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| 1 | A randomized controlled trial of imipramine in patients with irritable bowel syndrome显示文摘AIM: To study the efficacy of low-dose imipramine in relieving symptoms associated with the irritable bowel syndrome (IBS). METHODS: A randomized, double-blind trial of 25 mg imipramine vs matched placebo for 12 wk was performed. Doubling the dose was allowed once at week 2 in case of an unsatisfactory early response. Primary efficacy variables were subjective global symptom relief and quality of life (QoL) using SF-36 at week 12. RESULTS: One hundred and seven patients were enrolled by advertisement or referral by general practitioners and 56 (31 imipramine: 25 placebo) completed the 16-wk study. Baseline characteristics were comparable. A high overall dropout rate was noted in the imipramine and placebo arms (47.5% vs 47.9%, P > 0.05), a mean of 25.0 and 37.4 d from enrollment, respectively (P < 0.05). At the end of 12 wk, there was a significant difference in global symptom relief with imipramine over placebo (per-protocol: 80.6% vs48.0%, P = 0.01) and a trend on intent-to-treat (ITT) analysis (42.4% vs 25.0%, P = 0.06). This improvement was evident early and persisted to week 16 (P = 0.024 and 0.053 by per-protocol and ITT analyses, respectively). Mean cumulative and componentspecific SF-36 scores improved in the imipramine group only (per-protocol, P < 0.01). Drug-related adverse events leading to patient dropout were more common in the imipramine group (25.4% vs 12.5%, P > 0.05). CONCLUSION: Imipramine may be effective in the treatment of IBS patients and is associated with improved QoL. Careful patient selection, initiation of a low dose with gradual escalation and monitoring for side effects may result in an improved therapeutic response. | Heitham Abdul-Baki Ihab I El Hajj Lara ElZahabi Cecilio Azar Elie Aoun Assaad Skoury Hani Chaar Ala I Sharara | 2009 | World Journal of Gastroenterology2009，15，29： | 11 |
| 2 | 在 esophagogastroduodenoscopy 使用 lidocaine 的实用性与 propofol 表现在镇静下面显示文摘 AIM:To determine whether topical lidocaine benefits esophagogastroduoduenoscopy(EGD) by decreasing propofol dose necessary for sedation or procedurerelated complications.METHODS:The study was designed as a prospective,single centre,double blind,randomised clinical trial and was conducted in 2012 between January and May(NCT01489891).Consecutive patients undergoing EGD were randomly assigned to receive supplemental topical lidocaine(L;50 mg in an excipient solution which was applied as a spray to the oropharynx) or placebo(P;taste excipients solution without active substance,similarly delivered) prior to the standard propofol sedation procedure.The propofol was administered as a bolus intravenous(iv) dose,with patients in the L and P groups receiving initial doses based on the patient’s American Society of Anaesthesiologists(ASA) classification(ASAⅠ-Ⅱ:0.50-0.60 mg/kg;ASA Ⅲ-Ⅳ:0.25-0.35 mg/kg),followed by 10-20 mg iv dose every 30-60 s at the anaesthetist’s discretion.Vital signs,anthropometric measurements,amount of propofol administered,sedation level reached,examination time,and the subjective assessments of the endoscopist’s and anaesthetist’s satisfaction(based upon a four point Likert scale) were recorded.All statistical tests were performed by the Stata statistical software suite(Release 11,2009;StataCorp,LP,College Station,TX,United States).RESULTS:No significant differences were found between the groups treated with lidocaine or placebo in terms