|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | LAMOST Experiment for Galactic Understanding and Exploration (LEGUE)——The survey's science plan显示文摘We describe the current plans for a spectroscopic survey of millions of stars in the Milky Way galaxy using the Guo Shou Jing Telescope (GSJT, formerly called the Large sky Area Multi-Object fiber Spectroscopic Telescope - LAMOST). The survey will obtain spectra for 2.5 million stars brighter than r < 19 during dark/grey time, and 5 million stars brighter than r < 17 or J < 16 on nights that are moonlit or have low transparency. The survey will begin in the fall of 2012, and will run for at least four years. The telescope's design constrains the optimal declination range for observations to 10 < δ < 50 , and site conditions lead to an emphasis on stars in the direction of the Galactic anticenter. The survey is divided into three parts with different target selection strategies: disk, anticenter, and spheroid. The resulting dataset will be used to study the merger history of the Milky Way, the substructure and evolution of the disks, the nature of the first generation of stars through identification of the lowest metallicity stars, and star formation through study of open clusters and OB associations. Detailed design of the LAMOST Experiment for Galactic Understanding and Exploration (LEGUE) survey will be completed in summer 2012, after a review of the results of the pilot survey. | Li-Cai Deng Heidi Jo Newberg Chao Liu Jeffrey L. Carlin Timothy C. Beers Li Chen Hsu-Tai Lee Carl J. Grillmair Puragra Guhathakurta] Zhan-Wen Han Jin-Liang Hou Sebastien Lepine Jing Li Xiao-Wei Liu Kai-Ke Pan J. A. Sellwood Bo Wang Hong-Chi Wang Fan Yang Brian Yanny Hao-Tong Zhang Yue-Yang Zhang Zheng Zheng Zi Zhu | 2012 | Research in Astronomy and Astrophysics2012，12，7： | 10 |
| 2 | Drought Stress and Preharvest Aflatoxin Contamination in Agricultural Commodity: Genetics, Genomics and Proteomics显示文摘Throughout the world, aflatoxin contamination is considered one of the most serious food safety issues concerning health. Chronic problems with preharvest aflatoxin contamination occur in the southern US, and are particularly troublesome in corn, peanut, cottonseed, and tree nuts. Drought stress is a major factor to contribute to preharvest aflatoxin contamination. Recent studies have demonstrated higher concentration of defense or stress-related proteins in corn kernels of resistant genotypes compared with susceptible genotypes, suggesting that preharvest field condition (drought or not drought) influences gene expression differently in different genotypes resulting in different levels of 'end products': PR(pathogenesis-related) proteins in the mature kernels. Because of the complexity of Aspergillus-plant interactions, better understanding of the mechanisms of genetic resistance will be needed using genomics and proteomics for crop improvement. Genetic improvement of crop resistance to drought stress is one component and will provide a good perspective on the efficacy of control strategy. Proteomic comparisons of corn kernel proteins between resistant or susceptible genotypes to Aspergillus flavus infection have identified stress-related proteins along with antifungal proteins as associated with kernel resistance. Gene expression studies in developing corn kernels are in agreement with the proteomic studies that defense-related genes could be upregulated or downregulated by abiotic stresses. | Baozhu Guo Zhi-Yuan Chen R. Dewey Lee Brian T. Scully | 2008 | Journal of Integrative Plant Biology2008，50，10： | 9 |
