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| 1 | Transcranial Doppler ultrasonography: From methodology to major clinical applications显示文摘Non-invasive Doppler ultrasonographic study of cerebral arteries [transcranial Doppler(TCD)] has been extensively applied on both outpatient and inpatient settings. It is performed placing a low-frequency(≤ 2 MHz) transducer on the scalp of the patient over specific acoustic windows, in order to visualize the intracranial arterial vessels and to evaluate the cerebral blood flow velocity and its alteration in many different conditions. Nowadays the most widespread indication for TCD in outpatient setting is the research of right to left shunting, responsable of so called 'paradoxical embolism', most often due to patency of foramen ovale which is responsable of the majority of cryptogenic strokes occuring in patients younger than 55 years old. TCD also allows to classify the grade of severity of such shunts using the so called 'microembolic signal grading score'. In addition TCD has found many useful applications in neurocritical care practice. It is useful on both adults and children for day-to-day bedside assessment of critical conditions including vasospasm in subarachnoidal haemorrhage(caused by aneurysm rupture or traumatic injury), traumatic brain injury, brain stem death. It is used also to evaluate cerebral hemodynamic changes after stroke. It also allows to investigate cerebral pressure autoregulation and for the clinical evaluation of cerebral autoregulatory reserve. | Antonello D'Andrea Marianna Conte Massimo Cavallaro Raffaella Scarafile Lucia Riegler Rosangela Cocchia Enrica Pezzullo Andreina Carbone Francesco Natale Giuseppe Santoro Pio Caso Maria Giovanna Russo Eduardo Bossone Raffaele Calabrò | 2016 | World Journal of Cardiology2016，8，7： | 10 |
| 2 | A Novel Gaussian Extrapolation Approach for 2D Gel Electrophoresis Saturated Protein Spots显示文摘Analysis of images obtained from two-dimensional gel electrophoresis (2D-GE) is a topic of utmost importance in bioinformatics research, since commercial and academic software available currently has proven to be neither completely effective nor fully automatic, often requiring manual revision and refinement of computer generated matches. In this work, we present an effective technique for the detection and the reconstruction of over-saturated protein spots. Firstly, the algorithm reveals overexposed areas, where spots may be truncated, and plateau regions caused by smeared and overlapping spots. Next, it reconstructs the correct distribution of pixel values in these overexposed areas and plateau regions, using a two-dimensional least-squares fitting based on a generalized Gaussian distribution. Pixel correction in saturated and smeared spots allows more accurate quantification, providing more reliable image analysis results. The method is validated for processing highly exposed 2D-GE images, comparing reconstructed spots with the corresponding non-saturated image, demonstrating that the algorithm enables correct spot quantification. | Massimo Natale Alfonso Caiazzo Enrico M. Bucci Elisa Ficarra | 2012 | Genomics, Proteomics & Bioinformatics2012，10，6： | 2 |
| 3 | FunMod: A Cytoscape Functional Modules in Networks Plugin for Identifying Undirected Protein-Protein显示文摘 | Massimo Natale Alfredo Benso Stefano Di Carlo Elisa Ficarra | 2014 | Genomics, Proteomics & Bioinformatics2014，12，4： | 1 |
