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| 1 | Laparoscopic versus open surgery for rectal cancer (COLOR II): short-term outcomes of a randomised, phase 3 trial显示文摘 | Martijn HGM van der Pas Eva Haglind Miguel A Cuesta Alois Fürst Antonio M Lacy Wim CJ Hop Hendrik Jaap Bonjer | 2013 | Lancet Oncology2013，，： | 17 |
| 2 | Elastic band ligation of hemorrhoids:Flexible gastroscope or rigid proctoscope?显示文摘AIM: To compare rigid proctoscope and flexible endoscope for elastic band ligation of internal hemorrhoids. METHODS: Patients between 18 and 80 years old, with chronic complaints (blood loss, pain, itching or prolapse) of internal hemorrhoids of grade I-Ⅲ, were randomized to elastic band ligation by rigid proctoscope or flexible endoscope (preloaded with 7 bands). Patients were re- treated every 6 wk until the cessation of complaints. Evaluation by three-dimensional anal endosonography was performed. RESULTS: Forty-one patients were included (median age 52.0, range 27-79 years, 20 men). Nineteen patients were treated with a rigid proctoscope and twenty two with a flexible endoscope. Twenty-nine patients had grade I hemorrhoids, 9 patients had grade Ⅱ hemorrhoids and 3 patients had grade Ⅲ hemorrhoids. All patients needed a minimum of 1 treatment and a maximum of 3 treatments. A median of 4.0 bands was used in the rigid proctoscope group and a median of 6.0 bands was used in the flexible endoscope group (P < 0.05). Pain after ligation tended to be more frequent in patients treated with the flexible endoscope (first treatment: 3 vs 10 patients, P < 0.05). Three- dimensional endosonography showed no sphincter defects or alterations in submucosal thickness. CONCLUSION: Both techniques are easy to perform, well tolerated and have a good and fast effect. It is easier to perform more ligations with the flexible endoscope. Additional advantages of the flexible scope are the maneuverability and photographic documentation. However, treatment with the flexible endoscope might be more painful and is more expensive. | M Cazemier RJF Felt-Bersma MA Cuesta CJJ Mulder | 2007 | World Journal of Gastroenterology2007，13，4： | 12 |
| 3 | Social Isolation in Male Rats During Adolescence Inhibits the Wnt/β-Catenin Pathway in the Prefrontal Cortex and Enhances Anxiety and Cocaine-Induced Plasticity in Adulthood显示文摘In adult animals,it is well established that stress has a proactive effect on psychostimulant responses.However,whether only a short period of stress during adolescence can also affect cocaine responses later in life and what mechanisms are involved are unknown.Here,we showed that 5 days of social isolation during rat adolescence had a long-term impact on anxiety-like behaviors,cocaine-induced conditioned place preference,and the expression of sensitization during adulthood.At the molecular level,social isolation decreased the activity of the Wnt/β-catenin pathway in the prefrontal cortex(PFC).Furthermore,after the expression of cocaine sensitization,isolated rats showed an increase in this pathway in the nucleus accumbens.Together,these findings suggest that,adolescent social isolation by altering the Wnt/β-catenin pathway in the developing PFC might increase the cocaine responses during adulthood,introducing this pathway as a novel neuroadaptation in the cortical-accumbens connection that may mediate a stress-induced increase in vulnerability to drugs. | Santiago Cuesta Alejandrina Funes Alejandra M.Pacchioni | 2020 | Neuroscience Bulletin2020，36，6： | 5 |
| 4 | Antibody engineering: facing new challenges in cancer therapy显示文摘Antibody-based therapeutics are beginning to realize the promise enclosed in their early denomination as “magic bullets”. Initial disappointment has turned into clinical and commercial success, and engineered antibodies currently represent over 30% of biopharmaceuticals in clinical trials. Recent structural and functional data have allowed the design of a new generation of therapeutic antibodies, with strategies ranging from complement-mediated and antibody-dependant cellular cytotoxicity enhancement to improved cytotoxic payloads using toxins, drugs,radionucleids and viral delivery. This review considers the structure of different types of recombinant antibodies, their mechanism of action and how their efficacy has been increased using a broad array of approaches. We will also focus on the additional benefits offered by the use of gene therapy methods for the in vivo production of therapeutic antibodies. | Laura S■NZ ■ngel M CUESTA Mana COMPTE Luis ■LVAREZ-VALLINA | 2005 | Acta Pharmacologica Sinica2005，26，6： | 5 |
| 5 | 维生素C和维生素E减轻热应激改善蛋鸡活质量和蛋品质显示文摘试验为研究维生素C和维生素E对热应激下蛋鸡活质量和蛋品质的影响。试验选用720羽39周龄白莱航蛋鸡,随机分为4个处理组,各组分别添加0、150 mg/kg维生素C、150 mg/kg(150 IU)维生素E和150 mg/kg维生素C+150 mg/kg维生素E。试验结束时各试验组的最终活质量、蛋质量、蛋黄质量、蛋清质量和蛋壳质量都显著高于对照组(P<0.05),其中添加维生素C+维生素E组的蛋壳质量最高。通过对蛋鸡活质量和蛋品质指标的跟踪观察发现,抗氧化添加剂的加入能缓解热应激造成的不良影响。 | J J Ajakaiye M Cuesta - Mazorra J R Garcia - Diaz 黄鑫 李彪 谭斌 | 2013 | 饲料研究2013，36，7： | 3 |
