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| 1 | Biochemical mechanisms in drug-induced liver injury:Certainties and doubts显示文摘Drug-induced liver injury is a significant and still unresolved clinical problem.Limitations to knowledge about the mechanisms of toxicity render incomplete the detection of hepatotoxic potential during preclinical development.Several xenobiotics are lipophilic substances and their transformation into hydrophilic compounds by the cytochrome P-450 system results in production of toxic metabolites.Aging,preexisting liver disease,enzyme induction or inhibition,genetic variances,local O2 supply and,above all,the intrinsic molecular properties of the drug may affect this process.Necrotic death follows antioxidant consumption and oxidation of intracellular proteins,which determine increased permeability of mitochondrial membranes,loss of potential,decreased ATP synthesis,inhibition of Ca2+-dependent ATPase,reduced capability to sequester Ca2+ within mitochondria,and membrane bleb formation.Conversely,activation of nucleases and energetic participation of mitochondria are the main intracellular mechanisms that lead to apoptosis.Non-parenchymal hepatic cells are inducers of hepatocellular injury and targets for damage.Activation of the immune system promotes idiosyncratic reactions that result in hepatic necrosis or cholestasis,in which different HLA genotypes might play a major role.This review focuses on current knowledge of the mechanisms of drug-induced liver injury and recent advances on newly discovered mechanisms of liver damage.Future perspectives including new frontiers for research are discussed. | Ignazio Grattagliano Leonilde Bonfrate Catia V Diogo Helen H Wang David QH Wang Piero Portincasa | 2009 | World Journal of Gastroenterology2009，15，39： | 30 |
| 2 | H pylori infection and systemic antibodies to CagA and heat shock protein 60 in patients with coronary heart disease显示文摘AIM: To determine the overall prevalence of H pylori and CagA positive H pylori infection and the prevalence of other bacterial and viral causes of chronic infection in patients with coronary heart disease (CHD), and the potential role of anti-heat-shock protein 60 (Hsp60) anti- body response to these proteins in increasing the risk of CHD development. METHODS: Eighty patients with CHD and 160 controls were employed. We also compared the levels of anti- heat-shock protein 60 (Hsp60) antibodies in the two groups. The H pylori infection and the CagA status were determined serologically, using commercially available enzyme-linked immunosorbent assays (ELISA), and a Western blotting method developed in our laboratory. Systemic antibodies to Hsp60 were determined by a sandwich ELISA, using a polyclonal antibody to Hsp60 to sensitise polystyrene plates and a commercially available human Hsp60 as an antigen. RESULTS: The overall prevalence of H pylori infec- tion was 78.7% (n = 63) in patients and 76.2% (n = 122) in controls (P = 0.07). Patients infected by CagA- positive (CagA+) H pylori strains were 71.4% (n = 45) vs 52.4% of infected controls (P = 0.030, OR = 2.27). Sys-temic levels of IgG to Hsp60 were increased in H pylori- negative patients compared with uninfected controls (P < 0.001) and CagA-positive infected patients compared with CagA-positive infected controls (P = 0.007). CONCLUSION: CagA positive H pylori infection may concur to the development of CHD; high levels of anti- Hsp60 antibodies may constitute a marker and/or a con- comitant pathogenic factor of the disease. | Cristina Lenzi Alberto Palazzuoli Nicola Giordano Giuliano Alegente Catia Gonnelli Maria Stella Campagna Annalisa Santucci Michele Sozzi Panagiotis Papakostas Fabio Rollo Ranuccio Nuti Natale Figura | 2006 | World Journal of Gastroenterology2006，12，48： | 23 |
