|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | In vivo theranostics with near-infraredemitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration显示文摘Carbon dots that exhibit near-infrared fluorescence(NIR CDs)are considered emerging nanomaterials for advanced biomedical applications with low toxicity and superior photostability and targeting compared to currently used photoluminescence agents.Despite progress in the synthesis of NIR CDs,there remains a key obstacle to using them as an in vivo theranostic agent.This work demonstrates that the newly developed sulfur and nitrogen codoped NIR CDs are highly efficient in photothermal therapy(PTT)in mouse models(conversion efficiency of 59%)and can be readily visualized by photoluminescence and photoacoustic imaging.The real theranostic potential of NIR CDs is enhanced by their unique biodistribution and targeting.Contrary to all other nanomaterials that have been tested in biomedicine,they are excreted through the body’s renal filtration system.Moreover,after intravenous injection,NIR CDs are accumulated in tumor tissue via passive targeting,without any active species such as antibodies.Due to their accumulation in tumor tissue without the need for intratumor injection,high photothermal conversion,excellent optical and photoacoustic imaging performance,and renal excretion,the developed CDs are suitable for transfer to clinical biomedical practice. | Xin Bao Ye Yuan Jingqin Chen Bohan Zhang Di Li Ding Zhou Pengtao Jing Guiying Xu Yingli Wang Kateřina Holá Dezhen Shen Changfeng Wu Liang Song Chengbo Liu Radek Zbořil Songnan Qu | 2018 | Light(Science & Applications)2018，7，1： | 13 |
| 2 | Simultaneous elution of polycyclic aromatic hydrocarbons and heavy metals from contaminated soil by two amino acids derived from β-cyclodextrins显示文摘Two highly water-soluble amino acids,which derived from β-CDs,i.e.,glutamic acid-β-cyclodextrin (GluCD) and ethylene-diamineβ-cyclodextrin (EDCD),were synthesized and were examined for their effect on solubilization of anthracene (ANT),complexation of cadmium (Cd2+),and elution removal of ANT and Cd2+ in soil.The results showed that GluCD and EDCD were powerful complexant for ANT and Cd2+.In the presence of 10 g/L GluCD and EDCD,the solubilization of ANT increased by 47.04 and 23.85 times compared to the control,respectively.GluCD resulted in approximately 90% complexation of Cd2+ while 70% complexation was observed for EDCD.Simultaneously,GluCD and EDCD could greatly enhance the elution removal of ANT and Cd 2+ from soil.GluCD resulted in the highest elution efficiency of ANT and Cd2+.With the addition of 10 g/L GluCD,53.5% of ANT and 85.6% of Cd2+ were eluted,respectively.The ANT had a negligible effect on the Cd2+ removal due to different complexing sites of ANT and Cd2+,while Cd2+ enhanced the ANT removal under the addition of GluCD because Cd2+ neutralized the-COOH group of GluCD.Adversely,the removal of ANT was decreased with Cd2+ under the addition of EDCD,this was due to the fact that Cd2+ enhanced the polarity of EDCD molecule and inhibited the complexation between ANT and EDCD.The study suggested that GluCD could be preferred and be successfully applied to remediation of heavy metals or organic compounds in contaminated soil. | Chengjian Yang Qingru Zeng Yunzhong Wang Bohan Liao Jian Sun Hui Shi Xingdou Chen | 2010 | Journal of Environmental Sciences2010，22，12： | 7 |
| 3 | MII:A Novel Text Classification Model Combining Deep Active Learning with BERT显示文摘Active learning has been widely utilized to reduce the labeling cost of supervised learning.By selecting specific instances to train the model,the performance of the model was improved within limited steps.However,rare work paid attention to the effectiveness of active learning on it.In this paper,we proposed a deep active learning model with bidirectional encoder representations from transformers(BERT)for text classification.BERT takes advantage of the self-attention mechanism to integrate contextual information,which is beneficial to accelerate the convergence of training.As for the process of active learning,we design an instance selection strategy based on posterior probabilities Margin,Intra-correlation and Inter-correlation(MII).Selected instances are characterized by small margin,low intra-cohesion and high inter-cohesion.We conduct extensive experiments and analytics with our methods.The effect of learner is compared while the effect of sampling strategy and text classification is assessed from three real datasets.The results show that our method outperforms the baselines in terms of accuracy. | Anman Zhang Bohan Li Wenhuan Wang Shuo Wan Weitong Chen | 2020 | Computers, Materials & Continua2020，，6： | 4 |
