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35篇 您的检索式:作者名="Bohan Li"
    题名 作者 年代 出处 被引量
1In vivo theranostics with near-infraredemitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration显示文摘Carbon dots that exhibit near-infrared fluorescence(NIR CDs)are considered emerging nanomaterials for advanced biomedical applications with low toxicity and superior photostability and targeting compared to currently used photoluminescence agents.Despite progress in the synthesis of NIR CDs,there remains a key obstacle to using them as an in vivo theranostic agent.This work demonstrates that the newly developed sulfur and nitrogen codoped NIR CDs are highly efficient in photothermal therapy(PTT)in mouse models(conversion efficiency of 59%)and can be readily visualized by photoluminescence and photoacoustic imaging.The real theranostic potential of NIR CDs is enhanced by their unique biodistribution and targeting.Contrary to all other nanomaterials that have been tested in biomedicine,they are excreted through the body’s renal filtration system.Moreover,after intravenous injection,NIR CDs are accumulated in tumor tissue via passive targeting,without any active species such as antibodies.Due to their accumulation in tumor tissue without the need for intratumor injection,high photothermal conversion,excellent optical and photoacoustic imaging performance,and renal excretion,the developed CDs are suitable for transfer to clinical biomedical practice.Xin Bao Ye Yuan Jingqin Chen Bohan Zhang Di Li Ding Zhou Pengtao Jing Guiying Xu Yingli Wang Kateřina Holá Dezhen Shen Changfeng Wu Liang Song Chengbo Liu Radek Zbořil Songnan Qu 2018Light(Science & Applications)2018,7,1:13
2MII:A Novel Text Classification Model Combining Deep Active Learning with BERT显示文摘Active learning has been widely utilized to reduce the labeling cost of supervised learning.By selecting specific instances to train the model,the performance of the model was improved within limited steps.However,rare work paid attention to the effectiveness of active learning on it.In this paper,we proposed a deep active learning model with bidirectional encoder representations from transformers(BERT)for text classification.BERT takes advantage of the self-attention mechanism to integrate contextual information,which is beneficial to accelerate the convergence of training.As for the process of active learning,we design an instance selection strategy based on posterior probabilities Margin,Intra-correlation and Inter-correlation(MII).Selected instances are characterized by small margin,low intra-cohesion and high inter-cohesion.We conduct extensive experiments and analytics with our methods.The effect of learner is compared while the effect of sampling strategy and text classification is assessed from three real datasets.The results show that our method outperforms the baselines in terms of accuracy.Anman Zhang Bohan Li Wenhuan Wang Shuo Wan Weitong Chen 2020Computers, Materials & Continua2020,,6:4
3Location and allocation problem for spare parts depots on integrated logistics support显示文摘In equipment integrated logistics support(ILS), the supply capability of spare parts is a significant factor. There are lots of depots in the traditional support system, which makes too many redundant spare parts and causes high cost of support. Meanwhile,the inconsistency among depots makes it difficult to manage spare parts. With the development of information technology and transportation, the supply network has become more efficient. In order to further improve the efficiency of supply-support work and the availability of the equipment system, building a system of one centralized depot with multiple depots becomes an appropriate way.In this case, location selection of the depots including centralized depots and multiple depots becomes a top priority in the support system. This paper will focus on the location selection problem of centralized depots considering ILS factors. Unlike the common location selection problem, depots in ILS require a higher service level. Therefore, it becomes desperately necessary to take the high requirement of the mission into account while determining location of depots. Based on this, we raise an optimal depot location model. First, the expected transportation cost is calculated.Next, factors in ILS such as response time, availability and fill rate are analyzed for evaluating positions of open depots. Then, an optimization model of depot location is developed with the minimum expected cost of transportation as objective and ILS factors as constraints. Finally, a numerical case is studied to prove the validity of the model by using the genetic algorithm. Results show that depot location obtained by this model can guarantee the effectiveness and capability of ILS well.WEN Meilin LU Bohan LI Shuyu KANG Rui 2019Journal of Systems Engineering and Electronics2019,30,6:3
