|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Expression of Notch pathway components (Numb, Itch, and Siah-1) in colorectal tumors: A clinicopathological study显示文摘BACKGROUND The role of the Notch pathway in carcinogenesis and tumor progression has been demonstrated in many organs,including the colon.Accordingly,studies aimed at developing therapies targeting this pathway in various cancers require the identification of several factors that may play a role in regulating Notch-1 expression.Although Numb,Itch,and seven in absentia homolog-1(Siah-1)have been shown to contribute to the regulation of Notch signaling,their role in colorectal carcinogenesis and tumor progression has not been fully elucidated to date.AIM To evaluate Numb,Itch,and Siah-1 expression in colorectal tumors to clarify their relationship with Notch-1 expression and their role in carcinogenesis and tumor behavior.METHODS Expression of Notch-1,Numb,Itch,and Siah-1 was investigated in 50 colorectal carcinomas,30 adenomas,and 20 healthy colonic tissues by immunohistochemistry and quantitative real-time polymerase chain reaction(PCR)analyses.RESULTS In contrast to Notch-1,which is expressed at higher levels in tumor tissues and adenomas,expression of Numb,Itch,and Siah-1 was stronger and more frequent in normal mucosa(P<0.01).There was a positive correlation between Notch-1 expression and high histological grade,the presence of lymph node metastasis,and advanced-stage tumors,whereas expression of Numb,Itch,and Siah-1 was absent or reduced in tumors with these clinicopathological parameters(P<0.05).In survival analysis,expression of Notch was related to poor prognosis but that of Numb,Itch,and Siah-1 correlated with improved survival(P<0.05).Multivariate analysis revealed Notch-1 expression and loss of Numb expression to be independent prognostic parameters together with lymph node metastasis(P<0.05).CONCLUSION Our findings support the role of Notch-1 in colorectal carcinoma and indicate that loss of Numb,Itch,and Siah-1 expression is associated with carcinogenesis.Our data also suggest that these three proteins might be involved in the Notch-1 pathway during colorectal carcinoma(CRC)progression and might play an essential role in approaches targeting Notch as novel molecular therapies for CRC. | Sinem Cil Gonulcu Betul Unal Ibrahim Cumhur Bassorgun Mualla Ozcan Hasan Senol Coskun Gulsum Ozlem Elpek | 2020 | World Journal of Gastroenterology2020，26，26： | 5 |
| 2 | 新型转动摩擦阻尼器在建筑工程中的应用显示文摘介绍了丹麦Mualla博士研发的一种基于转动概念的摩擦阻尼系统,这种阻尼器工作原理清晰,模型种类多样,从制作到安装都非常简单。对于地震、大风等动力荷载引起建筑结构的振动控制效果很好,目前已通过多个大型国际试验室的测试,并已在日本、印度和希腊等地震多发国家广泛应用。这些测试研究和实际工程表明,转动摩擦阻尼器是采用消能减震技术的优选之一。 | Imad Mualla 曹铁柱 廖膺铨 | 2012 | 建筑结构2012，42，S1： | 2 |
| 3 | Widespread ex-pression of GABA receptor subunits in peripheral tissues显示文摘 | MUALLA K AKINCI SCHOFIELD P R | 1999 | Neuro Res1999，35，1： | 1 |
| 4 | Sea-blue histioeytes in the bone marrow of a boy with sever congenital neutropenia assoiated with G6PC3 mutation显示文摘 | Betul T Mualla T Fatma G | 2014 | Brihaem2014，165，4： | 1 |
