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| 1 | Role of Ki-67 as a prognostic factor in gastrointestinal stromal tumors显示文摘AIM:To investigate primarily the prognostic value of Ki-67,as well as other parameters,in gastrointestinal stromal tumors(GISTs).METHODS:Ki-67,c-KIT,platelet-derived growth factor receptor-alpha(PDGFRα),smooth muscle actin(SMA),CD34,S100 were stained for immunohistochemistry which was performed on formalin-fixed,paraffinembeded sections on representative block from each case.Proliferation index counted by Ki-67 antibody was calculated as a number of positive nuclear reaction over 100 cells.Immunoreactivity for c-KIT and PDGFRα was evaluated semiquantitatively(weak,intermediate,strong) and for c-KIT type of reactivity was analyzed(cytoplasmic,membrane and 'dot-like' staining).Immunoreactivity for SMA,CD34 and S100 were was evaluated as positive or negative antigen expression.Pathologic parameters investigated in this study included tumor size,cell type(pure spindle,pured epitheloid mixed spindle and epitheloid),mitotic count,hemorrhage,necrosis,mucosal ulceration.Clinical data included age,gender,primary tumor location and spread of disease.χ 2 test and Student's t-test were used for comparisons of baseline characteristics.The Cox's proportional hazard model was used for univariable and multivariable analyses.Survival rates were calculated by Kaplan-Meier method and statistical significance was determined by the log-rank test.RESULTS:According to the stage of disease,there were 36 patients with localized disease,29 patients with initially localized disease but with its recurrence in the period of follow up,and finally,35 patients had metastatic disease from the very beginning of disease.Tumor originated most commonly in the stomach(41%),small intestine was the second most common location(36%).The mean size of primary tumors was 6.5 cm.The mean duration of follow-up was 60 mo.Multiple parameters were analyzed for their effect on overall survival,but no one reached statistical significance(P = 0.06).Analysis of time to progression/relapse in initially localized disease(univariate analysis),tumor size,mitotic count,Ki-67 and type of d-KIT distribution(cytoplasmic vs membrane/'dot-like') showed statistically significant correlation.In multivariate analysis in the group of patients with localized disease,there were only 2 parameters that have impact on relapse,Ki-67 and SMA(P < 0.0001 and P < 0.034,respectively).Furthermore,Ki-67 was analyzed in localized diseasevs localized with recurrence and metastatic disease.It was shown that there is a strict difference between these 2 groups of patients(median value was 2.5 for localized disease vs 10.0 for recurrent/metastatic disease,P < 0.0001).It was also shown that the cut-off value which is still statistically significant in terms of relapse on the level of 6%.The curves for survival on that cut-off level are significantly different(P < 0.04,Cox F).CONCLUSION:Ki-67 presents a significant prognostic factor for GIST recurrence which could be of great importance in evaluating malignant potential of disease. | Borislav Belev Iva Bri Juraj Prejac Zrna Antunac Golubi Damir Vrbanec Jadranka Bozikov Ivan Aleri Marko Boban Jasminka Jaki Razumovi | 2013 | World Journal of Gastroenterology2013，19，4： | 14 |
| 2 | 为瘤的劣等的静脉 cava 的切除术和重建显示文摘 AIM: To evaluate the results of an aggressive surgical approach of resection and reconstruction of the inferior vena cava (IVC). METHODS: The approach to caval resection depends on the extent and location of tumor involvement. The supraand infra-hepatic portion of the IVC was dissected and taped. Left and right renal veins were also taped to control the bleeding. In 12 of the cases with partial tangential resection of the IVC, the flow was reduced to less than 40% so that the vein was primarily closed with a running suture. In 3 of the cases, the lumen of the vein was significantly reduced, requiring the use of a polytetrafluoroethylene (PTFE) patch. In 2 of the cases with segmental resection of the IVC, a PTFE prosthesis was used and in 1 case, the IVC was resected without reconstruction due to shunting the blood through the azygos and hemiazygos veins. RESULTS: The mean operation time was 266 min (230-310 min) with an average intraoperative blood loss of 300 mL (200-2000 mL). The patients stayed in intensive care unit for 1.8 d (1-3 d). Mean hospital