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| 1 | 中国西部地区猎隼(Falco cherrug)繁殖生物学与保护显示文摘自2001—2006年,中国科学院与英国鸟类研究中心联合对新疆准噶尔盆地和昆仑山、青海玉树地区、西藏那曲地区的猎隼(Falco cherrug)分布状况与繁殖生态进行深入调查。考察行程上万公里。卫星跟踪显示在俄罗斯、蒙古繁殖的猎隼迁往青藏高原越冬。但是,实地调查表明,在新-青-藏还有一些繁殖种群;繁殖区的海拔高度从600m,上升至5200m。根据观察,猎隼喜欢沿用旧巢,多数巢属于“垃圾巢”。因为高原缺乏合适的巢材,那些人类遗弃的皮管、铁丝、皮带、破布、汽车零件、骨片、绳子等垃圾充斥于巢穴之中。考察期间,共找到100多只猎隼成鸟、约35个猎隼巢或巢区;分布地点涉及昆仑山脉、准噶尔盆地、卡拉麦里山脉、北塔山、可可西里、唐古拉山脉等,包括新疆奇台、且末、青河、塔城,青海楚玛尔河、五道梁、曲麻菜、雁石坪、玉树,西藏安多、那曲等。猎隼巢址多位于悬崖凹陷处(21个)、河岸砂土洞(5)、桥梁(2)等处;巢高于地面7—30m。通常沿用渡鸦、大鸳、棕尾鸳、金雕的旧巢,有同步繁殖现象。附近有鼠兔、雪雀、地鸦、岩鸽、石鸡、沙鸡等活动。巢区沿着山脉或者丘陵连续分布,巢间距最近2.5km,通常4—8km或更远。在准噶尔盆地其繁殖密度1.1~1.6对/1000km^2。通常4—5月产卵,窝卵数3—5枚;5月上旬和中旬已有部分幼乌出壳。虽然在中国捕捉猎隼现象十分猖獗,但考察结果依然令人振奋。建议中国猎隼研究小组(CSRG)积极开展国际合作,通过卫星跟踪、GPS定位、电子微芯片标记(PIT)、DNA指纹图谱分析、人工猎隼栖架和巢穴招引技术等,不断完善监测手段和管理机制,为猎隼的保护与合理利用做出努力。 | 马鸣 梅宇 Eugene Potapov 吴逸群 Andrew Dixon Dimitar Ragyov 徐峰 Nicholas C.Fox | 2007 | 干旱区地理2007，30，5： | 9 |
| 2 | 基于多轨道卫星观测数据分析尼泊尔地震长波辐射特征显示文摘综合已经在红外异常提取中应用的涡度和RST(Robust Satellite Technique)算法优点,提出了红外异常指数算法.并基于长时间尺度的中国静止卫星FY-2D和美国极轨卫星NOAA长波辐射数据,应用RST和异常指数算法,分别对2015年4月25日尼泊尔M_s8.1和5月12日M_s7.5地震前后卫星长波辐射变化特征进行了分析,开展了多轨道、多时空分辨率长波辐射同步地震热红外特征研究.结果表明,运用RST算法,两次地震前后,未能在震中周围发现明显的长波辐射异常.运用异常指数算法:(1)对于NOAA卫星,4月15日在M_s8.1地震震中以西出现热红外异常,到4月24日震中以西约100 km处出现异常最大值,随后逐渐消失.5月10日在M_s7.5地震震中以东约200 km发现异常;(2)在NOAA卫星长波辐射异常发现最大值当日,采用FY-2D卫星每3 h的数据分析可发现红外异常的动态演化过程,弥补NOAA卫星分辨率不足.以上结果为利用多轨道卫星监测地震热辐射变化提供了依据. | 孙珂 单新建 Dimitar Ouzounov 申旭辉 荆凤 | 2017 | 地球物理学报2017，60，9： | 9 |
| 3 | Atmosphere-ionosphere response to the M9 Tohoku earthquake revealed by multiinstrument space-borne and ground observations:Preliminary results显示文摘We retrospectively analyzed the temporal and spatial variations of four different physical parameters characterizing the state of the atmosphere and ionosphere several days before the M9 Tohoku,Japan earthquake of March 11,2011.The data include outgoing long wave radiation(OLR),GPS/TEC,lower Earth orbit ionospheric tomography and critical frequency foF2.Our first results show that on March 7th a rapid increase of emitted infrared radiation was observed from the satellite data and an anomaly developed near the epicenter.The GPS/TEC data indicate an increase and variation in electron density reaching a maximum value on March 8.Starting from this day in the lower ionosphere also there was confirmed an abnormal TEC variation over the epicenter.From March 3 to 11 a large increase in electron concentration was recorded at all four Japanese ground-based ionosondes,which returned to normal after the main earthquake.The joint preliminary analysis of atmospheric and ionospheric parameters during the M9 Tohoku,Japan earthquake has revealed the presence of related variations of these parameters implying their connection with the earthquake process.This study may lead to a better understanding of the response of the atmosphere/ionosphere to the great Tohoku earthquake. | Dimitar Ouzounov Sergey Pulinets Alexey Romanov Alexander Romanov Konstantin Tsybulya Dmitri Davidenko Menas Kafatos Patrick Taylor | 2011 | Earthquake Science2011，24，6： | 7 |
