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| 1 | Therapeutic targeting of epidermal growth factor receptor in human cancer: successes and limitations显示文摘Epidermal growth fac tor receptor (EGFR) is one of the most commonly altered genes in human cancer by way of over-expression, amplification, and mutation. Targeted inhibition of EGFR activity suppresses signal transduction pathways which control tumor cell growth, proliferation, and resistance to apoptosis. Small molecule tyrosine kinase inhibitors and monoclonal antibodies are among the most common EGFR-targeting agents and have been used clinically for treating various malignancies. This review discusses the successes and challenges of targeting EGFR in human cancer. The genetic alterations of EGFR tend to occur more often in some solid tumors than others, as do the mechanisms of resistance to targeted inhibition. The clinical and basic science experiences with these agents thus far have important implications for the future of therapeutic targeting of EGFR. | Jill Wykosky Tim Fenton Frank Furnari Webster K. Cavenee | 2011 | Chinese Journal of Cancer2011，30，1： | 24 |
| 2 | The 2007 WHO Classification of Tumours of the Central Nervous System显示文摘 | David N. Louis Hiroko Ohgaki Otmar D. Wiestler Webster K. Cavenee Peter C. Burger Anne Jouvet Bernd W. Scheithauer Paul Kleihues | 2007 | Acta Neuropathologica2007，，2： | 13 |
| 3 | Genes for epidermal growth factor receptor, transforming growth factor, epidermal growth factor and their expression in human gliomas in vivo显示文摘 | Ekstrancl AJ James CD Cavenee WK | 1991 | Cancer Res1991，51，8： | 2 |
| 4 | Genetics and malignant progression of human brain tumours显示文摘 | Furnari F B Huang H J Cavenee W K | 1995 | Cancer Surv1995，25，： | 1 |
| 5 | Pathology and genetics of tumours of the nervous system 显示文摘 | Kleihues P Webster K Cavenee W | 2006 | International Agency for Research on Cancer2006，6，1： | 1 |
| 6 | Expression of vascular endothelial growth factor in human brain tumors显示文摘 | R. Nishikawa Shi-Yuan Cheng Ritsuko Nagashima H.-J. S. Huang Webster K. Cavenee Masao Matsutani | 1998 | Acta Neuropathologica1998，，5： | 1 |
| 7 | Structure, chromosomal localization, and expression of 12 genes of the MAGE family显示文摘 | Etienne Plaen Catia Traversari José J. Gaforio Jean-Pierre Szikora Charles Smet Francis Brasseur Pierre Bruggen Bernard Lethé Christophe Lurquin Patrick Chomez Olivier Backer Thierry Boon Karen Arden Webster Cavenee Robert Brasseur | 1994 | Immunogenetics1994，，5： | 1 |
| 8 | Non-isotopic silver-stained SSCP is more sensitive than automated direct sequencing for the detection of PTEN mutations in a mixture of DNA extracted from normal and tumor cells显示文摘 | Fan X Furnari F B Cavenee W K | | 0，，05： | 1 |
| 9 | The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells显示文摘 | Furnari FB Huang HJ Cavenee WK | 1998 | Cancer Res1998，58，22： | 1 |
| 10 | The phosphoinositol phosphatase activity of PTEN mediates aserum-sensitive G1 growth arrest in glioma cells显示文摘 | Furnari FB Huang HJ Cavenee WK | 1998 | Cancer Res1998，58，12： | 1 |
| 11 | Chromosome 13 homozygosity in osteogenic sarcoma without retinoblastoma 显示文摘 | Dryja T Cavenee W Epstein J | 1984 | Am J Hum Genet1984，36，2： | 1 |
| 12 | Genes for epidermal growth factor, transforming growth factor alpha and epidermal growth factor and their expression in human gliomas in vivo 显示文摘 | Ekstrand A J James C D Cavenee W K | 1991 | Cancer Res1991，51，： | 1 |
| 13 | The 2007 WHO Classification of Tumours of the Central Nervous System显示文摘 | David N. Louis Hiroko Ohgaki Otmar D. Wiestler Webster K. Cavenee Peter C. Burger Anne Jouvet Bernd W. Scheithauer Paul Kleihues | 2007 | Acta Neuropathologica2007，，2： | 1 |
| 14 | Homozygous deletion in wilms minors of a zinc-finger gene identified by chromosome jumping显示文摘 | Gessler M Poustka A Cavenee W | 1990 | Nature1990，343，22： | 1 |
| 15 | Glioblastoma : from molecular pathology to targeted treatment 显示文摘 | Cloughesy TF Cavenee WK Mischel PS | 2014 | Annu Rev Pathol2014，9，1： | 1 |
| 16 | Homozygous deletion in Wilms turnouts of a zinc-finger gene identified by chromosome jumping显示文摘 | Gessler M Poustka A Cavenee W | 1990 | Nature1990，343，6260： | 1 |
| 17 | Non-isotopic silver-stained SSCP is more sensitive than automated direct sequencing for the detection of PTEN mutations in a mixture of DNA extracted from normal and tumor cells 显示文摘 | Fan X Fumari F B Cavenee W K | 2001 | Int J Oncol2001，18，5： | 1 |
| 18 | The 2007 WHO Classification of Tumours of the Central Nervous System显示文摘 | David N. Louis Hiroko Ohgaki Otmar D. Wiestler Webster K. Cavenee Peter C. Burger Anne Jouvet Bernd W. Scheithauer Paul Kleihues | 2007 | Acta Neuropathologica2007，，2： | 1 |
| 19 | The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells显示文摘 | Furnari FB Huang HJ Cavenee WK | 1998 | Cancer Res1998，58，22： | 1 |
| 20 | Re- placement of the p16/ CDKN2 gene suppresses human glioma cell growth 显示文摘 | Arap W Nishikama R Furnari FB Cavenee WK Huang HJ | 1996 | Cancer Res1996，55，6： | 1 |
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