| 4 | CT colonography after incomplete colonoscopy in subjects with positive faecal occult blood test显示文摘AIM: To report our experience with computed tomog- raphy colonography (CTC) systematically performed in subjects with positive faecal occult blood test (FOBT) and an incomplete colonoscopy in the setting of a population-based screening for colorectal cancer (CRC). METHODS: From April 2006 to April 2007, 43 290 indi- viduals (age range 50-70) who adhered to the regional screening program for the prevention of CRC under-went immunochemical FOBT. FOBT was positive in 1882 subjects (4.3%). 1463 (77.7%) of these subjects underwent colonoscopy, 903 performed in a single center. Of 903 colonoscopies 65 (7.2%) were incom- plete. Forty-two of these subjects underwent CTC. CTC was performed with a 16-MDCT scanner after standard bowel prep (polyethyleneglycole) in both supine and prone position. Subjects whose CTC showed polyps or masses were referred to the endoscopist for repeat colonoscopy under sedation or underwent surgery. Per-lesion and per-segment positive predictive values (PPV) were calculated. RESULTS: Twenty-one (50%) of 42 CTCs showed pol-yps or masses. Fifty-five of these subjects underwent a repeat colonoscopy, whereas 2 subjects underwentsurgery for colonic masses of indeterminate nature. Four subjects refused further examinations. CTC cor- rectly identified 2 colonic masses and 20 polyps. PPV for masses or polyps greater than 9 mm was of 87.5%. Per-lesion and per-segment PPV were, respectively, 83.3% and 83.3% for polyps greater or equal to 10 mm, and 77.8% and 85.7% for polyps of 6-9 mm. CONCLUSION: In the context of a screening program for CRC based on FOBT, CTC shows high per-segment and per-lesion PPV for colonic masses and polyps greater than 9 mm. Therefore, CTC has the potential to become a useful technique for evaluation of the non visualized part of the colon after incomplete colonos-copy. | Lapo Sali Massimo Falchini Andrea Giovanni Bonanomi Guido Castiglione Stefano Ciatto Paola Mantellini Francesco Mungai Ilario Menchi Natale Villari Mario Mascalchi | 2008 | World Journal of Gastroenterology2008，14，28： | 1 |
| 5 | Human chorionic gonadotropin patterns after a single dose of MTX for ectopic pregnancy显示文摘 | Andrea Natale Mauro Busacca Massimo Candiani | 2002 | European journal of Obstetrics & Gynecology and Reproductive Biology2002，100，： | 1 |
| 6 | Plasma levels of insulin and amyloid β42 are correlated in patients with amnestic Mild Cognitive Impairment显示文摘 | Patrizio Odetti Alessandra Piccini Luca Giliberto Roberta Borghi Alessia Natale Fiammetta Monacelli Monica Marchese Andrea Assini Monica Colucci Sergio Cammarata Massimo Tabaton | 2005 | Journal of Alzheimer’s Disease2005，，3： | 1 |
| 7 | Incremental value and safety of oral ivabradine for heart rate reduction in computed tomography coronary angiography显示文摘 | Andrea I. Guaricci Joanne D. Schuijf Filippo Cademartiri Natale Daniele Brunetti Deodata Montrone Erica Maffei Carlo Tedeschi Riccardo Ieva Luigi Di Biase Massimo Midiri Luca Macarini Matteo Di Biase | 2010 | International Journal of Cardiology2010，，1： | 1 |
| 8 | Antiarrhythmic Effect of Reverse Ventricular Remodeling Induced by Cardiac Resynchronization Therapy显示文摘 | Luigi Di Biase Maurizio Gasparini Maurizio Lunati Massimo Santini Maurizio Landolina Giuseppe Boriani Antonio Curnis Mario Bocchiardo Antonio Vincenti Alessandra Denaro Sergio Valsecchi Andrea Natale Luigi Padeletti | 2008 | Journal of the American College of Cardiology2008，，18： | 1 |
| 9 | Human c horionic gonadotropin patterns after a single dose of MTX for ectopic pregnancy显示文摘 | Andrea Natale Mauro Busacca Massimo Candiani | 2002 | European Journal of Obstetrics and Gynecology and Reproductive Biology2002，100，： | 1 |
| 10 | Cow's milk allergens identification by two-dimensional immunoblotting and mass spectrometry显示文摘 | Massimo Natale Carolina Bisson Giovanna Monti | 2004 | Molecular Nutrition & Food Research2004，48，5： | 1 |
| 11 | Clinical and procedural outcome of patients implanted with a quadripolar left ventricular lead: Early results of a prospective multicenter study显示文摘 | Giovanni B. Forleo Massimo Mantica Luigi Di Biase Germana Panattoni Domenico G. Della Rocca Lida P. Papavasileiou Matteo Santamaria Pasquale Santangeli Andrea Avella Domenico Sergi Luca Santini Claudio Tondo Andrea Natale Francesco Romeo | 2012 | Heart Rhythm2012，，11： | 1 |
