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| 1 | Review on microbiota and effectiveness of probiotics use in older显示文摘The aim of the present systematic review is to summarize the existing knowledge about the human microbiota in the elderly and the effects of probiotics in elderly population. The elderly subjects, compared to adult population, show a reduction in the diversity of the microbiota, characterized by a large interindividual variability, with lower numbers of Firmicutes, Bifidobacteria, Clostridium cluster XIV, Faecalibacterium Prausnitzii, Blautia coccoides-Eubacterium rectal and higher presence of Enterobacteriaceae and Bacteroidetes. These differences of the intestinal microbiota of the elderly may not necessarily be caused by aging, but they could be associated with the decline of the general state of health with malnutrition and with increased need for medication, such as antibiotics and nonsteroidal antiinflammatory drugs, situations that occur frequently in the elderly. Differences have been demonstrated in the composition of the microbiota between healthy elderly subjects and hospitalized or institutionalized elderly subjects. These findings which further indicates that the living conditions, health status, nutrition and drugs have a significant effect on the composition of the microbiota. According to the available knowledge, the use of probiotics is safe and could represent an useful intervention to prevent or treat antibioticassociated diarrhea, in addition to reducing the severity of symptoms, other than to help the management of constipation. | Mariangela Rondanelli Attilio Giacosa Milena Anna Faliva Simone Perna Francesca Allieri Anna Maria Castellazzi | 2015 | World Journal of Clinical Cases2015，3，2： | 10 |
| 2 | Stepwise approach and surgery for gallbladder adenomyomatosis: a mini-review显示文摘BACKGROUND: Gallbladder adenomyomatosis (GBA) is a hyperplastic disease affecting the wall of the gallbladder, with some typical features. It has historically been considered a benign condition, nevertheless recent reports highlighted a potential role of GBA in predisposing to malignancies of the gallbladder. DATA SOURCES: We reviewed the literature concerning GBA from its identification until July 2012. Owing to the relative rarity of the disease, studies often are case reports or case series. Thus we herein report a summary of the key-points concerning diagnosis and treatment of GBA, easily applicable in everyday practice, rather than a systematic review. Also, results are integrated with our recent experience. RESULTS: In our experience, we observed a trend toward an increase of GBA during the last years, probably due to enhanced ultrasonographic technical advancements and physician's expertise. GBA has distinctive imaging features. Several recent reports highlight the potential risk of cancer associated with GBA; however the disease is still classified as a benign condition. Although its correlation with malignancy has not been demonstrated, it is prudent to recommend cholecystectomy in some cases. However, in selected asymptomatic patients, a wait-and-see policy is a viable alternative. We propose an algorithm, based on GBA pathological pattern (diffuse, segmental, localized or fundal), suitable for decision-making.CONCLUSIONS: In symptomatic patients and if the diagnosis is doubtful, cholecystectomy is mandatory. Postponing surgery is an option to be offered to asymptomatic patients with low-risk GBA pattern who adhere to scheduled follow-ups. | Gianluca Pellino Guido Sciaudone Giuseppe Candilio Giuseppe Perna Antonio Santoriello Silvestro Canonico Francesco SelvaggiAuthor | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，2： | 9 |
