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| 1 | Petrogenesis of highly fractionated I-type granites in the Zayu area of eastern Gangdese, Tibet: Constraints from zircon U-Pb geochronology, geochemistry and Sr-Nd-Hf isotopes显示文摘The Cretaceous granitoids in the middle and northern Gangdese, Tibet are generally interpreted as the products of anatexis of thickened deep crust genetically associated with the Lhasa-Qiangtang collision. This paper reports bulk-rock major element, trace element and Sr-Nd isotopic data, zircon U-Pb age data, and zircon Hf isotopic data on the Zayu pluton in eastern Gangdese, Tibet. These data shed new light on the petrogenesis of the pluton. Our SHRIMP zircon U-Pb age dates, along with LA-ICPMS zircon U-Pb age dates recently reported in the literature, indicate that the Zayu pluton was emplaced at about 130 Ma, coeval with Early Cretaceous magmatic rocks in other areas of eastern Gangdese (e.g., Rawu, Baxoi areas) and the Middle Gangdese. The Zayu pluton samples lack amphibole and muscovite, and are compositionally characterized by high SiO2 (69.9%―76.8%), K2O (4.4%―5.7%), and low P2O5 (0.05%―0.12%). These samples also have A/CNK values of 1.00-1.05, and are enriched in Rb, Th, U, and Pb, and depleted in Ba, Nb, Ta, Sr, P, Ti, and Eu. These geochemical features suggest that the Zayu pluton samples are metaluminous to slightly peraluminous and are of highly fractionated I-type granite. The Zayu pluton samples have high εNd(t) values (-10.9--7.6) and low initial 87Sr/86Sr ratios (0.7120- 0.7179) relative to melts derived from mature continental crust in the Gangdese (e.g., Ningzhong Early Jurassic strongly peraluminous granite). The Zayu pluton samples are heterogeneous in zircon εHf(t) values (-12.8--2.9), yielding ancient zircon Hf crustal model ages of 1.4―2.0 Ga. The data obtained in this study together with the data in the recent literature suggest that the Early Cretaceous granitoids in eastern Gangdese represent the eastward extension of the Early Cretaceous magmatism in the middle Gangdese, and that the Lhasa micro-continent block with ancient basement may extend for ~2000 km from east to west. Zircon Hf isotopic data and bulk-rock zircon saturation temperature (789-821℃) indicate that mantle-derived materials likely played a role in the generation of the Zayu pluton. We propose that the Zayu pluton was most likely generated in a setting associated with southward sub- duction of the Bangong-Nujiang ocean floor, where mantle wedge-derived magmas may have providedthe heat and material for the anatexis of ancient crust of the Lhasa micro-continent, resulted in hybrid melts (i.e., mantle-derived basaltic magmas + crust-derived felsic magmas). Such hybrid melts with subsequent fractional crystallization are responsible for the highly evolved Zayu pluton (crust thick- ening is not a prerequisite). | ZHU DiCheng MO XuanXue WANG LiQuan ZHAO ZhiDan NIU Yaoling ZHOU ChangYong YANG YueHeng | 2009 | Science China Earth Sciences2009，52，9： | 107 |
| 2 | Identification and expansion of cancer stem cells in tumor tissues and peripheral blood derived from gastric adenocarcinoma patients显示文摘胃的癌症是世界范围的第四很普通的癌症,与死亡的高率和低 5 年的幸存率。迄今为止,有为胃的癌症的有效治疗学的协议的缺乏。最近的研究建议癌症干细胞(CSC ) 为肿瘤开始,侵略,转移,和抵抗负责到 anticancer 治疗。因此,指向胃的 CSC 的治疗是吸引人的。然而,在人的胃的腺癌(GAC ) 的 CSC 没被描述。这里,我们从 GAC 病人在肿瘤纸巾和外部血识别 CSC。从肿瘤纸巾和病人的外部血被孤立的人的 GAC (GCSC ) 的 CSC 带了 CD44 和 CD54 表面标记,当注入了 immunodeficient 老鼠时,高度类似于原来的人的肿瘤的产生肿瘤,在 vitro 区分了进胃的上皮的房间,并且在 vivo 并且在 vitro 自我更新。我们的调查结果建议有效治疗学的协议必须指向 GCSC。从 GAC 病人的循环的 GCSC 的俘获也为为肿瘤转移潜在地负责的一张批评房间人口的鉴定显示出大潜力,并且为早诊断并且胃的癌症的纵的监视提供一个有效协议。 | Tie Chen Kun Yang Jianhua Yu Wentong Meng Dandan Yuan Feng Bi Fang Liu Jie Liu Bing Dai Xinzu Chen Fang Wang Fan Zeng Hong Xu Jiankun Hu Xianming Mo | 2012 | Cell Research2012，22，1： | 50 |