| 3 | 结膜滤过泡组织病理学特性显示文摘目的:描述并比较在修复小梁切除术和由于疏忽造成的滤过泡时得到的的结膜的组织学特征并评价抗纤维变性药物的作用。方法:我们对经过晚期滤过泡修复的28只眼的结膜标本采用常规石蜡制作的方法和光学显微镜下检查进行仔细观察:19只眼为渗漏的小梁切除术滤过泡,5只眼为无渗漏的小梁切除术滤过泡,4只眼为由于疏忽造成的滤过泡。定量分析的组织学特征包括结膜上皮的厚度,基质血管供应,鳞状组织化生,基质炎症细胞浸润和杯状细胞的密度。并且分析了手术类型,存在渗漏,先前的局部用药,应用抗纤维化药物都与组织学检查所见并置对比。结果:与由于疏忽造成的滤过泡的对照组相比,小梁切除术的滤过泡(渗漏的和无渗漏的)显示上皮的厚度(P〈0.02),杯状细胞的密度(P〈0.001)和血管供应(P〈0.001)全部降低。接受过抗纤维化药物的结膜比先前未受抗纤维化药物影响的结膜的上皮细胞层数更少(P〈0.05)。结论:小梁切除术后切除的薄的滤过泡的组织学分析证明上皮的厚度和杯状细胞的密度与由于疏忽造成的滤过泡相比均降低。与正常结膜相比。 | Brian A. Francis Lee T. Du Kathryn Najafi Raghu Murthy Usha Kurumety Narsing Rao Don S. Minckler 李航(译) 申敏如(校) | 2005 | 美国医学会眼科杂志(中文版)2005，17，3： | 8 |
| 4 | Neuroimaging the brain-gut axis in patients with irritable bowel syndrome显示文摘AIM:To summarize and synthesize current literature on neuroimaging the brain-gut axis in patients with irritable bowel syndrome(IBS).METHODS:A database search for relevant literature was conducted using Pub Med,Scopus and Embase in February 2015.Date filters were applied from the year2009 and onward,and studies were limited to those written in the English language and those performed upon human subjects.The initial search yielded 797articles,out of which 38 were pulled for full text review and 27 were included for study analysis.Investigations were reviewed to determine study design,methodology and results,and data points were placed in tabular format to facilitate analysis of study findings across disparate investigations.RESULTS:Analysis of study data resulted in the abstraction of four key themes:Neurohormonal differences,anatomic measurements of brain structure and connectivity,differences in functional responsiveness of the brain during rectal distention,and confounding/correlating patient factors.Studies in this review noted alterations of glutamate in the left hippocampus(HIPP),commonalities across IBS subjects in terms of brain oscillation patterns,cortical thickness/gray matter volume differences,and neuroanatomical regions withincreased activation in patients with IBS:Anterio cingulate cortex,mid cingulate cortex,amygdala anterior insula,posterior insula and prefrontal cortex.A striking finding among interventions was the substantia influence that patient variables(e.g.,sex,psychologica and disease related factors)had upon the identification of neuroanatomical differences in structure and con nectivity.CONCLUSION:The field of neuroimaging can provide insight into underlying physiological differences that distinguish patients with IBS from a healthy population. | Kristen R Weaver Lee Anne B Sherwin Brian Walitt Gail D'Eramo Melkus Wendy A Henderson | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，2： | 8 |
