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| 1 | β-Arrestin 1 and 2 and G protein-coupled receptor kinase 2 expression in pituitary adenomas:role in the regulation of response to somatostatin analogue treatment in patients with acromegaly显示文摘Recent in vitro studies highlighted G protein-coupled receptor kinase(GRK)2 andβ-arrestins as important players in driving somatostatin receptor(SSTR)desensitization and trafficking.Our aim was to characterize GRK2 andβ-arrestins expression in different pituitary adenomas and to investigate their potential role in the response to somatostatin analog(SSA)treatment in GHsecreting adenomas(GHomas).We evaluated mRNA expression of multiple SSTRs,GRK2,β-arrestin 1,andβ-arrestin 2 in 41pituitary adenomas(31 GHomas,6 nonfunctioning[NFPAs],and 4 prolactinomas[PRLomas]).Within the GHomas group,mRNA data were correlated with the in vivo response to an acute octreotide test and with the GH-lowering effect of SSA in cultured primary cells.β-Arrestin 1 expression was low in all 3 adenoma histotypes.However,its expression was significantly lower in GHomas | Gatto F Feelders R van der Pas R Kros JM Dogan F van Koetsveld PM van der Lelij AJ Neggers SJ Minuto F de Herder W Lamberts SW Ferone D Hofland LJ | 2013 | 中国神经肿瘤杂志2013，11，4： | 2 |
| 2 | Corticosteroid therapy in severe illness显示文摘 | Lamberts SW Bruining HA de Jong FH | 1997 | N Engl J Med1997，337，18： | 1 |
| 3 | Somatostatin analog therapy in treatment of gastrointes anal disorders and tumors显示文摘 | De Herder WW Lamberts SW | 2003 | Endocrine2003，20，3： | 1 |
| 4 | Polymorphisms in the glucocortieoid receptor gene and their associations with metabolic parameters and body composition 显示文摘 | van Rossum EF Lamberts SW | 2004 | Recent Prog Horm Res2004，59，： | 1 |
| 5 | Somatostatin receptors in the gastrointestinaltractinhealthand disease显示文摘 | Reubi JC Krenning EP Lamberts SW | 1992 | Yale J Biol Med1992，65，5： | 1 |
| 6 | Circulating IGF-1 and its protective role in the pathogeness of diabetic angiopathy显示文摘 | Janssen JA Lamberts SW | 2000 | Clin Endocrinol2000，52，1： | 1 |
| 7 | Octreotide 显示文摘 | Lamberts SW Van Der Lely A J de Herder WW | 1996 | N Engl J Med1996，334，4： | 1 |
| 8 | Familial glucocorticoid resistance caused by a splice site deletion in the human glucocorticoid receptor gene 显示文摘 | KARL M LAMBERTS SW DETERA-WADLEIGH SD | 1993 | J Clln Endocrinol Metab1993，76，3： | 1 |
| 9 | The endocrinology of aging 显示文摘 | Lamberts SW van den Beld AW van der Lely AJ | 1997 | Science1997，278，5337： | 1 |
| 10 | Somatostatin and dopamine receptors as targets for medical treatment of Cushing's Syndrome 显示文摘 | de Bruin C Feelders RA Lamberts SW | 2009 | Rev Endocr Metab Disord2009，10，2： | 1 |
| 11 | The endocrinology of aging显示文摘 | Lamberts SW van den Beld AW van der Lely AJ | 1997 | Science1997，278，： | 1 |
| 12 | The pathophysiological consequences of somatostatin receptor internalization and resistance显示文摘 | Hofland LJ Lamberts SW | | Endocr Rev0，24，1： | 1 |
| 13 | The use of SRSin the differential diagnosis of pancreatic duct cancers and isletcell tumours显示文摘 | Van Eijck CH Lamberts SW Lemaire LC | 1996 | Ann Surg1996，224，： | 1 |
| 14 | Hereditary glucocorticoid resistance显示文摘 | Lamberts SW | 2001 | Ann Endocrinol (Paris)2001，62，164： | 1 |
| 15 | Somatostatin receptor subtype expression in human tumors 显示文摘 | Hofland LJ Lamberts SW | 2001 | Ann Oneol2001，12，2： | 1 |
| 16 | Polymorphisms in the glu- cocortieoid receptor gene and their associations with metabolic pa- rameters and body composltion显示文摘 | VAN ROSSUM EF LAMBERTS SW | 2004 | Recent Prog Horm Res2004，59，： | 1 |
| 17 | Thyroid hormone concentrations,disease,physical function,and mortality in elderly men显示文摘 | van den Beld AW Visser TJ Feelders RA Grobbee DE Lamberts SW | 2005 | J Clin Endocrinol Metab2005，90，12： | 1 |
| 18 | Polymorphisms in the glucocorticoid receptor gene and their associations with metabolic parameters and body composition 显示文摘 | Van Rossum EF Lamberts SW | 2004 | Recent Prog Horm Res2004，59，： | 1 |
| 19 | Polymorphisms in the glucocorticoid receptor gene and their associations with metabolic parameters and body composition 显示文摘 | van Rossum EF Lamberts SW | 2004 | Recent Prog Horm Res2004，59，： | 1 |
| 20 | Metabolic,cardiovascular,and cerebrovascular outcomes in growth hormone-deficient subjects with previous cushing's disease or non-functioning pituitary adenoma显示文摘 | Webb SM Mo D Lamberts SW | | 0，，02： | 1 |
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