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| 1 | Global epidemiology of hepatitis C virus infection: an up-date of the distribution and circulation of hepatitis C virus genotypes显示文摘AIM To review Hepatitis C virus(HCV) prevalence and genotypes distribution worldwide.METHODS We conducted a systematic study which represents one of the most comprehensive effort to quantify global HCV epidemiology,using the best available published data between 2000 and 2015 from 138 countries(about 90% of the global population),grouped in 20 geographical areas(with the exclusion of Oceania),as defined by the Global Burden of Diseases project(GBD). Countries for which we were unable to obtain HCV genotype prevalence data were excluded from calculations of regional proportions,although their populations were included in the total population size of each region when generating regional genotype prevalence estimates.RESULTS Total global HCV prevalence is estimated at 2.5%(177.5 million of HCV infected adults),ranging from 2.9% in Africa and 1.3% in Americas,with a global viraemic rate of 67%(118.9 million of HCV RNA positive cases),varying from 64.4% in Asia to 74.8% in Australasia. HCV genotype 1 is the most prevalent worldwide(49.1%),followed by genotype 3(17.9%),4(16.8%) and 2(11.0%). Genotypes 5 and 6 are responsible for the remaining < 5%. While genotypes 1 and 3 are common worldwide,the largest proportion of genotypes 4 and 5 is in lower-income countries. Although HCV genotypes 1 and 3 infections are the most prevalent globally(67.0% if considered together),other genotypes are found more commonly in lowerincome countries where still account for a significant proportion of HCV cases.CONCLUSION A more precise knowledge of HCV genotype distribution will be helpful to best inform national healthcare models to improve access to new treatments. | Arnolfo Petruzziello Samantha Marigliano Giovanna Loquercio Anna Cozzolino Carmela Cacciapuoti | 2016 | World Journal of Gastroenterology2016，22，34： | 69 |
| 2 | Silymarin in non alcoholic fatty liver disease显示文摘AIM: This study was undertaken to evaluate the hepatic effects of silybum marianum on non alcoholic fatty liver disease (NAFLD). METHODS: In 72 patients affected by NAFLD, main metabolic, hepatic and anti-inflammatory parameters were assayed after 3 mo of a restricted diet and before silymarin treatment (twice a day orally). The brightness of liver echography texture (hepatorenal ratio brightness) was also defined at same time. These evaluations were repeated after 6 mo of treatment. RESULTS: Serum levels of some metabolic and anti-inflammatory data nonsignificantly lowered after 6 mo of silymarin. On the contrary, Steato test, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyl transpeptidase were significantly (P < 0.001) reduced. Instead, the AST/ALT ratio unchanged. Finally, the hepatorenal brightness ratio, as an index of hepatic steatosis, significantly (P < 0.05) dropped. CONCLUSION: The obtained results indicate that silymarin appears to be effective to reduce the biochemical, inflammatory and ultrasonic indices of hepatic steatosis. Some parameters indicative of early stage of atherosclerosis were also lowered. | Fulvio Cacciapuoti Anna Scognamiglio Rossella Palumbo Raffaele Forte Federico Cacciapuoti | 2013 | World Journal of Hepatology2013，5，3： | 17 |
| 3 | Atom interferometry gravity-gradiometer for the determination of the Newtonian gravitational constant G显示文摘 | A. Bertoldi G. Lamporesi L. Cacciapuoti M. de Angelis M. Fattori T. Petelski A. Peters M. Prevedelli J. Stuhler G. M. Tino | 2006 | The European Physical Journal D2006，，2： | 2 |
