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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Liver stiffness reversibly increases during pregnancy and independently predicts preeclampsia显示文摘AIM To study liver stiffness(LS) during pregnancy and its association with complications during pregnancy.METHODS In this observational, diagnostic study, 537 pregnant women were prospectively enrolled at the Department of Obstetrics and Gynecology, University hospital Heidelberg and Salem Medical Center. LS was measured using the Fibroscan device(Echosens, Paris) in all women and in 41 cases 24 h after delivery. Clinical and morphological data were recorded and abdominal ultrasound and standard laboratory tests were performed. No complications were observed in 475 women(controls) while preeclampsia and intrahepatic cholestasis of pregnancy(ICP) developed in 22 and 40 women, respectively.RESULTS In controls, LS increased significantly from initially 4.5 ± 1.2 kPa in the second trimester to 6.0 ± 2.3 kPa(P < 0.001) in the third trimester. In the third trimester, 41% of women had a LS higher than 6 kPa. Elevated LS in controls was significantly correlated with alkaline phosphatase, leukocytes, gestational age and an increase in body weight and body mass index(BMI). In women with pregnancy complications, LS was significantly higher as compared to controls(P < 0.0001). Moreover, in multivariate analysis, LS was an independent predictor for preeclampsia with an odds ratio of 2.05(1.27-3.31) and a cut-off value of 7.6 kPa. In contrast, ICP could not be predicted by LS. Finally, LS rapidly decreased in all women within 24 h after delivery from 7.2 ± 3.3 kPa down to 4.9 ± 2.2 kPa(P < 0.001).CONCLUSION During pregnancy, LS significantly and reversibly increases in the final trimester of pregnant women without complications. In women with preeclampsia, LS is significantly elevated and an independent noninvasive predictor. | Franziska J Ammon Anna Kohlhaas Omar Elshaarawy Johannes Mueller Thomas Bruckner Christof Sohn Gabriele Fluhr Herbert Fluhr Sebastian Mueller | 2018 | World Journal of Gastroenterology2018，24，38： | 2 |
| 3 | Distinct Types of Tumor-Initiating Cells Form Human Colon Cancer Tumors and Metastases显示文摘 | Sebastian M. Dieter Claudia R. Ball Christopher M. Hoffmann Ali Nowrouzi Friederike Herbst Oksana Zavidij Ulrich Abel Anne Arens Wilko Weichert Karsten Brand Moritz Koch Jürgen Weitz Manfred Schmidt Christof von Kalle Hanno Glimm | 2011 | Cell Stem Cell2011，，4： | 2 |
| 4 | Hypertonic hyperoncotic solutions reduce the release of cardiac troponin Ⅰ and S-100 after successful cardiopulmonary resuscitation in pigs 显示文摘 | Heiner K Christof D Christoph J | 2002 | Anesth Analg2002，95，： | 1 |
| 5 | Dual antibiotic loaded bone cement in patients at high infection risks in arthroplasty: Rationale of use for prophylaxis and scientific evidence显示文摘In view of the demographic changes and projected increase of arthroplasty procedures worldwide,the number of prosthetic joint infection cases will naturally grow.Therefore,in order to counteract this trend more rigid rules and a stricter implementation of effective preventive strategies is of highest importance.In the absence of a'miracle weapon'priorities should lie in evidence-based measures including preoperative optimization of patients at higher infection risks,the fulfilment of strict hygiene rules in the operating theatre and an effective antibiotic prophylaxis regimen.Instead of a'one size fits all'philosophy,it has been proposed to adjust the antibiotic prophylaxis protocol to major infection risks taking into account important patient-and procedure-related risk factors.A stronger focus on the local application mode via use of high dose dual antibioticloaded bone cement in such risk situations may have its advantages and is easy to apply in the theatre.The more potent antimicrobial growth inhibition in vitro and the strong reduction of the prosthetic joint infection rate in risk for infection patients with aid of dual antibiotic-loaded bone cement in clinical studies align with this hypothesis. | Christof Ernst Berberich Jérome Josse Frédéric Laurent Tristan Ferry | 2021 | World Journal of Orthopedics2021，12，3： | 1 |
