|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | De-oncogenic HPV E6/E7 vaccine gets enhanced antigenicity and promotes tumoricidal synergy with cisplatin显示文摘以便与高风险的人的乳头状瘤病毒(HPV ) 对癌症开发更有效的治疗学的疫苗感染,它对关键提高 immunogenicity,消除 oncoproteins 的 oncogenicity,并且拿包含 E7 和包含 E6 疫苗的联合。它最近被看了那 PE ( III ) -E7-KDEL3 ( E7 ),包含 HPV16 oncoprotein E7 的熔化蛋白质和 Pseudomonas aeruginosa 外毒素 A 的 translocation 域,对因此,在鼠标接种的 TC-1 肿瘤房间是有效的我们设计了 PE ( III ) -E6-CRL-KDEL3 ( E6 ), E7 和 E6 熔化蛋白质的 de-oncogenic 版本[即 PE ( III )-E7(d)-KDEL3, E7 (d),和 PE ( III )-E6(d)-CRL-KDEL3, E6 (d)]并且作为单音测试了这些熔化蛋白质的 immunoefficacies --并且二原子价的疫苗。结果比它的野类型和 E6 熔化蛋白质扩充他们的 E7 对应物的 immunogenicity 和 antitumor 效果的显示 E7 (d) 得到更高的 immunogenicity。而且,面对 cisplatin,加 E6 (d) 的二原子价的疫苗的系统 E7 (d) 在 vivo 对确定的肿瘤显示出最好的 tumoristatic 和 tumoricidal 效果。因此,在进一步的优化之上,这个新奇治疗学的疫苗的系统可以在 HPV 相关的癌的临床的管理上打开新灯,这能被结束。 | Shaochun Chen Chaowei Liao Yiukay Lai Yan Fan Gang Lu Hua Wang Xiaoai Zhang Marie C.M. Lin Shuilong Leng Hsiang-Fu Kung | 2014 | Acta Biochimica et Biophysica Sinica2014，46，1： | 3 |
| 2 | Magnetic beads-based bioelectrochemical immunoassay of polycyclic aromatic hydrocarbons显示文摘 | Ying-Ying Lin Guodong Liu C.M. Wai Yuehe Lin | 2007 | Electrochemistry Communications2007，，7： | 1 |
| 3 | Suppression of FHL2 Expression Induces Cell Differentiation and Inhibits Gastric and Colon Carcinogenesis显示文摘 | Jide Wang Yi Yang Harry H.X. Xia Qing Gu Marie C.M. Lin Bo Jiang Ying Peng Guoqing Li Xiaomeng An Yali Zhang Zehao Zhuang Zhenshu Zhang Hsiang Fu Kung Benjamin C.Y. Wong | 2007 | Gastroenterology2007，，3： | 1 |
| 4 | Suppressing tumor growth of nasopharyngeal carcinoma by hTERTC27 polypeptide delivered through adeno-associated virus plus adenovirus vector cocktail显示文摘Nasopharyngeal carcinoma(NPC) is a metastatic carcinoma that is highly prevalent in Southeast Asia. Our laboratory has previously demonstrated that the C-terminal 27-kDa polypeptide of human telomerase reverse transcriptase (hTERTC27) inhibits the growth and tumorigenicity of human glioblastoma and melanoma cells. In this study, we investigated the antitumor effect of hTERTC27 in human C666-1 NPC cells xenografted in a nude mouse model. A cocktail of vectors comprising recombinant adeno-associated virus (rAAV) and recombinant adenovirus (rAdv) that each carry hTERTC27 (rAAV-hTERTC27 and rAdv- hTERTC27; the cocktail was abbreviated to rAAV/rAdv-hTERTC27) was more effective than either rAAV- hTERTC27 or rAdv-hTERTC27 alone in inhibiting the growth of C666-1 NPC xenografts. Furthermore, we established three tumors on each mouse and injected rAAV/rAdv-hTERTC27 into one tumor per mouse. Although hTERTC27 expression could only be detected in the injected tumors, reduced tumor growth was observed in the injected tumor as well as the uninjected tumors, demonstrating that the vector cocktail could provoke an antitumor effect on distant, metastasized tumors. Further studies showed the observed antitumor effects included inducing necrosis and apoptosis and reducing microvessel density. Together, our data suggest that the rAAV/rAdv-hTERTC27 cocktail can potently inhibit NPC tumor growth in both local and metastasized tumors and should be further developed as a novel gene therapy strategy for NPC. | Xiong Liu Xiang-Ping Li Ying Peng Samuel S.Ng Hong Yao Zi-Feng Wang Xiao-Mei Wang Hsiang-Fu Kung Marie C.M. Lin | 2012 | Chinese Journal of Cancer2012，31，12： | 1 |
| 5 | Sieving through the cancer secretome显示文摘 | Qifeng Lin Hwee Tong Tan Hannah Soo Rei Lim Maxey C.M. Chung | 2013 | BBA - Proteins and Proteomics2013，，： | 1 |
| 6 | H ∞ 2DOF control for the motion of a magnetic suspension positioning stage driven by inverter-fed linear motor显示文摘 | B.J. Kang L.S. Hung S.K. Kuo S.C. Lin C.M. Liaw | 2003 | Mechatronics2003，，7： | 1 |
| 7 | Revisit the complexation of PEI and DNA — How to make low cytotoxic and highly efficient PEI gene transfection non-viral vectors with a controllable chain length and structure?显示文摘 | Rui Deng Yanan Yue Fan Jin Yangchao Chen Hsiang-Fu Kung Marie C.M. Lin Chi Wu | 2009 | Journal of Controlled Release2009，，1： | 1 |
| 8 | 查看详情显示文摘 | Xu Z.H Li C.X Yang P.P Zhang C.M. Huang S.S. Lin J | | 0，，： | 1 |
| 9 | Heart extracellular matrix supports cardiomyocyte differentiation of mouse embryonic stem cells显示文摘 | Sayaka Higuchi Qingsong Lin Jigang Wang Teck Kwang Lim Shashikant B. Joshi Ganesh Srinivasan Anand Maxey C.M. Chung Michael P. Sheetz Hideaki Fujita | 2012 | Journal of Bioscience and Bioengineering2012，，： | 1 |
| 10 | The study of energy-saving strategy for direct expansion air conditioning system显示文摘 | C.B. Chiou C.H. Chiou C.M. Chu S.L. Lin | 2008 | Energy & Buildings2008，，9： | 1 |
| 11 | 拉曼散射研究微尺寸圆锥形状的GeSi合金薄膜的应力(英文)显示文摘We present the micro-Raman study of curved Ge_xSi_ 1-x/Ge_ySi_ 1-y heterostructure, and found the strain of the curved thin layer is proportional to the curvature, i.e. inversely proportional to the diameter. | C.M. Lin C.T. Chia V. I. Mashanov H.H. Cheng | 2005 | 光散射学报2005，17，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员