4High efficient catalytic oxidation of 5-hydroxymethylfurfural into 2,5-furandicarboxylic acid under benign conditions with nitrogen-doped graphene encapsulated Cu nanoparticles显示文摘Selective oxidation of 5-hydroxymethylfurfual(HMF) to 2,5-furandicarboxylic acid(FDCA) as a bioplastics monomer is efficiently promoted by a simple system without noble-metal and base additives. In this work, graphene oxide(GO) was first synthesised by an electrochemical method with flexible graphite paper(FGP) as start carbon material, then, nitrogen-doped graphene(NG) layers encapsulated Cu nanoparticles(NPs) was prepared by one-step thermal treatment of GO supported Cu2+ in flowing NH3 atmosphere. Compared with NG supported Cu NPs prepared by the traditional impregnation method, enhanced catalytic activity was achieved over Cu/NG and an FDCA yield of 95.2% was achieved under mild reaction conditions with tert-butylhydroperoxide(t-BuOOH) as the oxidant. Control experiments with different catalysts and different addition procedure of t-BuOOH showed the yield of HMF and various intermediates during reaction. From the changing of intermediates concentrations and reaction rates, a reaction pathway through HMF-DFF-FFCA-FDCA was proposed. This work gives a more convenient, more green,more economical and effective method in encapsulated metal NPs preparation and high selectivity in HMF oxidation to FDCA under mild conditions.Chaoxin Yang Xiao Li Zhenzhou Zhang Bohan Lv Jiachun Li Zhenjian Liu Wanzhen Zhu Furong Tao Guangqiang Lv Yongxing Yang 2020Journal of Energy Chemistry2020,29,11:3
5All in one theranostic nanoplatform enables efficient anti-tumor peptide I delivery for triple-modal imaging guided cancer therapy显示文摘Developing a reliable system to efficiently and safely deliver peptide drugs into tumor tissues still remains a great challenge since the instability of peptide drugs and low ability to traverse the cell membrane. Herein, we constructed a multifunctional nanoplatform based on porous europium/gadolinium (Eu/Gd)-doped NaLa(MoO4)2 nanoparticles (NLM NPs) to deliver antitumor peptide of B-cell lymphoma/leukemia-2-like protein 11 (BIM) for cancer therapy. The porous NLM NPs exhibited inherent photoluminescent, magnetic and X-ray absorbable properties, which enable them for triple-modal bioimaging, including fluorescence, magnetic resonance imaging (MRI) and computed tomography (CT). This triple-modal bioimaging can contribute to monitoring NLM NPs biodistribution and guiding therapy in vitro and in vivo. Furthermore, the NLM NPs showed negligible cytotoxicity in vitro and tissue toxicity in vivo. Importantly, NLM NPs could load the antitumor peptide of BIM and efficiently improve the resistance of peptide drugs to proteolysis. The BIM peptide was efficiently delivered into the tumor cells by NLM NPs, which can inhibit the growth and promote the apoptosis of cancer cells in vitro, significantly inhibit the tumor growth in vivo. Notably, NLM-BIM theranostic nanoplatform exhibits low systemic toxicity and fewer side effects in vivo. The NLM NPs can serve as a promising multifunctional peptide delivery nanoplatform for multi-modal bioimaging and cancer therapy.Xiaoyan Qu Zhengqing Liu Bohan Ma Na Li Hongyang Zhao Tian Yang Yumeng Xue Xiaozhi Zhang Yongping Shao Ying Chang Jun Xu Bo Lei Yaping Du 2019Nano Research2019,12,3:2
6Signaling pathways in obesity:mechanisms and therapeutic interventions显示文摘Obesity is a complex,chronic disease and global public health challenge.Characterized by excessive fat accumulation in the body,obesity sharply increases the risk of several diseases,such as type 2 diabetes,cardiovascular disease,and nonalcoholic fatty liver disease,and is linked to lower life expectancy.Although lifestyle intervention(diet and exercise)has remarkable effects on weight management,achieving long-term success at weight loss is extremely challenging,and the prevalence of obesity continues to rise worldwide.Over the past decades,the pathophysiology of obesity has been extensively investigated,and an increasing number of signal transduction pathways have been implicated in obesity,making it