stay was 9 d (7-15 d). Twelve patients (66.7%) had no complications and 6 patients (33.3%) had the following complications: acute bleeding in 2 patients; bile leak in 2 patients; intra abdominal abscess in 1 patient; pulmonary embolism in 2 patients; and partial thrombosis of the patch in 1 patient. General complications such as pneumonia, pleural effusion and cardiac arrest were observed in the same group of patients. In all but 1 case, the complications were transient and successfully controlled. The mortality rate was 11.1% (n = 2). One patient died due to cardiac arrest and pulmonary embolism in the operation room and the second one died 2 d after surgery due to coagulopathy. With a median follow-up of 24 mo, 5 (27.8%) patients died of tumor recurrence and 11 (61.1%) are still alive, but three of them have a recurrence on computed tomography. CONCLUSION: There are a variety of options for reconstruction after resection of the IVC that offers a higher resectable rate and better prognosis in selected cases. | Nikola Nikolov Vladov Vassil Ivanov Mihaylov Nikolai Vassilev Belev Ventzislav Metodiev Mutafchiiski Ivelin Rumenov Takorov Sergei Kirilov Sergeev Evelina Hristova Odisseeva | 2012 | World Journal of Gastrointestinal Surgery2012，4，4： | 2 |
| 3 | nm23 gene product expression in invasive breast cancer--immunohistochemical analysis and clinicopathological correlation显示文摘 | Belev B Aleric I Vrbanec D | 2002 | Acta Oncol2002，41，4： | 1 |
| 4 | Amorphous and polycrystal- line photoconductors for direct conversion flat panel X-ray image sensors显示文摘 | Kasap S Frey J B Belev G | 2011 | Sensors(Basel)2011，11，5： | 1 |
| 5 | Minimizing risk in high-tech programs 显示文摘 | Belev G C | 1989 | Cost Engineering1989，，10： | 1 |
| 6 | Performance of steel frames with a new friction damper device under earthquake excitation显示文摘 | Imad H. Mualla Borislav Belev | 2002 | Engineering Structures2002，，3： | 1 |
| 7 | Amorphous selenium and its alloys from early xeroradiography to high resolution X-ray image detectors and uhrasensitive imaging tubes显示文摘 | Kasap S Frey J B Belev G | 2009 | Physiea Status Soil di(b)2009，246，8： | 1 |
| 8 | Nm23 gene product expression in invasive breast cancer immunohistochemical analysis and clinicopathological correlatiorl显示文摘 | Belev B Alefic I Vrbanec D | 2002 | Acta Oncol2002，41，4： | 1 |
| 9 | nm23 gene product expression in invasive breast cancer-immunohistochemical analysis and clinicopathological correlation显示文摘 | Belev B Aleric I Vrbanec D | | 0，，： | 1 |
| 10 | Information Capabilities of Integrated Bridge Systems显示文摘 | Blagovest Charier Beleve | 2011 | The Journal of Navigation2011，57，1： | 1 |
| 11 | Genetic-epide-miologic study of adenoma and cancer of the large intestine显示文摘 | Samotyia EE Pikhut PM | 1999 | Ge-netika1999，35，4： | 1 |
| 12 | Information Capabilities of Integrated Bridge Systems显示文摘 | Blagovest Charier Beleve | 2011 | The Journal of Navigation2011，57，1： | 1 |
| 13 | nm23 gene product expression in invasive breast cancer-immunohistochemical analysis and clinicopahtological correlation显示文摘 | Belev B Aleric I Vrbanec D | 2002 | Acta Oncol2002，41，： | 1 |
| 14 | nm23 gene product expression in invasive breast cancer immunohistoehemieal analysis and clinicopathological correlation显示文摘 | Belev B Alerie I Vrbanec D | 2002 | Aeta 0ncol2002，41，4： | 1 |
| 15 | Nm23 gene product expression in invasive breast cancer immunohistochemical analysis and clinicopathological correlation显示文摘 | A leric I Vrbanec D | 2002 | Acta Oncol2002，41，4： | 1 |
| 16 | Genetic - epidemiologic study of adenoma and cancer of the large intestine 显示文摘 | Belev NF Samotyia EE Pikhut PM | 1999 | Genetika1999，35，4： | 1 |
| 17 | nm23 gene product expression in invasive breast cancer-immunohistochemical analysis and clinicopathological correlation 显示文摘 | Belev B Aleric I Vrbanec D | 2002 | Acta Oncol2002，41，4： | 1 |
| 18 | Amorphous and polycrystalline photoconductors for direct conversion flat panel X ray image sen- sor显示文摘 | Kasap S Frey JB Belev G | 2011 | Sensors (Basel)2011，11，5： | 1 |
| 19 | Nm23 gene product expression in invasive breast cancer-immunohistochemical analysis and clinicopathological correlation显示文摘 | Belev B Aleric I Vrbanec D | 2002 | Acta Oncol2002，41，4： | 1 |
| 20 | Information capabilities of integrated bridge systems显示文摘 | Belev B C | 2004 | Journal of Navigation2004，57，1： | 1 |
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