| 4 | Increased intestinal permeability in inflammatory bowel diseases assessed by iohexol test显示文摘AIM:To study intestinal permeability(IP) and its relationship to the disease activity in patients with inflammatory bowel diseases(IBD)-Crohn's disease(CD) and ulcerative colitis(UC).METHODS:Fifty-eight patients with active IBD(32 with CD and 26 with UC) and 25 healthy controls consented to participate in the study.The clinical activity of CD was estimated using the Crohn's Disease Activity Index(CDAI),and the endoscopic activity of UC using the Mayo scoring system.IP was assessed by the rise in levels of iohexol,which was administered orally(25 mL,350 mg/mL) 2 h after breakfast.Three and six hours later serum(SIC mg/L) and urine(UIC g/mol) iohexol concentrations were determined by a validated HPLC-UV technique.RESULTS:In the CD group,SIC values at 3 h(2.95 ± 2.11 mg/L) and at 6 h after ingestion(2.63 ± 2.18 mg/L) were significantly higher compared to those of healthy subjects(1.25 ± 1.40 mg/L and 1.11 ± 1.10 mg/L,respectively,P < 0.05).UIC(g/mol) values were also higher in patients,but the differences were significant only for UIC at 6 h.Significant positive correlation(P < 0.05) was found between the CDAI and IP,assessed by SIC at 3 h(r = 0.60) and 6 h(r = 0.74) after the ingestion.In comparison to controls,SIC and UIC of UC patients were higher in the two studied periods,but the differences were significant at 6 h only.Significantly higher values of SIC(P < 0.05) were found in patients with severe endoscopic activity of UC compared to those of patients with mild and moderate activity(3.68 ± 3.18 vs 0.92 ± 0.69 mg/L).CONCLUSION:Serum levels of iohexol at 3 h and 6 h after its ingestion reflect increased IP,which is related to the disease activity in patients with IBD. | Vanya A Gerova Simeon G Stoynov Dimitar S Katsarov Dobrin A Svinarov | 2011 | World Journal of Gastroenterology2011，17，17： | 6 |
| 5 | Stem cell application for osteoarthritis in the knee joint: A minireview显示文摘Knee osteoarthritis is a chronic, indolent disease that will affect an ever increasing number of patients, especially the elderly and the obese. It is characterized by degeneration of the cartilage substance inside the knee which leads to pain, stiffness and tenderness. By some estimations in 2030, only in the United States, this medical condition will burden 67 million people. While conventional treatments like physiotherapy or drugs offer temporary relief of clinical symptoms, restoration of normal cartilage function has been difficult to achieve. Moreover, in severe cases of knee osteoarthritis total knee replacement may be required. Total knee replacements come together with high effort and costs and are not always successful. The aim of this review is to outline the latest advances in stem cell therapy for knee osteoarthritis as well as highlight some of the advantages of stem cell therapy over traditional approaches aimed at restoration of cartilage function in the