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| 1 | 血栓性血小板减少性紫癜患者vWF裂解蛋白酶抗原和活性的检测及意义显示文摘目的研究血管性血友病因子裂解蛋白酶(ADAMTS13)抗原含量和活性在血栓性血小板减少性紫癜(TTP)患者及遗传性 TTP 家族突变携带者中变化的情况。方法用残余胶原结合实验(RCBA)检测13例 TTP 患者共28份血浆标本[含血浆置换(PE)前后]及10例携带者的 ADAMTS13活性;用新近建立的三抗体夹心酶联免疫反应法检测标本的 ADAMTS13抗原含量。结果正常对照组 ADAMTS13含量为(600.93±145.36)mU/ml(设白种人混合血浆的 ADAMTS13抗原含量为1000mU/ml),活性为(74.79±11.81)%。遗传性 TTP 患者 ADAMTS13抗原含量和活性治疗前和发病间期均明显减低,PE 后恢复;其家族中携带者 ADAMTS13抗原含量为(331.40±109.85)mU/ml,活性为(66.79±12.82)%(与对照组比较,P 值分别<0.01和>0.05);原发性 TTP 患者 PE 前 ADAMTS13抗原含量为(98.7±82.08)mU/ml,活性为(22.23±19.07)%(与对照组比较,P 值均<0.01);PE 后ADAMTS13 抗原含量为(449.4±232.33)mU/ml,活性为(60.92±22.33)%(与对照组比较,P 值分别<0.01和>0.05);1例继发性 TTP 患者 PE 后 ADAMTS13抗原含量远高于正常,活性仅为6.00%结论治疗前的 TTP 患者 ADAMTS13抗原含量和活性均明显减低。大多数患者两指标变化趋势一致,也有个别患者两指标变化趋势相反,前者可能因为遗传因素或体内免疫系统的廓清作用,后者可能因为抗 ADAMTS13抗体仅抑制了 ADAMTS13的活性而未影响其抗原的含量或其他未知原因所致。 | 刘芳 BF Hendrik 董宁征 白霞 V Karen D Hans 阮长耿 | 2006 | 中华血液学杂志2006，27，3： | 10 |
| 2 | RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening显示文摘AIM To assess serum levels of RANK-ligand(RANKL) and osteoprotegerin(OPG) as biomarkers for periprosthetic joint infection(PJI) and compare their accuracy with standard tests.METHODS One hundred and twenty patients presenting with a painful total knee or hip arthroplasty with indication for surgical revision were included in this prospective clinical trial. Based on standard diagnostics(joint aspirate, microbiological, and histological samples) and Musculoskeletal Infection Society consensus classification,patients were categorized into PJI, aseptic loosening,and control groups. Implant loosening was assessed radiographically and intraoperatively. Preoperative serum samples were collected and analyzed for RANKL, OPG, calcium, phosphate, alkaline phosphatase(AP), and the bone-specific subform of AP(b AP). Statistical analysis was carried out, testing for significant differences between the three groups and between stable and loose implants. RESULTS All three groups were identical in regards to age, gender, and joint distribution. No statistically significant differences in the serum concentration of RANKL(P = 0.16) and OPG(P = 0.45) were found between aseptic loosening and PJI, with a trend towards lower RANKL concentrations and higher OPG concentrations in the PJI group. The RANKL/OPG ratio was significant for the comparison between PJI and non-PJI(P = 0.005). A ratio > 60 ruled out PJI in all cases(specificity: 100%, 95%CI: 89, 11% to 100.0%) but only 30% of non-PJI patients crossed this threshold. The positive predictive value remained poor at any cut-off. In the differentiation between stable and loose implants, none of the parameters measured(calcium, phosphate, AP, and b AP) showed a significant difference, and only AP and b AP measurements showed a tendency towards higher values in the loosened group(with P = 0.09 for AP and P = 0.19 for b AP). CONCLUSION Lower RANKL and higher OPG concentrations could be detected in PJI, without statistical significance. | Max J Friedrich Matthias D Wimmer Jan Schmolders Andreas C Strauss Milena M Ploeger Hendrik Kohlhof Dieter C Wirtz Sascha Gravius Thomas M Randau | 2017 | World Journal of Orthopedics2017，8，4： | 4 |
| 3 | Pseudomonas aeruginosa biofilm formation and slime excretion on antibiotic-loaded bone cement显示文摘 | Neut D Hendriks JG van Horn JR | 2005 | Acta Orthopaed2005，76，1： | 1 |
