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| 1 | FOLFIRI regimen in metastatic pancreatic adenocarcinoma resistant to gemcitabine and platinum-salts显示文摘AIM: To evaluate the efficacy and safety of the FOLFIRI regimen in patients with metastatic pancreatic adenocarcinoma (PAC) after the failure of gemcitabine and platinum salts. METHODS: All consecutive patients with histologically confirmed, metastatic PAC and World Health Organiza-tion performance status (PS) ≤ 2 received FOLFIRI-1 [irinotecan 180 mg/m2 on day 1 and leucovorin 400 mg/m2 followed by 5-fluorouracil (5-FU) 400 mg/m2 bolus, then 5-FU 2400 mg/m2 as a 46-h infusion, biweekly] or FOLFIRI-3 (irinotecan 100 mg/m2 on day 1 and leucovorin 400 mg/m2, then 5-FU 2400 mg/m2 as a 46-h infusion and irinotecan 100 mg/m2 repeated on day 3, biweekly) after failure of gemcitabine and platinum-based chemotherapies as a systematic policy in two institutions between January 2005 and May 2010. Tumor response, time to progression (TTP), overall survival rate (OS) and grade 3-4 toxicities were retrospectively studied. Subgroup analyses were performed to search for prognostic factors. RESULTS: Sixty-three patients (52.4% male, median age 59 years) were analyzed. Among them, 42.9% were PS 0, 38.1% were PS 1 and 19.0% were PS 2. Fifty one patients (81.0%) had liver metastases. Before the FOLFIRI regimen, patients had received 1 line (n = 19), 2 lines (n = 39) or 3 lines (n = 5) of chemotherapy. Median TTP obtained with the line before FOLFIRI was 3.9 mo (95% CI: 3.4-5.3 mo). A total of 480 cycles was completed (median: 6 cycles, range: 1-51 cycles). The main reason for discontinuing FOLFIRI was tumor progression (90.3%). Tumor control was achieved in 25 patients (39.7%) (partial response: n = 5, stable disease: n = 20) with FOLFIRI. Median TTP was 3.0 mo (95% CI: 2.1-3.9 mo) and median OS was 6.6 mo (95% CI: 5.3-8.1 mo). Dose adaptation was required in 36 patients (57.1%). Fifteen patients (23.8%) had grade 3-4 toxicities, mainly hematological (n = 11) or digestive (n = 4). Febrile neutropenia occurred in 3 patients. There was no toxic death. PS 2 was significantly associated with poor TTP [hazard ratio (HR): 16.036, P < 0.0001] and OS (HR: 4.003, P = 0.004). CONCLUSION: The FOLFIRI regimen had an acceptable toxicity and an interesting efficacy in our study, limited to patients in good condition (PS 0-1). | Cindy Neuzillet Olivia Hentic Benot Rousseau Vinciane Rebours Léla Bengrine-Lefèvre Franck Bonnetain Philippe Lévy Eric Raymond Philippe Ruszniewski Christophe Louvet Pascal Hammel | 2012 | World Journal of Gastroenterology2012，18，33： | 3 |
| 2 | Short bowel syndrome and crohn’s disease显示文摘 | Jon S Thompson Kishore R Iyer John K DiBaise Renee L Young Cindy R Brown Alan N Langnas | 2003 | Journal of Gastrointestinal Surgery2003，，8： | 1 |
| 3 | Depression anxiety and quality of life in patients with epithelial ovarian cancer 显示文摘 | Diane Bodurka Bevers Karen Basen Engquist Cindy L Carmack | 2000 | Gynecologic oncology2000，78，3： | 1 |
| 4 | Comparison of Total Hip Arthroplasty performed with and without cement:a randomized trial显示文摘 | Andreas L Robert B Cecil Ik David F Peter T Cindy W | 2002 | J Bone Joint Surg Am2002，84，10： | 1 |
| 5 | MBR application will gain in popularity显示文摘 | Cindy W L James L B | 2001 | H2O MBR Special2001，12，6： | 1 |
| 6 | Endophytic bacteria and their potential applications显示文摘 | Cindy L Jaco V Fiona P | 2002 | Crit Rev Plant Sci2002，21，： | 1 |
| 7 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 8 | Oral car in the adult intensive care unit显示文摘 | Julie A Fitch Cindy L Munro Connie A Glass | 1999 | Am J Crit Care1999，8，5： | 1 |
| 9 | Benefits and risks of abeiximab use in primary angiopalasty for acute myocaniial infarction显示文摘 | James E David E Cindy L | 2003 | Circulation2003，108，11： | 1 |
| 10 | Chlorhexidine,tooth-brushing* and preventing ventilator-associated pneumonia incritically ill adults显示文摘 | Cindy L Mary Jo Deborah J | 2009 | Am J Crit Care2009，18，5： | 1 |
| 11 | Comparison of primary and facilitated percutaneous coronary interventions for ST-elevation myocardial infaretion: quantitative review of randomised trials 显示文摘 | Ellen C Keeley Judith A Boura Cindy L Grines | 2006 | Laneet2006，367，9510： | 1 |
| 12 | Impact of nephropathy after percutaneous coronary intervention and a method for risk stratification显示文摘 | Beth A Bartholomew Kishore J Harjai Srinivas Dukkipati Judith A Boura Michael W Yerkey Susan Glazier Cindy L Grines William W O’Neill | 2004 | The American Journal of Cardiology2004，，12： | 1 |
| 13 | Development and psychometric testing of the Breastfeeding Self-Efficany Scale显示文摘 | Cindy L D Sandra F | 1999 | Res Nurs Health1999，22，5： | 1 |
| 14 | Oral health and care in the intensive care unit:state of the science显示文摘 | Cindy L Munro Mary Jo Grap Ruth Kleinpell | 2004 | Am J Crit Care2004，13，1： | 1 |
| 15 | Oral health and care in the intensive care unit: state of scienee显示文摘 | Cindy L Munro Mary Jo Grap Ruth Kleinpell | 2004 | Am J Crit Care2004，13，1： | 1 |
| 16 | Comparative study of the radiosensitising and cell cycle effects of vinflunine and vinorelbine, in vitro显示文摘 | Cindy S Filip L Bea P | 2008 | BMC Cancer2008，8，： | 1 |
| 17 | Benefits and risks of abciximab use in primary angioplasty for acute myocardial infarction显示文摘 | James E David E Cindy L et at | 2003 | Circulation2003，108，11： | 1 |
| 18 | Relative bioavailability of β-carotene from supplement sources显示文摘 | Cindy J Fuller Dale N Butterfoss Mark L Failla | 2001 | Nutrition Research2001，21，： | 1 |
| 19 | Comparative study of the radiosen-sitising and cell cycle effects of vinflunine and vinorelbine,in vitro显示文摘 | Cindy S Filip L Bea P | 2008 | BMC Cancer2008，8，： | 1 |
| 20 | Is This Review Believable? A Study of Factors Affecting the Credibility of Online Consumer Reviews from an ELM Perspective显示文摘 | Cheung M Y Cindy M Y Sia C L | 2012 | Journal of the Association for Information Systems2012，13，8： | 1 |
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