| 3 | Adaptive immune response during hepatitis C virus infection显示文摘Hepatitis C virus(HCV)infection affects about 170 million people worldwide and it is a major cause of liver cirrhosis and hepatocellular carcinoma.HCV is a hepatotropic non-cytopathic virus able to persist in a great percentage of infected hosts due to its ability to escape from the immune control.Liver damage and disease progression during HCV infection are driven by both viral and host factors.Specifically,adaptive immune response carries out an essential task in controllingnon-cytopathic viruses because of its ability to recognize infected cells and to destroy them by cytopathic mechanisms and to eliminate the virus by non-cytolytic machinery.HCV is able to impair this response by several means such as developing escape mutations in neutralizing antibodies and in T cell receptor viral epitope recognition sites and inducing HCV-specific cytotoxic T cell anergy and deletion.To impair HCV-specific T cell reactivity,HCV affects effector T cell regulation by modulating T helper and Treg response and by impairing the balance between positive and negative co-stimulatory molecules and between pro-and antiapoptotic proteins.In this review,the role of adaptive immune response in controlling HCV infection and the HCV mechanisms to evade this response are reviewed. | Juan Ramon Larrubia Elia Moreno-Cubero Megha Uttam Lokhande Silvia Garcia-Garzon Alicia Lazaro Joaquin Miquel Cristian Perna Eduardo Sanz-de-Villalobos | 2014 | World Journal of Gastroenterology2014，20，13： | 7 |
| 4 | Resveratrol corrects aberrant splicing of RYR1 pre-mRNA and Ca2+ signal in myotonic dystrophy type 1 myotubes显示文摘Myotonic dystrophy type 1(DM1) is a spliceopathy related to the mis-splicing of several genes caused by sequestration of nuclear transcriptional RNA-binding factors from non-coding CUG repeats of DMPK pre-mRNAs. Dysregulation of ryanodine receptor 1(RYR1), sarcoplasmatic/endoplasmatic Ca^2+-ATPase(SERCA) and α1 S subunit of voltage-gated Ca^2+ channels(Cav1.1) is related to Ca^2+ homeostasis and excitation-contraction coupling impairment. Though no pharmacological treatment for DM1 exists, aberrant splicing correction represents one major therapeutic target for this disease. Resveratrol(RES, 3,5,4′-trihydroxy-trans-stilbene) is a promising pharmacological tools for DM1 treatment for its ability to directly bind the DNA and RNA influencing gene expression and alternative splicing. Herein, we analyzed the therapeutic effects of RES in DM1 myotubes in a pilot study including cultured myotubes from two DM1 patients and two healthy controls. Our results indicated that RES treatment corrected the aberrant splicing of RYR1, and this event appeared associated with restoring of depolarization-induced Ca^2+ release from RYR1 dependent on the electro-mechanical coupling between RYR1 and Cav1.1. Interestingly, immunoblotting studies showed that RES treatment was associated with a reduction in the levels of CUGBP Elav-like family member 1, while RYR1, Cav1.1 and SERCA1 protein levels were unchanged. Finally, RES treatment did not induce any major changes either in the amount of ribonuclear foci or sequestration of muscleblind-like splicing regulator 1. Overall, the results of this pilot study would support RES as an attractive compound for future clinical trials in DM1. Ethical approval was obtained from the Ethical Committee of IRCCS Fondazione Policlinico Universitario A. Gemelli, Rome, Italy(rs9879/14) on May 20, 2014. | Massimo Santoro Roberto Piacentini Alessia Perna Eugenia Pisano Anna Severino Anna Modoni Claudio Grassi Gabriella Silvestri | 2020 | Neural Regeneration Research2020，15，9： | 3 |
| 5 | The role of transthoracic echocardiography in the diagnosis and management of acute type A aortic syndrome显示文摘 | Moreno Cecconi Fabio Chirillo Carlo Costantini Gianfranco Iacobone Ercole Lopez Raffaele Zanoli Alberto Gili Stefano Moretti Marcello Manfrin Christopher Münch Lucia Torracca Gian Piero Perna | 2012 | American Heart Journal2012，，1： | 2 |
| 6 | Two-stage surgical treatment for septic non-union of the forearm显示文摘AIM To investigate the effectiveness of a two-stage surgical procedure for the treatment of septic forearm non-union.METHODS Septic non-unions are rare complications of forearm fractures. When they occur, they modify the relationship between forearm bones leading to a severe functional impairment. Treatment is challenging and surgery and antibiotic therapy are required to achieve infection resolution. It is even harder to obtain non-union healing with good functional results. The aim of this study is to present a two stages surgical treatment for septic forearm non-union with revision and temporary stabilization of the non-union until infection has cleared and subsequently perform a new