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| 1 | Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease显示文摘AIM: To evaluate the safety and feasibility of bone marrow cell (BMC) transplantation in patients with chronic liver disease on the waiting list for liver transplantation. METHODS: Ten patients (eight males) with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 ml of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. RESULTS: The median age of the patients was 52 years (range 24-70 years). All patients were discharged 48 h after BMC infusion. Two patients complained ofmild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 (2.19 ± 0.9) and 4 mo (2.10 ± 1.0) after cell transplantation that baseline levels (2.78 ± 1.2). Albumin levels 4 mo after BMC infusion (3.73 ± 0.5) were higher than baseline levels (3.47 ± 0.5). International normalized ratio (INR) decreased from 1.48 (SD = 0.23) to 1.43 (SD = 0.23) one month after cell transplantation. CONCLUSION: BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease. | Andre Castro lyra Milena Botelho Pereira Soares luiz Flavio Maia da Silva Marcos Fraga Fortes André Goyanna Pinheiro Silva Augusto César de Andrade Mota Sheilla A Oliveira Eduardo lorens Braga Wilson Andrade de Carvalho Bernd Genser Ricardo Ribeiro dos Santos luiz Guilherme Costa lyra | 2007 | World Journal of Gastroenterology2007，13，7： | 21 |
| 2 | Short-term complementary and alternative medicine on quality of life in women with fibromyalgia显示文摘BACKGROUND:Fibromyalgia(FMS)is a syndrome characterized by chronic widespread musculoskeletal pain,whose etiology is not completely understood.Different therapeutic approaches have been used with inconsistent results.This observation does not invalidate the continued search for alternative treatments aimed at improving quality of life(Qo L)in FMS.OBJECTIVE:This study compared three classical traditional Chinese medicine(TCM)therapies:acupuncture(AC),electroacupuncture(EAC)and moxibustion(MX)in the management of pain and promotion of Qo L in FMS patients.DESIGN,SETTING,PARTICIPANTS AND INTERVENTIONS:A preliminary,group-assigned,comparative study enrolled 30 women,mean age(46.90±9.24)years(range 20–60 years),who met the 1990 American College of Rheumatology criteria for FMS diagnosis and a pain-pressure threshold(PPT)< 4 kg/cm^2.The study was conducted in a teaching tertiary-care medical institution from May 2010 through April 2012.AC,EAC and MX were delivered for 30 min,once a week,for 8 weeks,bilaterally at Neiguan(PC6),Hegu(LI4),Yanglingquan(GB34),Sanyinjiao(SP6)and Taichong(LR3)acupoints.MAIN OUTCOME MEASURES:Each week,immediately before treatment and after treatment,subjects were tested for PPTs,Wong-Baker Faces Pain Scale(WBFPS;for pain intensity)and Medical Outcomes Study 36-item Short Form Health Survey(SF-36:for Qo L).RESULTS:There was no signifi cant improvement in pain or reduction of tender points in any of the groups studied,at the end of the 8th session.Signifi cant improvement of Qo L was perceived in vitality(after AC treatment)and in mental health(after EAC and MX treatments).CONCLUSION:TCM therapies(AC,EAC and MX)promoted an improvement in the Qo L in two areas(vitality and mental health)in FMS women.Further large-scale clinical trials are required to confi rm this effect. | Paulo Araujo Dias Andre Brito Bastos Guimaraes Andrea de Oliveira Albuquerque Karoline Lucas de Oliveira Maria Luzete Costa Cavalcante Sergio Botelho Guimaraes | 2016 | Journal of Integrative Medicine2016，14，1： | 7 |
| 3 | The role of mouse models in colorectal cancer research—The need and the importance of the orthotopic models显示文摘Colorectal cancer is a worldwide health burden,with high incidence and mortality,especially in the advanced stages of the disease.Preclinical models are very important and valuable to discover and validate early and specific biomarkers as well as new therapeutic targets.In order to accomplish that,the animal models must replicate the clinical evolution of the disease in all of its phases.In this article,we review the existent mouse models,with their strengths and weaknesses in the replication of human cancer disease progression,with major focus on orthotopic models. | Rui C.Oliveira Ana Margarida Abrantes JoseGuilherme Tralhao Maria Filomena Botelho | 2020 | Animal Models and Experimental Medicine2020，3，1： | 5 |
