3篇
您的检索式：作者名="Maria Filomena Botelho"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The role of mouse models in colorectal cancer research—The need and the importance of the orthotopic models显示文摘Colorectal cancer is a worldwide health burden,with high incidence and mortality,especially in the advanced stages of the disease.Preclinical models are very important and valuable to discover and validate early and specific biomarkers as well as new therapeutic targets.In order to accomplish that,the animal models must replicate the clinical evolution of the disease in all of its phases.In this article,we review the existent mouse models,with their strengths and weaknesses in the replication of human cancer disease progression,with major focus on orthotopic models. | Rui C.Oliveira Ana Margarida Abrantes JoseGuilherme Tralhao Maria Filomena Botelho | 2020 | Animal Models and Experimental Medicine2020，3，1： | 5 |
| 2 | Quantitative scintigraphic analysis of the apical seal in Thermafil/Topseal and Real Seal 1/Realseal filled root canals显示文摘AIM: To investigate the microleakage of two different root canal obturation systems, using the nuclear medicine approach.METHODS: Twenty-six single-rooted extracted teeth were selected. The crowns were sectioned to obtain 15-mm long root segments and each tooth was prepared using rotary Pro File instruments. The roots were divided into 2 experimental groups using Real Seal 1 and Real Seal sealer or Thermafil and Top Seal sealer as well as two control groups. On the 7th and the 28 th day the apices were submersed in a solution of 99 m TcPertechnetate during 3 h. The radioactivity was counted using a γ camera. RESULTS: The present study showed that none of the root canal-filled teeth was leakage free. The statistical analyses were made using Kruskal-Wallis and statistical significance was assessed using α = 0.05. Although apical leakage measured in counts per minute(cpm) in the Thermafil/Top Seal group was lower than in the Real Seal/Real Seal group(363 916 ± 180 707.7 cpm vs533 427 ± 414 020.6 cpm) on 7th day and(1 678 200 ± 567 217.4 cpm vs 2 240 518 ± 383 356.7 cpm) on 28 th day, there was no statistical difference(P > 0.05). In the Thermafil/Top Seal group and Real Seal 1/Real Seal group it was found that over time, the number of counts increased between 7 d and 28 d(363 916 ± 180 707.7 cpm vs 1 678 200 ± 567 217.4 cpm) and(533 427 ± 414 020.6 cpm vs 2 240 518 ± 383 356.7 cpm), respectively, with statistically significant differences(Thermafil/Top Seal group, P = 0.015 and Real Seal 1/Real Seal group, P = 0.036).CONCLUSION:Both carrier-based Realseal 1 and Thermafil techniques showed a similar sealing effect,but none of the materials was leakage free. | Manuel Marques Ferreira Margarida Abrantes Eunice Virgínia Carrilho Maria Filomena Botelho | 2013 | World Journal of Stomatology2013，2，2： | 2 |
| 3 | 氯己定漱口液作为防龋剂的系统评价显示文摘目的:评价在中高危息龋风险患者中使用氯己定漱口液中减少致龋菌的有效性。材料与方法:利用Cochrane Library、Embase、PubMed、Scopus和Web of Science完成文献系统评价。检索截止到2017年1月发表的英语、西班牙语和葡萄牙语文章。根据PICO策略设计检索问题。利用Cochrane干预系统评价手册的指南做偏倚风险评估。结论:所有作者都发现了在使用氯己定漱口液过程中及之后,变异链球菌水平有统计上的显著差异。尽管这些结果有启发性,但是仍有必要开展新的高质量长随访周期的研究以评估这些结果能否转化用于减缓龋齿的发展,从而评估这些产品是否应纳入防龋方案。 | Ana Sofia Estima Cunha Coelho Teresa Maria Palmeirao Carrilho Maria Filomena Rabaca Roque Botelho 马张珂(译) 张珊珊(审) 郑树国(审) | 2018 | 中国口腔医学继续教育杂志2018，21，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员