knee. In addition to the latest advances in the field, challenges associated with stem cell therapy regarding knee cartilage regeneration and chondrogenesis in vitro and in vivo are also outlined and analyzed. Furthermore, based on their critical assessment of the present academic literature the authors of this review share their vision about the future of stem cell applications in the treatment of knee osteoarthritis. | Kristin Uth Dimitar Trifonov | 2014 | World Journal of Stem Cells2014，6，5： | 6 |
| 6 | 单侧隐睾史不育患者的精子参数评价显示文摘目的:评价患者施行睾丸固定手术时的年龄对其后精子参数的可能影响。方法:47例单侧隐睾史不育患者,按照患者施行单侧睾丸固定术时的年龄分为A组(2-7岁,n=23),B组(8-13岁,n=14)和C组(14-17岁,n=10)。对3组患者的精液作精液分析和精子头-尾膜的完整性检测。结果:3组患者的精液中均可观察到活动精子,精子活动率和精子浓度有很大的个体差异,畸形精子率普遍较高,精子头-尾膜完整率低。少弱畸精子症的发生率在B组(35%)和C组(50%)升高。结论:单侧隐睾史不育患者会有较差的精子参数。单侧隐睾症患者在幼年阶段尽早治疗有利于成年后的精子发生。 | Petia Tzvetkova 朱伟杰 Dimitar Tzvetkov | 2006 | 生殖与避孕2006，26，5： | 6 |
| 7 | 新疆准噶尔盆地猎隼(Falco cherrug)繁殖期食性及其对鼠类的防控显示文摘2005年3~7月在新疆卡拉麦里山地区和北塔山地区的猎隼(Falco cherrug)食性研究中发现鼠类是其主要食物.调查中收集到猎隼食团342个,其中有鼠毛出现的食团是287个,占到83.9%.有鼠骨出现的食团是117个,占到34.2%.在鉴定出来的117个残留物种类中,大沙鼠出现次数超过15次.根据目击的结果分析,鼠类在食物种类中占绝对优势.由于繁殖季节对鼠类大量捕食,猛禽类能在生物防治鼠害中起到积极的作用. | 吴逸群 马鸣 徐峰 Andrew Dixon Dimitar Ragyov | 2006 | 新疆农业大学学报2006，29，2： | 4 |
| 8 | Sol-gel synthesis, surface and magnetic properties of nanocrystalline SmAlO_3显示文摘Nanocrystals of single-phase samarium monoaluminate (SmAlO3) were synthesized and studied for the first time. Malic acid was employed as a new complexing agent in the sol-gel process. The material was characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray analysis (EDS), specific surface area and density. The lowest size of the nanoparticles was about 50–60 nm and some of them formed agglomerates. The binding energies of core-level electrons of Sm (3d, 4d, 4f, 5p, 5s), Al (2s, 2p) and O (1s, 2s) in nanocrystalline SmAlO3 were obtained by X-ray photoelectron spectroscopy (XPS) and found shifted in respect to the correspond- ing values for the same elements. The temperature dependence of the AC magnetic susceptibility of the substance was determined between 2.5 and 250 K. The experimental molar magnetic susceptibility was compared with the theoretical one of Sm3+ ions. The nanomaterial was found paramagnetic in the specified temperature range with Curie-type paramagnetism below 12 K. | Dimitar Petrov Bogdan Angelov Vasil Lovchinov | 2010 | Journal of Rare Earths2010，28，4： | 3 |
| 9 | Long-term survival of a patient after resection of a gastrointestinal stromal tumor arising from the pancreas显示文摘BACKGROUND:Gastrointestinal stromal tumors (GISTs) may arise in any part of the gastrointestinal tract;extragastrointestinal locations are extremely rare.Only a few cases of extragastrointestinal stromal tumor arising from the pancreas were reported.None of the reports described a long-term follow-up of the patients.METHOD:This report describes an interesting and unusual case of GIST arising from the pancreas.RESULTS:A 74-year-old female presented with a palpable abdominal mass.CT scan showed a