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| 1 | Anisotropic coding metamaterials and their powerful manipulation of differently polarized terahertz waves显示文摘Metamaterials based on effective media can be used to produce a number of unusual physical properties(for example,negative refraction and invisibility cloaking)because they can be tailored with effective medium parameters that do not occur in nature.Recently,the use of coding metamaterials has been suggested for the control of electromagnetic waves through the design of coding sequences using digital elements‘0’and‘1,'which possess opposite phase responses.Here we propose the concept of an anisotropic coding metamaterial in which the coding behaviors in different directions are dependent on the polarization status of the electromagnetic waves.We experimentally demonstrate an ultrathin and flexible polarization-controlled anisotropic coding metasurface that functions in the terahertz regime using specially designed coding elements.By encoding the elements with elaborately designed coding sequences(both 1-bit and 2-bit sequences),the x-and y-polarized waves can be anomalously reflected or independently diffused in three dimensions.The simulated far-field scattering patterns and near-field distributions are presented to illustrate the dual-functional performance of the encoded metasurface,and the results are consistent with the measured results.We further demonstrate the ability of the anisotropic coding metasurfaces to generate a beam splitter and realize simultaneous anomalous reflections and polarization conversions,thus providing powerful control of differently polarized electromagnetic waves.The proposed method enables versatile beam behaviors under orthogonal polarizations using a single metasurface and has the potential for use in the development of interesting terahertz devices. | Shuo Liu Tie Jun Cui Quan Xu Di Bao Liangliang Du Xiang Wan Wen Xuan Tang Chunmei Ouyang Xiao Yang Zhou Hao Yuan Hui Feng Ma Wei Xiang Jiang Jiaguang Han Weili Zhang Qiang Cheng | 2016 | Light(Science & Applications)2016，5，1： | 36 |
| 2 | Mechanism of taurine-induced apoptosis in human colon cancer cells显示文摘公牛(字形物) 被显示了拥有癌症通过 apoptosis 的正式就职的治疗学的效果,当它的反癌症效果的内在的 molecularmechanism 很好没被理解时。美洲狮(apoptosis 的 p53-upregulated 调节的人) 在 p53 依赖、独立的 manners.However 在在许多人的肿瘤房间感应的 apoptosis 的过程玩 importantrole,美洲狮是否在癌症房间涉及导致字形物的 apoptosis 的过程,很好没被学习。在 thepresent 学习,我们与不同 concentrationsof 字形物对待人的 colorectal 癌症房间 HT-29 (变异的 p53 ) 和 LoVo (野类型的 p53 ) ,它在两根房间线导致了房间增长和 apoptosis 的正式就职的压抑。同时,我们 alsoobserved 美洲狮和高度的增加的表示 Bax/Bcl-2 比率。在导致字形物的 apoptosis 决定美洲狮的角色,我们使用了小介入的 RNA 干扰压制美洲狮表示。作为结果, apoptosis 在反应 toTau 治疗被减少。所有这些结果显示那美洲狮在人的 colorectalcancer 房间在导致字形物的 apoptosis 小径起一个关键作用。涉及字形物的反肿瘤效果的分子的机制的示范可能在为 p53 缺乏的 colorectal 癌症的 therapeutictarget 选择是有用的。 | Xiali Zhang Shuo Tu Yibing Wang Baohua Mu Fusheng Wan | 2014 | Acta Biochimica et Biophysica Sinica2014，46，4： | 12 |
| 3 | MmNet:Identifying Mikania micrantha Kunth in the wild via a deep Convolutional Neural Network显示文摘Mikania micrantha Kunth is an invasive alien weed and known as a plant killer around the world.Accurately and rapidly identifying M.micrantha in the wild is important for monitoring its growth status,as this helps management officials to take the necessary steps to devise a comprehensive strategy to control the invasive weed in the identified area.However,this approach still mainly depends on satellite remote sensing and manual inspection.The cost is high and the accuracy rate and efficiency are low.We acquired color images of the monitoring area in the wild environment using an Unmanned Aerial Vehicle(UAV)and proposed a novel network-MmNet-based on a deep Convolutional Neural Network(CNN)to identify M.micrantha in the images.The network consists of AlexNet Local Response Normalization(LRN),along with the GoogLeNet and continuous convolution of VGG inception models.After training and testing,the identification of 400 testing samples by MmNet is very good,with accuracy of 94.50%and time cost of 10.369 s.Moreover,in quantitative comparative analysis,the