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| 1 | Metastatic pattern in esophageal and gastric cancer:Influenced by site and histology显示文摘BACKGROUND Detailed information on metastatic patterns in of patients with esophageal and gastric cancer is limited.Early recognition of metastases is important to avoid futile locoregional treatments.Furthermore,knowledge on metastatic patterns is necessary for further development of personalized treatment modalities.AIM To gain insight into the metastatic pattern of gastroesophageal cancer.METHODS A nationwide retrospective autopsy study of 3876 patients with adenocarcinoma(AC)or squamous cell carcinoma(SCC)of the esophagus or stomach between 1990 and 2017 was performed.Only patient with metastases were included for analysis.The metastatic pattern was analyzed according to the primary tumor location and histological subtype.RESULTS Metastatic disease was found in 268 esophageal and 331 gastric cancer patients.In esophageal cancer,the most common metastatic locations were liver(56%),distant lymph nodes(53%)and lung(50%).Esophageal AC showed more frequently metastases to the peritoneum and bone compared with esophageal SCC.In gastric cancer,the most common metastatic locations were distant lymph nodes(56%),liver(53%)and peritoneum(51%).Intestinal-type AC of the stomach showed metastases to the liver more frequently,whereas metastases to the bone,female reproductive organs and colorectum were observed more frequently in diffuse-type gastric AC.CONCLUSION This study showed differences in metastatic patterns of patients with esophageal and gastric cancer according to the primary tumor location and histological subtype. | Moniek HP Verstegen Mitchell Harker Carlijn van de Water Jolanda van Dieren Niek Hugen Iris D Nagtegaal Camiel Rosman Rachel S van der Post | 2020 | World Journal of Gastroenterology2020，26，39： | 9 |
| 2 | Neutrophil-lymphocyte ratio:A prognostic tool in patients with inhospital cardiac arrest显示文摘BACKGROUND In-hospital cardiac arrest(IHCA) portends a poor prognosis and survival to discharge rate. Prognostic markers such as interleukin-6, S-100 protein and high sensitivity C reactive protein have been studied as predictors of adverse outcomes after return of spontaneous circulation(ROSC); however; these variables are not routine laboratory tests and incur additional cost making them difficult to incorporate and less attractive in assessing patient's prognosis. The neutrophil-lymphocyte ratio(NLR) is a marker of adverse prognosis for many cardiovascular conditions and certain types of cancers and sepsis. We hypothesize that an elevated NLR is associated with poor outcomes including mortality at discharge in patients with IHCA.AIM To determine the prognostic significance of NLR in patients suffering IHCA who achieve ROSC.METHODS A retrospective study was performed on all patients who had IHCA with the advanced cardiac life support protocol administered in a large urban community United States hospital over a one-year period. Patients were divided into two groups based on their NLR value(NLR < 4.5 or NLR ≥ 4.5). This cutpoint was derived from receiving operator characteristic curve analysis(area under the curve = 0.66) and provided 73% positive predictive value, 82% sensitivity and42% specificity for predicting in-hospital death after IHCA. The primary outcome was death or discharge at 30 d, whichever came first.RESULTS We reviewed 153 patients with a mean age of 66.1 ± 16.3 years; 48% were female.In-hospital mortality occurred in 65%. The median NLR in survivors was 4.9(range 0.6-46.5) compared with 8.9(0.28-96) in non-survivors(P = 0.001). A multivariable logistic regression model demonstrated that an NLR above 4.55[odds ratio(OR) = 5.20, confidence interval(CI): 1.5-18.3, P = 0.01], older age(OR= 1.03, CI: 1.00-1.07, P = 0.05), and elevated serum lactate level(OR = 1.20, CI:1.03-1.40, P = 0.02) were independent predictors of death.CONCLUSION An NLR ≥ 4.5 may be a useful marker of increased risk of death in patients with IHCA. | Vishal H Patel Philip Vendittelli Rajat Garg Susan Szpunar Thomas LaLonde John Lee Howard Rosman Rajendra H Mehta Hussein Othman | 2019 | World Journal of Critical Care Medicine2019，8，2： | 5 |
