|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease显示文摘AIM: To evaluate the safety and feasibility of bone marrow cell (BMC) transplantation in patients with chronic liver disease on the waiting list for liver transplantation. METHODS: Ten patients (eight males) with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 ml of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. RESULTS: The median age of the patients was 52 years (range 24-70 years). All patients were discharged 48 h after BMC infusion. Two patients complained ofmild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 (2.19 ± 0.9) and 4 mo (2.10 ± 1.0) after cell transplantation that baseline levels (2.78 ± 1.2). Albumin levels 4 mo after BMC infusion (3.73 ± 0.5) were higher than baseline levels (3.47 ± 0.5). International normalized ratio (INR) decreased from 1.48 (SD = 0.23) to 1.43 (SD = 0.23) one month after cell transplantation. CONCLUSION: BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease. | Andre Castro lyra Milena Botelho Pereira Soares luiz Flavio Maia da Silva Marcos Fraga Fortes André Goyanna Pinheiro Silva Augusto César de Andrade Mota Sheilla A Oliveira Eduardo lorens Braga Wilson Andrade de Carvalho Bernd Genser Ricardo Ribeiro dos Santos luiz Guilherme Costa lyra | 2007 | World Journal of Gastroenterology2007，13，7： | 21 |
| 2 | Nephrotoxicity in cancer treatment:An overview显示文摘Anticancer drug nephrotoxicity is an important and increasing adverse drug event that limits the efficacy of cancer treatment.The kidney is an important elimination pathway for many antineoplastic drugs and their metabolites,which occurs by glomerular filtration and tubular secretion.Chemotherapeutic agents,both conventional cytotoxic agents and molecularly targeted agents,can affect any segment of the nephron including its microvasculature,leading to many clinical manifestations such as proteinuria,hypertension,electrolyte disturbances,glomerulopathy,acute and chronic interstitial nephritis,acute kidney injury and at times chronic kidney disease.The clinician should be alert to recognize several factors that may maximize renal dysfunction and contribute to the increased incidence of nephrotoxicity associated with these drugs,such as intravascular volume depletion,the associated use of nonchemotherapeutic nephrotoxic drugs(analgesics,antibiotics,proton pump inhibitors,and bonetargeted therapies),radiographic ionic contrast media or radiation therapy,urinary tract obstruction,and intrinsic renal disease.Identification of patients at higher risk for nephrotoxicity may allow the prevention or at least reduction in the development and severity of this adverse effect.Therefore,the aim of this brief review is to provide currently available evidences on oncologic drug-related nephrotoxicity. | Maria Luísa Cordeiro Santos Breno Bittencourt de Brito Filipe Antonio FranÇa da Silva Anelise Costa dos Santos Botelho Fabrício Freire de Melo | 2020 | World Journal of Clinical Oncology2020，11，4： | 4 |
| 3 | The Diffusion of Cellular Phones in Portugal显示文摘 | Botelho A Pinto L C | 2004 | Telecommunications Policy2004，，28： | 1 |
| 4 | Use of Autologous Mesenchymal Stem Cells Derived from Bone Marrow for the Treatment of Naturally Injured Spinal Cord in Dogs显示文摘 | Euler Moraes Penha Cássio Santana Meira Elisalva Teixeira Guimar?es Marcus Vinícius Pinheiro Mendon?a Faye Alice Gravely Cláudia Maria Bahia Pinheiro Taiana Maria Bahia Pinheiro Stella Maria Barrouin-Melo Ricardo Ribeiro-dos-Santos Milena Botelho Pereira | 2014 | Stem Cells International2014，，： | 1 |
| 5 | Psyllium as a substitute for gluten in bread显示文摘 | ZANDONADI R P BOTELHO R B A ARAUJO W M C | 2009 | Journal of the American Dietetic Association2009，109，10： | 1 |
| 6 | The influence of weathering conditions on the properties of poly( vinyl chloride) for outdoor applications:An analytical study using surface analysis techniques 显示文摘 | L E Pimentel Real A M Ferraria A M Botelho do Rego | 2007 | Polymer Testing2007，26，： | 1 |
| 7 | Finite-difference prestack reverse-time migration using the P-SV wave equation显示文摘 | Botelho M A B Stoffa P L | 1991 | Expanded Abstracts of 61st Annual Internat SEG Mtg1991，，： | 1 |
| 8 | Studies on thermal and thermo-oxidative degradation of poly ( ethylene terephthalate ) and poly ( butylene terephthalate ) 显示文摘 | Botelho G Queir6s A Liberal S | 2001 | Polym Degrad Stab2001，74，1： | 1 |
| 9 | Syner-gism on antioxidant activity between natural compounds optimized byresponse surface methodology显示文摘 | CAPITANI C D CARVALHO A C L BOTELHO P B | 2009 | European Journal of Lipid Science andTechnology2009，111，11： | 1 |
| 10 | Partial oxidation of methane over bimetallic nickel-lanthanide oxides显示文摘 | Ferreira A C Ferraria A M Botelho do Rego A M Goncalves A P Correia M R Gasche T A Branco J B | | 0，，01： | 1 |
| 11 | Performance of electroactive poly(vinylidene fluoride) against UV radiation显示文摘 | Botelho G Silva M M Gonc A M | 2007 | Polymer Testing2007，27，7： | 1 |
| 12 | Effect of conjugated linoleic acid supplementation on lipoprotein lipase activity in 3T3-L1 adipocyte culture 显示文摘 | BOTELHO A P SANTOS-ZAGO L F OLIVEIRA A C | 2009 | Brazilian Journal of Nutrition2009，22，5： | 1 |
| 13 | Influence of cassava starch content and sintering temperature on the alumina consolidation technique 显示文摘 | Almeida F A Botelho E C Melo F C L | 2009 | Journal of the European Ceramic Society2009，29，： | 1 |
| 14 | XPS investigation of BxNyCz coatings deposited by laser assisted chemical vapour deposition显示文摘 | Oliveira M N Botelho do Rego A M Conde O | 1998 | Surf Coat Technol1998，，： | 1 |
| 15 | Methylene blue adsorption by algal biomass based materials:Biosorbents characterization and process behaviour显示文摘 | Vilar V J P Botelho C Boaventura R A R | 2007 | Journal of Hazardous Materials2007，147，1： | 1 |
| 16 | Processing a spodumene ore to obtain lithium concentrates for addition to glass and ceramic bodies显示文摘 | Amarante M M De Sousa A Botelho Leite M Machado | 1999 | Minerals Engineering1999，12，4： | 1 |
| 17 | Equilibrium and kinetic modeling of Cd ( II ) biosorption by algae Gelid- ium and agar extraction algal waste 显示文摘 | Vilar V I P Botelho C M S Boaventura R A R | 2006 | Water Research2006，40，3： | 1 |
| 18 | Reproductive effects of di(2-ethylhexyl) phthalate in immature male rats and its relation to cholesterol testosterone, and thyroxin levels 显示文摘 | Botelho G G Golin M Bufalo A C | 2009 | Archives of Environmental Contamination and Toxicology2009，57，4： | 1 |
| 19 | Gold nanoprobe assay for the identification of mycobacteria of the Mycobacterium tuberculosis complex显示文摘 | Costa P Amaro A Botelho A | 2010 | Clini Microbiol Infect2010，16，9： | 1 |
| 20 | A review of the use of red mud as adsorbent for the removal of toxic pollutants from water and wastewater显示文摘 | Bhatnagar A Vilar V J Botelho C M | 2011 | Environ Techn2011，32，34： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员