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| 1 | 延胡索酸水合酶缺陷型肾细胞癌32例临床病理和分子分析显示文摘延胡索酸水合酶缺陷型肾细胞癌属于罕见的、新近发现的与遗传性平滑肌瘤病和肾细胞癌综合征相关的肿瘤实体。延胡索酸水合酶缺陷型肾细胞癌可表现出多种临床和病理学表现,但通常表现为局部进展和转移性疾病,预后较差。作者通过延胡索酸水合酶免疫组化和(或)延胡索酸水合酶突变分析确定32例延胡索酸水合酶缺陷型肾细胞癌,并对其临床和病理特征进行回顾性分析。 | Lau H D Chan E Fan A C 魏建国(摘译) 方三高(审校) | 2020 | 临床与实验病理学杂志2020，36，3： | 19 |
| 2 | Role of gastroesophageal reflux disease in lung transplantation显示文摘Lung transplantation is one of the highest risk solid organ transplant modalities. Recent studies have demonstrated a relationship between gastroesophageal reflux disease(GERD) and lung transplant outcomes, including acute and chronic rejection. The aim of this review is to discuss the pathophysiology, evaluation, and management of GERD in lung transplantation, as informed by the most recent publications in the field. The pathophysiology of reflux-induced lung injury includes the effects of aspiration and local immunomodulation in the development of pulmonary decline and histologic rejection, as reflective of allograft injury. Modalities of reflux and esophageal assessment, including ambulatory p H testing, impedance, and esophageal manometry, are discussed, as well as timing of these evaluations relative to transplantation. Finally, antireflux treatments are reviewed, including medical acid suppression and surgical fundoplication, as well as the safety, efficacy, and timing of such treatments relative to transplantation. Our review of the data supports an association between GERD and allograft injury, encouraging a strategy of early diagnosis and aggressive reflux management in lung transplant recipients to improve transplant outcomes. Further studies are needed to explore additional objective measures of reflux and aspiration, better compare medical and surgical antireflux treatment options, extend followup times to capture longer-term clinical outcomes, and investigate newer interventions including minimally invasive surgery and advanced endoscopic techniques. | Kelly E Hathorn Walter W Chan Wai-Kit Lo | 2017 | World Journal of Transplantation2017，7，2： | 8 |
| 3 | 一种模拟堆石料的二维多边形离散单元法及程序显示文摘在考虑堆石料真实颗粒形状的基础上,将每个颗粒用一个多边形离散单元表示,基于一种线性搜索算法对多边形-多边形之间的接触详情进行检索计算,引入基于势能原理的法向多边形-多边形接触模型及切向库仑摩擦模型,形成了一种多边形离散元计算方法,并开发了相应的PDEM程序。可以从颗粒尺度层面展示颗粒之间的相互作用以及每个颗粒的位移和转动,帮助进一步揭示颗粒的细观特性(形状、大小、材料特性等)对堆石料的宏观强度和变形的影响。最后采用PDEM程序对某粗粒料的二维模型试验进行了数值模拟,得到了与室内试验一致的应力变形规律,展现了其方法和程序用于研究堆石料的有效性。 | 罗滔 OOI E T CHAN A H C 傅少君 | 2017 | 岩土力学2017，38，3： | 2 |
| 4 | Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes - Association analyses in 9,518 subjects显示文摘 | Owen, KR Groves, CJ Hanson, RL Knowler, WC Shuldiner, AR Elbein, SC Mitchell, BD Froguel,P Ng, MCY Chan, JC Jia, WP Deloukas, P Hitman, GA Walker, M Frayling, TM Hattersley, AT Zeggini, E McCarthy, MI | 2007 | 中国生物学文摘2007，21，11： | 2 |
| 5 | Luminescent quantum dots for multiplexed biological detection and imaging显示文摘 | Warren C.W Chan Dustin J Maxwell Xiaohu Gao Robert E Bailey Mingyong Han Shuming Nie | 2002 | Current Opinion in Biotechnology2002，，1： | 2 |
| 6 | Efficacy of transient elastography in screening for large esophageal varices in patients with suspicious or proven liver cirrhosis显示文摘 | Huay‐Min WANG Gin‐Ho LO Wen‐Chi CHEN Ping‐I HSU Hsien‐Chung YU Chiun‐Ku LIN Hoi‐Hung CHAN Wei‐Lun TSAI Feng‐Woei TSAY Tsan‐Ping LIU E‐Ming WANG Kwok‐Hung LAI | 2012 | Journal of Digestive Diseases2012，，8： | 2 |
| 7 | Defining the nature of human pluripotent stem cell progeny显示文摘当人的 pluripotent 干细胞(hPSCs ) 能区分产生各种各样的房间类型的一件礼服,是清楚的时,在 vitro,开发怎么仔细反射那,是未知的哪个发生在 vivo。决定人的胚胎的干细胞(hESCs ) 和导致人的 pluripotent 干细胞(hiPSCs ) 是否做相等的子孙,并且是否也使房间成为那类似于导出织物的房间,我们执行了净化的 PSC 衍生物和他们的导出织物的对应物介绍的全面 transcriptome。表示介绍证明 hESCs 和 hiPSCs 在 hiPSC 子孙用外长的 reprogramming 因素为重新表示的神经、肝、间充质的系,和缺席做将近相同的子孙。不管多么与一个导出织物的对应物相比, hESCs 和 hiPSCs 的子孙维持了通常与早哺乳动物的开发联系的基因的一个子集的表示,不管产生的房间的类型。当 pluripotent 基因(OCT4, SOX2, REX1,和 NANOG ) 看起来在从 hPSCs 的区别之上立即是 silenced 时,对早胚胎(LIN28A, LIN28B, DPPA4,和其它) 通常独特的基因不是充分在 hPSC 衍生物的 silenced。从在早人的胎儿的织物(开发的 3-16 星期) 的表达式模式的这些数据和证据建议 hPSCs 的区分的子孙很早人的开发是反射的(< 6 个星期) 。这些调查结果为 hPSCs 能在早人的开发的 vitro 模型作为有用服务的想法提供支持,而且为疾病建模和 hPSC 衍生物的临床的申请提出重要问题。 | Michaela Patterson David N Chan IrisHa Dana Case Yongyan Cui Ben Van Hande Hanna KA Mikkola William E Lowry | 2012 | Cell Research2012，22，1： | 2 |