proposed MmNet not only has high accuracy and efficiency but also simple construction and outstanding repeatability.Compared with recently popular CNNs,MmNet is more suitable for the identification of M.micrantha in the wild.However,to meet the challenge of wild environments,more M.micrantha images need to be acquired for MmNet training.In addition,the classification labels need to be sorted in more detail.Altogether,this research provides some theoretical and scientific basis for the development of intelligent monitoring and early warning systems for M.micrantha and other invasive species. | QIAO Xi LI Yan-zhou SU Guang-yuan TIAN Hong-kun ZHANG Shuo SUN Zhong-yu YANG Long WAN Fang-hao QIAN Wan-qiang | 2020 | Journal of Integrative Agriculture2020，19，5： | 7 |
| 4 | Information theory of metasurfaces显示文摘We propose a theory to characterize the information and information processing abilities of metasurfaces,and demonstrate the relation between the information of the metasurface and its radiation pattern in the far-field region.By incorporating a general aperturemodel with uncertainty relation in L2-space,we propose a theory to predict the upper bound of information contained in the radiation pattern of a metasurface,and reveal the theoretical upper limit of orthogonal radiation states.Theproposed theory also provides guidance for inverse design of the metasurface with respect to given functionalities.Through investigation of the information of disordered-phase modulated metasurfaces,we find the information invariance(1?γ,whereγis Euler’s constant)of chaotic radiation patterns.That is to say,the information of the disordered-phase modulated radiation patterns is always equal to 1?γ,regardless of variations in size,the number of elements and the phase pattern of metasurface.This value might be the lower bound of radiation-pattern information of the metasurface,which can provide a theoretical limit for information modulation applications,including computational imaging,stealth technologies and wireless communications. | Haotian Wu Guo Dong Bai Shuo Liu Lianlin Li Xiang Wan Qiang Cheng Tie Jun Cui | 2020 | National Science Review2020，7，3： | 5 |
| 5 | MII:A Novel Text Classification Model Combining Deep Active Learning with BERT显示文摘Active learning has been widely utilized to reduce the labeling cost of supervised learning.By selecting specific instances to train the model,the performance of the model was improved within limited steps.However,rare work paid attention to the effectiveness of active learning on it.In this paper,we proposed a deep active learning model with bidirectional encoder representations from transformers(BERT)for text classification.BERT takes advantage of the self-attention mechanism to integrate contextual information,which is beneficial to accelerate the convergence of training.As for the process of active learning,we design an instance selection strategy based on posterior probabilities Margin,Intra-correlation and Inter-correlation(MII).Selected instances are characterized by small margin,low intra-cohesion and high inter-cohesion.We conduct extensive experiments and analytics with our methods.The effect of learner is compared while the effect of sampling strategy and text classification is assessed from three real datasets.The results show that our method outperforms the baselines in terms of accuracy. | Anman Zhang Bohan Li Wenhuan Wang Shuo Wan Weitong Chen | 2020 | Computers, Materials & Continua2020，，6： | 4 |
| 6 | Protective Efficacy of Inactivated Vaccine against SARS-CoV-2 Infection in Mice and Non-Human Primates显示文摘The ongoing coronavirus disease 2019(COVID-19)pandemic caused more than 96 million infections and over 2 million deaths worldwide so far.However,there is no approved vaccine available for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the disease causative agent.Vaccine is the most effective approach to eradicate a pathogen.The tests of safety and efficacy in animals are pivotal for developing a vaccine and before the vaccine is applied to human populations.Here we evaluated the safety,immunogenicity,and