| 4 | Chip-Based High-Dimensional Optical Neural Network显示文摘Parallel multi-thread processing in advanced intelligent processors is the core to realize high-speed and high-capacity signal processing systems.Optical neural network(ONN)has the native advantages of high parallelization,large bandwidth,and low power consumption to meet the demand of big data.Here,we demonstrate the dual-layer ONN with Mach-Zehnder interferometer(MZI)network and nonlinear layer,while the nonlinear activation function is achieved by optical-electronic signal conversion.Two frequency components from the microcomb source carrying digit datasets are simultaneously imposed and intelligently recognized through the ONN.We successfully achieve the digit classification of different frequency components by demultiplexing the output signal and testing power distribution.Efficient parallelization feasibility with wavelength division multiplexing is demonstrated in our high-dimensional ONN.This work provides a high-performance architecture for future parallel high-capacity optical analog computing. | Xinyu Wang Peng Xie Bohan Chen Xingcai Zhang | 2022 | Nano-Micro Letters2022，14，12： | 2 |
| 5 | MRP3/Mrp3(ABCC3/Abcc3) is up egulated by TNFα via cholesterol 7 hydroxylase promoter factor (CPF) and is hepatoprotective in obstructive cholestasis显示文摘 | Bohan A Chen WS Lee A | 2003 | Hepatology2003，38，4： | 1 |
| 6 | Characteristics of windshield cracking upon low-speed impact:Numerical simulation based on the extended finite element method显示文摘 | Xu Jun Li Yibing Chen Xi Yan Yuan Ge Dongyun Zhu Mengyi Liu Bohan | | 0，，03： | 1 |
| 7 | Tumor necrosis factor alpha-dependent up-regulation of Lrh-1 and Mrp3 (Abcc3) reduces liver injury in obstructive cholestasis 显示文摘 | Bohan A Chen WS Denson LA | 2003 | J Biol Chem2003，278，36： | 1 |
| 8 | Tumor necrosis factor alphadependent up-regulation of Lrh-1 and Mrp3 ( Abcc3 ) reduces liver injury in obstructive choldstasis 显示文摘 | Bohan A Chen W S Denson L A | 2003 | J Biol Chem2003，278，36： | 1 |
| 9 | Tumor necrosis factor alpha-dependent up-regulation of Lrh-1 and Mrp3(Abcc3)reduces liver injury in obstructive cholestasis显示文摘 | Bohan A Chen WS Denson LA | 2003 | J Bio Chem2003，278，36： | 1 |
| 10 | Tumor necrosis factor alpha-dependent up-regulation of Lrh-1 and Mrp3(Abcc3) reduces liver injury in obstructive cholestasis显示文摘 | Bohan A Chen WS Denson LA | 2003 | Biol Chem2003，278，36： | 1 |
| 11 | Long-range gene regulation network of the MGMT enhancer modulates glioma cell sensitivity to temozolomide显示文摘Approximately 80%of primary tumors in the central nervous system are malignant glioma,and>50%of those are diagnosed as glioblastoma(GBM),the most aggressive glioma.Despite treatment advances,GBM prognosis is unsatisfying,and the median survival time of patients is only 14-17 months. | Bohan Chen Anshun He Jinfang Bi Shupeng Sun Yiping Ma Wenbin Wang Dianhao Guo Jun Chen Yuyang Qian Tengfei Shi Guohui Nie Zhongfang Zhao Jiandang Shi Hongzhen Yang Lei Zhang Wange Lu | 2021 | Journal of Genetics and Genomics2021，48，10： | 1 |
| 12 | Tumor necrosis factor a-dependent up-regulation of Lrh-1 and Mrp3 ( Abcc3 ) reducesliver injury in obstructive cholestasis显示文摘 | Bohan A Chen WS Denson LA | 2003 | J Biol Chem2003，278，36： | 1 |
| 13 | Tumor necrosis factor alpha-dependent up-regulation of Lrh-1 and Mrp3 ( Abcc3) reduces liver inju-ry in obstructive cholestasis显示文摘 | Bohan A Chen W S Denson L A ef al | 2003 | J Biol Chem2003，278，36： | 1 |