| 5 | Dental Age Estimation Based on X-ray Images显示文摘Chronological age estimation using panoramic dental X-ray images is an essential task in forensic sciences.Various statistical approaches have proposed by considering the teeth and mandible.However,building automated dental age estimation based on machine learning techniques needs more research efforts.In this paper,an automated dental age estimation is proposed using transfer learning.In the proposed approach,features are extracted using two deep neural networks namely,AlexNet and ResNet.Several classifiers are proposed to perform the classification task including decision tree,k-nearest neighbor,linear discriminant,and support vector machine.The proposed approach is evaluated using a number of suitable performance metrics using a dataset that contains 1429 dental X-ray images.The obtained results show that the proposed approach has a promising performance. | Noor Mualla Essam H Houssein M.R.Hassan | 2020 | Computers, Materials & Continua2020，，2： | 1 |
| 6 | Dynamic Behavior of safety butterfly valves 显示文摘 | J Elis W Mualla | 1984 | Water Power & Dam Construction1984，，4： | 1 |
| 7 | Performance of steel frames with a new friction damper device under earthquake excitation显示文摘 | Imad H. Mualla Borislav Belev | 2002 | Engineering Structures2002，，3： | 1 |
| 8 | Water de- mand forecasting in Umm A1 - Quwain (UAE) using the IWR- MAIN specify forecasting model 显示文摘 | Mohamed M Mohamed Aysha A AI - Mualla | 2010 | Water Resour Manage2010，24，4： | 1 |
| 9 | Temel dynamic model for monitoring landslides with emphasis on underground water in Trabzon Province, Northeastern lhlrkey显示文摘 | MUALLA B | 2003 | Journal of Surveying Engineering2003，129，3： | 1 |
| 10 | Interactions between verapamil and digoxin in Langendorff-perfused rat hearts: the role of inhibition of P-glycoprotein in the heart 显示文摘 | Mualla AA Emrah K Omer D | 2010 | Basic Clin Pharmacol Toxicol2010，107，： | 1 |
| 11 | Association between gene expression profile and tumor invasion in oral squa mous cell carcinoma显示文摘 | Gokce AT Celal U Mualla A | 2004 | Cancer Genetics and Cytogenetics2004，154，1： | 1 |
| 12 | Modelling and performance analysis of DOA estimation in adaptive signal processing arrays 显示文摘 | BELHOUL FAHAD A SHUBAIR RAED M MUALLA MOBAMMED E | 2003 | IEEE International Conference on2003，1，： | 1 |
| 13 | Ibuprofen release from porous hydroxyapatite tablets显示文摘 | Mualla Oner | 2011 | Ceram Int2011，37，7： | 1 |
| 14 | Comparison of static, kinematic and dynamic geodetic deformation models for Kutlugun landslide in Northeastern Turkey显示文摘 | Mualla Yalcinkaya Temel Bayrak | 2005 | Natural Hazards2005，34，1： | 1 |
| 15 | Is quantitativemagnetic resonance imaging valuable in the assessment oftrabecular bone structure in osteoporosis? 显示文摘 | Nil Tokgoz Mualla Akdeniz Murat Ucar | 2013 | Eklem HastalikCerrahisi2013，24，1： | 1 |
| 16 | The inhibitory effects of inulin biopolymers on the seeded growth of hydroxyapatite显示文摘 | Ozlem DOGAN Mualla 0NER 0zge CINEL | 2010 | Joumal of the Ceramic Society of Japan2010，118，7： | 1 |
| 17 | The relationship between he- matological findings and coronary artery afleurysm in kawasaki dis- ease显示文摘 | Burcin B Sule U Mualla C | 2014 | Turk J Haemat012014，31，2： | 1 |
| 18 | Temporal error concealment using motion field interpolation 显示文摘 | Canagarajah N Bull D R | 1999 | IEE Electronics Letters1999，35，3： | 1 |
| 19 | PER-FORMANCE EALUATION OF THE LMS ADAPTIVE BEAMFORMING ALGORITHM USED IN SMART ANTENNA SYSTEMS显示文摘 | ARDI E M MSHUBAIR R MUALLA M A | 2003 | The 46th IEEE International Midwest Symposium on Circuits and Systems2003，111，2730： | 1 |
| 20 | Motion field interpolation for temporal error concealment 显示文摘 | Mualla M A Canagarajah N Bull D R | 2000 | IEEE Processings of Visual Image Signal Processing2000，147，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员