| 4 | The role of an- timullerian hormone in prediction of outcome after IVF: comparison with the antral follicle count显示文摘 | Broer SL Mol BW Hendriks D | 2009 | Fertil Ster- il2009，91，3： | 1 |
| 5 | Environmentally acceptable specialty lubricantsan interpretation of the environmental regulations of North Sea(world)显示文摘 | Stringfellow W D Jacobs N L Hendriks R V | 1993 | NLGI Spokesman1993，57，9： | 1 |
| 6 | Special points for Brillouin-zone intergrations显示文摘 | HENDRIK J MONKHORST PACK J D | 1976 | Phys Rev B1976，13，： | 1 |
| 7 | A systematic review of testspredicting ovarian reserve and IVF outcome显示文摘 | Broekmans F Kwee J Hendriks D | 2006 | Human Reprod Update2006，12，6： | 1 |
| 8 | Accumlation of organochlorines and brominated flame retardants in estuarine and marine food chains:Field measurements and model calculations显示文摘 | VELTMAN K HENDRIKS J HUIJBREGTS M LEONARDS P HEUVEL-GREVE M V D VETHAAK D | 2005 | Mar Pollut Bull2005，50，10： | 1 |
| 9 | Determination of Tetracycline Antibiotics in Cow's Milk by Liquid Chromatography/Tandem Mass Spectrometry显示文摘 | HENDRIK DR HERMAN D R | 2007 | Rapid Communications in Mass Spectrometry2007，21，： | 1 |
| 10 | Antral follicle count in the prediction of poor ovarian response and pregnancy after in vitro fertilization: a meta -analysis and comparison with basal follicle- stimulating hormone level 显示文摘 | Hendriks D J Mol BW Bancsi LF | 2005 | Fertil Steril2005，83，2： | 1 |
| 11 | A systematic review of tests predicting ovarian reserve and IVF outcome 显示文摘 | Broekmans FJ Kwee J Hendriks D J | 2006 | Hum Reprod Update2006，12，： | 1 |
| 12 | Antralfollicle count in the prediction of poor ovarian response and pregnancy after in vitro fertilization:ameta-analysis and comparison with basal folliclestimulating hormone level显示文摘 | Hendriks D J Mol BW Bancsi F J | 2005 | Fertil Steril2005，83，2： | 1 |
| 13 | Dynamis CO2 quality recommendations显示文摘 | Visser E D Hendriks C Barrio M | 2008 | International Journal o{ Green- house Gas Control2008，2，4： | 1 |
| 14 | Characterisation of a carboxypeptidase in human serum distinct from carboxypeptidase N显示文摘 | SCHARPé S van SANDE M | 1989 | J Clin Chem Clin Biochem1989，27，： | 1 |
| 15 | Root responses to nutrients and soil biota: drivers of species coexistence and ecosystem productivity显示文摘 | Kroon H D Hendriks M Ruijven J V | 2012 | Journal of Ecology2012，100，1： | 1 |
| 16 | Measurement of procarboxypeptidase U (TAFI) in human plasma: A laboratory challenge 显示文摘 | WILLEMSE J L HENDRIKS D F | 2006 | Clin Chem2006，52，： | 1 |
| 17 | Detection the influence of recombinant factor Ⅶa on coagulation by thromboelastography in liver transplantation显示文摘 | Hendriks H G D Meijer K Dewolf I T M | 2002 | Blood Coagulation and Fibrinolysis2002，13，4： | 1 |
| 18 | Survival and growth of western rock lobster Panulirus cygnus (George) fed formulated diets with and without fresh mussel supplement显示文摘 | JOHNSTON D MELVILLE-SMITH R HENDRIKS B | 2007 | Aquaculture2007，273，： | 1 |
| 19 | Levosimendan in early sepsis:when good ideas give poor results显示文摘 | Daniel D Hendrik B | 2009 | Anesth Analg2009，109，5： | 1 |
| 20 | Special points for Bril-louin-zone integrations 显示文摘 | Monkhorst Hendrik J Pack James D | 1976 | Phys Rev1976，13，： | 1 |
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