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| 1 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 2 | Genetic ancestry analysis in non-alcoholic fatty liver disease patients from Brazil and Portugal显示文摘AIM:To study the association between genetic ancestry,non-alcoholic fatty liver disease(NAFLD) metabolic characteristics in two cohorts of patients,from Brazil and Portugal. METHODS:We included 131 subjects from Brazil [(n = 45 with simple steatosis(S. Steatosis) and n = 86 with nonalcoholic steatohepatitis(NASH)] and 90 patients from Portugal(n = 66,S. Steatosis; n = 24,NASH). All patients had biopsy-proven NAFLD. In histologic evaluation NAFLD activity score was used to assess histology and more than 5 points defined NASH in this study. Patients were divided into two groups according to histology diagnosis:simple steatosis or non-alcoholic statohepatitis. Genetic ancestry was assessed using real-time polymerase chain reaction. Seven ancestry informative markers(AT3-I/D,LPL,Sb19.3,APO,FYNull,PV92,and CKMM) with the greatest ethnicgeographical differential frequencies(≥ 48%) were used to define genetic ancestry. Data were analyzed using R PROJECTS software. Ancestry allele frequencies between groups were analyzed by GENEPOP onlineand the estimation of genetic ancestry contribution was evaluated by ADMIX-95 software. The 5% alpha-error was considered as significant(P < 0.05). RESULTS:In the Brazilian sample,NASH was significantly more frequent among the elderly patients with diabetes(NASH 56 ± 1.1 years old vs S. Steatosis 51 ± 1.5 years old,P = 3.7 x 10-9),dyslipidemia(NASH 63% vs S. Steatosis 37%,P = 0.009),higher fasting glucose levels(NASH 124 ± 5.2 vs S. Steatosis 106 ± 5.3,P = 0.001) and Homeostatic Model of Assessment index > 2.5 [NASH 5.3(70.8%) vs S. Steatosis 4.6(29.2%) P = 0.04]. In the Portuguese study population,dyslipidemia was present in all patients with NASH(P = 0.03) and hypertension was present in a larger percentage of subjects in the S. Steatosis group(P = 0.003,respectively). The genetic ancestry contribution among Brazilian and Portuguese individuals with NASH was similar to those with S. Steatosis from each cohort(Brazilian cohort:P = 0.75; Portuguese cohort:P = 0.97). Nonetheless,the genetic ancestry contribution of the Brazilian and Portuguese population were different,and a greater European and Amerindian ancestry contribution was detected in the Portuguese population while a higher African genetic ancestry contribution was observed in Brazilian population of both NASH and S. Steatosis groups.CONCLUSION:There was no difference between the genetic ancestry contribution among Brazilian and Portuguese individuals with NASH and S. Steatosis from each cohort. | Lourianne Nascimento Cavalcante Jose Tadeu Stefano Mariana V Machado Daniel F Mazo Fabiola Rabelo Kiyoko Abe Sandes Flair Jose Carrilho Helena Cortez-Pinto Andre Castro Lyra Claudia P de Oliveira | 2015 | World Journal of Hepatology2015，7，10： | 2 |
| 3 | Regeneration of transgenic plants of Prunus amleniaca confaining the coat protein gene of plum pox virus显示文摘 | Machado MC Hanzer V | 1992 | Plant Cell Rep1992，，11： | 1 |
| 4 | Recent history of fractional calculus显示文摘 | MACHADO J T KIRYAKOVA V MAINARDI F | 2011 | Commun Nonlinear Sci Numer Simulat2011，16，： | 1 |