large mass 11×8×4 cm originating from the tail of the pancreas.Percutaneous biopsy revealed a GIST predominantly with spindle cells,but some parts also contained epitheloid cells.The patient was treated by distal pancreatic resection with splenectomy.Immunohistochemistry of the tumor showed a staining pattern characteristic of GIST.The patient has achieved a long-term survival of five years and six months without any sign of recurrence of the disease.CONCLUSION:This is the first reported case of an extragastrointestinal stromal tumor arising from the pancreas treated surgically,with a long-term survival. | Filip eka Bohumil Jon Alexander Ferko Zdeněk ubrt Dimitar H Nikolov Věra Tyová | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 3 |
| 10 | 批量下载GenBank基因序列数据的新工具--NCBIminer显示文摘核苷酸序列是生物体遗传信息的载体,是现代生物学和生态学的基础数据。随着测序技术的进步,大量核苷酸序列被提取并存储在公共数据平台中,其中Gen Bank(http://gffzz16a62c593b5540cehxcow5w5xwuc66onk.ffgz.tsg.suse.edu.cn/genbank/)是目前最大的核苷酸序列数据平台之一。截至2015年2月,该平台收录核苷酸序列总数已超过1.8亿条、覆盖全球超过30万个物种。但如何从如此海量的数据中准确、快速查找并下载所需数据已成为限制基因数据广泛使用的障碍之一。为此,我们开发了一款可高效、准确下载Gen Bank数据的生物信息学软件NCBIminer。NCBIminer可根据用户提供的核苷酸序列名称、数据类型、一或多条初始化参考序列,查找并下载用户指定的多个物种或类群的特定基因序列数据。该软件下载地址为http://gffzz188fe103f8f1460asxcow5w5xwuc66onk.ffgz.tsg.suse.edu.cn/greengirl/NCBIminer/releases/,可在Windows、Linux和MAC操作系统下免费使用;同时,其操作简单,用户无需生物信息学背景。为方便该软件的使用,本文将介绍该软件的工作流程与算法、安装及使用过程中的参数设置等。 | 徐晓婷 王志恒 Dimitar Dimitrov Carsten Rahbek | 2015 | 生物多样性2015，23，4： | 3 |
| 11 | 准噶尔盆地东部棕尾鸟狂繁殖生态学研究显示文摘2005年4月至6月,在新疆准噶尔盆地东部地区对棕尾鵟的繁殖生物学进行了研究.通过对棕尾鵟(Buteo rufinus)10个巢的观察,发现巢体大多在山体阴面.对棕尾鵟的26枚卵进行测量,长径是56.24 mm±2.58 mm,短径是43.10 mm±0.93 mm.通过对亲鸟孵卵及育雏情况的观察,此地区棕尾鵟的窝卵数2~4枚,孵化率是0.433,幼鸟成活率为0.692,棕尾鵟繁殖力为0.499.在研究中发现,巢内的毛皮、布片、塑料袋等铺垫物由于被风吹起盖住卵而导致亲鸟弃巢的现象严重.10只卵由于巢内铺垫物的覆盖而导致孵化失败. | 吴逸群 马鸣 徐峰 Andrew Dixon Dimitar Ragyov | 2006 | 干旱区地理2006，29，2： | 3 |
| 12 | Fungal diversity notes 367-490:taxonomic and phylogenetic contributions to fungal taxa显示文摘This is a continuity of a series of taxonomic papers where materials are examined,described and novel combinations are proposed where necessary to improve our traditional species concepts and provide updates on their classification.In addition to extensive morphological descriptions and appropriate asexual and sexual connections,DNA sequence data are also analysed from concatenated datasets(rDNA,TEF-a,RBP2 and b-Tubulin)to infer phylogenetic relationships and substantiate systematic position of taxa within appropriate ranks.Wherever new species or combinations are being proposed,we apply an integrative approach(morphological and molecular data as well as ecological features wherever applicable).Notes on 125 fungal taxa are compiled in this paper,including eight new genera,101 new species,two new combinations,one neotype,four reference specimens,new host or distribution records for eight species and one alternative morphs.The new genera introduced in this paper are Alloarthopyrenia,Arundellina,Camarosporioides,Neomassaria,Neomassarina,Neotruncatella,Paracapsulospora and Pseudophaeosphaeria.The new species