| 4 | Nephrotoxicity in cancer treatment:An overview显示文摘Anticancer drug nephrotoxicity is an important and increasing adverse drug event that limits the efficacy of cancer treatment.The kidney is an important elimination pathway for many antineoplastic drugs and their metabolites,which occurs by glomerular filtration and tubular secretion.Chemotherapeutic agents,both conventional cytotoxic agents and molecularly targeted agents,can affect any segment of the nephron including its microvasculature,leading to many clinical manifestations such as proteinuria,hypertension,electrolyte disturbances,glomerulopathy,acute and chronic interstitial nephritis,acute kidney injury and at times chronic kidney disease.The clinician should be alert to recognize several factors that may maximize renal dysfunction and contribute to the increased incidence of nephrotoxicity associated with these drugs,such as intravascular volume depletion,the associated use of nonchemotherapeutic nephrotoxic drugs(analgesics,antibiotics,proton pump inhibitors,and bonetargeted therapies),radiographic ionic contrast media or radiation therapy,urinary tract obstruction,and intrinsic renal disease.Identification of patients at higher risk for nephrotoxicity may allow the prevention or at least reduction in the development and severity of this adverse effect.Therefore,the aim of this brief review is to provide currently available evidences on oncologic drug-related nephrotoxicity. | Maria Luísa Cordeiro Santos Breno Bittencourt de Brito Filipe Antonio FranÇa da Silva Anelise Costa dos Santos Botelho Fabrício Freire de Melo | 2020 | World Journal of Clinical Oncology2020，11，4： | 4 |
| 5 | 【特刊综述】睾酮和雌二醇检测方法面临的挑战和取得的进展显示文摘在患者护理、公共卫生、科学研究过程中类固醇激素的检测方法需要正确而精准,因为这些检测的标准可以保证所有的临床机构和研究机构的结果具有可比性。本文陈述了目前有关检验结果易变的主要问题以及最近美国疾病预防控制中心(CDc)针对提升检验效果所做的工作。目前,睾酮和雌二醇的检测方法还无法达到高度的正确性和精准性。虽然类固醇激素检测方法已经有了长足的进步,但是实验室内部和实验室之间的检测差异仍然未能得到相应的改善。检测标准和特异性的差异被认为是测量精度变异性的来源。最终认为,类固醇激素检测的不准确性似乎是由综合因素造成的,其中不一致的检验标准和缺乏特异性被认为是产生结果变异的两个主要因素。目前,同一批次内的化验结果也变异较大,特别是在样本浓度低的情况下。2007至2011年间的质谱分析法和CDC参考方法之间的平均绝对偏差下降了50%,由此可以看出CDC激素标准化测试程序正在提高临床化验的准确性。这种测试程序可以为CDC参考方法提供追朔源头的途径,从而减少产生测量结果变异的因素。 | Hubert W Vesper Julianne C Botelho Yuesong Wang | 2014 | Asian Journal of Andrology2014，16，2： | 3 |
| 6 | Quantitative scintigraphic analysis of the apical seal in Thermafil/Topseal and Real Seal 1/Realseal filled root canals显示文摘AIM: To investigate the microleakage of two different root canal obturation systems, using the nuclear medicine approach.METHODS: Twenty-six single-rooted extracted teeth were selected. The crowns were sectioned to obtain 15-mm long root segments and each tooth was prepared using rotary Pro File instruments. The roots were divided into 2 experimental groups using Real Seal 1 and Real Seal sealer or Thermafil and Top Seal sealer as well as two control groups. On the 7th and the 28 th day the apices were submersed in a solution of 99 m TcPertechnetate during 3 h. The radioactivity was counted using a γ camera. RESULTS: The present study showed that none of the root canal-filled teeth was leakage free. The statistical analyses were made using Kruskal-Wallis and statistical significance was assessed using α = 0.05. Although apical leakage measured in counts per minute(cpm) in the Thermafil/Top Seal group was lower than in the Real Seal/Real Seal group(363 916 ± 180 707.7 cpm vs533 427 ± 414 020.6 cpm) on 7th day and(1 678 200 ± 567 217.4 cpm vs 2 240 518 ± 383 356.7 cpm) on 28 th day, there was no statistical difference(P > 0.05). In the Thermafil/Top Seal group and Real Seal 1/Real Seal group it was