| 5 | 21世纪的卒中新定义:美国心脏协会/美国卒中协会对医疗专业人员的声明显示文摘尽管脑血管病的影响广泛且对其病理生理学的理解已取得一些进展,但“卒中”一词在临床实践、临床研究和公共卫生评价中的定义并不统一。经典的卒中定义主要是临床定义,不能反映科学技术的进步。因此,美国心脏协会卒中委员会/美国卒中协会召集了一个写作组,旨在对21世纪的卒中新定义制定一份专家共识文件。中枢神经系统(centralnervoussystem,CNS)梗死被定义为缺血导致的脑、脊髓或视网膜细胞死亡,并且具有永久性损伤的神经病理学、神经影像学和(或)临床证据。CNS梗死具有一系列临床表现:缺血性卒中特指伴有明显症状的CNS梗死,而无症状梗死则顾名思义不引起明显症状。广义的卒中还包括脑出血和蛛网膜下腔出血。卒中的新定义结合了临床和组织学标准,因此能被融入临床实践、研究和公共卫生评价。 | Ralph L. Sacco Scott E. Kasner Joseph P. Broderick Louis R. Caplan J.J. (Buddy) Connors Antonio Culebras Mitchell S.V. Elkind Mary G. George Allen D. Hamdan Randall T. Higashida Brian L. Hoh L. Scott Janis Carlos S. Kase Dawn O. Kleindorfer Jin-Moo Lee Michael E. Moseley Eric D. Peterson Tanya N. Turan Amy L. Valderrama Harry V. Vinters 王胜男(译) 吴齐恒(译) 邓镇(译) 周晓(译) 袁超(译) 潘速跃(译) | 2014 | 国际脑血管病杂志2014，22，1： | 7 |
| 6 | Experimental and modeling study of de novo formation of PCDD/PCDF on MSW fly ash显示文摘polychlorinateddibenzo-p-dioxins ( PCDD )和 polychlorinated dibenzo呋喃( PCDF )的形成上的硫二氧化物( SO2 )的效果在模仿的浪费燃烧 conditions.A chlorinationmodel basedon 下面在anentrained流动反应堆( EFR )被学习了有条件的概率被采用评估 PCDD andPCDFs.Results revealedthat 的相当或相同事物模式 SO2 的存在尽管 SO2suppressed PCDD/F formation.The 预言模型 ofPCDF 显示出好 ag 。 | LI Xiao-dong ZHANG Ji YAN Jian-hua CEN Ke-fa RYAN Shawn P GULLETT Brian K LEE Chunwai | 2007 | Journal of Environmental Sciences2007，19，1： | 6 |
| 7 | Risk of complications and urinary incontinence following cytoreductive prostatectomy: a multi-institutional study显示文摘当时,新兴的证据建议了 cytoreductive 前列腺切除术(CRP ) 允许优异 oncologic 控制与照顾雄激素剥夺标准的电流相比治疗独自一个。然而,在变形前列腺癌症(mPCa ) 的 cytoreduction 的安全和利益没被证明。因此,我们评估了在最新与 mPCa 诊断的人跟随 CRP 的复杂并发症的发生。在四个第三级的外科的中心从 2006 ~ 2014 经历了 CRP 的 68 个病人的一个总数与为临床上局部性的前列腺癌症(PCa ) 经历了激进的前列腺切除术的 598 个人相比。尿不能自制被定义为任何垫的使用。CRP 有更长起作用的时间(200 min 对 140 min, P < 0.0001 ) 并且更高估计的血损失(250 ml 对 125 ml, P < 0.0001 ) 与控制组相比。然而,外套(8.82% 对 5.85%) 和主要复杂并发症率(4.41% 对 2.17%) 在二个组之间是可比较的。重要地,尿不能自制率在在外科以后 1 年在 CRP 组是显著地更高的(57.4% 对 90.8% , P < 0.0001 ) 。Univariate 逻辑分析证明估计的血损失在 unadjusted 模型两个都是 perioperative 复杂并发症的唯一的独立预言者(或:1.18;95% CI:1.02-1.37;P = 0.025 ) 并且外科调整类型的模型(或:1.17;95% CI:1.01-1.36;P = 0.034 ) 。在结论, CRP 比激进的前列腺切除术更挑战性、与尿不能自制的尤其是更高的发生联系。不过, CRP 是为选择谁的 PCa 病人的一个技术上可行、安全的手术与节点积极或多骨的转移在场当由富有经验的外科医生表现了时。未来的、多机构的临床的试用当前是在进行之中的验证这个概念。 | Dae Keun Kim Jaspreet Singh Parihar Young Suk Kwon Sinae Kim Brian Shinder Nara Lee Nicholas Farber Thomas Ahlering Douglas Skarecky Bertram Yuh Nora Ruel Wun-lae Kim Koon Ho Rha Isaac Yi Kim | 2018 | Asian Journal of Andrology2018，20，1： | 5 |
| 8 | Monitoring the Expression of Maize Genes in Developing Kernels under Droug ht Stress usingOligo-microarray显示文摘Preharvest aflatoxin contamination of grain grown on the US southeastern Coast Plain is provoked and aggravated by abiotic stress. The primary abiotic stress is drought along with high temperatures. The objectives of the present study were to monitor gene expression in developing kernels in response to drought stress and to identify drought-responsive genes for possible use in germplasm assessment. The maize breeding line Tex6 was used, and gene expression profiles were analyzed in developing kernels under drought stress verses well-watered conditions at the stages of 25, 30, 35, 40, 45 d after pollination (DAP) using the 70 mer maize oligo-arrays. A total of 9 573 positive array spots were detected with unique gene IDs, and 7 988 were common in both stressed and well-watered samples. Expression patterns of some genes in several stress response-associated pathways, including abscisic acid, jasmonic acid and phenylalanine ammonia-lyase, were examined, and these specific genes were responsive to drought stress positively. Real-time quantitative polymerase chain reaction validated microarray expression data. The comparison between Tex6 and B73 revealed that there were significant differences in specific gene expression, patterns and levels. Several defense-related genes had been downregulated, even though some defense-related or drought responsive genes were upregulated at the later stages. | Meng Luo Jia Liu R. Dewey Lee Brian T. Scully Baozhu Guo | 2010 | Journal of Integrative Plant Biology2010，52，12： | 5 |