| 6 | Laparoscopy in Combination with Fast Track Multimodal Management is the Best Perioperative Strategy in Patients Undergoing Colonic Surgery: A Randomized Clinical Trial (LAFA-study)显示文摘 | Malaika S. Vlug Jan Wind Markus W. Hollmann Dirk T. Ubbink Huib A. Cense Alexander F. Engel Michael F. Gerhards Bart A. van Wagensveld Edwin S. van der Zaag Anna A.W. van Geloven Mirjam A.G. Sprangers Miguel A. Cuesta Willem A. Bemelman | 2011 | Annals of Surgery2011，，6： | 3 |
| 7 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet . 2012 (9829)2012，，： | 3 |
| 8 | 高血压患者肾素血管紧张素系统阻断的血浆分子标志:肾损害与初发蛋白尿的新预测指标显示文摘蛋白尿是一个与心血管病密切相关的危险因素,也是一般人群的首位死亡原因。虽然已经明确肾素血管紧张素系统(renin-angiotensin system,RAS)阻断剂能延缓高血压患者初发蛋白尿进展、减少蛋白尿排出,但仍不能忽视高血压患者发生初发蛋白尿的比例。 | Baldan-Martin M Mourino-Alvarez L Gonzalez-Calero L Moreno-Luna R Sastre-Oliva T Ruiz-Hurtado G Segura J Lopez JA Vazquez J Vivanco F Alvarez-Llamas G Ruilope LM de la Cuesta F Barderas MG 赵狄 练桂丽 | 2016 | 中华高血压杂志2016，24，6： | 2 |
| 9 | Impact of changes in the treatment of nasopharyngeal carcinoma: an experience of 30 years 显示文摘 | Santos JA Gonzalez C Cuesta P | 1995 | Radiotherapy and Oncology1995，36，2： | 2 |
| 10 | Subepithelial collagen deposition, profibrogenic cytokine gene expression, and changes after prolonged fluticasone propionate treatment in adult eosinophilic esophagitis: A prospective study显示文摘 | Alfredo J. Lucendo ángel Arias Livia C. De Rezende Jose Luis Yagüe-Compadre Teresa Mota-Huertas Sonia González-Castillo Rubén A. Cuesta José M. Tenias Teresa Bellón | 2011 | The Journal of Allergy and Clinical Immunology2011，，： | 2 |
| 11 | Comparison of two clinical scales for causality assessment in hepatotoxicity显示文摘 | Ma Isabel Lucena Raquel Camargo Raúl J. Andrade Carlos J. Perez-Sanchez Felipe Sanchez De La Cuesta | 2001 | Hepatology2001，，1： | 2 |
| 12 | Biogenic amine production by wild lactococcal and leuconostoc strains显示文摘 | D. GonzálezDe Llano Cuesta Rodríguez | 2002 | Letters in Applied Microbiology2002，，4： | 2 |
| 13 | Hepatocellular carcinoma and multidrug resistance: Past, present and new challenges for therapy improvement显示文摘Hepatocellular carcinoma(HCC) is the most frequent form of liver cancer and the third most common cause of cancer-related death in the world. The main risk factor worldwide for this type of malignancy is chronic hepatitis caused by hepatitis B virus and hepatitis C virus infections. Advances in early detection and treatmenthave improved life expectancy of patients with HCC. However, this disorder remains as a disease with poor prognosis. In fact, epidemiological studies have revealed that there is an 8-mo median survival rate in patients, approximately 20% of whom survive one year while only 5% remain alive after three years. Additionally, HCC is particularly difficult to treat because of its high recurrence rate, and its resistance to conventional chemotherapy is due, among other mechanisms, to several members of the ATP-Binding Cassette protein family involved in drug transport being overexpressed. Fortunately, there is evidence that these patients may benefit from alternative molecular-targeted therapies. This manuscript intends to provide further insight into the etiology and molecular mechanisms related to HCC development and the latest therapeutic approaches to treat this malignancy. The development of effective delivery systems of antitumor drugs able to target the liver parenchyma is also assessed. Finally, the prospects in the development of more efficient drug therapies to overcome multidrug resistance are also examined. | María L Cuestas José R Oubia Verónica L Mathet | 2015 | World Journal of Pharmacology2015，4，1： | 2 |
| 14 | Neuroendocrine small cell carcinoma of the bladder显示文摘 | Cuesta Alcala JA Ripa Saldias L Aldave VJ | 2002 | Arch Esp Urol2002，55，： | 2 |
| 15 | Production of free conjugated linoleic acid by Lactobacillus acidophilus and Lactobacillus casei of human intestinal origin显示文摘 | ALONSO L CUESTA E P GILLILAND S E | 2003 | J Dairy Sci2003，86，6： | 1 |
| 16 | Simplified R-factor relationships for strong ground motions显示文摘 | Cuesta I Aschheim A Fajfar P | 2003 | Earthquake Spectra2003，19，1： | 1 |
| 17 | Colorectal carcinomas with high microsatellite instability:defining a distinct immunologic and molecular entity with respect to prognostic markers显示文摘 | Edmonston T B Cuesta K H Burkholder S | | 0，，： | 1 |
| 18 | Microperforated insertion units: An alternative strategy to design microperforated panels显示文摘 | Jaime Pfretzschner Pedro Cobo Francisco Simón María Cuesta Alejandro Fernández | 2005 | Applied Acoustics2005，，1： | 1 |
| 19 | Toll-like receptors, in- flammation, metabolism and obesity 显示文摘 | Fresno M Alvarez R Cuesta N | 2011 | Arch Physiol Bio- chem2011，117，： | 1 |
| 20 | Control of the chemical structure of perhydrous coals : FTIR and Py-GC/MS investigation显示文摘 | IGLESIAS M J del RIIO J C LAGGOUN-D FARGE F CUESTA M J SU REZ-RUIZ I | 2002 | J Anal Appl Pyrolysis2002，62，1： | 1 |
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