possible to fight obesity in a more effective and precise way.In this review,we summarize recent advances in the pathogenesis of obesity from both experimental and clinical studies,focusing on signaling pathways and their roles in the regulation of food intake,glucose homeostasis,adipogenesis,thermogenesis,and chronic inflammation.We also discuss the current antiobesity drugs,as well as weight loss compounds in clinical trials,that target these signals.The evolving knowledge of signaling transduction may shed light on the future direction of obesity research,as we move into a new era of precision medicine.Xue Wen Bohan Zhang Beiyi Wu aitao Xiao Zehua Li Ruoyu Li Xuewen Xu Tao Li 2022Signal Transduction and Targeted Therapy2022,7,9:2
7Ultra-strong phosphorescence with 48% quantum yield from grinding treated thermal annealed carbon dots and boric acid composite显示文摘Metal-free room-temperature phosphorescence(RTP)materials are of great significance for many applications;however,they usually exhibit low efficiency and weak intensity.This article reports a new strategy for the preparation of a high-efficiency and strong RTP materials from crystalline thermal-annealed carbon dots(CDs)and boric acid(BA)composite(g-t-CD@BA)through grinding-induced amorphous to crystallization transition.Amorphous thermal-annealed CDs and BA composite(t-CD@BA)is prepared following a thermal melting and super-cooling route,where the CDs are fully dispersed in molten BA liquid and uniformly frozen in an amorphous thermal annealed BA matrix after super-cooling to room temperature.Upon grinding treatment,the fracture and fragmentation caused by grinding promote the transformation of the high-energy amorphous state to the lower energy crystalline counterparts.As a result,the CDs are uniformly in situ embedded in the BA crystal matrix.This method affords maximum uniform embedding of the CDs in the BA crystals,decreases nonradiative decay,and promotes intersystem crossing by restraining the free vibration of the CDs,thus producing strong RTP materials with the highest reported phosphorescence quantum yield(48%).Remarkably,RTP from g-t-CD@BA powder is strong enough to illuminate items with a delay time exceeding 9 s.Qijun Li Zhenxiao Zhao Shuai Meng Yuchen Li Yunyang Zhao Bohan Zhang Zikang Tang Jing Tan Songnan Qu 2022SmartMat2022,3,2:2
8Characteristics of windshield cracking upon low-speed impact:Numerical simulation based on the extended finite element method显示文摘Xu Jun Li Yibing Chen Xi Yan Yuan Ge Dongyun Zhu Mengyi Liu Bohan 0,,03:1
9A silk-based self-adaptive flexible opto-electro neural probe显示文摘The combination of optogenetics and electrophysiological recording enables high-precision bidirectional interactions between neural interfaces and neural circuits,which provides a promising approach for the study of progressive neurophysiological phenomena.Opto-electrophysiological neural probes with sufficient flexibility and biocompatibility are desirable to match the low mechanical stiffness of brain tissue for chronic reliable performance.However,lack of rigidity poses challenges for the accurate implantation of flexible neural probes with less invasiveness.Herein,we report a hybrid probe(Silk-Optrode)consisting of a silk protein optical fiber and multiple flexible microelectrode arrays.The Silk-Optrode can be accurately inserted into the brain and perform synchronized optogenetic stimulation and multichannel recording in freely behaving animals.Silk plays an important role due to its high transparency,excellent biocompatibility,and mechanical controllability.Through the hydration of the silk optical fiber,the Silk-Optrode probe enables itself to actively adapt to the environment after implantation and reduce its own mechanical stiffness to implant into the brain with high fidelity while maintaining mechanical compliance with the surrounding tissue.The probes with 128 recording channels can detect high-yield well-isolated single units while performing intracranial light stimulation with low optical losses,surpassing previous work of a similar type.Two months of post-surgery results suggested that as-reported Silk-Optrode probes exhibit better implant-neural interfaces with less immunoreactive glial responses and tissue lesions.Yu Zhou Chi Gu Jizhi Liang Bohan Zhang Huiran Yang Zhitao Zhou Meng Li Liuyang Sun Tiger H.Tao Xiaoling Wei 2022Microsystems & Nanoengineering2022,8,6:1
10The therapeutic efficacy of Ulinastatin for rats with smoking inhalation injury显示文摘Xiaochen Qiu Shizhao Ji Junjie Wang Hengyu Li Ting Xia Bohan Pan Shichu Xiao Zhaofan Xia 2012International Immunopharmacology2012,,3:1