are Alfaria spartii,Alloarthopyrenia italica,Anthostomella ravenna,An.thailandica,Arthrinium paraphaeospermum,Arundellina typhae,Aspergillus koreanus,Asterina cynometrae,Bertiella ellipsoidea,Blastophorum aquaticum,Cainia globosa,Camarosporioides phragmitis,Ceramothyrium menglunense,Chaetosphaeronema achilleae,Chlamydotubeufia helicospora,Ciliochorella phanericola,Clavulinopsis aurantiaca,Colletotrichum insertae,Comoclathris italica,Coronophora myricoides,Cortinarius fulvescentoideus,Co.nymphatus,Co.pseudobulliardioides,Co.tenuifulvescens,Cunninghamella gigacellularis,Cyathus pyristriatus,Cytospora cotini,Dematiopleospora alliariae,De.cirsii,Diaporthe aseana,Di.garethjonesii,Distoseptispora multiseptata,Dis.tectonae,Dis.tectonigena,Dothiora buxi,Emericellopsis persica,Gloniopsis calami,Helicoma guttulatum,Helvella floriforma,H.oblongispora,Hermatomyces subiculosa,Juncaceicola italica,Lactarius dirkii,Lentithecium unicellulare,Le.voraginesporum,Leptosphaeria cirsii,Leptosphaeria irregularis,Leptospora galii,Le.thailandica,Lindgomyces pseudomadisonensis,Lophiotrema bambusae,Lo.fallopiae,Meliola citri-maximae,Minimelanolocus submersus,Montagnula cirsii,Mortierella fluviae,Muriphaeosphaeria ambrosiae,Neodidymelliopsis ranunculi,Neomassaria fabacearum,Neomassarina thailandica,Neomicrosphaeropsis cytisi,Neo.cytisinus,Neo.minima,Neopestalotiopsis cocoe¨s,Neopestalotiopsis musae,Neoroussoella lenispora,Neotorula submersa,Neotruncatella endophytica,Nodulosphaeria italica,Occultibambusa aquatica,Oc.chiangraiensis,Ophiocordyceps hemisphaerica,Op.lacrimoidis,Paracapsulospora metroxyli,Pestalotiopsis sequoiae,Peziza fruticosa,Pleurotrema thailandica,Poaceicola arundinis,Polyporus mangshanensis,Pseudocoleophoma typhicola,Pseudodictyosporium thailandica,Pseudophaeosphaeria rubi,Purpureocillium sodanum,Ramariopsis atlantica,Rhodocybe griseoaurantia,Rh.indica,Rh.luteobrunnea,Russula indoalba,Ru.pseudoamoenicolor,Sporidesmium aquaticivaginatum,Sp.olivaceoconidium,Sp.pyriformatum,Stagonospora forlicesenensis,Stagonosporopsis centaureae,Terriera thailandica,Tremateia arundicola,Tr.guiyangensis,Trichomerium bambusae,Tubeufia hyalospora,Tu.roseohelicospora and Wojnowicia italica.New combinations are given for Hermatomyces mirum and Pallidocercospora thailandica.A neotype is proposed for Cortinarius fulvescens.Reference specimens are given for Aquaphila albicans,Leptospora rubella,Platychora ulmi and Meliola pseudosasae,while new host or distribution records are provided for Diaporthe eres,Di.siamensis,Di.foeniculina,Dothiorella iranica,Do.sarmentorum,Do.vidmadera,Helvella tinta and Vaginatispora fuckelii,with full taxonomic details.An asexual state is also reported for the first time in Neoacanthostigma septoconstrictum.This paper contributes to a more comprehensive update and improved identification of many ascomycetes and basiodiomycetes. | Kevin D.Hyde Sinang Hongsanan Rajesh Jeewon D.Jayarama Bhat Eric H.C.McKenzie E.B.Gareth Jones Rungtiwa Phookamsak Hiran A.Ariyawansa Saranyaphat