of total propofol dose(310.7 ± 139.2 mg/kg per minute vs 280.1 ± 87.7 mg/kg per minute,P = 0.15) or intraprocedural propofol dose(135.3 ± 151.7 mg/kg per minute vs 122.7 ± 96.5 mg/kg per minute,P = 0.58).Only when the L and P groups were analysed with the particular subgroups of female,< 65-year-old,and lower anaesthetic risk level(ASA Ⅰ-Ⅱ) was a statistically significant difference found(L:336.5 ± 141.2 mg/kg per minute vs P:284.6 ± 91.2 mg/kg per minute,P = 0.03) for greater total propofol requirements).The total incidence of complications was also similar between the two groups,with the L group showing a complication rate of 32.2%(95%CI:21.6-45.0) and the P group showing a complication rate of 26.7%(95%CI:17.0-39.0).In addition,the use of lidocaine had no effect on the anaesthetist’s or endoscopist’s satisfaction with the procedure.Thus,the endoscopist’s satisfaction Likert assessments were equally distributed among the L and P groups:unsatisfactory,[L:6.8%(95%CI:2.2-15.5) vs P:0%(95%CI:0-4.8);neutral,L:10.1%(95%CI:4.2-19.9) vs P:15%(95%CI:7.6-25.7)];satisfactory,[L:25.4%(95%CI:10-29.6) vs P:18.3%(95%CI:15.5-37.6);and very satisfactory,L:57.6%(95%CI:54-77.7) vs P:66.6%(95%CI:44.8-69.7)].Likewise,the anaesthetist’s satisfaction Likert assessments regarding the ease of maintaining a patient at an optimum sedation level without agitation or modification of the projected sedation protocol were not affected by the application of lidocaine,as evidenced by the lack of significant differences between the scores for the placebo group:unsatisfactory,L:5.8%(95%CI:1.3-13.2) vs P:0%(95%CI:0-4.8);neutral,L:16.9%(95%CI:8.9-28.4) vs P:16.7%(95%CI:8.8-27.7);satisfactory,L:15.2%(95%CI:7.7-26.1) vs P:20.3%(95%CI:11.3-31.6);and very satisfactory,L:62.7%(95%CI:49.9-74.3) vs P:63.3%(95%CI:50.6-74.7).CONCLUSION:Topical pharyngeal anaesthesia is safe in EGD but does not reduce the necessary dose of propofol or improve the anaesthetist’s or endoscopist’s satisfaction with the procedure. | Felipe de la Morena Cecilio Santander Carlos Esteban Beatriz de Cuenca Juan Antonio García Javier Sánchez Ricardo Moreno | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，5： | 3 |
| 3 | A brief history of the Rheic Ocean显示文摘Rheic 海洋是古生代的时代的最重要的海洋之一。它从早奥陶纪躺了在 Laurentia 和 Gondwana 之间并且关门了在 Pangea 的集会期间生产广阔 Ouachita-Alleghanian-Variscan orogen。Rifting 开始了在象沿着以前的缝术的线从北 Gondwana 的大陆人边缘用几个 Neoproterozoic 弧岩层的分离在早奥陶纪打开的 Neoproterozoic orogenic 活动和海洋的继续寒武纪。海洋开的快速的率建议它被平板拉在舷外的 Iapetus 海洋驾驶。海洋在志留纪与 Iapetus 和 peri-Gondwanan 弧岩层的生长的闭合到达了它的最大的宽度到 Laurentia。海洋闭合在泥盆纪开始了并且继续通过象到到形式 Pangea 的 Laurussia 的 Gondwana sutured 密西西比河。海洋因而在北美洲的 Appalachian-Ouachita 造山运动起一个主导的作用,在南部的欧洲的地下室地质学,并且在古生代沉积,结构并且来自中间的美洲的 tectonothermal 记录到中东。它的闭合把古生代的时代带到一个目的。 | R.Damian Nance Gabriel Gutirrez-Alonso J.Duncan Keppie Ulf Linnemann J.Brendan Murphy Cecilio Quesada Rob A.Strachan Nigel H.Woodcock | 2012 | Geoscience Frontiers2012，3，2： | 3 |
| 4 | Endoscopic ultrasound-guided celiac plexus neurolysis显示文摘Endoscopic celiac plexus neurolysis(CPN)has become the procedure of choice for the management of patients with pancreatic cancer and abdominal pain unresponsive to medical treatment.It is necessary to differentiate between CPN and endoscopic celiac plexus block performed in patients with benign disease.In this review we describe the technique of this procedure with special emphasis on technical details. | Assaad M Soweid Cecilio Azar | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，6： | 3 |
