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| 1 | A randomized controlled trial of imipramine in patients with irritable bowel syndrome显示文摘AIM: To study the efficacy of low-dose imipramine in relieving symptoms associated with the irritable bowel syndrome (IBS). METHODS: A randomized, double-blind trial of 25 mg imipramine vs matched placebo for 12 wk was performed. Doubling the dose was allowed once at week 2 in case of an unsatisfactory early response. Primary efficacy variables were subjective global symptom relief and quality of life (QoL) using SF-36 at week 12. RESULTS: One hundred and seven patients were enrolled by advertisement or referral by general practitioners and 56 (31 imipramine: 25 placebo) completed the 16-wk study. Baseline characteristics were comparable. A high overall dropout rate was noted in the imipramine and placebo arms (47.5% vs 47.9%, P > 0.05), a mean of 25.0 and 37.4 d from enrollment, respectively (P < 0.05). At the end of 12 wk, there was a significant difference in global symptom relief with imipramine over placebo (per-protocol: 80.6% vs48.0%, P = 0.01) and a trend on intent-to-treat (ITT) analysis (42.4% vs 25.0%, P = 0.06). This improvement was evident early and persisted to week 16 (P = 0.024 and 0.053 by per-protocol and ITT analyses, respectively). Mean cumulative and componentspecific SF-36 scores improved in the imipramine group only (per-protocol, P < 0.01). Drug-related adverse events leading to patient dropout were more common in the imipramine group (25.4% vs 12.5%, P > 0.05). CONCLUSION: Imipramine may be effective in the treatment of IBS patients and is associated with improved QoL. Careful patient selection, initiation of a low dose with gradual escalation and monitoring for side effects may result in an improved therapeutic response. | Heitham Abdul-Baki Ihab I El Hajj Lara ElZahabi Cecilio Azar Elie Aoun Assaad Skoury Hani Chaar Ala I Sharara | 2009 | World Journal of Gastroenterology2009，15，29： | 11 |
| 2 | A randomized open-label trial of on-demand rabeprazole vs ranitidine for patients with non-erosive reflux disease显示文摘AIM:To compare the efficacy of the proton-pump inhibitor,rabeprazole,with that of the H 2-receptor antagonist,ranitidine,as on-demand therapy for relieving symptoms associated with non-erosive reflux disease(NERD).METHODS:This is a single center,prospective,randomized,open-label trial of on-demand therapy with rabeprazole(group A) vs ranitidine(group B) for 4 wk.Eighty-three patients who presented to the American University of Beirut Medical Center with persistent gastroesophageal reflux disease(GERD) symptoms and a normal upper gastrointestinal endoscopy were eligible for the study.Patients in group A(n = 44) were allowed a maximum rabeprazole dose of 20 mg twice daily,while those in group B(n = 39) were allowed a maximum ranitidine dose of 300 mg twice daily.Efficacy was assessed by patient evaluation of global symptom relief,scores of the SF-36 quality of life(QoL) questionnaires,total number of pills used,and number of medication-free days.RESULTS:Among the 83 patients who were enrolled in the study,76 patients(40 in the rabeprazole group and 36 in the ranitidine group) completed the 4-wk trial.Baseline characteristics were comparable between both groups.After 4 wk,there was no significant difference in the subjective global symptom relief between the rabeprazole and the ranitidine groups(71.4% vs 65.4%,respectively;P = 0.9).There were no statistically significant differences between mean cumulative scores of the SF-36 QoL questionnaire for the two study groups(rabeprazole 22.40 ± 27.53 vs ranitidine 17.28 ± 37.06;P = 0.582).There was no significant difference in the mean number of pills used(rabeprazole 35.70 ± 29.75 vs ranitidine 32.86 ± 26.98;P = 0.66).There was also no statistically significant difference in the mean number of medication-free days between both groups.CONCLUSION:Rabeprazole has a comparable efficacy compared to ranitidine when given on-demand for the treatment of NERD.Both medications were associated with improved quality of life. | Abdallah A Kobeissy Jana G Hashash Faek R Jamali Assaad M Skoury Reham Haddad Sarah El-Samad Rami Ladki Rola Aswad Assaad M Soweid | 2012 | World Journal of Gastroenterology2012，18，19： | 4 |
