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| 1 | Metastatic pattern in esophageal and gastric cancer:Influenced by site and histology显示文摘BACKGROUND Detailed information on metastatic patterns in of patients with esophageal and gastric cancer is limited.Early recognition of metastases is important to avoid futile locoregional treatments.Furthermore,knowledge on metastatic patterns is necessary for further development of personalized treatment modalities.AIM To gain insight into the metastatic pattern of gastroesophageal cancer.METHODS A nationwide retrospective autopsy study of 3876 patients with adenocarcinoma(AC)or squamous cell carcinoma(SCC)of the esophagus or stomach between 1990 and 2017 was performed.Only patient with metastases were included for analysis.The metastatic pattern was analyzed according to the primary tumor location and histological subtype.RESULTS Metastatic disease was found in 268 esophageal and 331 gastric cancer patients.In esophageal cancer,the most common metastatic locations were liver(56%),distant lymph nodes(53%)and lung(50%).Esophageal AC showed more frequently metastases to the peritoneum and bone compared with esophageal SCC.In gastric cancer,the most common metastatic locations were distant lymph nodes(56%),liver(53%)and peritoneum(51%).Intestinal-type AC of the stomach showed metastases to the liver more frequently,whereas metastases to the bone,female reproductive organs and colorectum were observed more frequently in diffuse-type gastric AC.CONCLUSION This study showed differences in metastatic patterns of patients with esophageal and gastric cancer according to the primary tumor location and histological subtype. | Moniek HP Verstegen Mitchell Harker Carlijn van de Water Jolanda van Dieren Niek Hugen Iris D Nagtegaal Camiel Rosman Rachel S van der Post | 2020 | World Journal of Gastroenterology2020，26，39： | 9 |
| 2 | Outcomes of curative esophageal cancer surgery in elderly:A metaanalysis显示文摘BACKGROUND An increasing number of older patients is undergoing curative,surgical treatment of esophageal cancer.Previous meta-analyses have shown that older patients suffered from more postoperative morbidity and mortality compared to younger patients,which may lead to patient selection based on age.However,only studies including patients that underwent open esophagectomy were included.Therefore,it remains unknown whether there is an association between age and outcome in patients undergoing minimally invasive esophagectomy.AIM To perform a systematic review on age and postoperative outcome in esophageal cancer patients undergoing esophagectomy.METHODS Studies comparing older with younger patients with primary esophageal cancer undergoing curative esophagectomy were included.Meta-analysis of studies using a 75-year age threshold are presented in the manuscript,studies using other age thresholds in the Supplementary material.MEDLINE,Embase and the Cochrane Library were searched for articles published between 1995 and 2020.Risk of bias was assessed with the Newcastle-Ottawa Scale.Primary outcomes were anastomotic leak,pulmonary and cardiac complications,delirium,30-and 90-d,and in-hospital mortality.Secondary outcomes included pneumonia and 5-year overall survival.RESULTS Seven studies(4847 patients)using an age threshold of 75 years were included for meta-analysis with 755 older and 4092 younger patients.Older patients(9.05%)had higher rates of 90-d mortality compared with younger patients(3.92%),(confidence interval=1.10-5.56).In addition,older patients(9.45%)had higher rates of in-hospital mortality compared with younger patients(3.68%),(confidence interval=1.01-5.91).In the subgroup of 2 studies with minimally invasive esophagectomy,older and younger patients had comparable 30-d,90-d and in-hospital mortality rates.CONCLUSION Older patients undergoing curative esophagectomy for esophageal cancer have a higher postoperative mortality risk.Minimally invasive esophagectomy may be important for minimizing mortality in older patients. | Nikolaj S Baranov Cettela Slootmans Frans van Workum Bastiaan R Klarenbeek Yvonne Schoon Camiel Rosman | 2021 | World Journal of Gastrointestinal Oncology2021，13，2： | 3 |