| 6 | Distinct Types of Tumor-Initiating Cells Form Human Colon Cancer Tumors and Metastases显示文摘 | Sebastian M. Dieter Claudia R. Ball Christopher M. Hoffmann Ali Nowrouzi Friederike Herbst Oksana Zavidij Ulrich Abel Anne Arens Wilko Weichert Karsten Brand Moritz Koch Jürgen Weitz Manfred Schmidt Christof von Kalle Hanno Glimm | 2011 | Cell Stem Cell2011，，4： | 1 |
| 7 | Technical advances in digital audio radio broadcasting显示文摘 | CHRISTOF F BIING-HWANG J | 2002 | Proceeding of the IEEE2002，90，8： | 1 |
| 8 | Absolute interferometric test of aspheres by use of twin computer-generated holograms 显示文摘 | STEPHAN R CHRISTOF P TIZIANI H J | 2003 | Applied Optics2003，42，22： | 1 |
| 9 | Bridging the Adoption Gap Developing a Roadmap for Trading in Grids显示文摘 | Neumann D Christof Weinhardt J S | 2008 | Electronic Markets2008，18，1： | 1 |
| 10 | Myosin-V is a mechanical racket显示文摘 | Christof J Gebhardt M Anabel EM | 2006 | Proc Natl Acad Sci2006，103，： | 1 |
| 11 | CD24 polymorphisms in breast cancer: impact on prognosis and risk显示文摘 | Katharina Buck Sarah Hug Petra Seibold Irmgard Ferschke Peter Altevogt Christof Sohn Andreas Schneeweiss Barbara Burwinkel Dirk J?ger Dieter Flesch-Janys Jenny Chang-Claude Frederik Marmé | 2013 | Breast Cancer Research and Treatment2013，，3： | 1 |
| 12 | Particle deposition velocity onto a face-up flat surface in a laminar parallel flow considering Brownian diffusion and gravitational settling显示文摘 | Se J Y Christof A Kang H A | 2010 | Journal of Aerosol Science2010，41，6： | 1 |
| 13 | Evaluation of Virtual Touch Tissue Imaging Quantification, a New Shear Wave Velocity Imaging Method, for Breast Lesion Assessment by Ultrasound显示文摘 | Michael Golatta Mirjam Schweitzer-Martin Aba Harcos Sarah Schott Christina Gomez Anne Stieber Geraldine Rauch Christoph Domschke Joachim Rom Florian Schütz Christof Sohn J?rg Heil Hui-Xiong Xu | 2014 | BioMed Research International2014，，： | 1 |
| 14 | Hypertonic hyperoncotic solations reduce the release of cardiac troponin Ⅰ and S - 100 after successful cardiopulmonary resuscitation in pigs 显示文摘 | Heiner K Christof D Christoph J | 2002 | Anesth Analg2002，95，： | 1 |
| 15 | Diagnostic value of pelvic examination,ultrasound,and Serum CA125 in postmenopausal women with a pelvic mass:An International Multicenter Study显示文摘 | PETER KENEMANS CHRISTOF SOHN | 1994 | Cancer1994，74，： | 1 |
| 16 | Polymerse chain reaction in the detection of micrometastasises显示文摘 | CHRISTOF J ROTERN D | 2000 | J Urol2000，6，1： | 1 |
| 17 | Complete resequencing and reannotation of the Lactobacillus plantarum WCFS1 genome显示文摘 | Roland J Siezen Christof Francke Bernadet Renekens | 2012 | Journal of Bacteruology2012，194，1： | 1 |
| 18 | Myosin-V isl a mechanical racket显示文摘 | Christof J Gebhardt M Anabel EM | 2006 | Proc Natl Acad Sci2006，103，： | 1 |
| 19 | ‘Observations and Modelling of Cold-air Advection over Arctic Sea Ice’显示文摘 | Timo Vihma Christof Lüpkes J?rg Hartmann Hannu Savij?rvi | 2005 | Boundary - Layer Meteorology2005，，2： | 1 |
| 20 | SAP HANA database显示文摘 | Franz F?rber Sang Kyun Cha Jürgen Primsch Christof Bornh?vd Stefan Sigg Wolfgang Lehner | 2012 | ACM SIGMOD Record2012，，4： | 1 |
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