The role of mouse models in colorectal cancer research—The need and the importance of the orthotopic models

查看全文 作　　者：Rui [1,2]C.Oliveira;Ana Margarida [1,3]Abrantes;JoseGuilherme [1,3,4]Tralhao;Maria Filomena [1,3]Botelho

机构地区：[1]Biophysics Unit,Faculty of Medicine,University of Coimbra,Coimbra,Portugal;[2]Pathology Department,University Hospital(CHUC),Coimbra,Portugal;[3]Centre of Investigation on Environment,Genetics and Oncobiology(CIMAGO),Coimbra,Portugal;[4]Surgery A Department,Faculty of Medicine,University Hospital(CHUC),Coimbra,Portugal

出　　处：《Animal Models and Experimental Medicine》索引2020年第3卷第1期,共8页

摘　　要：Colorectal cancer is a worldwide health burden,with high incidence and mortality,especially in the advanced stages of the disease.Preclinical models are very important and valuable to discover and validate early and specific biomarkers as well as new therapeutic targets.In order to accomplish that,the animal models must replicate the clinical evolution of the disease in all of its phases.In this article,we review the existent mouse models,with their strengths and weaknesses in the replication of human cancer disease progression,with major focus on orthotopic models. 关键词：colorectal cancer mouse model orthotopic model

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The role of mouse models in colorectal cancer research—The need and the importance of the orthotopic models

参考文献(111)

引证文献(8)

耦合文献(15)

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