| 3 | 失眠在创伤后应激障碍与高血压关系中的作用显示文摘创伤后应激障碍(posttraumatic stress disorder,PTSD)与高血压发病相关。PTSD还与失眠症相关,尽管对两者关系知之甚少,但它会增加高血压患病风险。失眠是否会增加PTSD相关的高血压风险目前仍是未知的。方法:研究者检索了1109名女性退伍军人队列研究(women veterans cohort study)参与者[平均年龄为(43.8±10.9)岁;52%为女性,81%为白人]的问卷调查和电子健康记录数据,评估其PTSD症状严重程度、近期失眠症状与高血压的横断面关系。 | 周卫(译) 袁源(审校) Gaffey AE Redeker NS Rosman L Mullington MJ Brandt CA Haskell SG Burg MM | 2020 | 中华高血压杂志2020，28，9： | 3 |
| 4 | Ophthalmology simulation for undergraduate and postgraduate clinical education显示文摘This is a review education paper on the current ophthalmology simulators utilized worldwide for undergraduate and postgraduate training. At present,various simulators such as the EYE Exam Simulator(Kyoto Kagaku Co. Ltd., Kyoto, Japan), Eyesi direct ophthalmoscope simulator(VRmagic, Gmb H, Mannheim,Germany), Eyesi indirect ophthalmoscope simulator(VRmagic, Gmb H, Mannheim, Germany) and Eyesi cataract simulators(VRmagic, Gmb H, Mannheim,Germany). These simulators are thought to be able to reduce the initial learning curve for the ophthalmology training but further research will need to be conducted to assess the effectiveness of the simulation-assisted ophthalmology training. Future research will be of great value to assess the medical students and residents' responses and performance regarding the usefulness of the individual eye simulator. | Daniel Shu Wei Ting Shaun Sebastian Khung Peng Sim Christine Wen Leng Yau Mohamad Rosman Ai Tee Aw Ian Yew San Yeo | 2016 | International Journal of Ophthalmology(English edition)2016，9，6： | 3 |
| 5 | Outcomes of curative esophageal cancer surgery in elderly:A metaanalysis显示文摘BACKGROUND An increasing number of older patients is undergoing curative,surgical treatment of esophageal cancer.Previous meta-analyses have shown that older patients suffered from more postoperative morbidity and mortality compared to younger patients,which may lead to patient selection based on age.However,only studies including patients that underwent open esophagectomy were included.Therefore,it remains unknown whether there is an association between age and outcome in patients undergoing minimally invasive esophagectomy.AIM To perform a systematic review on age and postoperative outcome in esophageal cancer patients undergoing esophagectomy.METHODS Studies comparing older with younger patients with primary esophageal cancer undergoing curative esophagectomy were included.Meta-analysis of studies using a 75-year age threshold are presented in the manuscript,studies using other age thresholds in the Supplementary material.MEDLINE,Embase and the Cochrane Library were searched for articles published between 1995 and 2020.Risk of bias was assessed with the Newcastle-Ottawa Scale.Primary outcomes were anastomotic leak,pulmonary and cardiac complications,delirium,30-and 90-d,and in-hospital mortality.Secondary outcomes included pneumonia and 5-year overall survival.RESULTS Seven studies(4847 patients)using an age threshold of 75 years were included for meta-analysis with 755 older and 4092 younger patients.Older patients(9.05%)had higher rates of 90-d mortality compared with younger patients(3.92%),(confidence interval=1.10-5.56).In addition,older patients(9.45%)had higher rates of in-hospital mortality compared with younger patients(3.68%),(confidence interval=1.01-5.91).In the subgroup of 2 studies with minimally invasive esophagectomy,older and younger patients had comparable 30-d,90-d and in-hospital mortality rates.CONCLUSION Older patients undergoing curative esophagectomy for esophageal cancer have a higher postoperative mortality risk.Minimally invasive esophagectomy may be important for minimizing mortality in older patients. | Nikolaj S Baranov Cettela Slootmans Frans van Workum Bastiaan R Klarenbeek Yvonne Schoon Camiel Rosman | 2021 | World Journal of Gastrointestinal Oncology2021，13，2： | 3 |