efficacy of an inactivated vaccine based on the whole viral particles in human ACE2 transgenic mouse and in non-human primates.Our data showed that the inactivated vaccine successfully induced SARS-CoV-2-specific neutralizing antibodies in mice and non-human primates,and subsequently provided partial(in low dose)or full(in high dose)protection of challenge in the tested animals.In addition,passive serum transferred from vaccine-immunized mice could also provide full protection from SARS-CoV-2 infection in mice.These results warranted positive outcomes in future clinical trials in humans. | Yan-Feng Yao Ze-Jun Wang Ren-Di Jiang Xue Hu Hua-Jun Zhang Yi-Wu Zhou Ge Gao Ying Chen Yun Peng Mei-Qin Liu Ya-Nan Zhang Juan Min Jia Lu Xiao-Xiao Gao Jing Guo Cheng Peng Xu-Rui Shen Qian Li Kai Zhao Lian Yang Xin Wan Bo Zhang Wen-Hui Wang Jia Wu Peng Zhou Xing-Lou Yang Shuo Shen Chao Shan Zhi-Ming Yuan Zheng-Li Shi | 2021 | Virologica Sinica2021，36，5： | 4 |
| 7 | Phosphor-free single chip GaN-based white light emitting diodes with a moderate color rendering index and significantly enhanced communications bandwidth显示文摘To achieve high quality lighting and visible light communication(VLC)simultaneously,Ga N based white light emitting diodes(WLEDs)oriented for lighting in VLC has attracted great interest.However,the overall bandwidth of conventional phosphor converted WLEDs is limited by the long lifetime of phosphor,the slow Stokes transfer process,the resistance-capacitance(RC)time delay,and the quantum-confined Stark effect(QCSE).Here by adopting a self-assembled In Ga N quantum dots(QDs)structure,we have fabricated phosphor-free single chip WLEDs with tunable correlated color temperature(CCT,from 1600 K to 6000 K),a broadband spectrum,a moderate color rendering index(CRI)of 75,and a significantly improved modulation bandwidth(maximum of150 MHz)at a low current density of 72 A∕cm^2.The broadband spectrum and high modulation bandwidth are ascribed to the capture of carriers by different localized states of In Ga N QDs with alleviative QCSE as compared to the traditional In Ga N/Ga N quantum well(QW)structures.We believe the approach reported in this work will find its potential application in Ga N WLEDs and advance the development of semiconductor lighting-communication integration. | Rongqiao Wan Xiang Gao Liancheng Wang Shuo Zhang Xiongbin Chen Zhiqiang Liu Xiaoyan Yi Junxi Wang Junhui Li Wenhui Zhu Jinmin Li | 2020 | Photonics Research2020，8，7： | 3 |
| 8 | Design,synthesis characterization and in vitro biological activity of a series of 3-aryl-6-(bromoarylmethyl)-7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives as the novel acetylcholinesterase inhibitors显示文摘Bromination 被用作策略在药用的化学改进生物活动。以便在与 7H-thiazolo 的新奇 acetylcholinesterase 禁止者的 structureactivity 关系上学习[ 3,2-b ]-1, 2 , 4-triazin-7-one 支架基于我们的以前的工作并且分子的建模,一系列新奇3-aryl-6-( bromoarylmethyl )-7H-thiazolo[3,2-b]-1, 2 , 4-triazin-7-one 衍生物被分子的停靠设计,由集体系列,红外线的系列,质子 NMR 和元素的分析综合了并且描绘。疼痛的学习禁止的活动与 huperzine 用 Ellman 比色的试金被执行 -- 是的 A 积极控制。大多数所有目标混合物在 10 mol/L 展出了超过 45% 抑制。初步的 structureactivity 关系在在父母原子核的 C6 位置的苯基戒指是溴原子和氢氧根组在目标混合物的疼痛禁止的活动的起的重要角色。 | He Nan Xu Zhe Jin Si Jie Liu Hong Min Liu Shuo Li Huang Quan Lin David Chicheong Wan Chun Hu | 2012 | Chinese Chemical Letters2012，23，7： | 3 |
| 9 | The Influence of Diabetes, Hypertension, and Hyperlipidemia on the Onset of Age-Related Macular Degeneration in North China: The Kailuan Eye Study显示文摘Objective To analyze the prevalence of dry and wet age-related macular degeneration(AMD)in patients with diabetes,hypertension and hyperlipidemia,and to analyze the risk factors for AMD.Methods A population-based cross-sectional epidemiologic study was conducted involving 14,440 individuals.We assessed the prevalence of dry and wet AMD in diabetic and non-diabetic subjects and analyzed the risk factors for AMD.Results The prevalence of wet AMD in diabetic and non-diabetic patients was 0.3%and 0.5%,respectively,and the prevalence of dry AMD was 17%and 16.4%,respectively.The prevalence of wet AMD in healthy,hypertensive,hyperlipidemic,and hypertensive/hyperlipidemic