| 8 | Is there an anatomical endophenotype for neurodevelopmental disorders? A review of dual disorder anatomical likelihood estimation (ALE) meta-analyses of grey matter volumes显示文摘The term 'neurodevelopmental disorder' broadly encompasses conditions thought to arise early in development and includes schizophrenia, bipolar disorder and autism among others. These conditions share a number of genetic and environmental risk factors postulated to lead to common difficulties in socio-emotional processing, communication and cognitive function. The alternative position is that, while the same traits are affected across these conditions, the nature or direction in which they are modified may be distinct. MRI studies provide a rapidly expanding and rich database which we propose can be used to contribute to this debate. Anatomical likelihood estimation (ALE) is a method of meta-analysis applied to voxel-based MRI studies. We have adapted this method to explore the extent to which schizophrenia and bipolar disorder and schizophrenia and autism share a common brain structural phenotype. We will review this work here and discuss whether there is sufficient other evidence to justify a common framework for further research into the inter-relatedness of such conditions. | MCALONAN Grainne M YU Kevin K CHAN Raymond C K CHUA Siew E CHEUNG Charlton | 2011 | Chinese Science Bulletin2011，56，32： | 2 |
| 9 | Three-dimensional finite-element formulation for problems involving time-varying fields, relative motion, and magnetic saturation 显示文摘 | S Williamson E K C Chan | 1993 | IEE Proceedings-A1993，140，2： | 1 |
| 10 | Effects of tumor necrosis factor alpha on host immune response in chronic persistent tuberculosis: possible role for limiting pathology显示文摘 | Mohan VP Scanga CA Yu K Scott HM Tanaka KE Tsang E Tsai MM Flynn JL Chan J | 2001 | Infect Immune2001，69，3： | 1 |
| 11 | Determinants of successful design- build projects 显示文摘 | Lam E Chan A Chan D | 2008 | Journal of Eonstruction Engineering and Management2008，134，5： | 1 |
| 12 | Antitumor activity and underlying mechanisms of ganopoly,the refined polysaccharides extracted from Ganoderma lucidum,in mice显示文摘 | GAO Y GAO H CHAN E | 2005 | Immunol Invest2005，34，2： | 1 |
| 13 | Effect of supplementation with dietary seal oil on selected cardiovascular risk factors and hemostatic variables in healthy male subjects 显示文摘 | Conquer JA Cheryk LA Chan E | 1999 | ThrombRes1999，96，3： | 1 |
| 14 | Framework of Success Criteria for Design Build Projects 显示文摘 | A P C Chan D Scott E W M Lam | 2002 | Journal of Management in Engineering2002，18，3： | 1 |
| 15 | Crk I and Crk Ⅱ funtion as key signaling integrators for migration and invasion of cancer cells显示文摘 | Rodrigues S P Fathers K E Chan G | 2005 | Mol Cancer Res2005，3，4： | 1 |
| 16 | Maintenance of Continuously Monitored Degrading Systems 显示文摘 | Liao H T Elsayed E A Chan L Y | 2006 | European Journal of Operational Research2006，175，2： | 1 |
| 17 | Effect of supplementation with dietary seal oil on selected cardiovascular risk factors and hemostatic variables in healthy male subjects显示文摘 | Conquer JA Cheryk LA Chan E | 1999 | Thromb Res1999，96，3： | 1 |
| 18 | Effect of interdiffusion on the subbands in an Alx Ga1-xAs single quantum-well structure显示文摘 | Li E H Weiss B L Chan K S | 1992 | Phys Rev B1992，46，15： | 1 |
| 19 | Wavalet-based image coding using nonlinear interpolative vector quantization显示文摘 | Wang X Chan E Mandal M K Panchanathan S | 1996 | IEEE Transactions on Image Processing1996，15，3： | 1 |
| 20 | Strategic Information Systems Alignment显示文摘 | CHAN Y E HUFF S L | 1993 | Business Quarterly1993，58，1： | 1 |
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