitors such as proton pump inhibitors are widely and increasingly used,often without objective evidence or investigations to guide treatment.Several studies have shown that these medications are ineffective at treating symptoms associated with reflux in the absence of endoscopically proven oesophagitis.With a lack of evidence for efficacy,attention is now being turned to the potential risks of gastric acid suppression.Previously assumed safety of these medications is being challenged with evidence of potential side effects including GI and respiratory infections,bacterial overgrowth,adverse bone health,food allergy and drug interactions. | Mark Safe Wei H Chan Steven T Leach Lee Sutton Kei Lui Usha Krishnan | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 2 |
| 18 | Pointwise equilibrating polynomial element for nonlinear analysis of frames 显示文摘 | Chan S L Zhou H Z | 1994 | J Struct Engng ASCE1994，120，6： | 2 |
| 19 | Chemotherapy in locally advanced nasopharyngeal carcinoma: An individual patient data meta-analysis of eight randomized trials and 1753 patients显示文摘 | Bertrand Baujat Hélène Audry Jean Bourhis Anthony T.C. Chan Haluk Onat Daniel T.T. Chua Dora L.W. Kwong Muhyi al-Sarraf Kwan-Hwa Chi Masato Hareyama Sing F. Leung Kullathorn Thephamongkhol Jean-Pierre Pignon | 2006 | International Journal of Radiation Oncology, Biology, Physics2006，，1： | 2 |
| 20 | TSC1-mTOR-PLK轴以阶段特异性方式调节从施旺细胞增殖到髓鞘形成的内稳态开关显示文摘恰如其分的外周髓鞘形成取决于雪旺细胞增殖与分化进程间的平衡。丝氨酸/苏氨酸激酶(mTOR)整合多种环境因素,是细胞生长、代谢、发挥作用的中枢调节者。本文报道了一种mTOR的负性调节剂——结节性硬化复合体(TSC1),通过控制细胞增殖和髓鞘稳态,建立了雪旺细胞谱系进展和髓鞘形成的阶段依赖性程序。小鼠雪旺细胞祖细胞中TSC1的解离导致mTOR信号通路激活,继而导致雪旺细胞过量增殖,分化受阻,髓鞘形成减少。转录组分析显示,TSC1突变体中的mTOR活化使得polo样激酶(PLK)依赖性通路和细胞周期调节剂上调。弱化mTOR或者对PLK进行药理抑制部分挽救了因TSC1缺失导致的外周神经发育过程中的髓鞘形成减少。相较之下,成年小鼠成熟雪旺细胞中TSC1缺失可导致髓鞘的过度增殖和过度生长。本文的发现提示了TSC1-mTOR-PLK信号轴在控制雪旺细胞的发育过程中,从增殖到分化和髓鞘内稳态中起到的阶段特异性功能。 | Jiang M Rao R Wang J Wang J1 Xu L Wu LM Chan JR Wang H Lu QR 聂昊(编译) | 2018 | 神经损伤与功能重建2018，13，5： | 2 |
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