populations was 0.5%,0.3%,0.2%,and 0.7%,respectively.The prevalence of dry AMD in healthy,hypertensive,hyperlipidemic,and hypertensive/hyperlipidemic populations was 16.6%,16.2%,15.2%,and 17.2%,respectively.Age,sex,body mass index,and use of hypoglycemic drugs or lowering blood pressure drugs were corrected in the risk factor analysis of AMD.Diabetes,diabetes/hypertension,diabetes/hyperlipidemia,and diabetes/hypertension/hyperlipidemia were analyzed.None of the factors analyzed in the current study increased the risk for the onset of AMD.Conclusion There was no significant difference in the prevalence of wet and dry AMD among diabetic and non-diabetic subjects.Similarly,there was no significant difference in the prevalence of wet and dry AMD among subjects with hypertension and hyperlipidemia.Diabetes co-existing with hypertension and hyperlipidemia were not shown to be risk factors for the onset of dry AMD. | ZHANG Yong Peng WANG Ya Xing ZHOU Jin Qiong WANG Qian YAN Yan Ni YANG Xuan YANG Jing Yan ZHOU Wen Jia WANG Ping SHEN Chang YANG Ming LUAN Ya Nan WANG Jin Yuan WU Shou Ling CHEN Shuo Hua WANG Hai Wei FANG Li Jian WAN Qian Qian ZHU Jing Yuan NIE Zi Han CHEN Yu Ning XIE Ying JONAS JB WEI Wen Bin | 2022 | Biomedical and Environmental Sciences2022，35，7： | 2 |
| 10 | Generic classification of Asian horned toads(Anura:Megophryidae: Megophryinae) and monograph of Chinese species显示文摘The subfamily Megophryinae,as a representative batrachian group of the Oriental Realm and one of the most diverse groups of amphibians,has attracted considerable attention due to continued conjecture regarding its generic classification and failure to reach a satisfactory consensus.China boasts the richest diversity of Asian horned toads,containing some two thirds of the total species cataloged.However,most species have a complicated taxonomic history,resulting in multiple misidentifications.As such,an overall clarification of historical records and regional checklists is required.In the current investigation,we established the phylogeny of the Asian horned toads and performed detailed examinations with redefinitions of several important morphological traits.Based on the phylogenetic relationships and morphological differences,we propose a new ten-genus classification for the Asian horned toad subfamily Megophryinae:i.e.,Brachytarsophrys,Atympanophrys,Grillitschia,Sarawakiphrys gen.nov.,Jingophrys gen.nov.,Xenophrys,Megophrys,Pelobatrachus,Ophryophryne,and Boulenophrys.Revisions on the diagnosability,distribution,and content of each genus are provided.Furthermore,we present a careful review of the taxonomic history of Asian horned toad species from China and provide a monograph of congeners,including six species of Brachytarsophrys,four species of Atympanophrys,five species of Jingophrys gen.nov.,10 species of Xenophrys,two species of Ophryophryne,and 60 species of Boulenophrys.Finally,we discuss the importance of traditional morphological traits based on multiple populations in taxonomic work as well as taxonomic inflation caused by the genetic species delimitation. | Zhi-Tong Lyu Shuo Qi Jian Wang Si-Yu Zhang Jian Zhao Zhao-Chi Zeng Han Wan Jian-Huan Yang Yun-Ming Mo Ying-Yong Wang | 2023 | Zoological Research2023，44，2： | 2 |
| 11 | Control over π-π stacking of heteroheptacene-based nonfullerene acceptors for 16% efficiency polymer solar cells显示文摘Nonfullerene acceptors are being investigated for use in polymer solar cells(PSCs),with their advantages of extending the absorption range,reducing the energy loss and therefore enhancing the power conversion efficiency(PCE).However,to further boost the PCE,mobilities of these nonfullerene acceptors should be improved.For nonfullerene acceptors,the π-π stacking distance between cofacially stacked molecules significantly affects their mobility.Here;we demonstrate a strategy to increase the mobility of heteroheptacene-based nonfullerene acceptors by reducing their n'-7r stacking distances via control over the bulkiness of lateral side chains.Incorporation of 2-butyloctyl substituents into the nonfullerene acceptor(M36)leads to an increased mobility with a reduced π-π stacking distance of 3.45 A.Consequently,M36 affords an enhanced PCE of 16%,which is the highest among all acceptor-donor-acceptor-type nonfullerene acceptors to date.This strategy of control over the bulkiness of side chains on nonfullerene acceptors should aid the development of more efficient PSCs. | Yunlong Ma Dongdong Cai Shuo Wan Pan Yin Pengsong Wang Wenyuan Lin Qingdong Zheng | 2020 | National Science Review2020，7，12： | 2 |