| 14 | Flat soliton microcomb source显示文摘Mode-locked microcombs with flat spectral profiles provide the high signal-to-noise ratio and are in high demand for wavelength division multiplexing(WDM)-based applications,particularly in future high-capacity communication and parallel optical computing.Here,we present two solutions to generate local relatively flat spectral profiles.One microcavity with ultra-flat integrated dispersion is pumped to generate one relatively flat single soliton source spanning over 150 nm.Besides,one extraordinary soliton crystal with single vacancy demonstrates the local relatively flat microcomb lines when the inner soliton spacings are slightly irregular.Our work paves a new way for soliton-based applications owing to the relatively flat spectral characteristics. | Xinyu Wang Xuke Qiu Mulong Liu Feng Liu Mengmeng Li Linpei Xue Bohan Chen Mingran Zhang Peng Xie | 2023 | Opto-Electronic Science2023，2，12： | 1 |
| 15 | Tumor necrosis factor alpha-dependent up-regulation of Lrh-1 and Mrp3 ( Ab- cc3) reduces liver injury in obstructive cholestasis显示文摘 | Bohan A Chen W S Denson L A | 2003 | J Bi- ol Chem2003，278，36： | 1 |
| 16 | Tumor necrosis factor alpha-dependent up-regulation of Lrh-1 and Mrp3(Abcc3) reduces liver injury in obstructive cholestasis显示文摘 | BOHAN A CHEN W S DENSON L A | 2003 | J Biol Chem2003，278，36： | 1 |
| 17 | Tumor necrosis factor alphadependent up-regulation of Lrh-1 and Mrp3 ( Abce3 ) reduces liver injury in obstructive cholestasis 显示文摘 | Bohan A Chen WS Denson LA | 2003 | J Biol Chem2003，278，36： | 1 |
| 18 | Vacancy engineering induced reaction kinetics enhancement of cobalt metaphosphate for pH-universal hydrogen evolution显示文摘Developing efficient pH-universal hydrogen evolution reaction(HER)catalysts is critical in the field of water electrolysis,however,which is severely hampered by the sluggish kinetics in alkaline media.Herein,a ruthenium(Ru)incorporation induced vacancy engineering strategy is firstly proposed to precisely construct oxygen vacancy(V_(O))-riched cobalt-ruthenium metaphosphate(CRPO)for high-efficiency pH-universal HER.The V_(O) modifies the electronic structure,improves the superficial hydrophilic and gas spillover capacity,it also reduces the coordination number of Ru atoms and regulates the coordination environment.Theoretical calculations indicate that Ru tends to adsorb H_(2)O and H^(*),whereas V_(O) tends to adsorb OH^(-),which greatly promotes the H_(2)O adsorption and the dissociation of HO-H bond.Ultimately,CRPO-2 exhibits remarkable HER performance,the mass activity is about 18.34,21.73,and 38.07 times higher than that of Pt/C in acidic,neutral,and alkaline media,respectively,at the same time maintain excellent stability.Our findings may pave a new avenue for the rational design of electrocatalysts toward pH-universal water electrolysis. | Yuting Chen Tian Meng Zhicai Xing Yueying Yan Yang Yang Bohan Yao Dewen Wang Xiurong Yang | 2024 | Nano Research2024，17，5： | 0 |
| 19 | Unknown constrained mechanisms operation based on dynamic interactive control显示文摘 | Hesheng Wang Bohan Yang Weidong Chen | 2016 | CAAI Transactions on Intelligence Technology2016，1，3： | 0 |
| 20 | Controlling the mechanical properties and corrosion behavior of biomedical TiZrNb alloys by combining recrystallization and spinodal decomposition显示文摘Excellent comprehensive mechanical properties and corrosion resistance of TiZrNb equiatomic ratio medium-entropy alloy were obtained through recrystallization and spinodal decomposition.In addition to solid solution strengthening and recrystallization,the excellent mechanical properties can also be attributed to the hindering effect of nanoprecipitation formed via spinodal decomposition on the movement of dislocations.The high atomic arrangement density due to spinodal decomposition reduces the surface energy of the alloy passivation film,thereby increasing the activation energy of dissolution and the bonding energy between atoms,which improve the corrosion resistance and stability of the alloy passivation film.This work provides a new strategy to control the mechanical properties and corrosion resistance by combining recrystallization and spinodal decomposition. | Pengfei Ji Bohan Chen Shuguang Liu Bo Li Chaoqun Xia Xinyu Zhang Mingzhen Ma Riping Liu | 2022 | Journal of Materials Science & Technology2022，，15： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员