Boonmee Qi Zhao Faten Awad Abdel-Aziz Mohamed A.Abdel-Wahab Supharat Banmai Putarak Chomnunti Bao-Kai Cui Dinushani A.Daranagama Kanad Das Monika C.Dayarathne Nimali Ide Silva Asha J.Dissanayake Mingkwan Doilom Anusha H.Ekanayaka Tatiana Baptista Gibertoni Aristóteles Góes-Neto Shi-Ke Huang Subashini C.Jayasiri Ruvishika S.Jayawardena Sirinapa Konta Hyang Burm Lee Wen-Jing Li Chuan-Gen Lin Jian-Kui Liu Yong-Zhong Lu Zong-Long Luo Ishara S.Manawasinghe Patinjareveettil Manimohan Ausana Mapook Tuula Niskanen Chada Norphanphoun Moslem Papizadeh Rekhani H.Perera Chayanard Phukhamsakda Christian Richter AndréL.C.Mde A.Santiago E.Ricardo Drechsler-Santos Indunil C.Senanayake Kazuaki Tanaka T.M.D.S.Tennakoon Kasun M.Thambugala Qing Tian Saowaluck Tibpromma Benjarong Thongbai Alfredo Vizzini Dhanushka N.Wanasinghe Nalin N.Wijayawardene Hai-Xia Wu Jing Yang Xiang-Yu Zeng Huang Zhang Jin-Feng Zhang Timur S.Bulgakov Erio Camporesi Ali H.Bahkali Mohammad A.Amoozegar Lidia Silva Araujo-Neta Joseph F.Ammirati Abhishek Baghela R.P.Bhatt Dimitar Bojantchev Bart Buyck Gladstone Alves da Silva Catarina Letícia Ferreira de Lima Rafael JoséVilela de Oliveira Carlos Alberto Fragoso de Souza Yu-Cheng Dai Bálint Dima Tham Thi Duong Enrico Ercole Fernando Mafalda-Freire Aniket Ghosh Akira Hashimoto Sutakorn Kamolhan Ji-Chuan Kang Samantha C.Karunarathna Paul M.Kirk Ilkka Kytovuori Angela Lantieri Kare Liimatainen Zuo-Yi Liu Xing-Zhong Liu Robert Lücking Gianfranco Medardi Peter E.Mortimer Thi Thuong Thuong Nguyen Itthayakorn Promputtha K.N.Anil Raj Mateus A.Reck Saisamorn Lumyong Seyed Abolhassan Shahzadeh-Fazeli Marc Stadler Mohammad Reza Soudi Hong-Yan Su Takumasa Takahashi Narumon Tangthirasunun Priyanka Uniyal Yong Wang Ting-Chi Wen Jian-Chu Xu Zhong-Kai Zhang Yong-Chang Zhao Jun-Liang Zhou Lin Zhu | 2016 | Fungal Diversity2016，，5： | 2 |
| 13 | Production of bioethanol from wheat straw: An overview on pretreatment, hydrolysis and fermentation显示文摘 | Farid Talebnia Dimitar Karakashev Irini Angelidaki | 2009 | Bioresource Technology2009，，13： | 2 |
| 14 | Chronic lymphocytic leukemia: A tale of one or two signals?显示文摘 | Nicholas Chiorazzi Dimitar G Effemov | 2013 | Cell Research2013，23，2： | 2 |
| 15 | CeO_2修饰介孔TiO_2和ZrO_2负载金催化剂催化废气中CO和挥发性有机化合物降解(英文)显示文摘Mesoporous 氧化物 TiO 2 和 ZrO 2, 经由中立 C 13(EO)6–Zr(OC3 H 7)4 集会小径,和 deposition–precipitation (DP ) 准备的修改 ceria 的 TiO 2 和 ZrO 2, 方法,展示高表面区域和一致毛孔尺寸分布被用作对金催化剂的支持。支持的金催化剂为空气污染物质的催化消退被估计,即,公司, CH 3 哦,并且(CH 3)2 O。金牌被一个 DP 方法在 mesoporous 氧化物上支持。支持和催化剂被粉末 X 光检查衍射,高分辨率的传播电子显微镜学, N 2 adsorption–desorption 分析,和规划温度的减小技术描绘。在象由 ceria 的结构、催化的性质的积极修正一样的 ceria 和 mesoporous ZrO 2 和 TiO 2 之间的 synergistic 相互作用的高度被观察。ceria 添加剂与 mesoporous 氧化物交往并且在支持的 reducibility 上导致强壮的效果。催化剂的催化行为被讨论决定修改在金 nanoparticles 和 ceria-mesoporous 氧化物支持之间的添加剂和可能的相互作用的 ceria 的角色。在修改 ceria 的 mesoporous ZrO 2 上支持的金催化剂显示了优异催化活动(在 10 °C 和 CH 3 在 60 °C 的 OH ) 。高催化的活动能被归因于支持的能力帮助氧空缺形成。研究显示修改 ceria 的 mesoporous 氧化物支持作为对基于黄金的催化剂的支持有潜力。 | Vasko Idakiev Dimitar Dimitrov Tatyana Tabakova Krasimir Ivanov Zhong-Yong Yuan Bao-Lian Su | 2015 | 催化学报2015，36，4： | 2 |