| 3 | Prevalence and factors associated with irritable bowel syndrome among university students in Lebanon:Findings from a cross-sectional study显示文摘AIM: To describe the bowel habits and the prevalence of irritable bowel syndrome(IBS) and to investigate the influence of health behavior and social factors on IBS prevalence in university students. METHODS: This cross-sectional study was conducted at five major universities in Greater Beirut and its suburbs, between February and June 2014. Using a convenience sample, a total of 813 students aged 18 years old and above participated in this study. Participants were asked to complete a comprehensive anonymous questionnaire which detailed characteristics on socio-demographic, health-related, and lifestyle factors, as well as IBS. The ROME Ⅲ criteria were used as a tool to ascertain IBS. A χ2 test was used to determine differences between categorical variables; stepwise logistic regression was used to measure the association between IBS and its risk factors.RESULTS: An overall prevalence of IBS of 20% was recorded among university students. The bivariate analysis showed that females were significantly more likely to report having IBS than males(29.1% vs 18.2%, P < 0.01). Those living at the school dormitory or in a private residence(39.5%) were more likely to have IBS than those living with their families(16.3%)(P < 0.01). The multivariate analysis showed that those who had a relatively high family income level(US$ > 2000) were almost 6 times more likely to report havingIBS than their counterparts.CONCLUSION: This is the first study to describe the nature of IBS among young adults in Lebanon. The prevalence of IBS among university students in our sample was higher than that reported in the West. | Christy Costanian Hala Tamim Shafika Assaad | 2015 | World Journal of Gastroenterology2015，21，12： | 3 |
| 4 | Endoscopic ultrasound-guided celiac plexus neurolysis显示文摘Endoscopic celiac plexus neurolysis(CPN)has become the procedure of choice for the management of patients with pancreatic cancer and abdominal pain unresponsive to medical treatment.It is necessary to differentiate between CPN and endoscopic celiac plexus block performed in patients with benign disease.In this review we describe the technique of this procedure with special emphasis on technical details. | Assaad M Soweid Cecilio Azar | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，6： | 3 |
| 5 | Posterior lingual lidocaine: A novel method to improve tolerance in upper gastrointestinal endoscopy显示文摘AIM: To evaluate the effect of posterior lingual lidocaine swab on patient tolerance to esophagogastro-duodenoscopy, the ease of performance of the procedure, and to determine if such use will reduce the need for intravenous sedation. METHODS: Eighty patients undergoing diagnostic esophagogastroduodenoscopy in a tertiary care medical center were randomized to either lidocaine swab or spray. Intravenous meperidine and midazolam were given as needed during the procedure. RESULTS: Patients in the lidocaine swab group (SWG) tolerated the procedure better than those in the spray group (SPG) with a median tolerability score of 2 (1, 4) compared to 4 (2, 5) (P < 0.01). The endoscopists encountered less diffi culty performing the proceduresin the SWG with lower median difficulty scores of 1 (1, 5) compared to 4 (1, 5) in the SPG (P < 0.01). In addition, the need for intravenous sedation was also lower in the SWG compared to the SPG with fewer patients requiring intravenous sedation (13/40 patients vs 38/40 patients, respectively, P < 0.01). The patients in the SWG were more satisfi ed with the mode of local anesthesia they received as compared to the SPG. In addition, the endoscopists were happier with the use of lidocaine swab. CONCLUSION: The use of a posterior lingual lidocaine swab in esophagogastroduodenoscopy improves patient comfort and tolerance and endoscopist satisfaction and decreases the need for intravenous sedation. | Assaad M Soweid Shadi R Yaghi Faek R Jamali Abdallah A Kobeissy Michella E Mallat Rola Hussein Chakib M Ayoub | 2011 | World Journal of Gastroenterology2011，17，47： | 2 |
