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| 1 | TSC1-mTOR-PLK轴以阶段特异性方式调节从施旺细胞增殖到髓鞘形成的内稳态开关显示文摘恰如其分的外周髓鞘形成取决于雪旺细胞增殖与分化进程间的平衡。丝氨酸/苏氨酸激酶(mTOR)整合多种环境因素,是细胞生长、代谢、发挥作用的中枢调节者。本文报道了一种mTOR的负性调节剂——结节性硬化复合体(TSC1),通过控制细胞增殖和髓鞘稳态,建立了雪旺细胞谱系进展和髓鞘形成的阶段依赖性程序。小鼠雪旺细胞祖细胞中TSC1的解离导致mTOR信号通路激活,继而导致雪旺细胞过量增殖,分化受阻,髓鞘形成减少。转录组分析显示,TSC1突变体中的mTOR活化使得polo样激酶(PLK)依赖性通路和细胞周期调节剂上调。弱化mTOR或者对PLK进行药理抑制部分挽救了因TSC1缺失导致的外周神经发育过程中的髓鞘形成减少。相较之下,成年小鼠成熟雪旺细胞中TSC1缺失可导致髓鞘的过度增殖和过度生长。本文的发现提示了TSC1-mTOR-PLK信号轴在控制雪旺细胞的发育过程中,从增殖到分化和髓鞘内稳态中起到的阶段特异性功能。 | Jiang M Rao R Wang J Wang J1 Xu L Wu LM Chan JR Wang H Lu QR 聂昊(编译) | 2018 | 神经损伤与功能重建2018，13，5： | 2 |
| 2 | Adhesiveness of mononuclear cells in hypercholesterolemic humans is normalized by dietary L-arginine显示文摘 | Theilmeier G Chan JR Zalpour C | 1997 | Arterioscler Thromb Vasc Biol1997，17，： | 1 |
| 3 | Development,cytokine profile and function of human interleukin 17-producing helper T cells显示文摘 | Wilson NJ Boniface K Chan JR | | 0，，09： | 1 |
| 4 | Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon显示文摘 | Taylor BF Jr Chan A Esmon CT | 1987 | J Clin Invest1987，79，： | 1 |
| 5 | Electro- cardiographic diagnosis of acute myocardial infarction显示文摘 | Brady W J Jr Aufderheide T P Chan T | 2001 | Emerg Med Clin North AM2001，19，2： | 1 |
| 6 | Does regional anaes- thesia improve outcome after total hip arthroplasty? A systematic re- view显示文摘 | Macfarlane A JR Prasad GA Chan VWS | 2009 | Br J Anaesth2009，103，3： | 1 |
| 7 | IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implica- tions for psoriasis pathogenesis 显示文摘 | Chan JR Blumenschein W Murphy E | 2006 | J Exp Med2006，203，12： | 1 |
| 8 | neurotrophin receptor P75NTR as a positive modulator of myelination显示文摘 | Cosgaya JM Chan JR Shooter EM | 2002 | Science2002，298，5596： | 1 |
| 9 | Development, cytokine profile and function of human interleukin 17-producing helper T cells显示文摘 | Wilson NJ Boniface K Chan JR | 2007 | Nat Immunol2007，8，9： | 1 |
| 10 | Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis显示文摘 | Hinchey J Lee S Jeon BY Basaraba RJ Venkataswamy MM Chen B Chan J Braunstein M Orme IM Derrick SC Morris SL Jacobs WR Jr Porcelli SA | 2007 | J Clin Invest2007，117，8： | 1 |
| 11 | Cytokine-mediated regulation of antimicrobial proteins 显示文摘 | Kolls JK McCray PB Jr Chan YR | 2008 | Nat Rev Immunol2008，8，11： | 1 |
| 12 | Focal myositis:a new cause for the neck mass显示文摘 | Isaacson G Chan KH Heffner RR Jr | 1991 | Arch Otolaryngol Head Neck Surg1991，117，1： | 1 |
| 13 | Development, cytokine profile and function of human interleukin 17-producing helper T cells显示文摘 | Wilson NJ Boniface K Chan JR | 2007 | Natimmunol2007，8，9： | 1 |
| 14 | Factors affecting postopera- tive stereopsis in acquired nonaccommodative esotropia显示文摘 | Chan TY Mao AJ Piggott JR | 2012 | Can J Ophthalmol2012，47，6： | 1 |
| 15 | Development, cytokine profile and function of human interleukin 17-producing helper T cells 显示文摘 | Wilson N J Boniface K Chan JR | 2007 | Nat Immunol2007，8，9： | 1 |
| 16 | DNA-lipo-some versus adenoviral mediated genetransfer of transforming growth factor β1 in vascularized cardiac allografts;differential cneitvity of CD4^+ and CD8^+ T cells to transforming growth factor-1显示文摘 | Chan SY Goodman RE Szmuszkovicz JR | 2000 | Transplantation2000，20，9： | 1 |
| 17 | Peak expiratory flow in 6-12 year oldchildren from Merida,Yucatan,Mexico显示文摘 | Baeza Bacab MA Davila Velazquez JR Palma Chan AG Albertos Alpuche Nlpuche NE | 2004 | Rev Alerg Mex2004，51，3： | 1 |
| 18 | Cytikine regulation of chronic cardiac allograft rejection : evidence against arole for TH1 in eh disease process显示文摘 | Piccotti JR Li K Chan SY | 1999 | Transplantation1999，67，12： | 1 |
| 19 | Recurrent atypical hemolyt-ic uremic syndrome associated with factor I mutation in a living relatedrenal transplant recipient显示文摘 | Chan MR Thomas CP Torrealba JR | 2009 | American Journal of Kidney Diseases2009，53，2： | 1 |
| 20 | Development,cytokine profile and function of human interleukin 17-producing helper T cells显示文摘 | Wilson NJ Boniface K Chan JR | 2007 | Nat Immunol2007，8，9： | 1 |
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