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| 1 | Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease显示文摘AIM: To evaluate the safety and feasibility of bone marrow cell (BMC) transplantation in patients with chronic liver disease on the waiting list for liver transplantation. METHODS: Ten patients (eight males) with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 ml of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. RESULTS: The median age of the patients was 52 years (range 24-70 years). All patients were discharged 48 h after BMC infusion. Two patients complained ofmild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 (2.19 ± 0.9) and 4 mo (2.10 ± 1.0) after cell transplantation that baseline levels (2.78 ± 1.2). Albumin levels 4 mo after BMC infusion (3.73 ± 0.5) were higher than baseline levels (3.47 ± 0.5). International normalized ratio (INR) decreased from 1.48 (SD = 0.23) to 1.43 (SD = 0.23) one month after cell transplantation. CONCLUSION: BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease. | Andre Castro lyra Milena Botelho Pereira Soares luiz Flavio Maia da Silva Marcos Fraga Fortes André Goyanna Pinheiro Silva Augusto César de Andrade Mota Sheilla A Oliveira Eduardo lorens Braga Wilson Andrade de Carvalho Bernd Genser Ricardo Ribeiro dos Santos luiz Guilherme Costa lyra | 2007 | World Journal of Gastroenterology2007，13，7： | 21 |
| 2 | Bone marrow-derived monocyte infusion improves hepatic fibrosis by decreasing osteopontin,TGF-β1,IL-13 and oxidative stress显示文摘AIM To evaluate the therapeutic effects of bone marrowderived CD11b+CD14+ monocytes in a murine model of chronic liver damage. METHODS Chronic liver damage was induced in C57BL/6 mice by administration of carbon tetrachloride and ethanol for 6 mo. Bone marrow-derived monocytes isolated by immunomagnetic separation were used for therapy. The cell transplantation effects were evaluated by morphometry,biochemical assessment,immunohistochemistry and enzyme-linked immunosorbent assay. RESULTS CD11b+CD14+ monocyte therapy significantly reduced liver fibrosis and increased hepatic glutathione levels. Levels of pro-inflammatory cytokines,including tumor necrosis factor-α,interleukin(IL)-6 and IL-1β,in addition to pro-fibrotic factors,such as IL-13,transforming growth factor-β1 and tissue inhibitor of metalloproteinase-1 also decreased,while IL-10 and matrix metalloproteinase-9 increased in the monocytetreated group. CD11b+CD14+ monocyte transplantation caused significant changes in the hepatic expression of α-smooth muscle actin and osteopontin. CONCLUSION Monocyte therapy is capable of bringing about improvement of liver fibrosis by reducing oxidative stress and inflammation,as well as increasing antifibrogenic factors. | Veruska Cintia Alexandrino de Souza Thiago Almeida Pereira Valéria Wanderley Teixeira Helotonio Carvalho Maria Carolina Accioly Brelaz de Castro Carolline Guimaraes D’assuncao Andreia Ferreira de Barros Camila Lima Carvalho Virgínia Maria Barros de Lorena Vláudia Maria Assis Costa Alvaro Aguiar Coelho Teixeira Regina Celia Bressan Queiroz Figueiredo Sheilla Andrade de Oliveira | 2017 | World Journal of Gastroenterology2017，23，28： | 6 |
| 3 | Communicating with the non-dominant hemisphere:Implications for neurological rehabilitation显示文摘Aphasic syndromes usually result from injuries to the dominant hemisphere of the brain. Despite the fact that localization of language functions shows little interindividual variability, several brain areas are simultaneously activated when language tasks are undertaken. Mechanisms of language recovery after brain injury to the dominant hemisphere seem to be relatively stereotyped, including activations of perilesional areas in the acute phase and of homologues of language areas in the non-dominant hemisphere in the subacute phase, later returning to dominant hemisphere activation in the chronic phase. Plasticity mechanisms reopen the critical period of language development, more specifically in what leads to disinhibition of the non-dominant hemisphere when brain lesions affect the dominant hemisphere. The non-dominant hemisphere plays an important role during recovery from aphasia, but currently available rehabilitation therapies have shown limited results for efficient language improvement. Large-scale randomized controlled trials that evaluate well-defined interventions in patients with aphasia are needed for stimulation of neuroplasticity mechanisms that enhance the role of the non-dominant hemisphere for language recovery. Ineffective treatment approaches should be replaced by more promising ones and the latter should be evaluated for proper application. The data generated by such studies could substantiate evidence-based rehabilitation strategies for patients with aphasia. | Fabricio Ferreira de Oliveira Sheilla de Medeiros Correia Marin Paulo Henrique Ferreira Bertolucci | 2013 | Neural Regeneration Research2013，8，13： | 2 |