| 6 | Spontaneous complete regression of hepatic epithelioid haemangioendothelioma显示文摘 | Zaher K Otrock Aghiad Al-Kutoubi Mireille M Kattar Ghazi Zaatari Assaad Soweid | 2006 | Lancet Oncology2006，，5： | 2 |
| 7 | How to account for CO 2 emissions from biomass in an LCA显示文摘 | Ari Rabl Anthony Benoist Dominique Dron Bruno Peuportier Joseph V. Spadaro Assaad Zoughaib | 2007 | The International Journal of Life Cycle Assessment2007，，5： | 2 |
| 8 | Use of anti tumor necrosis factor-alpha monoclonal antibody for ulcerative jejunoileitis显示文摘Ulcerative jejunoileitis is an uncommon clinical syndrome consisting of abdominal pain,weight loss associated with diarrhea,and multiple inflammatory ulcerations and strictures of the small bowel.Ulcerative jejunoileitis can complicate established celiac disease or develop in patients de novo.Increased levels of tumor necrosis factor-alpha(TNF-α) in the small intestine of patients with untreated celiac disease are associated with a role in the immune pathogenesis of this disorder.No specific therapy has been shown to change the course of ulcerative jejunoileitis.We report a case of severe ulcerative jejunoileitis previously unresponsive to traditional therapies,including high dose corticosteroids and cyclosporine.The patient had a dramatic resolution of symptoms and a complete normalization of endoscopic findings after anti-TNF-α monoclonal antibody,infliximab(Remicade). | Gulseren Seven Adel Assaad Thomas Biehl Richard A Kozarek | 2012 | World Journal of Gastroenterology2012，18，36： | 2 |
| 9 | Study of the fundamental Lamb modes interaction with symmetrical notches显示文摘 | Benmeddour F Grondel S Assaad J | 2008 | NDT&E International2008，41，1： | 1 |
| 10 | Variation of formwork pressure with thixotropy of self-consolidating concrete 显示文摘 | Assaad J Khayat K H Mesbah H | 2003 | ACI Materials Journal2003，100，1： | 1 |
| 11 | Effect of super oxide dismute on a rabbit model of chronic allergic asthma显示文摘 | Assaad AH Brallard ET sebastian KD | 2008 | Ann AIlergy Asthma Hnmunol2008，，12： | 1 |
| 12 | Glucagon-like peptide-1 prevents beta cell glucolipotoxicity显示文摘 | Buteau J El Assaad W Rhodes C J | 2004 | Diabetologia2004，47，5： | 1 |
| 13 | Signal processing for damage detection using two different array trans ducers显示文摘 | El-Youbi F Grondel S Assaad J | 2004 | Ultrasonics2004，42，19： | 1 |
| 14 | Kinetics and thermodynamics studies of copper exchange on Na-montmorillonite clay mineral显示文摘 | El B M Sadek O M Assaad F F | 2003 | Journal of Colloid and Interface Science2003，，2： | 1 |
| 15 | Alcohol promotes dopamine release in the human nucleus accumbens 显示文摘 | Boileau I Assaad JM Pihl RO | 2003 | Synapse2003，49，4： | 1 |
| 16 | Malonyl-CoA signaling,lipid partitioning,and glucolipotoxicity:role in beta-cell adaptation and failure in the etiology of diabetes显示文摘 | PRENTKI M JOJY E EL ASSAAD W | 2002 | Diabetes2002，51，3： | 1 |
| 17 | Comparison of Field-Oriented Test Methods to Assess Dynamic Stability of Self-Consolidating Concrete 显示文摘 | Khayat K H Assaad J Daczko J | 2004 | ACI Materials Journal2004，101，2： | 1 |
| 18 | Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death显示文摘 | EL ASSAAD W BUTEA J PEYOT M L | 2003 | Endocrinology2003，144，9： | 1 |
| 19 | A detailed experimental investigation of well-defined, turbulent evaporating spray jets of acetone显示文摘 | Yung-Cheng Chen Sten H. St?rner Assaad R. Masri | 2005 | International Journal of Multiphase Flow2005，，4： | 1 |
| 20 | Improvement of functional properties and antioxidant activities of cuttlefish ( Sepia officinalis ) muscle proteins hydrolyzed by Bacillus mojavensis A21 proteases显示文摘 | Noomen Hmidet Rafik Balti Rim Nasri Assaad Sila Ali Bougatef Moncef Nasri | 2011 | Food Research International2011，，9： | 1 |
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