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| 1 | Treating comorbid anxiety and depression: Psychosocial and pharmacological approaches显示文摘Comorbid anxiety with depression predicts poor outcomes with a higher percentage of treatment resistance than either disorder occurring alone. Overlap of anxiety and depression complicates diagnosis and renders treatment challenging. A vital step in treatment of such comorbidity is careful and comprehensive diagnostic assessment. We attempt to explain various psychosocial and pharmacological approaches for treatment of comorbid anxiety and depression. For the psychosocial component, we focus only on generalized anxiety disorder based on the following theoretical models:(1) 'the avoidance model';(2) 'the intolerance of uncertainty model';(3) 'the meta-cognitive model';(4) 'the emotion dysregulation model'; and(5) 'the acceptance based model'. For depression, the following theoretical models are explicated:(1) 'the cognitive model';(2) 'the behavioral activation model'; and(3) 'the interpersonal model'. Integration of these approaches is suggested. The treatment of comorbid anxiety and depression necessitates specific psychopharmacological adjustments as compared to treating either condition alone. Serotonin reuptake inhibitors are considered first-line treatment in uncomplicated depression comorbid with a spectrum of anxiety disorders. Short-acting benzodiazepines(BZDs) are an important 'bridging strategy' to address an acute anxiety component. In patients with comorbid substance abuse, avoidance of BZDs is recommended and we advise using an atypical antipsychotic in lieu of BZDs. For mixed anxiety and depression comorbid with bipolar disorder, we recommend augmentation of an antidepressant with either lamotrigine or an atypical agent. Combination and augmentation therapies in the treatment of comorbid conditions vis-à-vis monotherapy may be necessary for positive outcomes. Combination therapy with tricyclic antidepressants, gabapentin and selective serotonin/norepinephrine reuptake inhibitors(e.g., duloxetine) are specifically useful for comorbid chronic pain syndromes. Aripiprazole, quetiapine, risperidone and other novel atypical agents may be effective as augmentations. For treatment-resistant patients, we recommend a 'stacking approach' not dissimilar from treatment of hypertension In conclusion, we delineate a comprehensive approach comprising integration of various psychosocial approaches and incremental pharmacological interventions entailing bridging strategies, augmentation therapies and ultimately stacking approaches towards effectively treating comorbid anxiety and depression. | Jeremy D Coplan Cindy J Aaronson Venkatesh Panthangi Younsuk Kim | 2015 | World Journal of Psychiatry2015，5，4： | 7 |
| 2 | Acute kidney injury and hepatorenal syndrome in cirrhosis显示文摘Acute kidney injury(AKI)in cirrhosis,including hepatorenal syndrome(HRS),is a common and serious complication in cirrhotic patients,leading to significant morbidity and mortality.AKI is separated into two categories,non-HRS AKI and HRS-AKI.The most recent definition and diagnostic criteria of AKI in cirrhosis and HRS have helped diagnose and prognosticate the disease.The pathophysiology behind non-HRS-AKI and HRS is more complicated than once theorized and involves more processes than just splanchnic vasodilation.The common biomarkers clinicians use to assess kidney injury have significant limitations in cirrhosis patients;novel biomarkers being studied have shown promise but require further studies in clinical settings and animal models.The overall management of non-HRS AKI and HRS-AKI requires a systematic approach.Although pharmacological treatments have shown mortality benefit,the ideal HRS treatment option is liver transplantation with or without simultaneous kidney transplantation.Further research is required to optimize pharmacologic and nonpharmacologic approaches to treatment.This article reviews the current guidelines and recommendations of AKI in cirrhosis. | Kapil Gupta Abhishek Bhurwal Cindy Law Scott Ventre Carlos D Minacapelli Savan Kabaria You Li Christopher Tait Carolyn Catalano Vinod K Rustgi | 2021 | World Journal of Gastroenterology2021，27，26： | 5 |