| 4 | HBV transmission from an occult carrier with five mutations in the major hydrophilic region of HBsAg to an immunosuppressed plasma recipient显示文摘 | Nicola Coppola Giovanna Loquercio Gilda Tonziello Rosa Azzaro Mariantonietta Pisaturo Gaetano Di Costanzo Mario Starace Giuseppe Pasquale Carmela Cacciapuoti Arnolfo Petruzziello | 2013 | Journal of Clinical Virology2013，，： | 2 |
| 5 | Olive oil phenolic compounds inhibit homocysteine-induced endothelial cell adhesion regardless of their different antioxidant activity显示文摘 | Manna C Napoli D Cacciapuoti G | 2009 | J Agrie Food Chem2009，57，9： | 1 |
| 6 | Hyper -homocysteinemia:a novel risk factor or a power- ful marker for cardiovascular diseases? Pathogenetic and therapeutical uncertainties显示文摘 | Cacciapuoti F | 2011 | J Thrombo Thromboly2011，32，1： | 1 |
| 7 | Hyper-homocysteineimia:a novel risk factor or a powerful marker for cardiovascular diseases? Pathogenetic and therapeutical uncertainties显示文摘 | Cacciapuoti F | 2011 | J Thromb Thromolysis2011，32，： | 1 |
| 8 | Echocardiographic evaluation of right heart function and pulmonary vascular bed 显示文摘 | CACCIAPUOTI F | 2009 | lnt J Cardiovasc Ima- ging2009，25，7： | 1 |
| 9 | Role of ubiquitin-proteasome system (UPS) in left ventricular hypertrophy (LVH)显示文摘 | Cacciapuoti F | 2014 | Am J Cardiovasc Dis2014，4，1： | 1 |
| 10 | In vitro and in vivo activities of SCH 56592 (posaconazole), a new triazole antifungal agent, against Aspergillus and Candida 显示文摘 | CACCIAPUOTI A LOEBENBERG D CORCORAN E | 2000 | Antimicrob Agents Chemother2000，44，8： | 1 |
| 11 | Cor- relation-Aware User Selection for Cooperative Spectrum Sensing in Cognitive Radio Ad Hoc Networks 显示文摘 | CACCIAPUOTI A S AKYILDIZ I F PAURA L | 2012 | Selected Areas in Communica- tions IEEE Journal on2012，30，2： | 1 |
| 12 | In vitro and in vivo activities of SCH 56592 (posaconazole), a new triazole antifungal agent, against aspergillus and candida显示文摘 | Cacciapuoti A Loebenberg D Corcoran E | 2000 | Antimicrob Agents Chemother2000，44，8： | 1 |
| 13 | Age and Gender Distribution of Hepatitis C Virus Genotypes in the Metropolitan Area of Naples显示文摘 | Petruzziello Arnolfo Coppola Nicola Diodato Anna Maria Iervolino Vincenzo Azzaro Rosa Di Costanzo Gaetano Di Macchia Catia Addolorata Di Meo Tommaso Loquercio Giovanna Pasquale Giuseppe Cacciapuoti Carmela | 2013 | Intervirology2013，，3： | 1 |
| 14 | Cloning and sequencing of the gene coding for S-adenosylhomocysteine hydrolase in the thermophilic archaeon Sulfolobus solfataricus显示文摘 | Porcelli M Cacciapuoti G Fusco S | 1996 | Gene1996，177，12： | 1 |
| 15 | Finite-sample performance analysis of widely linear multiuser receivers for DS-CDMA Systems显示文摘 | CACCIAPUOTI A S GELLI G PAURA L | 2008 | IEEE Trans on Signal Processing2008，56，4： | 1 |
| 16 | Widely linear versus linear blind multiuser detection with subspace-based channel estimation:finite sample-size effects显示文摘 | CACCIAPUOTI A S GELLI G PAURA L | 2009 | IEEE Trans on Signal Processing2009，57，4： | 1 |
| 17 | Insulin resistance is an independent risk factor for atherosclerosis in rheu- matoid arthritis显示文摘 | LA MONTAGNA G CACCIAPUOTI F BUONO R | 2007 | Diab Vasc Dis Res2007，4，2： | 1 |
| 18 | Lowering homocysteine levels with folic acid and B-vitamins do not reduce early atherosclerosis, but could interfere withcognitive decline and Alzheimer^s disease显示文摘 | Cacciapuoti F | 2012 | J Thromb Thrombolysis2012，21，： | 1 |
| 19 | Non~thermal effects of microwaves on proteins:thermophilic enzymes as model system显示文摘 | Porcelli M Cacciapuoti G Fusco S | 1997 | FEBS letter1997，30，： | 1 |
| 20 | Non-thermal effects of microwaves on proteins: thermophilic enzymes as modelsystem显示文摘 | M Porcelli G Cacciapuoti S Fusco | 1997 | FEBS lettem1997，402，： | 1 |
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