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| 1 | 腹腔镜与开腹楔形切除术治疗胃的胃肠间质瘤临床疗效比较显示文摘目的 比较腹腔镜与开腹楔形切除术治疗胃的胃肠间质瘤(GIST)的临床疗效。方法 回顾性分析了2009年1月至2014年12月华中科技大学同济医学院附属同济医院胃肠外科收治的行腹腔镜楔形切除的55例胃GIST患者(腹腔镜组)和行开腹楔形切除的61例胃GIST患者(开腹组)的临床资料,分析两组患者的手术情况和预后。结果 腹腔镜组和开腹组患者的手术时间分别为(108.2±27.2)min和(139.9±75.3)min,术中出血量分别为(57.1±48.7)ml和(100.6±45.8)ml,术后通气或排便时间分别为(2.2±1.4)d和(3.5±1.8)d,术后住院康复时间分别为(5.7±1.3)d和(6.9±2.1)d,差异均有统计学意义(均P〈0.01)。腹腔镜组患者术中无肿瘤破裂,无明显围手术期并发症。腹腔镜组患者复发1例,开腹组患者复发4例。结论 在熟练掌握腹腔镜技术并严格把握手术适应证的前提下,腹腔镜治疗胃GIST的疗效优于传统开腹手术,不仅能在术中达到R0切除标准,维持肿瘤完整性,同时能明显缩短手术时间、减少术中创伤、加快术后康复、预后良好,具有可行性佳、安全系数高、微创和快速康复等优势。 | 贾凌威 来森艳 吴剑宏 | 2016 | 中华肿瘤杂志2016，38，7： | 14 |
| 2 | Laparoscopicmanagementofgastricgastrointestinalstromaltumors显示文摘Gastrointestinal stromal tumors (GISTs) are the most frequent gastrointestinal tumors of mesodermal origin. Gastric GISTs represent approximately 70% of all gas-trointestinal GISTs. The only curative option is surgical resection. Many surgical groups have shown good results with the laparoscopic approach. There have not been any randomized controlled trials comparing the open vs laparoscopic approach, and all recommenda-tions have been based on observational studies. The experience obtained from gastric laparoscopic surgery during recent decades and the development of specific devices have allowed the treatment of most gastric GISTs through the laparoscopic approach. | Correa-Cote J Morales-Uribe C Sanabria A | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，7： | 7 |
| 3 | 内镜黏膜下剥离术后溃疡修复与抑酸治疗研究进展显示文摘内镜黏膜下剥离术(ESD)是近年来开展的先进内镜技术,目前已广泛应用于消化道早期肿瘤如早期食管癌、早期胃癌以及某些位于胃壁的胃肠间质肿瘤的切除。而术后溃疡的修复程度直接关系到ESD治疗效果,因此也引起了更多的关注。本文将重点探讨ESD术后溃疡的特点及损伤修复机制、ESD术后溃疡修复与抑酸治疗等方面的研究现状及进展。 | 易航 胡兵 | 2013 | 中华临床医师杂志(电子版)2013，7，21： | 5 |
| 4 | Enucleation for gastrointestinal stromal tumors at the esophagogastric junction:Is this an adequate solution?显示文摘The authors discussed the proposal by Coccolini and colleagues to treat gastrointestinal stromal tumors (GISTs) at the esophagogastric junction with enucleation and,if indicated,adjuvant therapy,reducing the risks related to esophageal and gastroesophageal resection.They concluded that,because the prognostic impact of a T1 high-mitotic rate on esophageal GIST is worse than that of a T1 high-mitotic rate on gastric GIST,enucleation may not be an adequate surgery for esophagogastric GISTs with a high mitotic rate in which the guarantee of negative resection margins and adjuvant therapies can be the only chance of survival. | Nadia Peparini Giovanni Carbotta Piero Chirletti | 2011 | World Journal of Gastroenterology2011，17，16： | 3 |
| 5 | Tumor rupture during surgery for gastrointestinal stromal tumors: Pay attention!显示文摘In a recently published letter to the editor, we debated the proposal by Coccolini et al to treat gastrointestinal stromal tumors (GISTs) of the esophagogastric junction with enucleation and, if indicated, adjuvant therapy. We highlighted that, because the prognostic impact of a T1 high-mitotic rate esophageal GIST is worse than that of a T1 high-mitotic rate gastric GIST, enucleation may not be adequate surgery for esophagogastric GISTs with a high mitotic rate. In rebuttal, Coccolini et al pointed out the possible bias in assessment of the mitotic rates due to the lack of standardized methods and underlined that the site and features of the tumor need to be carefully considered in evaluation of the risk-benefit balance. Here we confirm that, apart from the problematic issue of mitotic counting, enucleation should not be indicated for GISTs at any site to reduce the risk of tumor rupture, which has been recently considered to be an unfavorable prognostic factor, and to avoid microscopic residual tumor. | Nadia Peparini Piero Chirletti | 2013 | World Journal of Gastroenterology2013，19，12： | 3 |
| 6 | Gastrointestinal stromal tumor and mitosis,pay attention显示文摘The difference between stages Ⅰ and Ⅲ of gastric gastrointestinal stromal tumor depends principally on the number of mitosis.According with TNM classification,the presence in the tumor of high mitotic rate determines the upgrading.Many studies exposed different count techniques in evaluating the number of mitosis.An international standardized method to assess mitotic rate is needed. | Federico Coccolini Fausto Catena Luca Ansaloni Antonio Daniele Pinna | 2012 | World Journal of Gastroenterology2012，18，6： | 2 |
| 7 | 巨大食管胃肠道间质瘤报道1例并文献复习显示文摘胃肠道间质瘤(GIST)是一类比较罕见的消化道疾病,食管GIST则更为罕见。本文回顾性分析四川省内江市第一人民医院(以下简称“我院”)收治的1例巨大食管间质瘤患者,肿瘤大小10.7 cm×7.9 cm×1.6 cm。患者以吞咽梗阻为主要症状,既往误诊为“晚期食管癌”而未能及时行手术治疗。我院胸心外科成功经右胸、腹两切口(Ivor Lewis手术)为其行手术治疗,术后病理诊断为GIST。按计划患者术后第7天正常进食并于术后第10天顺利出院。术后给予伊马替尼辅助治疗,定期复查未见复发。因此,巨大的GIST通过术前综合评估,制订个体化手术方案,术后靶向药物辅助治疗等综合治疗有助于改善GIST患者生活质量并延长其生存率。为此,本文对GIST起源、诊断、治疗进行文献复习,以期临床医生提高对本病的重视。 | 罗雷 张月娥 杨彦辉 李季 谢晓阳 刘蔡杨 雷雨 王毅 | 2023 | 中国医药导报2023，20，18： | 0 |
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