synthesis with plate, opposite bone graft strut and intercalary graft. We retrospectively reviewed 18 patients with a mean age at the time of primary injury of 34.5 years(19-57 years) and a mean follow-up of 6 years(2-10 years). All patients presented an atrophic nonunion with a mean length of the bone defect of 1.8 cm(1.2-4 cm). Complications and clinical results after surgical treatment were recorded. RESULTS Mean time to resolution of the infectious process was 8.2 wk(range 4-20 wk) after the first surgery and specific antibiotic therapy. All the non-union healed with an average time of 5 mo(range 2-10 mo) after the second step surgery. Cultures on intraoperative samples werepositive in all cases. No major intraoperative complications occurred. Two patients developed minor complications and one needed a second surgical debridement for infection resolution. At the last follow-up functional results were excellent in 5(27.8%) patients, satisfactory in 10(55.5%) and unsatisfactory in 3(16.7%) patients. No activities of daily living(ADLs) limitations were reported by 12(66.6%) patients, slight by 3(16.6%) and severe limitation by 3(16.6%) patients. Mean visual analog scale at the last follow-up was 1(0-3).CONCLUSION The two-step technique has proven to be effective to achieve resolution of the infectious process and union with good functional results and low rate of complications. | Fabrizio Perna Federico Pilla Matteo Nanni Lisa Berti Giada Lullini Francesco Traina Cesare Faldini | 2017 | World Journal of Orthopedics2017，8，6： | 2 |
| 7 | Neuronal and glial properties coexist in a novel mouse CNS immortalized cell line显示文摘 | Tino A Pernas Alonso R | 1999 | Exp Cell Res1999，252，2： | 1 |
| 8 | High levels of troponin T are associated with ventricular remodeling and adverse in-hospital outcome in heart failure显示文摘 | Macin SM Cimbaro-Canella JP | 2004 | Med Sci Monit2004，10，3： | 1 |
| 9 | Ultrasound guided tfhrombin injection for the treatment of postcatheterixation pseudoaneurysms显示文摘 | Perna LL Olin JW Goines D | 2000 | Circulation2000，102，： | 1 |
| 10 | Improved dissolved oxygen status following removal of exotic weed mats in important fish habitat lagoons of the tropical Burdekin river floodplain, Australia 显示文摘 | Perna C Burrows D | 2005 | Marine Pollution Bulletin2005，51，14： | 1 |
| 11 | Ischemia-reperfusion-induced apoptosis and P53expression in the courseof rat heterotopic heart transplantation显示文摘 | Formigli L Ibba-Manneschi L Perna AM | 1998 | Microvasc Res1998，56，3： | 1 |
| 12 | Achievements and limita- tions of complement inhibition by eculizumab in paroxysmal nocturnal hemoglobinuria:the role of complement component 3 显示文摘 | Risitano AM Perna F Selleri C | 2011 | Mini Rev Med Chem2011，11，6： | 1 |
| 13 | Understanding differences in the choice of college attended:The role of state public policies显示文摘 | Perna L.W Titus M.A | | 0，，04： | 1 |
| 14 | Levofloxacin-based triple therapy for Helicobacter pylori re-treatment:role of bacterial resistance显示文摘 | Perna F Zullo A Ricci C | 2007 | Dig Liver Dis2007，39，11： | 1 |
| 15 | Outcomes following plate fixation of fractures of both bones of the forearm in adults显示文摘 | Droll KP Perna P Potter J | 2007 | Bone Joint Surg Am2007，12，： | 1 |
| 16 | Nonimmunosurppressive therapy of membranous nephropathy 显示文摘 | SCHIEPPATI A RUGGENENTI P PERNA A | 2003 | Semin Nephrol2003，23，： | 1 |
| 17 | Hydrogen sul- phide-generating pathways in haemodialysis patients: a study on relevant metabolites and transcriptional regulation of genes encoding for key enzymes 显示文摘 | Perna AF Luciano MG Ingrosso D | 2009 | Nephrol Dial Transplant2009，24，12： | 1 |
| 18 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 19 | Time to reperfusion in acute myocardial infarction, it is time to re- duce it显示文摘 | Barbagelate A Perna ER lemmensen P | 2007 | J Elecrocardial2007，40，： | 1 |
| 20 | Static and rotational intensity modulated techniques for head-neck cancer radiotherapy: A planning comparison显示文摘 | Sara Broggi Lucia Perna Francesco Bonsignore Giuseppe Rinaldin Claudio Fiorino Anna Chiara Cristina Frigerio Ivana Butti Giulia Sangalli Italo Dell’Oca Nadia Di Muzio Giovanni Mauro Cattaneo Fausto Declich | 2014 | Physica Medica2014，，： | 1 |
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