11Human periodontal ligament stem cells repair mental nerve injury显示文摘Human periodontal ligament stem cells are easily accessible and can differentiate into Schwann cells. We hypothesized that human periodontal ligament stem cells can be used as an alternative source for the autologous Schwann cells in promoting the regeneration of injured peripheral nerve.To validate this hypothesis, human periodontal ligament stem cells(1 × 106) were injected into the crush-injured left mental nerve in rats. Simultaneously, autologous Schwann cells(1 × 106) and PBS were also injected as controls. Real-time reverse transcriptase polymerase chain reaction showed that at 5 days after injection, mRNA expression of low affinity nerve growth factor receptor was significantaly increased in the left trigeminal ganglion of rats with mental nerve injury. Sensory tests,histomorphometric evaluation and retrograde labeling demonstrated that at 2 and 4 weeks after injection, sensory function was significantly improved, the numbers of retrograde labeled sensory neurons and myelinated axons were significantly increased, and human periodontal ligament stem cells and autologous Schwann cells exhibited similar therapeutic effects. These findings suggest that transplantation of human periodontal ligament stem cells show a potential value in repair of mental nerve injury.Bohan Li Hun-Jong Jung Soung-Min Kim Myung-Jin Kim Jeong Won Jahng Jong-Ho Lee 2013Neural Regeneration Research2013,8,30:1
12Peripheral nerve regeneration with cotransplantation of umbilical cord mesenchymal stem cells and Schwann cells in rat sciatic nerve defect显示文摘Previous research has demonstrated that cotransplantation of umbilical cord mesenchymal stem cells (UCMSCs) and Schwann cells (SCs) can repair spinal nerve injury, but few studies have investigated their use in peripheral nerve regeneration. In the present study, we cotransplanted UCMSCs and SCs to repair 5-mm left sciatic nerve defects in rats, and compared the effects of UCMSCs + SCs transplantation with UCMSCs or SCs transplantation alone. After UCMSCs + SCs transplantation, nerve conduction velocity of the left sciatic nerve and gait were both improved. Retrograde tracing analysis demonstrated that the mean count of fluorogold-labeled neurons, as well as the mean axon count and axon density, were significantly greater in the left sciatic nerve after UCMSCs + SCs transplantation, compared with UCMSCs or SCs transplantation alone. Improvements in conduction velocity and increased sheath thickness in the left sciatic nerve were similar after UCMSCs transplantation and UCMSCs + SCs transplantation. These findings suggest that UCMSCs transplantation can promote the repair of sciatic nerve defects to some extent, but that combined UCMSCs + SCs transplantation has a significantly greater regenerative effect.Jin-Yong Lee Hun-Jong Jung Mohammad S. Alrashdan Bohan Li Mi-Ae sung Sang BaeYoo Soung-Min Kim Myung-Jin Kim Jeong Won Jahng Jong-Ho Lee 2011Neural Regeneration Research2011,6,7:1
13Flat soliton microcomb source显示文摘Mode-locked microcombs with flat spectral profiles provide the high signal-to-noise ratio and are in high demand for wavelength division multiplexing(WDM)-based applications,particularly in future high-capacity communication and parallel optical computing.Here,we present two solutions to generate local relatively flat spectral profiles.One microcavity with ultra-flat integrated dispersion is pumped to generate one relatively flat single soliton source spanning over 150 nm.Besides,one extraordinary soliton crystal with single vacancy demonstrates the local relatively flat microcomb lines when the inner soliton spacings are slightly irregular.Our work paves a new way for soliton-based applications owing to the relatively flat spectral characteristics.Xinyu Wang Xuke Qiu Mulong Liu Feng Liu Mengmeng Li Linpei Xue Bohan Chen Mingran Zhang Peng Xie 2023Opto-Electronic Science2023,2,12:1