| 12 | Hanging Pt hollow nanoerystal assemblies on graphene resulting in an enhanced eleetrocatalyst 显示文摘 | XIAO Yuping WAN Shuo ZHANG Xing | 2012 | Chem Commun2012，48，10： | 1 |
| 13 | Effects of various degrees of oxidative stress induced by intermittent hypoxia in rat myocardial tissues显示文摘 | WEI ZHOU SHUO LI NANSHENG WAN ZHEN ZHANG RUN GUO BAOYUAN CHEN | 2012 | Respirology2012，，5： | 1 |
| 14 | Improvement on the Effectiveness of Marine Stock Enhancement in the Artificial Reef Area by a New Cage-Based Release Technique显示文摘The release technique,affecting the survival rate of fish species released for stock enhancement,plays a vital role in the effectiveness of the enhancement.In order to improve the probability of released fish settling down to bottom,a new cage-based release technique was designed and tested via a water tank with artificial reef models.Two coral reef fish species,Sebastes schlegelii and Paralichthys olivaceus were assessed using this technique.Fish behavior and distribution in water tank were recorded and compared with the traditional release release techniques.Results showed that in the case of cage-based release technique:1)when the release process is just finished,the distribution index(DI)of juveniles S.schlegelii and P.olivaceus were 97.8%and 98.9%at reef area,40%and 71.1%at release point,respectively,which was higher than those using two alternative techniques;2)its impact duration was less than that in the other two conditions,where the DI within 4 hours was higher after releasing,especially for S.schiegelii.These findings indicated that the new cage-based technique could release the fish into the specified location,and has a potential to mitigate the stress reaction of fish caused by releasing process. | ZHANG Junbo HE Yufeng GUO Zhixing JI Shuheng ZHANG Shuo TANG Yanli SHENG Huaxiang WAN Rong KITAZAWA Daisuke | 2021 | Journal of Ocean University of China2021，20，4： | 1 |
| 15 | Fabrication of ultrathin Zn(OH)2 nanosheets as drug carriers显示文摘Ultrathin 二维(2D ) 多孔的 Zn (哦)2 nanosheets (PN ) 作为脊梁借助于一个维的 Cu nanowires 被制作。PN 有约 3.8 nm 的厚度和 4-10 nm 的毛孔尺寸。形成聪明的多孔的 nanosheets, DNA aptamers covalently 被结合到 PN 的表面。好 biocompatibility,有效细胞的举起,和有希望的刺激 pH 的药释放的这些 ultrathin nanosheets 表演。 | Ren Cai Dan Yang Jin Wu Liqin Zhang Cuichen Wu Xigao Chen Yanyue Wang Shuo Wan Fengwei HOU Qingyu Yan Weihong Tan | 2016 | Nano Research2016，9，8： | 1 |
| 16 | Description of a New Species of Amolops (Anura:Ranidae) from Tibet,China显示文摘A new species,Amolops pallasitatus sp.nov.is described based on specimens collected from Chentang Town,Dinggyê County,southern Tibet,China.The new species can be distinguished from other known congeners by mitochondrial divergence and morphological characteristics including:(1)medium body size,SVL 70.6–72.3 mm in adult females;(2)skin smooth over the entire body;(3)absence of dorsolateral fold;(4)tympanum small,edge indistinct,less than half of eye diameter;(5)vomerine teeth in two short oblique;(6)circummarginal and transverse grooves absent on disk of the first finger;(7)presence of inner metacarpal tubercle;(8)toes fully webbed,webbing formula Ⅰ0-0^-Ⅱ0-1/2Ⅲ0-1^+Ⅳ1^+-0Ⅴ;(9)absence of outer metatarsal tubercle and tarsal glands;(10)tibiotarsal articulation of the hind limb reaches posterior corners of the eye;(11)dorsum yellow-green,with irregular dark brown blotches without margins;(12)blotches concentrated on the dorsum,less on the flanks.In morphology,Amolops pallasitatus sp.nov.is similar to A.himalayanus and A.formosus,the difference between them is length of hind limbs,web of toe and dorsal colour pattern.The systematic placement of the new species within the genus is unresolved and it is not assigned to any recognized species group,for the lack of convictive evidences. | Shuo QI Zhengyan ZHOU Zhitong LYU Yuyan LU Han WAN Mian HOU Keji GUO Pipeng LI | 2019 | Asian Herpetological Research2019，10，4： | 1 |