| 16 | Novel MLH1 frameshift mutation in an extended hereditary nonpolyposis colorectal cancer family显示文摘AIM: To present novel frameshift mutation c.31delC [p.L11X] in the MLH1 gene identified in an extended Bulgarian hereditary non-polyposis colorectal cancer (HNPCC) family and to analyze the molecular and clinical findings within the pedigree concerning the proposal of adequate individual prophylactic strategy for all mutation carriers. METHODS: The pedigree of the family consists of 42 members in four generations. Search for mutations in the MLH1 and hMSH2 genes was performed in the pro-band. After PCR amplification of all exons including flanking intronic regions, amplicons were directly sequenced. RESULTS: The mutation was found in nine from the thirteen pedigree members who signed informed consent to participate in the study. In three adenocarcinomas, microsatellite instability and lack of the MLH1 protein expression were detected. The only one tubulovillous adenoma analyzed was microsatellite stable and the MLH1 protein showed an intact staining. CONCLUSION: The newly described mutation c.31delC is HNPCC causative. Besides the typical clinical features of the syndrome, we found a specific pathologic manifestation such as moderate to high differentiated adenocarcinomas of the colon. One of the mutation carriers developed a benign giant cell soft tissue tumor. The primary tumor localizations were frequently extracolonic and detailed yearly gastrointestinal and gynecological examinations have been proposed to the mutation carriers. We emphasize the importance of including the HNPCC genetic counseling and testing as well in the following surveillance of all patients at risk in the services covered by the health insurance in Bulgaria. | Tanya Kirilova Kadiyska Radka Petrova Kaneva Dimitar Georgiev Nedin Alexandrina Borisova Alexandrova Antonina Todorova Gegova Stoyan Ganchev Lalchev Tatyana Christova Vanio Ivanov Mitev Juergen Horst Nadja Bogdanova Ivo Marinov Kremensky | 2006 | World Journal of Gastroenterology2006，12，48： | 2 |
| 17 | Application of COHERENS model for hydrodynamic investigation of Sacca di Goro coastal lagoon( Italian Adriatic Sea shore) 显示文摘 | Dimitar Marinov Alain Norro Jos'e-Manuel Zald'lvar | 2006 | Ecological Modelling2006，193，： | 1 |
| 18 | Expression of ICAM-1, VCAM-1, E-selectin and TNF-α on the endothelium of femoral and iliac arteries in thromboangiitis obliterans显示文摘 | Krasimira Halacheva Maya V. Gulubova Irena Manolova Dimitar Petkov | 2002 | Acta Histochemica2002，，2： | 1 |
| 19 | Production of bioethanol from wheat straw : An overview on pretreatment, hydrolysis and fermentation 显示文摘 | Talebnia Farid Karakashev Dimitar Angelidaki Irini | 2010 | Bioresource Technology2010，101，13： | 1 |
| 20 | Managing and Con- trolling Extrabudgetary Funds 显示文摘 | Richard Allen and Dimitar Radev | 2006 | OECD Journal on Bud- geting2006，，4： | 1 |
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