14An AIEgen/graphene oxide nanocomposite(AIEgen@GO)-based two-stage“turn-on”nucleic acid biosensor for rapid detection of SARS-CoV-2 viral sequence显示文摘The ongoing outbreak of Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)pandemic has posed significant challenges in early viral diagnosis.Hence,it is urgently desirable to develop a rapid,inexpensive,and sensitive method to aid point-of-care SARS-CoV-2 detection.In this work,we report a highly sequence-specific biosensor based on nanocomposites with aggregationinduced emission luminogens(AIEgen)-labeled oligonucleotide probes on graphene oxide nanosheets(AIEgen@GO)for one step-detection of SARS-CoV-2-specific nucleic acid sequences(Orf1ab or N genes).A dual“turn-on”mechanism based on AIEgen@GO was established for viral nucleic acids detection.Here,the first-stage fluorescence recovery was due to dissociation of the AIEgen from GO surface in the presence of target viral nucleic acid,and the second-stage enhancement of AIEbased fluorescent signal was due to the formation of a nucleic acid duplex to restrict the intramolecular rotation of the AIEgen.Furthermore,the feasibility of our platform for diagnostic application was demonstrated by detecting SARS-CoV-2 virus plasmids containing both Orf1ab and N genes with rapid detection around 1 h and good sensitivity at pM level without amplification.Our platform shows great promise in assisting the initial rapid detection of the SARS-CoV-2 nucleic acid sequence before utilizing quantitative reverse transcription-polymerase chain reaction for second confirmation.Qin Zhang Bohan Yin Jianhua Hao Linjie Ma Yingying Huang Xueying Shao Chuanqi Li Zhiqin Chu Changqing Yi Siu Hong Dexter Wong Mo Yang 2023Aggregate2023,4,1:0
15Improved conditional differential attacks on lightweight hash family QUARK显示文摘Nonlinear feedback shift register(NFSR)is one of the most important cryptographic primitives in lightweight cryptography.At ASIACRYPT 2010,Knellwolf et al.proposed conditional differential attack to perform a cryptanalysis on NFSR-based cryptosystems.The main idea of conditional differential attack is to restrain the propagation of the difference and obtain a detectable bias of the difference of the output bit.QUARK is a lightweight hash function family which is designed by Aumasson et al.at CHES 2010.Then the extended version of QUARK was published in Journal of Cryptology 2013.In this paper,we propose an improved conditional differential attack on QUARK.One improvement is that we propose a method to select the input difference.We could obtain a set of good input differences by this method.Another improvement is that we propose an automatic condition imposing algorithm to deal with the complicated conditions efficiently and easily.It is shown that with the improved conditional differential attack on QUARK,we can detect the bias of output difference at a higher round of QUARK.Compared to the current literature,we find a distinguisher of U-QUARK/D-QUARK/S-QUARK/C-QUARK up to 157/171/292/460 rounds with increasing 2/5/33/8 rounds respectively.We have performed the attacks on each instance of QUARK on a 3.30 GHz Intel Core i5 CPU,and all these attacks take practical complexities which have been fully verified by our experiments.As far as we know,all of these results have been the best thus far.Xiaojuan Lu Bohan Li Meicheng Liu Dongdai Lin 2022Cybersecurity2022,5,3:0
16Exclusion and Co-expression of Aversive Olfactory Long-Term Memories in Drosophila显示文摘Long-term memory(LTM)allows animals to use remote past experiences to guide current and future decisions.One of the widely-used animal models for LTM research is the fruit-fly Drosophila melanogaster,which can form different types of LTM after different learning paradigms[1-6].Spaced training-induced LTM(spLTM),perhaps the most studied Drosophila LTM,requires multiple repeated learning trials with a 15-min resting interval between each trial.For decades,spLTM has been considered the only aversive olfactory LTM that can last for>7 days[1].Recently,two other types of LTM,context-dependent LTM(cLTM)[5]and merged LTM(mLTM)[6],have been discovered with the same long duration as spLTM,and can be formed with only one aversive learning trial.Bohan Zhao Xuchen Zhang Janjan Zhao Qian Li 2022Neuroscience Bulletin2022,38,6:0
17Accelerate Single Image Super-Resolution Using Object Detection Process显示文摘Image Super-Resolution(SR)research has achieved great success with powerful neural networks.The deeper networks with more parameters improve the restoration quality but add the computation complexity,which means more inference time would be cost,hindering image SR from practical usage.Noting the spatial distribution of the objects or things in images,a twostage local objects SR system is proposed,which consists of two modules,the object detection module and the SR module.Firstly,You Only Look Once(YOLO),which is efficient in generic object detection tasks,is selected to detect the input images for obtaining objects of interest,then put them into the SR module and output corresponding High-Resolution(HR)subimages.The computational power consumption of image SR is optimized by reducing the resolution of input images.In addition,we establish a dataset,TrafficSign500,for our experiment.Finally,the performance of the proposed system is evaluated under several State-Of-The-Art(SOTA)YOLOv5 and SISR models.Results show that our system can achieve a tremendous computation improvement in image SR.Xiaolin Xing Shujie Yang Bohan Li 2023Computers, Materials & Continua2023,76,8:0