| 5 | Estimating the Export and Import Demandfor Manufactured Goods-The Role of FDI 显示文摘 | Mariam Camarero Cecilio Tamarit | 2004 | Review of World Economics2004，，3： | 1 |
| 6 | Electrochemical assessment of the self-healing properties of Ce-doped silane solutions for the pre-treatment of galvanised steel substrates 显示文摘 | TRABELSI W CECILIO P FERREIRA M G S | 2005 | Progress in Organic Coatings2005，54，4： | 1 |
| 7 | Electrochemical assessment of the self - healing properties of Ce - doped silane solutions for the pre - treatment of galvanised steel substrates 显示文摘 | TRABELSI W CECILIO P FERREIRA M G | 2005 | Progress in Organic Coatings2005，54，4： | 1 |
| 8 | Surface evaluation and electrochemical behaviour of doped silane pre-treatments on galvanised steel substrates显示文摘 | Trabelsi W Cecilio P Ferreira M G S | 2007 | Progress in Organic Coatings2007，，59： | 1 |
| 9 | Prevalence of endoscopically identified heterotopic gastric mucosa in the proximal esophagus endoscopist depen-dent显示文摘 | Cecilio A Faek J Hala T | | 0，，05： | 1 |
| 10 | Electrochemical and analytical assessment of galvanized steel reinforcement pre-treated with Ce and La salts under alkaline media显示文摘 | Sanchez M Alonso M C Cecilio P | 2006 | Cement & Concrete Composites2006，28，3： | 1 |
| 11 | Genomic analysis of grapevine retrotransposon 1 (Gret1)in Vitiz vinifera显示文摘 | PEREIRA H S BARAO A DELGADO M LEONOR MORAIS- CECILIO L VIEGAS W | 2005 | Theor Appl Genet2005，111，： | 1 |
| 12 | Characterization of g enetic variation and 3′-azido-3′deoxythymidineresistance mutations of human i mm unodeficiency virus by the RNase amidmatchcleavagemethod显示文摘 | Cecilio LG Jose MR Rafael N | 1991 | Proc Natl Acad Sci (USA)1991，88，10： | 1 |
| 13 | Interfacial and foaming properties of soy protein and their hydrolysates显示文摘 | Karina D. Martínez Cecilio Carrera Sánchez Juan M. Rodríguez Patino Ana M.R. Pilosof | 2009 | Food Hydrocolloids2009，，8： | 1 |
| 14 | Electro-chemical assessment of the self-healing properties of Ce-doped silane solutions for the pretreatment of galvanised steel substrates 显示文摘 | Trabelsi W Cecilio P Ferreira M G | 2005 | Progress in Organic Coatings2005，54，4： | 1 |
| 15 | Surface evaluation and electrochemical behaviour of doped silane pre treatments on galvanised steel substrates显示文摘 | Trabelsi W Cecilio P Ferreira M G S | 2007 | Progress in Organic Coatings2007，59，： | 1 |
| 16 | Electrochemical assessment of the selfhealing properties of Ce-doped silane solutions for the pretreatment of galvanised steel substrates 显示文摘 | W Trabelsi P Cecilio | 2005 | Progress in Organic Coatings2005，54，： | 1 |
| 17 | Support vector machines used to estimate the battery state of charge显示文摘 | Juan Carlos Alvarez Anton Paulino Jose Garca Nieto Cecilio Blanco Viejo | 2013 | IEEE Transactions on Power Electronics2013，28，12： | 1 |
| 18 | Electrochemical assessment of the self-healing properties of Ce-doped silane solutions for the pre-treatment of galvanised steel substrates 显示文摘 | TRABELSI W CECILIO P FERREIRA M G S | 2005 | Progress in Organic Coatings2005，54，4： | 1 |
| 19 | Morphological and structural cha- racteristics of monoglyceride monolayers at the air-water interface observed by brewster angle microscopy 显示文摘 | Patino Juan M Rodr guez Stnchez Cecilio Carrera Nifio M Rosario Rodriguez | 1999 | Langmuir1999，15，7： | 1 |
| 20 | Surface evaluation and electrochemical behaviour of doped silane pretreatments on galvanized steel substrates 显示文摘 | Trabelsi W Cecilio P Ferreira M G S | 2007 | Progress in Organic Coatings2007，59，： | 1 |
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