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| 1 | The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis显示文摘Exosomes 是 endocytic 起源的 nanoparticles,由由他们调制 cell-to-cell 通讯的能力的优点正在吸引增加的注意的无数房间人口藏匿了。他们也在许多免疫学的问题正在吸引注意,包括 autoimmunity 和,特别地调整 cytokine 和 chemokine 激活的他们的能力。主要胆汁的肝硬化(PBC ) 被认为一个模型自体免疫疾病,它对胆汁的上皮的房间有高度集中的细胞毒素的回答。我们与 PBC 和 30 健康控制(HC ) 从 29 个病人从血浆孤立 exosomes,并且用一个前 vivo 系统在 mononuclear 房间人口在 co-stimulatory 分子表示和 cytokine 生产上学习了这些 exosomes 的效果。我们也与 HC exosomes 相比在 PBC 识别了 microRNA (miRNA ) 人口。我们此处报导尽管 exosomes 不改变 cytokine 生产,他们显著地确实在介绍抗原的人口上改变 co-stimulatory 分子表示。进一步,我们在 CD14 + 单核白血球上表明了那 CD86 起来调整的表情,而在 CD11c + 上起来调整的 CD40 由从有 PBC 的病人的 exosomes 的树枝状的房间。另外,有在有 PBC 的病人的传播 exosomes 的 miRNA 表示的差别。这些数据基于 co-stimulatory 分子玩的观察有重要重要性在 T 房间激活的规定的一个微分角色。我们的观察显示从 PBC 的异常 exosomes 有选择地在介绍抗原的房间的不同子集导致 co-stimulatory 分子的表示。这些改变可以在自体免疫的肝疾病的致病包含。 | Takashi Tomiyama Guo-Xiang Yang Ming Zhao Weici Zhang Hajime Tanaka Jing Wang Patrick SC Leung Kazuiclli Okazaki Xiao-Song He Qianjin Lu Ross L Coppel Christopher L Bowlus M Eric Gershwin | 2017 | Cellular & Molecular Immunology2017，14，3： | 18 |
| 2 | Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one- compound peptide libraries显示文摘one-bead-one-compound (OBOC ) 组合的肽图书馆是一个强大的工具识别 ligand 和受体相互作用。这里,我们使用了 OBOC 图书馆技术识别对主要贝壳变应原 tropomyosin 的免疫球蛋白 E (IgE ) epitopes 特定的 mimotopes。有 8-12 氨基酸残余的 OBOC 肽图书馆为 tropomyosin 的 IgE mimotopes 与贝壳过敏症从病人与浆液样品被屏蔽。25 mimotopes 从屏蔽被识别,他们到 tropomyosin 特定的 IgE 的有约束力的反应被肽 ELISA 证实。这些 mimotopes 能基于顺序相同被划分成七簇,并且由聚类的 mimotopes 的 EpiSearch 印射的 epitope 被执行描绘并且证实 mimotopes 的有效性。五从六预言的 epitopes 被发现与 tropomyosin 的以前识别的 epitopes 重叠。为了推进,证实 mimotopes 的模仿潜力, BALB/c 老鼠被使免疫, mimotopes 结合了到锁眼恋栈者 hemocyanin 和 assayed 让他们的能力导致 tropomyosin 特定的抗体。那收到的 mimotope 免疫被发现有 tropomyosin 特定的免疫球蛋白 G 的提高的水平的 BALB/c 老鼠,然而并非收到了无关的 mimotope 的老鼠。这研究用整个 sera 开创 OBOC 图书馆的成功的申请屏蔽并且识别多重虾变应原 mimotopes 并且验证他们在 vitro 使用的模仿潜力,在 vivo,并且在 silico 方法。 | Nicki YH Leung Christine YY Wai Marco HK Ho Ruiwu Liu Kit S Lam Jin Jun Wang Shang An Shu Ka Hou Chu Patrick SC Leung | 2017 | Cellular & Molecular Immunology2017，14，3： | 6 |
| 3 | Xenobiotics and loss of tolerance in primary biliary cholangitis显示文摘Data from genome wide association studies and geoepidemiological studies established that a com-bination of genetic predisposition and environmental stimulation is required for the loss of tolerance in primary biliary cholangitis(PBC).The serologic hallmark of PBC are the presence of high titer anti-mitochondrial autoantibodies(AMA)that recognize the lipoyl domain of the mitochondrial pyruvate dehydrogenase E2(PDC--E2)subunit.Extensive efforts have been directed to investigate the molecular basis of AMA.Recently,experimental data has pointed to the thesis that the breaking of tolerance to PDC--E2 is a pivotal event in the initial etiology of PBC,including environmental xenobiotics including those commonly found in cos-metics and food additives,suggesting that chemical modification of the PDC--E2 epitope may render its vulnerable to become a neo-antigen and trigger an immune response in genetically susceptible hosts.Here,we will discuss the natural history,genetics and immunobiology of PBC and structural constraints of PDC--E2 in AMA recognition which makes it vulnerable to chemical modification. | Jinjun Wang Guoxiang Yang Alana Mari Dubrovsky Jinjung Choi Patrick SC Leung | 2016 | World Journal of Gastroenterology2016，22，1： | 4 |