| 9 | Phase stability and mechanical properties of wire+arc additively manufactured H13 tool steel at elevated temperatures显示文摘Wire+arc additive manufacturing(WAAM)is considered an innovative technology that can change the manufacturing landscape in the near future.WAAM offers the benefits of inexpensive initial system setup and a high deposition rate for fabricating medium-and large-sized parts such as die-casting tools.In this study,AISI H13 tool steel,a popular die-casting tool metal,is manufactured by cold metal transfer(CMT)-based WAAM and is then comprehensively analyzed for its microstructural and mechanical properties.Location-dependent phase combinations are observed,which could be explained by nonequilibrium thermal cycles that resulted from the layer-by-layer stacking mechanism used in WAAM.In addition,remelting and reheating of the layers reduces welding anomalies(e.g.,pores and voids).The metallurgical characteristics of the H13 strongly correlate with the mechanical properties.The combinations of phases at different locations of the additively manufactured part exhibit a periodic microhardness profile.Martensite,Retained Austenite,Ferrite,and Carbide phases are found in combination at different locations of the part based on the part’s temperature distribution during additive deposition.Moreover,the tensile properties at elevated temperatures(23℃,300℃,and 600℃)are comparable to those from other WAAM and additive manufacturing(AM)processes.The X-ray diffraction results verify that the microstructural stability of the fabricated parts at high temperatures would allow them to be used in high temperatures. | A.N.M.Tanvir Md.R.U.A hsan Gijeong Seo Brian Bates Chanho Lee Peter K.Liaw Mark Noakese Andrzej Nycz Changwook Ji Duck Bong Kim | 2021 | Journal of Materials Science & Technology2021，，8： | 5 |
| 10 | The Hemodynamic and Adrenergic Effects of Perioperative Dexmedetomidine Infusion after Vascular Surgery显示文摘 | Pekka Talke Richard Chen Brian Thomas Anil Aggarwall Alexandru Gottlieb Per Thorborg Stephen Heard Albert Cheung Stanley Lee Son Antero Kallio | 2000 | Anesthesia & Analgesia2000，，4： | 3 |
| 11 | An Updated Definition of Stroke for the 21st Century: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association显示文摘 | Ralph L. Sacco Scott E. Kasner Joseph P. Broderick Louis R. Caplan J.J. (Buddy) Connors Antonio Culebras Mitchell S.V. Elkind Mary G. George Allen D. Hamdan Randall T. Higashida Brian L. Hoh L. Scott Janis Carlos S. Kase Dawn O. Kleindorfer Jin-Moo Lee Mi | 2013 | Stroke2013，，7： | 3 |
| 12 | 澳大利亚海洋公园对我国渔民增收的启示显示文摘近年来海洋环境日益恶化,渔业资源逐步退化,渔民收入、增收存在一定的困难。面对这一问题,澳大利亚建立了海洋公园并对其进行分区管理,虽然减少了捕捞收入,但是保护了海洋环境,促进了海洋旅游业的发展,增加了旅游业相关收入,使得当地渔民总体收入增加,这一方法较好的解决了环境保护与经济发展的矛盾,对我国促进渔民增收有很好的借鉴作用。 | 赵领娣 张燕 WANG Xiaohua BRIAN Lees | 2008 | 渔业经济研究2008，，2： | 2 |