| 3 | A silybin-phospholipids complex counteracts rat fatty liver degeneration and mitochondrial oxidative changes显示文摘AIM:To investigate the effectiveness of antioxidant compounds in modulating mitochondrial oxidative alterations and lipids accumulation in fatty hepatocytes.METHODS:Silybin-phospholipid complex containing vitamin E(Realsil) was daily administered by gavage(one pouch diluted in 3 mL of water and containing 15 mg vitamin E and 47 mg silybin complexed with phospholipids) to rats fed a choline-deprived(CD) or a high fat diet [20% fat,containing 71% total calories as fat,11% as carbohydrate,and 18% as protein,high fat diet(HFD)] for 30 d and 60 d,respectively.The control group was fed a normal semi-purified diet containing adequate levels of choline(35% total calories as fat,47% as carbohydrate,and 18% as protein).Circulating and hepatic redox active and nitrogen regulating molecules(thioredoxin,glutathione,glutathione peroxidase),NO metabolites(nitrosothiols,nitrotyrosine),lipid peroxides [malondialdehyde-thiobarbituric(MDA-TBA)],and pro-inflammatory keratins(K-18) were measured on days 0,7,14,30,and 60.Mitochondrial respiratory chain proteins and the extent of hepatic fatty infiltration were evaluated.RESULTS:Both diet regimens produced liver steatosis(50% and 25% of liver slices with CD and HFD,respectively) with no signs of necro-inflammation:fat infiltration ranged from large droplets at day 14 to disseminated and confluent vacuoles resulting in microvesicular steatosis at day 30(CD) and day 60(HFD).In plasma,thioredoxin and nitrosothiols were not significantly changed,while MDA-TBA,nitrotyrosine(from 6 ± 1 nmol/L to 14 ± 3 nmol/L day 30 CD,P < 0.001,and 12 ± 2 nmol/L day 60 HFD,P < 0.001),and K-18(from 198 ± 20 to 289 ± 21 U/L day 30 CD,P < 0.001,and 242 ± 23 U/L day 60 HFD,P < 0.001) levels increased significantly with ongoing steatosis.In the liver,glutathione was decreased(from 34.0 ± 1.3 to 25.3 ± 1.2 nmol/mg prot day 30 CD,P < 0.001,and 22.4 ± 2.4 nmol/mg prot day 60 HFD,P < 0.001),while thioredoxin and glutathione peroxidase were initially increased and then decreased.Nitrosothiols were constantly increased.MDA-TBA levels were five-fold increased from 9.1 ± 1.2 nmol/g to 75.6 ± 5.4 nmol/g on day 30,P < 0.001(CD) and doubled with HFD on day 60.Realsil administration significantly lowered the extent of fat infiltration,maintained liver glutathione levels during the first half period,and halved its decrease during the second half.Also,Realsil modulated thioredoxin changes and the production of NO derivatives and significantly lowered MDA-TBA levels both in liver(from 73.6 ± 5.4 to 57.2 ± 6.3 nmol/g day 30 CD,P < 0.01 and from 27.3 ± 2.1 nmol/g to 20.5 ± 2.2 nmol/g day 60 HFD,P < 0.01) and in plasma.Changes in mitochondrial respiratory complexes were also attenuated by Realsil in HFD rats with a major protective effect on Complex Ⅱ subunit CII-30.CONCLUSION:Realsil administration effectively contrasts hepatocyte fat deposition,NO derivatives formation,and mitochondrial alterations,allowing the liver to maintain a better glutathione and thioredoxin antioxidant activity. | Ignazio Grattagliano Catia V Diogo Maria Mastrodonato Ornella de Bari Michele Persichella David QH Wang Adriana Liquori Domenico Ferri Maria Rosaria Carratù Paulo J Oliveira Piero Portincasa | 2013 | World Journal of Gastroenterology2013，19，20： | 6 |
| 4 | An in vitro prototype of a porcine biomimetic testis-like cell culture system: a novel tool for the study of reassembled Sertoli and Leydig cells显示文摘目前,有在 vitro 不可靠像睾丸的 biomimetic 机关文化系统设计了在 Sertoli 和 Leydig 房间上估计人的 gonadotropins 的功能的效果的装配 prepubertal。精子发生被调整由内分泌, paracrine,和 juxtacrine 因素(阴囊的串音) ,主要由象 luteinizing 荷尔蒙(LH ) 和由分别地刺激 Leydig 和 Sertoli 房间起一个枢轴的作用的刺激滤泡的荷尔蒙(FSH ) 那样的 gonadotropins 安排了。我们的学习的目的是建立一在里面 vitro prepubertal 是的猪的 bioengineered 构造为重新集合的 Sertoli 和 Leydig 房间上的试验性的研究的一个新模型。我们评估了从 15- 获得到 20-day-old 的 Sertoli 和 Leydig 房间新生的猪睾丸以纯净和功能。随后,净化了 Sertoli 并且充实 Leydig 房间受到 coincubation 获得一在里面 vitro prepubertal 猪的像睾丸的文化系统。我们为 anti-M 执行了连接酶的 immunosorbent 试金(ELISA ) | Iva Arato Giovanni Luca Francesca Mancuso Catia Bellucci Cinzia Lilli Mario Calvitti Barbara C Hansen Domenico Milardi Giuseppe Grande Riccardo Calafiore | 2018 | Asian Journal of Andrology2018，20，2： | 4 |