| 5 | In vitro activity of Brazilian medicinal plants,naturally occurring naphthoquinones and their analogues,against methicillin-resistant staphylococcus aureus显示文摘 | MACHADO T B PINTO A V PINTO M C | 2003 | Int J Antimicrob Ag2003，21，3： | 1 |
| 6 | Progress in pathogenmed iated resistance breeding against plum pox virus 显示文摘 | Machado MC Hanzer V | 1995 | Acta Hort1995，386，： | 1 |
| 7 | The effect of light on in vitro microtuberization of potato cultivars显示文摘 | Slimmon T Machado V Coffin R | 1989 | American Potato Journal1989，66，12： | 1 |
| 8 | Acute ghrelin administration reverses depressive like behavior induced by bilateral olfactory bulbeetomy in mice显示文摘 | Carlini V P Machado D G Buteler F | 2012 | Peptides2012，35，2： | 1 |
| 9 | Regeneration of transgenic plants of Prunus armeniaca containing the coat protein gene of Plum pox virus显示文摘 | MACHADO AC HANZER V | 1992 | Plant Cell Reports1992，11，： | 1 |
| 10 | Evolution of Peroxide-induced Thermomechanical Degradation of Polypropylene along the Extruder显示文摘 | A V Machado J M Maia S V Canevarolo | 2004 | J Appl Polym Sci2004，91，4： | 1 |
| 11 | When your child with epilepsy die suddenly : febrile seizures are part of the process 显示文摘 | TERRA V C MACHADO H R SAKAMOTO A C | 2011 | Arq Neuropsiquiatr2011，69，2： | 1 |
| 12 | Morphology development and phase inversion during dynamic vuleanisation of EPDM/PP blends 显示文摘 | ANTUNES C F MACHADO A V VAN DU1N M | 2011 | European Polymer Journal2011，47，7： | 1 |
| 13 | 牙周炎与高血压的相关性显示文摘牙周炎是一种常见的慢性炎症性疾病,可能会对血压产生重要影响。本研究旨在探究:(1)在一项大型代表性队列中研究牙周健康与血压的相关性;(2)牙周炎在未明确诊断血压升高患者中的诊断预测价值;(3)年龄是否在牙周健康与血压的相关性中起介导作用。在纳入随机招募的参与者1057例[平均年龄(60.9±16.3)岁,57.7%为女性]中行牙周临床评估,并使用自动血压计测量单次血压。 | 袁源(摘译) 练桂丽(审校) Machado V Aguilera EM Botelho J Hussain SB Leira Y Proenca L D’Aiuto F Mendes JJ | 2020 | 中华高血压杂志2020，28，9： | 1 |
| 14 | Effect of polyoliln stuctureon maleic anhydride rafting显示文摘 | Machado A V Covas J A Vanduin M | 2001 | Polymer2001，42，8： | 1 |
| 15 | Source,level and age differences in fat utilization in broilers 显示文摘 | Machado L P Vieira S L Quadros R V | 2003 | Poul Sci2003，82，： | 1 |
| 16 | Photosynthetic photon flux density, carbon dioxide concentration, and vapor pressure deficit effects on photosynthesis in cacao seedlings显示文摘 | Baligar V C Bunce J A Machado R C R et ol | 2008 | Photosynthetica2008，46，2： | 1 |
| 17 | Regeneration of transgenic plants of Prunus armeniaca containing the coat protein gene of Plum Pox Virus显示文摘 | da CAMARA MACHADO M L da CAMARA MACHADO A HANZER V WEISS H REGNER F STEINKELINER H | 1992 | Plant Cell Rep1992，11，： | 1 |
| 18 | EPDM-based thermoplastic vuleanisates : Crosslinking chemistry and dynamic vulcanisati- on along the extruder axis 显示文摘 | van DUIN M MACHADO A V | 2005 | Polym Degrad Stab2005，90，： | 1 |
| 19 | Evaluation of Candida albicans adhesion and biofilm formation on a den- ture base acrylic resin containing silver nanoparticles 显示文摘 | Wady AF Machado AL Zucolotto V | 2012 | J Appl Microbiol2012，112，6： | 1 |
| 20 | Sediments as monitors of heavy metal contamination in the Ave River Basin (Portugal): Multivariate analysis of data 显示文摘 | Soares H M V M Boaventura R A R Machado A A SC | 1999 | Environmental Pollution1999，105，： | 1 |
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