| 3 | Biomarkers for diet and cancer prevention research:potentials and challenges显示文摘当癌症发生被投射增加十年,对有效预防策略有需要。幸好,证据继续到改变饮食的习惯是为减少癌症风险并且为修改肿瘤的生物行为的一条有效、成本效率的途径的山。预兆,验证并且敏感简历标记,包括可靠地评估“吸入”或暴露到特定的食物或简历的那些活跃部件,估计被连接到癌症的至少一特定的生物“效果”,并且有效地作为滋养营养素的相互作用和遗传的功能预言单个“危险性”,对评估基本将从饮食的 interventions.These 简历标记有益于大多数的人,一定容易地温和,容易并且可靠地 assayed ,并且涉及 cancer.Theresponse 到食物的一个关键过程( es )预兆被简历的有效集中决定不仅到达目标织物的活跃食物部件,而且由目标 requiringmodification.Thus 的数量,对食物和他们的部件的这阀值回答将从对理解个性化的回答是更大的知识 ofnutrigenomics , proteomics 和 metabolomics 关键的单个 toindividual.The 变化。 | Cindy D DAVIS John A MILNER | 2007 | Acta Pharmacologica Sinica2007，28，9： | 2 |
| 4 | Traumatic aortic rupture,30 years of experience显示文摘 | Cindy M Sabrina H Kim D Geert M Inge F | | 0，，： | 1 |
| 5 | Characterization of multidrug-resistant, qnrB2-positive and extended-spectrum-b-lactamase-producing Salmonella Concord and Salmonella Senftenberg isolates显示文摘 | Kees V Cindy D Alieda EZ | 2010 | J Antimicrob Chemother2010，65，： | 1 |
| 6 | DNA Methylation,Cancer Susceptibility,and Nutrient Interactions显示文摘 | Cindy D Davis Eric O | | 0，，： | 1 |
| 7 | Changes in dietary zinc and copper affect zinc-status indicators of postmenopausal women, notably, extracellular superoxide dismutase and amyloid precursor proteins 显示文摘 | Cindy D Davis David B Milne Forrest H Nielsen | 2000 | Am J Clin Nutr2000，71，3： | 1 |
| 8 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 9 | Net economic value of hunting unique species in Idaho bighorn sheep,mountain goat,oose,and antelope显示文摘 | Dennis D Cindy F S | 1985 | USDA Forest Service Resource Bulletin1985，10，3： | 1 |
| 10 | Dietary Selenium and Ar-senic Affect DNA Ethylation in Vitro in Caco-2 Cells and Invivo Rat Liver and Colon显示文摘 | Eric OV John WF | 2000 | American Society for Nutrictional Sciences2000，，： | 1 |
| 11 | Development and psychometric testing of the Breastfeeding Self-Efficany Scale显示文摘 | Cindy L D Sandra F | 1999 | Res Nurs Health1999，22，5： | 1 |
| 12 | Frontiers in nutrigenomics, proteomics, metabolomicsand cancer prevention显示文摘 | Cindy D Davis John Milner | 2004 | Mutation Research2004，551，： | 1 |
| 13 | Dissolving pulp draws renewed interesi:显示文摘 | Cindy M D | 2011 | Pulp & Paper Canada2011，112，3： | 1 |
| 14 | A Synthetic Factor Approach to the Estimation of Value-at-Risk of a Portfolio of Interest Rate Swaps显示文摘 | Cindy I N Robin D H Richard B F | 2000 | Journal of Banking & Finance2000，24，： | 1 |
| 15 | Rarity of genomic instability in pathogenesis of systemic anaplastic large cell lymphoma(ALCL)in immunocompetent patients显示文摘 | KURT B HODGES M D CINDY L | 1999 | Hum Pathol1999，30，2： | 1 |
| 16 | Adrenomedullin gene delivery attenuates hypertension,cardiac remodeling,and renal injury in deoxycorticosterone acetate-salt hypertension rats显示文摘 | Cindy W Julie C | 2000 | Hypertension2000，36，： | 1 |
| 17 | The Role of Centralized Reading of Endoscopy in a Randomized Controlled Trial of Mesalamine for Ulcerative Colitis显示文摘 | Brian G. Feagan William J. Sandborn Geert D'Haens Suresh Pola John W.D. McDonald Paul Rutgeerts Pia Munkholm Ulrich Mittmann Debra King Cindy J. Wong Guangyong Zou Allan Donner Lisa M. Shackelton Denise Gilgen Sigrid Nelson Margaret K. Vandervoort Mariann | 2013 | Gastroenterology2013，，1： | 1 |
| 18 | The Role of Centralized Reading of Endoscopy in a Randomized Controlled Trial of Mesalamine for Ulcerative Colitis显示文摘 | Brian G. Feagan William J. Sandborn Geert D’Haens Suresh Pola John W.D. McDonald Paul Rutgeerts Pia Munkholm Ulrich Mittmann Debra King Cindy J. Wong Guangyong Zou Allan Donner Lisa M. Shackelton Denise Gilgen Sigrid Nelson Margaret K. Vandervoort Mariann | 2013 | Gastroenterology2013，，1： | 1 |
| 19 | Adrenomedullin gene delivery attenuates hypertension, cardiac remodeling, and renal injury in deoxycorticosterone acetate-salt hypertension Rats显示文摘 | Ecri D Cindy W Julie C | 2000 | Hypertension2000，36，： | 1 |
| 20 | Metallothionein prolongs survival and antagonizes senescence-associated cardiomyocyte diastolic dysfunction:Role of oxidative stress显示文摘 | Xiao-ping YANG Thomas A D Cindy X F | 2006 | FASEB J2006，20，7： | 1 |
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