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| 1 | Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice显示文摘AIM To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer(CAC). METHODS C57 BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water(5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacil us rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16 Sr RNA Illumina Hi Seq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by Real Time-PCR(Polymerase Chain Reaction); and serum cytokines by Multiplex assay. All tests were two-sided. The level of significance was set at P < 0.05. Graphs were generated and statistical analysis performed using the software Graph Pad Prism 5.0. The project was approved by the institutional review board committee. RESULTS At day 60 after azoxymethane injection, the mean number of tumours in the probiotic group was 40% lower than that in the control group, and the probiotic group exhibited tumours of smaller size(< 2 mm)(P < 0.05). There was no difference in richness and diversity between groups. However, there was a significant difference in beta diversity in the multidimensional scaling analysis. The abundance of the genera Lactobacillus, Bifidobacterium, Allobaculum, Clostridium XI and Clostridium XVⅢ increased in the probiotic group(P < 0.05). The microbial change was accompanied by reduced colitis, demonstrated by a 46% reduction in the colon inflammatory index; reduced expression of the serum chemokines RANTES and Eotaxin; decreased p-IKK and TNF-α and increased IL-10 expression in the colon. CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC. Probiotic supplementation changes microbiota structure and regulates the inflammatory response, reducing colitis and preventing CAC. | Maria Carolina S Mendes Daiane SM Paulino Sandra R Brambilla Juliana A Camargo Gabriela F Persinoti José Barreto C Carvalheira | 2018 | World Journal of Gastroenterology2018，24，18： | 17 |
| 2 | Role of endoglin and VEGF family expression in colorectal cancer prognosis and anti-angiogenic therapies显示文摘Colorectal cancer(CRC)is one of the cancer models and most of the carcinogenic steps are presently well understood.Therefore,successful preventive measures are currently used in medical practice.However,CRC is still an important public health problem as it is the third most common cancer and the fourth most frequent cause of cancer death worldwide.Nowadays,pathologic stage is a unique and well-recognized prognostic indicator,however,more accurate indicators of the biologic behavior of CRC are expected to improve the specificity of medical treatment.Angiogenesis plays an important role in the growth and progression of cancer but its role as a prognostic factor is still controversial.Probably the most important clinical implication of tumor angiogenesis is the development of anti-angiogenic therapy.The goal of this review is to critically evaluate the role of angiogenic markers,assessed by either endoglin-related microvessel density or expression of vascular endothelial growth factor family members in the CRC setting and discuss the role of these angiogenic markers in antiangiogenic therapies. | Sandra F Martins Rui M Reis Antonio Mesquita Rodrigues Fátima Baltazar Adhemar Longatto Filho | 2011 | World Journal of Clinical Oncology2011，2，6： | 9 |
| 3 | Human endostatin-derived synthetic peptides possess potent antiangiogenic properties in vitro and in vivo 显示文摘 | Maria GC Sandra P Pierangelo F | 2003 | Experimental Cell Research2003，283，2： | 1 |
| 4 | Corruption, Political Connections and Municipal Finance 显示文摘 | Butler A W Larry F Sandra M | 2009 | Review of Finance2009，，22： | 1 |
| 5 | Ameloblastoma induces asteoclastogenesis:A possible role of ameloblastoma in expanding in the bone显示文摘 | Sandra F Hendarmin L Kukita T | 2005 | Oral Oncol2005，41，6： | 1 |
| 6 | Water absorption, dimensional change and radial pressure in resin matrix dental restorative materials 显示文摘 | John F M Sandra R | 2004 | Biomaterials2004，25，： | 1 |
| 7 | Considerations on ultra trace analysis of carbamates in water samples显示文摘 | NOGUEIRA J M F SANDRA T SANDRA P | 2003 | Journal of Chromatography A2003，996，： | 1 |
| 8 | African Americans,hypertension and the renin angiotensin system显示文摘African Americans have exceptionally high rates of hypertension and hypertension related complications. It is commonly reported that the blood pressure lowering efficacy of renin angiotensin system(RAS) inhibitors is attenuated in African Americans due to a greater likelihood of having a low renin profile. Therefore these agents are often not recommended as initial therapy in African Americans with hypertension. However, the high prevalence of comorbid conditions, such as diabetes, cardiovascular and chronic kidney disease makes treatment with RAS inhibitors more compelling. Despite lower circulating renin levels and a less significant fall in blood pressure in response to RAS inhibitors in African Americans, numerous clinical trials support the efficacy of RAS inhibitors to improve clinical outcomes in this population, especially in those with hypertension and risk factors for cardiovascular and related diseases. Here, we discuss the rationale of RAS blockade as part of a comprehensive approach to attenuate the high rates of premature morbidity and mortality associated with hypertension among African Americans. | Sandra F Williams Susanne B Nicholas Nosratola D Vaziri Keith C Norris | 2014 | World Journal of Cardiology2014，6，9： | 1 |
| 9 | Closed suctioning of intubated neonates maintains better physiologic stability:a randomized trial显示文摘 | Angela K Susan B Sandra F | 2003 | J Perinatol2003，23，3： | 1 |
| 10 | Effects of me- chanical stress on cell adhesion: a possible mechanism for mor- phological changes 显示文摘 | Boccafoschi F Bosetti M Sandra P M | 2010 | Cell Adh Migr2010，4，1： | 1 |
| 11 | Closed suetioning of intuba- ted neonates maintains better physiologic stability : a random- ized tria显示文摘 | Kalyn A Blatz S Sandra F | 2003 | J Perinatol2003，23，3： | 1 |
| 12 | Semi-conductor-assisted photodegradation of liglin, dye, and kraft effluent by Ag-doped ZnO 显示文摘 | Carlos A K Goerver F W Sandra G M | 2000 | Chenmosphere2000，40，4： | 1 |
| 13 | Challenging the status quo:what mo-tivates proactive behavior显示文摘 | Sandra O Charlotte F | 2007 | Journal of Occupational and Organizational Psychology2007，80，4： | 1 |
| 14 | Production of surfactant from Bacillus subtilis ATCC 21332 using potato substrates显示文摘 | SANDRA L F GREG A B | 2000 | Bioresource Technology2000，75，： | 1 |
| 15 | Aqueous tape casting processing of low dielectric constant cordierite-based glass-ceramics-Selection of binder显示文摘 | MEI Sen YANG Juan XU Xin Sandra Q Simeon A Ferreirajose M F | 2006 | J Euro Ceram Soc2006，26，12： | 1 |
| 16 | Sustainability issues for start-up entrepreneurs 显示文摘 | Hildegard S Sandra M Jurgen F | 2002 | Greener Management International2002，，38： | 1 |
| 17 | Midkine induced growth of ameloblastoma through MAPK and Akt pathways 显示文摘 | Sandra F Harada H Nakamura N | 2004 | Oral Oncol2004，40，3： | 1 |
| 18 | 显示文摘 | David F Sandra P | 1999 | Jounal of chromatography A1999，842，： | 1 |
| 19 | Multi-residue Screening of Pesticides in Vegetables, Fruits and Baby Food by Stir Bar Sorptive Extraction-thermal Desorption-capillary Gas Chromatography- Mass Spectrometry显示文摘 | SANDRA P TIENPONT B DAVID F | 2003 | J Chromatogr A2003，1000，12： | 1 |
| 20 | Small renal cell carcinomas-How dangerous are they really?Results of a large multicenter study显示文摘 | Sandra S Kerstin J Roos F C | 2014 | European Journal of Cancer2014，50，4： | 1 |
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