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| 1 | A randomized controlled trial of imipramine in patients with irritable bowel syndrome显示文摘AIM: To study the efficacy of low-dose imipramine in relieving symptoms associated with the irritable bowel syndrome (IBS). METHODS: A randomized, double-blind trial of 25 mg imipramine vs matched placebo for 12 wk was performed. Doubling the dose was allowed once at week 2 in case of an unsatisfactory early response. Primary efficacy variables were subjective global symptom relief and quality of life (QoL) using SF-36 at week 12. RESULTS: One hundred and seven patients were enrolled by advertisement or referral by general practitioners and 56 (31 imipramine: 25 placebo) completed the 16-wk study. Baseline characteristics were comparable. A high overall dropout rate was noted in the imipramine and placebo arms (47.5% vs 47.9%, P > 0.05), a mean of 25.0 and 37.4 d from enrollment, respectively (P < 0.05). At the end of 12 wk, there was a significant difference in global symptom relief with imipramine over placebo (per-protocol: 80.6% vs48.0%, P = 0.01) and a trend on intent-to-treat (ITT) analysis (42.4% vs 25.0%, P = 0.06). This improvement was evident early and persisted to week 16 (P = 0.024 and 0.053 by per-protocol and ITT analyses, respectively). Mean cumulative and componentspecific SF-36 scores improved in the imipramine group only (per-protocol, P < 0.01). Drug-related adverse events leading to patient dropout were more common in the imipramine group (25.4% vs 12.5%, P > 0.05). CONCLUSION: Imipramine may be effective in the treatment of IBS patients and is associated with improved QoL. Careful patient selection, initiation of a low dose with gradual escalation and monitoring for side effects may result in an improved therapeutic response. | Heitham Abdul-Baki Ihab I El Hajj Lara ElZahabi Cecilio Azar Elie Aoun Assaad Skoury Hani Chaar Ala I Sharara | 2009 | World Journal of Gastroenterology2009，15，29： | 11 |
| 2 | Endoscopic ultrasound-guided celiac plexus neurolysis显示文摘Endoscopic celiac plexus neurolysis(CPN)has become the procedure of choice for the management of patients with pancreatic cancer and abdominal pain unresponsive to medical treatment.It is necessary to differentiate between CPN and endoscopic celiac plexus block performed in patients with benign disease.In this review we describe the technique of this procedure with special emphasis on technical details. | Assaad M Soweid Cecilio Azar | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，6： | 3 |
| 3 | A randomized single-blind trial of split-dose PEG-electrolyte solution without dietary restriction compared with whole dose PEG-electrolyte solution with dietary restriction for colonoscopy preparation <ce:link locator='fx1'/>显示文摘 | Elie Aoun Heitham Abdul-Baki Cecilio Azar Fadi Mourad Kassem Barada Zeina Berro Mohsen Tarchichi Ala I. Sharara | 2005 | Gastrointestinal Endoscopy2005，，2： | 1 |
| 4 | A randomized, controlled, double-blind trial of the adjunct use of tegaserod in whole-dose or split-dose polyethylene glycol electrolyte solution for colonoscopy preparation显示文摘 | Heitham Abdul-Baki Jana G. Hashash Ihab I. ElHajj Cecilio Azar Lara El Zahabi Fadi H. Mourad Kassem A. Barada Ala I. Sharara | 2008 | Gastrointestinal Endoscopy2008，，2： | 1 |
| 5 | Solitary rectal ulcer syndrome: endoscopic spectrum and review of the literature显示文摘 | Ala I. Sharara Cecilio Azar Samir S. Amr Maurice Haddad Mohamad A. Eloubeidi | 2005 | Gastrointestinal Endoscopy2005，，5： | 1 |
| 6 | A randomized, controlled, double-blind trial of the adjunct use of tegaserod in whole-dose or split-dose polyethylene glycol electrolyte solution for colonoscopy preparation显示文摘 | Heitham Abdul-Baki Jana G. Hashash Ihab I. ElHajj Cecilio Azar Lara El Zahabi Fadi H. Mourad Kassem A. Barada Ala I. Sharara | 2008 | Gastrointestinal Endoscopy2008，，2： | 1 |
| 7 | A randomized single-blind trial of split-dose PEG-electrolyte solution without dietary restriction compared with whole dose PEG-electrolyte solution with dietary restriction for colonoscopy preparation <ce:link locator='fx1'/>显示文摘 | Elie Aoun Heitham Abdul-Baki Cecilio Azar Fadi Mourad Kassem Barada Zeina Berro Mohsen Tarchichi Ala I. Sharara | 2005 | Gastrointestinal Endoscopy2005，，2： | 1 |
| 8 | Prevalence of Endoscopically Identified Heterotopic Gastric Mucosa in the Proximal Esophagus: Endoscopist Dependent?显示文摘 | Cecilio Azar Faek Jamali Hala Tamim Heitham Abdul-Baki Assaad Soweid | 2007 | Journal of Clinical Gastroenterology2007，，5： | 1 |
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