found that over time, the number of counts increased between 7 d and 28 d(363 916 ± 180 707.7 cpm vs 1 678 200 ± 567 217.4 cpm) and(533 427 ± 414 020.6 cpm vs 2 240 518 ± 383 356.7 cpm), respectively, with statistically significant differences(Thermafil/Top Seal group, P = 0.015 and Real Seal 1/Real Seal group, P = 0.036).CONCLUSION:Both carrier-based Realseal 1 and Thermafil techniques showed a similar sealing effect,but none of the materials was leakage free. | Manuel Marques Ferreira Margarida Abrantes Eunice Virgínia Carrilho Maria Filomena Botelho | 2013 | World Journal of Stomatology2013，2，2： | 2 |
| 7 | Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study显示文摘 | Andre Castro Lyra Milena Botelho Pereira Soares Luiz Flavio Maia da Silva Eduardo Lorens Braga Sheilla A. Oliveira Marcos Fraga Fortes Andre Goyanna Pinheiro Silva Daniele Brustolim Bernd Genser Ricardo Ribeiro dos Santos Luiz Guilherme Costa Lyra | 2010 | European Journal of Gastroenterology & Hepatology2010，，1： | 2 |
| 8 | Electrodeposition of black chromium spectral- ly selective coatings from a Cr(III) - ionic liquid solution显示文摘 | Sonia Eugenio Carmen Mireya Rangel Rui Vilar Ana Maria Botelho do Rego | 2011 | Thin Solid Films2011，519，2： | 1 |
| 9 | Motor develop-ment evaluated by Test of Infant Motor Performance : com-parison between preterm and full-term infants 显示文摘 | Guimaraes CL Reinaux CM Botelho AC | 2011 | RevBras Fisioter2011，15，5： | 1 |
| 10 | The Diffusion of Cellular Phones in Portugal显示文摘 | Botelho A Pinto L C | 2004 | Telecommunications Policy2004，，28： | 1 |
| 11 | machinery for artificial emotions显示文摘 | LuiS Miguel Botelho Helder Coelho | | Cybernetics And Systems: An International Journal0，2001，： | 1 |
| 12 | Home assessment of adherence to long-term medication in the elderly显示文摘 | Botelho RJ Dudrak R 2nd | 1992 | J Fam Pract1992，35，1： | 1 |
| 13 | Use of Autologous Mesenchymal Stem Cells Derived from Bone Marrow for the Treatment of Naturally Injured Spinal Cord in Dogs显示文摘 | Euler Moraes Penha Cássio Santana Meira Elisalva Teixeira Guimar?es Marcus Vinícius Pinheiro Mendon?a Faye Alice Gravely Cláudia Maria Bahia Pinheiro Taiana Maria Bahia Pinheiro Stella Maria Barrouin-Melo Ricardo Ribeiro-dos-Santos Milena Botelho Pereira | 2014 | Stem Cells International2014，，： | 1 |
| 14 | Physico-chemical and rheological characterization of poly-gamma-glutamic acid produced by a new strain of Bacillus subtilis显示文摘 | Alessandra de Cesaro Suse Botelho da Silva Vanessa Zimmer da Silva Marco Ant?nio Záchia Ayub | 2014 | European Polymer Journal2014，，： | 1 |
| 15 | Psyllium as a substitute for gluten in bread显示文摘 | ZANDONADI R P BOTELHO R B A ARAUJO W M C | 2009 | Journal of the American Dietetic Association2009，109，10： | 1 |
| 16 | Determinants of postoper- ative acute kidney injury 显示文摘 | Abelha FJ Botelho M Fernandes V | 2009 | Crit Care2009，13，3： | 1 |
| 17 | Increased prevalence of early cochlear damage in young patients with type 1 diabetes detected by distortion product otoacoustic emissions 显示文摘 | Botelho CT Carvalho SA Silva IN | 2014 | Int J Audiol2014，53，6： | 1 |
| 18 | 牙周炎与高血压的相关性显示文摘牙周炎是一种常见的慢性炎症性疾病,可能会对血压产生重要影响。本研究旨在探究:(1)在一项大型代表性队列中研究牙周健康与血压的相关性;(2)牙周炎在未明确诊断血压升高患者中的诊断预测价值;(3)年龄是否在牙周健康与血压的相关性中起介导作用。在纳入随机招募的参与者1057例[平均年龄(60.9±16.3)岁,57.7%为女性]中行牙周临床评估,并使用自动血压计测量单次血压。 | 袁源(摘译) 练桂丽(审校) Machado V Aguilera EM Botelho J Hussain SB Leira Y Proenca L D’Aiuto F Mendes JJ | 2020 | 中华高血压杂志2020，28，9： | 1 |
| 19 | Treating viral exacerbations of chronic obstructive pulmonary disease: insights from a mouse model of cigarette smoke and H1N1 influenza infection显示文摘 | Bauer CM Zavitz CC Botelho FM | 2010 | PLoS One2010，5，13： | 1 |
| 20 | The influence of weathering conditions on the properties of poly( vinyl chloride) for outdoor applications:An analytical study using surface analysis techniques 显示文摘 | L E Pimentel Real A M Ferraria A M Botelho do Rego | 2007 | Polymer Testing2007，26，： | 1 |
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