| 4 | 急性儿茶酚胺暴露引起可逆的无心脏细胞再生的心肌细胞损伤显示文摘儿茶酚胺增加心脏收缩力,但暴露于高浓度儿茶酚胺或长时间暴露可引起心脏损伤。最近的一项研究表明,小鼠单次皮下注射异丙肾上腺素(isoproterenol,ISO;200 mg/kg)导致急性心肌细胞死亡(8%-10%),但在1个月之内心脏完整修复。心脏再生是通过内源性原癌基因蛋白质cKit+心脏干细胞介导新的心肌细胞形成。 | 刘莉 叶鹏 Wallner M Duran JM Mohsin S Troupes CD Vanhoutte D Borghetti G Vagnozzi RJ Gross P Yu D Trappanese DM Kubo H Toib A Sharp TE Harper SC Volkert MA Starosta T Feldsott EA Berretta RM Wang T Barbe MF Molkentin JD Houser SR | 2016 | 中华高血压杂志2016，24，8： | 4 |
| 5 | Experimental study of gold distribution in the algae-organic matter-fluid system显示文摘THE previous simulating experiments show that many algae can greatly accumulate goldfrom solution under some conditions. Some other experiments further indicate that organ-ic matter and crude oil can also play an important role in gold geochemistry processes such asleaching, migration, reduction and precipitation. However, these biometallogeneses are | Xie, SC Yin, HF Wang, HM Zhou, XG Fu, JM Sheng, GY Zhang, HZ Lu, JL | 1997 | Chinese Science Bulletin1997，42，19： | 3 |
| 6 | Upregulation of IKKalpha/IKKbeta by integrin-linked kinase is required for HER2/neu-induced NF-kappaB antiapoptotic pathway 显示文摘 | Makino K Day CP Wang SC | 2004 | Oncogene2004，23，21： | 2 |
| 7 | Temporal changes in proton MRS metabolites after kainic acid-induced seizures in rat brain 显示文摘 | Najm IM Wang Y Hong SC | 1997 | Epilepsia1997，38，1： | 1 |
| 8 | Preliminary development and testing of instru- ments to measure self-care agency and social support of women in tal- wan显示文摘 | Wang HH Laffrey SC | 2000 | Kaohsiung J Med Sci2000，16，9： | 1 |
| 9 | Upregulation of IKKa/IKKb by integrin-linked kinase is required for HER2/neu-induced NF-jB antiapoptoticpathway显示文摘 | Makino K Day CP Wang SC | 2004 | Oncogene2004，23，21： | 1 |
| 10 | Preliminary study on biomechanics of vertebroplasty - A computational fluid dynamics and solid mechanics combined approach 显示文摘 | Teo J Wang SC Teoh SH | 2007 | Spine2007，32，12： | 1 |
| 11 | Modeling tracer trans- port in an osteon under cyclic loading显示文摘 | Wang L Cowin SC Weinbaum S | 2000 | Ann Biomed Eng2000，28，10： | 1 |
| 12 | Secondary structure of mitochondrial 12S rRNA among fish and its phylogenetic applications 显示文摘 | Wang HY Lee SC | 2002 | Mol Biol Evol2002，19，2： | 1 |
| 13 | Preparation and structural analysis of sulfated derivatives of lentinan 显示文摘 | Wang SC Fang JN | 1999 | Acta Biochem Biophys Sin1999，31，5： | 1 |
| 14 | Is previous abdominal surgery a contraindication to laparoscopic cholecystectomy? 显示文摘 | Yu SC Chen SC Wang SM | 1994 | J Lapa- roendosc Surg1994，4，11： | 1 |
| 15 | Evaluation of serum autoantibody levels in the diagnosis of ovarian endometrioma显示文摘 | Yi YC Wang SC Chao CC | | 0，，5： | 1 |
| 16 | Emergence of extensive- ly drug-resistant Acinetobacter baurnannii complex over 10 years:Nationwide data from the Taiwan Surveillance of Anti- microbial Resistance (TSAR) program显示文摘 | Kuo SC Chang SC Wang HY etal | 2012 | BMC Infect Dis2012，28，12： | 1 |
| 17 | Multiple resuscitation regimens in a near-fatal porcine aortic injury hemorrhage model显示文摘 | Stern SA Dronen SC Wang X | 1995 | Acad Emerg Med1995，2，2： | 1 |
| 18 | Predictors for and impact of high peritonitis rate in Taiwanese continuous ambulatory per- itoneal dialysis patients显示文摘 | Hsieh YP Chnag CC Wang SC et 01 | 2015 | Int Urol Nephrol2015，47，1： | 1 |
| 19 | Inhibitory effect of digoxin on testosterone secretion through mechanisms involving decreases of cyclic AMP production and cytochrome P450scc activity in rat testicular interstitial ceils 显示文摘 | Lin H Wang SW Tsai SC | 1998 | BrJ Pharmacol1998，125，8： | 1 |
| 20 | Nuclear EGFR is required for cisplatin resistance and DNA repair显示文摘 | Hsu SC Miller SA Wang Y | 2009 | Am J Transl Res2009，1，3： | 1 |
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