| 12 | Clinical and procedural outcome of patients implanted with a quadripolar left ventricular lead: Early results of a prospective multicenter study显示文摘 | Giovanni B. Forleo Massimo Mantica Luigi Di Biase Germana Panattoni Domenico G. Della Rocca Lida P. Papavasileiou Matteo Santamaria Pasquale Santangeli Andrea Avella Domenico Sergi Luca Santini Claudio Tondo Andrea Natale Francesco Romeo | 2012 | Heart Rhythm2012，，11： | 1 |
| 13 | The heart in uremia:role of hypertension,hypotension,and sleep apnea显示文摘 | Natale G Massimo C Alesssandra MD | 2001 | J Am Kidney Diseases2001，38，： | 1 |
| 14 | Craving variations in patients with substance use disorder and gambling during COVID-19 lockdown:The Italian experience显示文摘BACKGROUND Following the development of the coronavirus disease-2019(COVID-19)pandemic in Italy,a strict lockdown was imposed from March 9 to May 5,2020.The risks of self-medication through alcohol or psychoactive substance abuse were increased,as well as the tendency to adopt pathological behaviors,such as gambling and internet addiction.AIM To evaluate the impact of the COVID-19 pandemic and associated containment measures on craving in a group of patients suffering from substance use disorder and/or gambling disorder who were in treatment in outpatient units or in residency programs as inpatients.METHODS One hundred and fifty-three patients completed a structured questionnaire evaluating craving and other behaviors using a visual analogue scale(VAS).Forty-one subjects completed a pencil and paper questionnaire during the interview.The clinician provided an online questionnaire to 112 patients who had virtual assessments due to lockdown restrictions.Statistical analyses were performed using Statistica version 8.0.Quantitative parameters are presented as the mean±SD and qualitative parameters as number and percentage per class.The Kolmogorov-Smirnov test was used to check for normality of distributions.Analysis of variance and Duncan post hoc test were employed to analyze differences among subgroup means.The associations between variables were measured using Pearson's correlation.A P value of<0.05 was considered significant.RESULTS The variation in craving between the present and the month before showed VASrelated reductions of craving in 57%,increases in 24%,and no significant change in 19%of the sample.The level of craving was significantly higher(F=4.36;P<0.05)in outpatients(n=97;mean=3.8±3.1)living in their own home during the quarantine compared with inpatients(n=56;mean=2.8±2.8)in residential programs.Craving for tetrahydrocannabinol was the greatest(4.94,P<0.001)among various preferred substances.CONCLUSION The unexpected result of this study may be explained by a perceived lack of availability of substances and gambling areas and/or decreased social pressure on a subject usually excluded and stigmatized,or the acquisition of a new social identity based on feelings of a shared common danger and fate that overshadowed the sense of exclusion and rejection in the abuser. | Maria Chiara Alessi Giovanni Martinotti Domenico De Berardis Antonella Sociali Chiara Di Natale Gianna Sepede Daniela Pia Rosaria Cheffo Laura Monti Pietro Casella Mauro Pettorruso Stefano Sensi Massimo Di Giannantonio | 2022 | World Journal of Clinical Cases2022，10，3： | 0 |
| 15 | New Software for the Identification and Characterization of Peptides Generated during Fontina Cheese Ripening Using Mass Spectrometry Data显示文摘 | Sabina Valentni Massimo Natale Elisa Ficarra Andrea Barmaz | 2012 | Journal of Chemistry and Chemical Engineering2012，6，4： | 0 |
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