| 3 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet . 2012 (9829)2012，，： | 3 |
| 4 | Learning curves in minimally invasive esophagectomy显示文摘Surgical innovation and pioneering are important for improving patient outcome, but can be associated with learning curves. Although learning curves in surgery are a recognized problem, the impact of surgical learning curves is increasing, due to increasing complexity of innovative surgical procedures, the rapid rate at which new interventions are implemented and a decrease in relative effectiveness of new interventions compared to old interventions. For minimally invasive esophagectomy(MIE), there is now robust evidence that implementation can lead to significant learning associated morbidity(morbidity during a learning curve, that could have been avoided if patients were operated by surgeons that have completed the learning curve). This article provides an overview of the evidence of the impact of learning curves after implementation of MIE. In addition, caveats for implementation and available evidence regarding factors that are important for safe implementation and safe pioneering of MIE are discussed. | Frans van Workum Laura Fransen Misha DP Luyer Camiel Rosman | 2018 | World Journal of Gastroenterology2018，24，44： | 2 |
| 5 | Formation of rigid polyurethane foams with semi-fluorinated diblock copolymeric surfactants显示文摘 | Maarten J Krupers Camiel F Bartelink Henri J M Grunhauer | 1998 | Polymer1998，39，10： | 1 |
| 6 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet2012，，9829： | 1 |
| 7 | Characterization of a large chromosomal 'high -pathogenicity island' in biotype lB Yersinia enterocolitica显示文摘 | Camiel E Guilvout I Prentice M | 1996 | J Bacteriol1996，178，23： | 1 |
| 8 | The Yersinia high- pathogenicity island is present in different members of the family Enterocoliticeae显示文摘 | Sandrine Bach Alzira de Almeida Elisabeth Camiel | 2000 | FEMS Micriobiol Lett2000，183，2： | 1 |
| 9 | Efficient subtyping of pathogenic Yersinia enterocolitica strains by pulsed-field gel electrophoresis 显示文摘 | Najdenski H Iteman I Camiel E | 1994 | J Clin Microbiol1994，32，： | 1 |
| 10 | Characterization of a large chromosomal-'high-pathogenicity island'in biotype 1 B Yersinia enterocolitica显示文摘 | Camiel E J Guilvout I Prentice M | 1996 | J Bacteriol1996，178，23： | 1 |
| 11 | Subthreshold Micropulse Laser (577 nm) Treatment in Chronic Central Serous Chorioretinopathy显示文摘 | Paula Scholz Lebriz Ersoy Camiel JF Boon Sascha Fauser | 2015 | Ophthalmologica2015，，： | 1 |
| 12 | Experimental- numerical analysis of minipig's multi-rooted teeth 显示文摘 | Natali A N Camiel E L Pavan P G | 2007 | Journal of Biomechanies2007，40，8： | 1 |
| 13 | Comparision of the effects of deferiprone versus Deferoxamine on growth and virulence of yersinia enterocolitical显示文摘 | Lesic B Foulon J Camiel E | 2002 | Antimicrob Agents Chemother2002，46，6： | 1 |
| 14 | Experimental - numeri-cal analysis of minipig 's multi - rooted teeth 显示文摘 | Natali AN Camiel EL Pavan PG e? al | 2007 | J Biomech2007，40，8： | 1 |
| 15 | Formation of rigid polyurethane foams with semi-fluorinated diblock copolymeric surfactants显示文摘 | Maarten J Krupers Camiel F Bartelink Henri J M Grunhauer | 1998 | Polymer1998，39，10： | 1 |
| 16 | Geranylgeranyi diphosphate synthase activity and taxane production in Taxus baccata cells显示文摘 | Gregory L Camiel F D Mondher J | 1999 | Phytochemistry1999，50，1： | 1 |
| 17 | Poor Prognosis of Rare Sarcom- eric Gene Variants in Patients with Dilated Cardiomyopathy显示文摘 | Merlo M Sinagra G Camiel E | 2013 | Clini- cal and Translational Science2013，69，6： | 1 |
| 18 | Characterization of a large chromosomal 'high-pathogenicity island' in biotype 1B Yersinia enterocolitica 显示文摘 | Camiel E Guilvout I Prentice M | 1996 | J Bacteriol1996，178，23： | 1 |
| 19 | Transfusion-transmitted Yersinia enterocolitica sepsis显示文摘 | GUINET F CAMIEL E LECLERCQ A | 2011 | Clinical Infectious Diseases2011，53，6： | 1 |
| 20 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet2012，，9829： | 1 |
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