18Fundamental limits for transmission modulation in VO_(2) metasurfaces显示文摘The interest in dynamic modulation of light by ultra-thin materials exhibiting insulator–metal phase transition,such as VO_(2),has rapidly grown due to the myriad industrial applications,including smart windows and optical limiters.However,for applications in the telecommunication spectral band,the light modulation through a thin VO_(2) film is low due to the presence of strong material loss.Here,we demonstrate tailored nanostructuring of VO_(2) to dramatically enhance its transmission modulation,reaching a value as high as 0.73,which is 2 times larger than the previous modulation achieved.The resulting designs,including free-topology optimization,demonstrate the fundamental limit in acquiring the desired optical performance,including achieving positive or negative transmission contrast.Our results on nanophotonic management of lossy nanostructured films open new opportunities for applications of VO_(2) metasurfaces.BOHAN LI ROCIO CAMACHO-MORALES NEUTON LI ANDREA TOGNAZZI MARCO GANDOLFI DOMENICO DE CEGLIA COSTANTINO DE ANGELIS ANDREY A.SUKHORUKOV ANDDRAGOMIR N.NESHEV 2023Photonics Research2023,11,1:0
19Plastic Crystal Neopentyl Glycol/Multiwall Carbon Nanotubes Composites for Highly Efficient Barocaloric Refrigeration System显示文摘Plastic crystal neopentyl glycol(NPG)exhibits colossal barocaloric effect with high entropy changes.However,their application is restricted in several aspects,such as low thermal conductivity,substantial supercooling effect,and poor springback properties.In this work,multi-walled carbon nanotubes(MWCNTs)with ultra-high thermal conductivity and high mechanical strength were selected for performance enhancement of NPG.The optimal mixing ratio was determined to be NPG with 3 wt%MWCNTs composites,which showed a 6K reduction in supercooling without affecting the phase change enthalpy.Subsequently,comprehensive performance of the composites with optimal mixing ratio was compared with pure NPG At 40 MPa,390J·K^(-1)·kg^(-1)change in entropy and 9.9 K change in temperature were observed.Furthermore,the minimum driving pressure required to achieve reversible barocaloric effect was reduced by 19.2%.In addition,the thermal conductivity of the composite was increased by approximately 28%,significantly reducing the heat exchange time during a barocaloric refrigeration cycle.More importantly,ultra-high pressure release rate resulted in a73.7%reduction in the springback time of the composites,offering new opportunities for the recovery of expansion work.DAI Zhaofeng SHE Xiaohui SHAO Bohan YIN Ershuai DING Yulong LI Yongliang ZHANG Xiaosong ZHAO Dongliang 2024Journal of Thermal Science2024,33,1:0
20Controlling the mechanical properties and corrosion behavior of biomedical TiZrNb alloys by combining recrystallization and spinodal decomposition显示文摘Excellent comprehensive mechanical properties and corrosion resistance of TiZrNb equiatomic ratio medium-entropy alloy were obtained through recrystallization and spinodal decomposition.In addition to solid solution strengthening and recrystallization,the excellent mechanical properties can also be attributed to the hindering effect of nanoprecipitation formed via spinodal decomposition on the movement of dislocations.The high atomic arrangement density due to spinodal decomposition reduces the surface energy of the alloy passivation film,thereby increasing the activation energy of dissolution and the bonding energy between atoms,which improve the corrosion resistance and stability of the alloy passivation film.This work provides a new strategy to control the mechanical properties and corrosion resistance by combining recrystallization and spinodal decomposition.Pengfei Ji Bohan Chen Shuguang Liu Bo Li Chaoqun Xia Xinyu Zhang Mingzhen Ma Riping Liu 2022Journal of Materials Science & Technology2022,,15:0
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