| 6 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet . 2012 (9829)2012，，： | 3 |
| 7 | Learning curves in minimally invasive esophagectomy显示文摘Surgical innovation and pioneering are important for improving patient outcome, but can be associated with learning curves. Although learning curves in surgery are a recognized problem, the impact of surgical learning curves is increasing, due to increasing complexity of innovative surgical procedures, the rapid rate at which new interventions are implemented and a decrease in relative effectiveness of new interventions compared to old interventions. For minimally invasive esophagectomy(MIE), there is now robust evidence that implementation can lead to significant learning associated morbidity(morbidity during a learning curve, that could have been avoided if patients were operated by surgeons that have completed the learning curve). This article provides an overview of the evidence of the impact of learning curves after implementation of MIE. In addition, caveats for implementation and available evidence regarding factors that are important for safe implementation and safe pioneering of MIE are discussed. | Frans van Workum Laura Fransen Misha DP Luyer Camiel Rosman | 2018 | World Journal of Gastroenterology2018，24，44： | 2 |
| 8 | Phase-behavior properties of CO2- reservoir oil systems显示文摘 | Simon R Rosman A Zana E | 1978 | SPE Journal1978，18，1： | 1 |
| 9 | An overview of the features influencing pain after inguinal hernia repair 显示文摘 | Nienhuijs SW Rosman C Strobbe LJ | 2008 | Int J Surg2008，6，4： | 1 |
| 10 | TGFBR1 6A enhances themigration and invasion of MCF-7 breast cancer cells through RhoAactivation显示文摘 | Rosman DS Phukan S Huang CC | 2008 | Cancer Res2008，68，5： | 1 |
| 11 | IUPAC table of isotopic compositions of the elements显示文摘 | ROSMAN K J R TAYLOR P D P | 1998 | Pure and Applied Chemistry1998，70，1： | 1 |
| 12 | Hydrodynamics and water quality models applied to Sepetiba Bay 显示文摘 | CUNHA C D D ROSMAN P C C FENREIRA A P | 2006 | Continental Shelf Research2006，26，16： | 1 |
| 13 | Helpful Self-Control:autonomy support, vitality, and depletion显示文摘 | Muraven M Gagn6 M Rosman H | 2008 | J Exp Soc Psychol2008，44，3： | 1 |
| 14 | TGFBR1 6A enhances the migration and invasion of MCF-7 breast cancer cells through RhoA activation 显示文摘 | Rosman DS Phukan S Huang CC | 2008 | Cancer Res2008，68，5： | 1 |
| 15 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet2012，，9829： | 1 |
| 16 | Livestock wastewater treatment using aerobic granular sludge显示文摘 | Inawati Othman Aznah Nor Anuar Zaini Ujang Noor Hasyimah Rosman Hasnida Harun Shreeshivadasan Chelliapan | 2013 | Bioresource Technology2013，，： | 1 |
| 17 | Disc protrusion in the growing child 显示文摘 | Kamel M Rosman M | 1984 | Clin Orthop Relat Res1984，，185： | 1 |
| 18 | Glycoprotein Ⅱb/Ⅲa receptor antagonists and risk of bleeding:a single-center experience in 1020 patient显示文摘 | Ali A Hashem M Rosman HS | 2004 | J Clin Pharmacol2004，44，11： | 1 |
| 19 | Family lunch session: an introduction to family therapy in anorexia nervosa显示文摘 | Rosman B L Minuehin S Liebman R | 1975 | Am J Or- thopsychiatry1975，45，5： | 1 |
| 20 | Isolation and characterization of human cDNAs encoding a cGMP - stimulated 3',5'- cyclic nucleotide phosphodiesterase显示文摘 | Rosman GJ Martins TJ Sonnenburg WK | 1997 | Gene1997，191，1： | 1 |
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