| 13 | FOCUS: Future of fecal calprotectin utility study in inflammatory bowel disease显示文摘AIM To evaluate the perspective of gastroenterologists regarding the impact of fecal calprotectin(FC) on the management of patients with inflammatory bowel disease(IBD).METHODS Patients with known IBD or symptoms suggestive of IBD for whom the physician identified that FC would be clinically useful were recruited. Physicians completed an online 'pre survey' outlining their rationale for the test. After receipt of the test results, the physicians completed an online 'post survey' to portray their perceived impact of the test result on patient management. Clinical outcomes for a subset of patients with follow-up data available beyond the completion of the 'post survey' were collected and analyzed.RESULTS Of 373 test kits distributed, 290 were returned, resulting in 279 fully completed surveys. One hundred and ninety patients were known to have IBD; 147(77%) with Crohn's Disease, 43(21%) Ulcerative Colitis and 5(2%) IBD unclassified. Indications for FC testing included: 90(32.2%) to differentiate a new diagnosis of IBD from Irritable Bowel Syndrome(IBS), 85(30.5%) to distinguish symptoms of IBS from IBD in those known to have IBD and 104(37.2%) as an objective measure of inflammation. FC levels resulted in a change in management 51.3%(143/279) of the time which included a significant reduction in the number of colonoscopies(118) performed(P < 0.001). Overall, 97.5%(272/279) of the time, the physicians found the test sufficiently useful that they would order it again in similar situations. Follow-up data was available for 172 patients with further support for the clinical utility of FC provided.CONCLUSION The FC test effected a change in management 51.3% of the time and receipt of the result was associated with a reduction in the number of colonoscopies performed. | Greg Rosenfeld Astrid-Jane Greenup Andrew Round Oliver Takach Lawrence Halparin Abid Saadeddin Jin Kee Ho Terry Lee Robert Enns Brian Bressler | 2016 | World Journal of Gastroenterology2016，22，36： | 2 |
| 14 | Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro显示文摘 | Brian J. Lee Yasuhiro Egi Klaus van Leyen Eng H. Lo Ken Arai | 2009 | Brain Research2009，，： | 2 |
| 15 | S100A4 released from highly bone-metastatic breast cancer cells plays a critical role in osteolysis显示文摘Bone destruction induced by breast cancer metastasis causes severe complications,including death,in breast cancer patients.Communication between cancer cells and skeletal cells in metastatic bone microenvironments is a principal element that drives tumor progression and osteolysis.Tumor-derived factors play fundamental roles in this form of communication.To identify soluble factors released from cancer cells in bone metastasis,we established a highly bone-metastatic subline of MDA-MB-231 breast cancer cells.This subline(mtMDA)showed a markedly elevated ability to secrete S100A4 protein,which directly stimulated osteoclast formation via surface receptor RAGE.Recombinant S100A4 stimulated osteoclastogenesis in vitro and bone loss in vivo.Conditioned medium from mtMDA cells in which S100A4 was knocked down had a reduced ability to stimulate osteoclasts.Furthermore,the S100A4 knockdown cells elicited less bone destruction in mice than the control knockdown cells.In addition,administration of an anti-S100A4 monoclonal antibody(mAb)that we developed attenuated the stimulation of osteoclastogenesis and bone loss by mtMDA in mice.Taken together,our results suggest that S100A4 released from breast cancer cells is an important player in the osteolysis caused by breast cancer bone metastasis. | Haemin Kim Bongjun Kim Sang Il Kim Hyung Joon Kim Brian YRyu Junho Chung Zang Hee Lee Hong-Hee Kim | 2019 | Bone Research2019，7，4： | 2 |