| 4 | Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study显示文摘 | Andre Castro Lyra Milena Botelho Pereira Soares Luiz Flavio Maia da Silva Eduardo Lorens Braga Sheilla A. Oliveira Marcos Fraga Fortes Andre Goyanna Pinheiro Silva Daniele Brustolim Bernd Genser Ricardo Ribeiro dos Santos Luiz Guilherme Costa Lyra | 2010 | European Journal of Gastroenterology & Hepatology2010，，1： | 2 |
| 5 | Therapy with bone marrow cells reduces liver alterations in mice chronically infected by Schistosoma mansoni显示文摘AIM: To investigate the potential of bone marrow mononuclear cells (BM-MCs) in the regeneration of hepatic lesions induced by Schistosoma mansoni (S.mansoni) chronic infection. METHODS: Female mice chronically infected with S.mansoni were treated with BM-MCs obtained from male green fluorescent protein (GFP) transgenic mice by intravenous or intralobular injections. Control mice received injections of saline in similar conditions. Enzyme-linked immunosorbent assay (ELISA) assay fortransforming growth factor-beta (TGF-β), polymerase chain reaction (PCR) for GFP DNA, immunofluorescence and morphometric studies were performed. RESULTS: Transplanted GFP+ cells migrated to granuloma areas and reduced the percentage of liver fibrosis. The presence of donor-derived cells was confirmed by Fluorescence in situ hybridization (FISH) analysis for detection of cells bearing Y chromosome and by PCR analysis for detection of GFP DNA. The levels of TGF-β, a cytokine associated with fibrosis deposition, in liver fragments of mice submitted to therapy were reduced. The number of oval cells in liver sections of S.mansoni-infected mice increased 3-4 fold after transplantation. A partial recovery in albumin expression, which is decreased upon infection with S.mansoni, was found in livers of infected mice after cellular therapy. CONCLUSION: In conclusion, transplanted BMCs migrate to and reduce the damage of chronic fibrotic liver lesions caused by S.mansoni. | Sheilla Andrade Oliveira Bruno Solano Freitas Souza Carla Adriana Guimares-Ferreira Elton Sá Barreto Siane Campos Souza Luiz Antonio Rodrigues Freitas Ricardo Ribeiro-dos-Santos Milena Botelho Pereira Soares | 2008 | World Journal of Gastroenterology2008，14，38： | 1 |
| 6 | World's fastest modeling job,or architecture:What is it?The multidisciplinary adventures of two phD students显示文摘 | Sheilla O Denn Kelly L Maglaughlin | 2000 | Bulletin of the American Society for Information Science2000，26，5： | 1 |
| 7 | Research Progress on the Application of Cluster Nursing Mode in ECMO-Assisted Patients显示文摘Cluster care,also known as cluster therapy,cluster intervention,or bundled therapy,is a series of evidence-based supportive joint care measures developed to improve the quality of care for specific patients or nursing issues.It is highly reliable and can effectively improve patient prognosis.This article summarized the application of cluster nursing care in extracorporeal membrane oxygenation(ECMO)-assisted patients and the problems faced to provide a reference for evidence-based decision-making in clinical practice. | Ling Liu Sheilla Magbanua Trajera | 2024 | Journal of Clinical and Nursing Research2024，8，3： | 0 |
| 8 | Dynapenia in all-cause mortality and its relationship with sedentary behavior in community-dwelling older adults显示文摘The aim of the present study was to investigate the relationship of dynapenia combined with sedentary behavior(SB)on the risk of mortality in older adults living in a Brazilian community.A total of 322 participants aged60 years from the ELSIA(Longitudinal Study of Elderly Health in Alcobaça)prospective cohort were included.Dynapenia was diagnosed when the handgrip strength was<27 kg for men and<16 kg for women.The exposure time to SB was assessed considering the total time spent sitting during one day in the week and one day on the weekend.When combined with dynapenia,we derived the construction of four groups:best behavior(absence of dynapenia and low SB),intermediate behavior(absence of dynapenia and high SB;presence of dynapenia and low SB)and worst behavior(presence of dynapenia and high SB).Mortality was assessed by the follow-up time until death and/or censorship.During the 5-year follow-up of the study,55 participants progressed to death.In the adjusted models,the dynapenia and the time spent exposed to SB were analyzed in a combined way,the older adults with worse behavior(high SB and dynapenia)had higher risk ratios for mortality(hazard ratio 2.46;95%confidence interval 1.01–5.97)than the best behavior group.Older adults with dynapenia are at greater risk for all-cause mortality,which is aggravated by the addition of longer exposure to SB. | Rizia Rocha Silva Lucas Lima Galvão Joilson Meneguci Douglas de Assis Teles Santos Jair Sindra Virtuoso Júnior Sheilla Tribess | 2022 | Sports Medicine and Health Science2022，4，4： | 0 |
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