| 5 | Autism Spectrum Disorders: Is Mesenchymal Stem Cell Personalized Therapy the Future?显示文摘 | Dario Siniscalco Anna Sapone Alessandra Cirillo Catia Giordano Sabatino Maione Nicola Antonucci Ken-ichi Isobe | 2012 | Journal of Biomedicine and Biotechnology2012，，： | 2 |
| 6 | Intra-brain microinjection of human mesenchymal stem cells decreases allodynia in neuropathic mice显示文摘 | Dario Siniscalco Catia Giordano Umberto Galderisi Livio Luongo Nicola Alessio Giovanni Bernardo Vito Novellis Francesco Rossi Sabatino Maione | 2010 | Cellular and Molecular Life Sciences2010，，4： | 2 |
| 7 | Tissue-specific SMARCA4 binding at active and repressed reguLatory elements during embryogenesis显示文摘 | Catia A Alex SN Zhu YW et at | 2014 | Genome Res2014，24，92： | 1 |
| 8 | Economic growth and environmental quality:an econometric and a decomposition analysis 显示文摘 | Catia C | 2007 | Management of Environmental Quality2007，，5： | 1 |
| 9 | Electrode materials for ionic liquid-based supercapacitors显示文摘 | Catia A Sabina B Mariachiara L | 2007 | J Power Sources2007，174，： | 1 |
| 10 | TiO2 in commercial sun- screen lotion:Flow field - flow fractionation and ICP - AES together for size analysis显示文摘 | CATIA CONTADO ANTONELLA PAGNONI | 2008 | Anal Chem2008，0，： | 1 |
| 11 | Structure, chromosomal localization, and expression of 12 genes of the MAGE family显示文摘 | Etienne Plaen Catia Traversari José J. Gaforio Jean-Pierre Szikora Charles Smet Francis Brasseur Pierre Bruggen Bernard Lethé Christophe Lurquin Patrick Chomez Olivier Backer Thierry Boon Karen Arden Webster Cavenee Robert Brasseur | 1994 | Immunogenetics1994，，5： | 1 |
| 12 | Cell-Autonomous Inactivation of the Reelin Pathway Impairs Adult Neurogenesis in the Hippocampus显示文摘 | Catia M. Teixeira Michelle M. Kron Nuria Masachs Helen Zhang Diane C. Lagace Albert Martinez Isabel Reillo Xin Duan Carles Bosch Lluis Pujadas Lucas Brunso Hongjun Song Amelia J. Eisch Victor Borrell Brian W. Howell Jack M. Parent Eduardo Soriano | 2012 | Journal of Neuroscience2012，，35： | 1 |
| 13 | Carbon paper as three-dimensional conducting substrate for tin anodes in lithium-ion batteries显示文摘 | Catia Arbizzani Sabina Beninati Mariachiara Lazzari | | 0，，01： | 1 |
| 14 | Economic Growth and Environmental Quality: An Econometric and a Decomposition Analysis 显示文摘 | Catia C | 2007 | Management of Environmental Quality2007，18，5： | 1 |
| 15 | Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I–II study显示文摘 | Fabio Ciceri Chiara Bonini Maria Teresa Lupo Stanghellini Attilio Bondanza Catia Traversari Monica Salomoni Lucia Turchetto Scialini Colombi Massimo Bernardi Jacopo Peccatori Alessandra Pescarollo Paolo Servida Zulma Magnani Serena K Perna Veronica Valtol | 2009 | Lancet Oncology2009，，5： | 1 |
| 16 | Age and Gender Distribution of Hepatitis C Virus Genotypes in the Metropolitan Area of Naples显示文摘 | Petruzziello Arnolfo Coppola Nicola Diodato Anna Maria Iervolino Vincenzo Azzaro Rosa Di Costanzo Gaetano Di Macchia Catia Addolorata Di Meo Tommaso Loquercio Giovanna Pasquale Giuseppe Cacciapuoti Carmela | 2013 | Intervirology2013，，3： | 1 |
| 17 | Polymer based supercapacitors显示文摘 | Marina Mastragostino Catia Arbizzani Francesca Soavi | 2001 | Journal of power sources2001，，： | 1 |
| 18 | Graphene and carbon nanotube structures supported on mesoporous xerogel carbon as catalysts for oxygen reduction reaction in proton-exchange-membrane fuel cells显示文摘 | Catia Arbizzani Sara Righi Francesca Soavi Marina Mastragostino | 2011 | International Journal of Hydrogen Energy2011，，8： | 1 |
| 19 | Differentiation of T regulatory cells by immature dendritic cells显示文摘 | Maria Grazia Roncarolo Megan K Catia Traversari | | 0，，： | 1 |
| 20 | Multiproduct firms and markets tructure: An explorative application to the product life cycle显示文摘 | Paul Allanson Catia Montagna | 2005 | International Journal of Industrial Organization2005，23，78： | 1 |
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