| 16 | Hyperglycemia, Insulin Resistance, Impaired Pancreatic β-Cell Function, and Risk of Pancreatic Cancer显示文摘 | Brian M. Wolpin Ying Bao Zhi Rong Qian Chen Wu Peter Kraft Shuji Ogino Meir J. Stampfer Kaori Sato Jing Ma Julie E. Buring Howard D. Sesso I-Min Lee John Michael Gaziano Anne McTiernan Lawrence S. Phillips Barbara B. Cochrane Michael N. Pollak JoAnn E. Ma | 2013 | JNCI Journal of the National Cancer Institute2013，，14： | 2 |
| 17 | Synthesis and electrocatalytic applications of flower-like motifs and associated composites of nitrogen-enriched tungsten nitride(W2N3)显示文摘We have sought to improve the electrocatalytic performance of tungsten nitride through synthetic control over chemical composition and morphology.In particular,we have generated a thermodynamically unstable but catalytically promising nitrogen-rich phase of tungsten via a hydrothermal generation of a tungsten oxide intermediate and subsequent annealing in ammonia.The net product consisted of three-dimensional(3D)micron-scale flower-like motifs of W2N3;this architecture not only evinced high structural stability but also incorporated the favorable properties of constituent two-dimensional nanosheets.From a performance perspective,as-prepared 3D W2N3 demonstrated promising hydrogen evolution reaction(HER)activities,especially in an acidic environment with a measured overpotential value of−101 mV at a current density of 10 mA/cm^2.To further enhance the electrocatalytic activity,small amounts of precious metal nanoparticles(such as Pt and Au),consisting of variable sizes,were uniformly deposited onto the underlying 3D W2N3 motifs using a facile direct deposition method;these composites were applied towards the CO2 reduction reaction(CO2RR).A highlight of this series of experiments was that Au/W2N3 composites were found to be a much more active HER(as opposed to either a CO2RR or a methanol oxidation reaction(MOR))catalyst. | Sha Tan Brian M.Tackett Qun He Ji Hoon Lee Jingguang G.Chen Stanislaus S.Wong | 2020 | Nano Research2020，13，5： | 2 |
| 18 | Total mesorectal excision: Assessment of the laparoscopic approach显示文摘 | John E. Hartley Brian J. Mehigan Akhtar E. Qureshi Graham S. Duthie Peter W. R. Lee Dr. John R. T. Monson | 2001 | Diseases of the Colon & Rectum2001，，3： | 2 |
| 19 | An Interaction of Race and Ethnicity With Socioeconomic Status in Rectal Cancer Outcomes显示文摘 | Joseph Kim Avo Artinyan Brian Mailey Stefanie Christopher Wendy Lee Shaun McKenzie Steven L. Chen Smita Bhatia Alessio Pigazzi Julio Garcia-Aguilar | 2011 | Annals of Surgery2011，，4： | 2 |
| 20 | Markedly Elevated Levels of Vascular Endothelial Growth Factor in Malignant Ascites显示文摘 | Brian K. Zebrowski MD Wenbiao Liu MD Karen Ramirez BS Yoshito Akagi MD Gordon B. Mills MD Lee M. Ellis MD | 1999 | Annals of Surgical Oncology1999，，4： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员