| 17 | Recent advances in flexible alkaline zinc-based batteries:Materials,structures,and perspectives显示文摘The development of wearable electronic systems has generated increasing demand for flexible power sources.Alkaline zinc(Zn)-based batteries,as one of the most mature energy storage technologies,have been considered as a promising power source owing to their exceptional safety,low costs,and outstanding electrochemical performance.However,the conventional alkaline Zn-based battery systems face many challenges associated with electrodes and electrolytes,causing low capacity,poor cycle life,and inferior mechanical performance.Recent advances in materials and structure design have enabled the revisitation of the alkaline Zn-based battery technology for applications in flexible electronics.Herein,we summarize the up-to-date works in flexible alkaline Zn-based batteries and analyze the strategies employed to improve battery performance.Firstly,we introduce the three most reported cathode materials(including Ag-based,Ni-based,and Co-based materials)for flexible alkaline Zn-based batteries.Then,challenges and modifications in battery anodes are investigated.Thirdly,the recently advanced gel electrolytes are introduced from their properties,functions as well as advanced fabrications.Finally,recent works and the advantages of sandwich-type,fiber-type and thin film-type flexible batteries are summarized and compared.This review provides insights and guidance for the design of high-performance flexible Zn-based batteries for next-generation electronics. | Yanzhe Zhu Peiyuan Guan Renbo Zhu Shuo Zhang Ziheng Feng Mengyao Li Tao Wan Long Hu Yunjian Liu Qin Li Juan Yu Dewei Chu | 2023 | Journal of Energy Chemistry2023，，12： | 0 |
| 18 | Medicinal chemistry strategies in the discovery and optimization of HBV core protein allosteric modulators(2018-2022 update)显示文摘Despite the improving coverage of preventative vaccines,hepatitis B remains a severe global public health problem,with more than 250 million patients living with hepatitis B virus(HBV)infection.Current available therapies,including nucleos(t)ide analogs and peginterferon,can control HBV replication but fail to eliminate covalently closed circular DNA(cccDNA)and achieve a cure.The HBV core protein(Cp)is a well-conserved structural protein,self-assembling to form the viral capsid.It involves in or modulates almost every stage of the HBV lifecycle,which makes it an attractive target for the development of new anti-HBV therapies.HBV core protein allosteric modulators(CpAMs)have become a hotspot in recent years.Herein,we provide a concise report focusing on the various medicinal chemistry strategies involved in the latest research(2018-2022)of HBV CpAMs,including high throughput screening(HTS),virtual screening(VS),drug repositioning,natural products,substitution decorating approach,scaffold hopping,molecular hybridization,prodrug strategy and conformational constraint strategy,to provide guidance for further development of new and effective anti-HBV drugs. | Xiaoyu Shao Shujing Xu Xufeng Wan Yang Zhou Shuo Wang Shuo Wu Yuhuan Li Xinyong Liu Peng Zhan | 2023 | Chinese Chemical Letters2023，34，11： | 0 |
| 19 | Formation mechanism of hierarchical twins in the CoCrNi medium entropy alloy显示文摘The three-dimensional hierarchical twin network has been proved to be the source of the excellent strength-ductility combination in the CoCrNi medium entropy alloy.Revealing the formation mechanism of hierarchical twins,however,remains a challenge using either the post-mortem or the in-situ microstructural characterization.In this study,the atomistic formation mechanism of hierarchical twins was investigated using molecular dynamics simulations,with special focus on the effects of strain rate and deformation temperature.Compared to the primary twin boundaries