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| 1 | Rare earth-based MOF@mesoporous silica nanoplatform for long-term and luminescence trackable chemotherapy显示文摘Developing the multifunctional nanocarriers for long-term drug release and luminescence traceability is a challenging assignment.In this task,we designed a novel nanoplatform for long-term and luminescence trackable chemotherapy,which is prepared via a hollow ZIF-8(where ZIF is zeolitic imidazolate frameworks)coated by the Eu^(3+)-doped mesoporous silica(ZIF-8@mesoporous silica).The hollow ZIF-8 is used as a drug library for loading the anticancer drug,and the pH-sensitive properties of ZIF-8 can targeted-release drugs in the tumor and cut down the poisonousness of drugs to normal cells.The shell layer of mesoporous silica can achieve the long-term drug release,which solves the problem of short drug circulation time in the body,reduces the drug administration frequency,and improves the therapeutic effect.Notably,the ZIF-8@mesoporous+doxorubicin(DOX)is injected only once during the 14-day chemotherapy.In addition,Eu^(3+)doped in mesoporous silica ensures luminescence tracking and detection of drug pathways in living cells.Hence,this nanoplatform provides a whole new strategy for the longterm treatment of tumors. | Lu-Min Wang Wen-Yan Liu Ming-Liang Hu Jia-Sai Yao Ping Wang Jia-Hao Liu Miao He Yi Gao Zhen-Xing Li | 2022 | Rare Metals2022，41，8： | 1 |
| 2 | 纳米载体用于包载生物活性多肽的研究进展显示文摘多肽药物因其适应症广、安全性高且疗效显著,已广泛应用于肿瘤、肝炎、糖尿病、艾滋病等疾病的预防、诊断和治疗。但是,天然多肽进入人体后易被迅速降解并通过血液循环被迅速清除,安全递送是其发挥功效的基础。通过物理包埋、化学键合等手段合成基于多肽的纳米药物系统已解决这一问题的重要手段,具有生物安全性高,生物相容性好,易于修饰等特点,相关的开发研究正逐渐成为热点。综述多肽纳米给药系统的设计进展,总结抗菌肽、抗肿瘤肽、抗炎肽和肽疫苗等用于纳米药物递送的应用成果,展望未来生物活性多肽的临床应用前景,为当前构建负载多肽的纳米药物递送系统的研发提供有益建议。 | 郑珊珊 蔡悦 龚瑜贝 洪煜璐 孙漩嵘 | 2023 | 中国生物医学工程学报2023，42，2： | 0 |
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