kink-driven hierarchical twinning tendency in pure FCC metals,the chemical inhomogeneity in CoCrNi can reduce the necessary kink height to trigger conjugate twins(CTWs),fascinating the formation of twin networks.At room temperature,the plastic deformation is dominated by primary twins(PTWs)and conjugate slips at a relatively lower strain rate(e.g.,5×10^(7)s^(−1)).The hierarchical twins can be activated in cases of deforming at a higher strain rate(e.g.,2×10^(8)s^(−1)).Further increasing the strain rate(e.g.,1×10^(10) s^(−1))leads to the phase-transformation induced plasticity.At cryogenic temperatures,the hierarchical twins are promoted within a large range of strain rates(e.g.,5×10^(7)–1×10^(10) s^(−1)).A higher temperature leads to the synergy of CTWs and primary slips at a lower strain rate,but hierarchical twins at a higher strain rate.On this basis,a qualitative comparison and scalable trends between experiments and simulations were revealed.The present study would not only provide the basic understanding for the twinning behavior found experimentally,but also contribute to the design of medium/high entropy alloys with excellent mechanical performances by tuning microstructures. | Dongpeng Hua Xiaorong Liu Wan Wang Qing Zhou Qiaosheng Xia Shuo Li Junqin Shi Haifeng Wang | 2023 | Journal of Materials Science & Technology2023，，9： | 0 |
| 20 | Effect and Mechanism of Hai Tong-pi Decoction Ointment on Antiinflammation and Analgesia by Transcutaneous Administration in Mice显示文摘Objectve:To investigate the effect and mechanism of Hai Tongpi decoction ointment on analgesic and anti-inflammatory effects in mice after transdermal administration.Methods:The hot plate method and the acetic acid writhing experiment were used to verify the analgesic effect of Hai tong-pi extract on pain model mice;the xylene-induced auricular swelling model and the carrageenan-induced right foot swelling model were used,combined with the ELISA method to determine the analgesic effect.The levels of TNF-α,IL-1βand IL-6 in the serum of mice were observed.Anti-inflammatory effect of Haitongpi Tang decoction ointment on inflammation model mice.Results:In terms of analgesia,compared with the model group,both the treatment group 1 and the treatment group 2 can significantly prolong the hot plate pain threshold and the latency of the writhing response(P<0.05),and significantly reduce the writhing in the mice.The number of times(P<0.001),and the effect of process 1 is more obvious(P<0.05);In terms of antiinflammatory,compared with the blank group,the swelling degree and swelling rate of the right hind paw of the mice in the model group were significantly increased(P<0.01),indicating that the acute inflammation model was successfully established in the mice.Compared with the model group,both the process group 1 and the process group 2 can significantly reduce the swelling degree and swelling rate of the mice feet(P<0.05),and reduce the auricle swelling degree of the mice,and increase the swelling inhibition rate(P<0.05),and the effective effect of process 1 group was more significant(P<0.05).At the same time,compared with the blank group,the contents of TNF-α,IL-1βand IL-6 in the model group were significantly increased(P<0.01).Compared with the process group 2,the process group 1 had a more significant decrease in the content of IL-1β(P<0.05),and IL-6 content of the two had no statistical difference(P>0.05).Conclusion:The Hai tong-pi decoction ointment prepared by two different processes have good analgesic and antiinflammatory effects on mice after transdermal administration.inflammatory cytokine expression.The anti-inflammatory and analgesic effect of process group 1 was better than that of process group 2,which may be related to the separate extraction and storage of volatile oil of traditional Chinese medicine,which ensured the long-term pharmacological activity of volatile oil. | LI Fa-jie GU Jin-yu ZHANG-Yue SHEN Shuo YAO Yao WAN Tian-hao XIA Di ZHANG Qing | 2022 | Journal of Hainan Medical University2022，28，16： | 0 |
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