| 3 | The Sequence of Magmatic-Tectonic Events and Orogenic Processes of the Yanshan Belt, North China显示文摘This paper emphasizes that the interactive constraints of geology and isotopic dating is the best approach to construct the geological event sequence, and has compiled 106 data of reasonable isotopic ages for the igneous rocks of the Yanshan belt. We propose a sequence of mgmatic-tectonic events in the Jurassic-Cretaceous Yanshan orogen of North China. Five orogenic episodes are divided, (1) pre-and initial orogenic episode (Early Jurassic); (2) early orogenic episode (Middle Jurassic); (3) peak orogenic episode (Late Jurassic); (4) late orogenic episode (early Early Cretaceous),and (5) post-orogenic episode. Each episode is a short cycle, all of the orogenic processes construct a longer cycle, and they, in general, followed a counter-clockwise (ccw) PTt path. Finally, it is suggested that the Yanshanian movement was so intensive that the magmatism and tectonic deformation had involved all the lithosphere thickness and the lateAchaean-formed cratonic lithosphere had been significantly reworked. | DENG Jinfu, SU Shangguo, MO Xuanxue, ZHAO Guochun, XIAO Qinghiu, JI Guangyi,QIU Ruizhao, ZHAO Hailing, LUO Zhaohua, WANG Yang and LIU Cui China University of Geosciences, Beijing 100083 and Key Laboratory of Lithospheric Tectonics and Lithoprobe Techniques, Ministry of Education of China | 2004 | Acta Geologica Sinica(English Edition)2004，78，1： | 35 |
| 4 | Regulatory T cells as a new therapeutic target for atherosclerosis显示文摘动脉粥样硬化是贡献 T 和 B 房间免疫者回答的过多的激活的 self-self-antigens 和 non-self-antigens 引起的自体免疫的疾病。这些回答进一步加重脉管的 infiammation 并且经由释放 pro-infiammatory cytokines 支持到匾的动脉粥样硬化和危险的前进。特别地,规章的 T 房间( Tregs )由压制象 T 和 B 房间,生来的杀手( NK )房间,单核白血球,和树枝状的房间( DC )那样的各种各样的房间的有免疫力的回答作为主要 immunoregulatory 房间导致并且维持有免疫力的动态平衡和忍耐,象由 secreting 一样处于生理、病理学的状态的禁止的 cytokines interleukin ( IL )-10, IL-35 和抄写生长因素(TGF-)。众多的证据证明 Treg 的减少的数字和机能障碍可以是在动脉粥样硬化致病的 involveved。增加或恢复并且改进 Tregs 的抑制免疫力的能力数字可以用作基本免疫疗法对待动脉粥样硬化患者心血管的疾病。在这篇文章,我们 briefiy 介绍 Treg 子集的当前的知识,总结在 Tregs 和动脉粥样硬化开发之间的关系,并且讨论调整为动脉粥样硬化致病和匾稳定性的改进的预防的 Tregs 的可能性。尽管对动脉粥样硬化的调停 Treg 的保护的准确分子的机制尚待被阐明,为指向 Tregs 的规定的策略可以为动脉粥样硬化患者的预防和治疗提供特定、重要的途径心血管的疾病。 | Han-xiao OU Bing-bing GUO Qi LIU Yu-kun LI Zhen YANG Wen-jie FENG Zhong-cheng MO | 2018 | Acta Pharmacologica Sinica2018，39，8： | 24 |
| 5 | Changing patterns and survival improvements of young breast cancer in China and SEER database, 1999-2017显示文摘Objective: Breast cancer in young females was usually considered more aggressive and requires aggressive therapy. We investigated whether early detection and improved treatments changed the patterns of characteristics,management and outcomes of young breast cancer patients over time.Methods: Females under 40 years of age diagnosed with breast cancer during the periods 1999-2017 and1999-2015 were identified in the Fudan University Shanghai Cancer Center(FUSCC) and the population-based Surveillance, Epidemiology, and End Results(SEER) registry, respectively. Clinicopathologic characteristics and treatment information were collected. Patients diagnosed before 2013 were followed up.Results: The proportions of young breast cancer patients were 15.0% and 5.3% in the FUSCC and SEER cohorts, respectively. In the FUSCC cohort, there was a significant increase in the proportion of ductal carcinoma in situ(DCIS)(from 8.8% to 16.9%;P<0.0001) and it remained stable in SEER cohort. The proportion of T1-stage tumors increased dramatically in the FUSCC cohort(from 35.3% to 41.9%;P=0.008), whereas it decreased in SEER cohort(from 42.4% to 33.0%;P<0.0001). The percentage of estrogen receptor(ER)-positive cancers was consistently increased in both the invasive ductal carcinoma(IDC) and DCIS patients in the two cohorts. Breastconserving surgery and immediate implant reconstruction after mastectomy both exhibited increased use over time in the FUSCC cohort. Both the FUSCC and SEER cohorts showed a significantly better prognosis in the recent time period.Conclusions: With the increased early-stage and ER-positive diseases in young patients as well as better systemic treatment strategies, improved survival has been observed in recent years. There has been a substantial deescalation in surgical therapies in young breast cancer patients. | Rong Guo Jing Si Jingyan Xue Yonghui Su Miao Mo Benlong Yang Qi Zhang Weiru Chi Yayun Chi Jiong Wu | 2019 | Chinese Journal of Cancer Research2019，31，4： | 24 |
| 6 | Ten cities cross-sectional questionnaire survey of children asthma and other allergies in China显示文摘Asthma,rhinitis and eczema(allergic or non-allergic)have increased throughout the world during the last decades,especially among children.Changes in the indoor environment are suspected to be important causes.China has experienced a dramatic change in indoor environmental exposures during the past two decades.However,such changes and their associations with children’s asthma and other health aspects have not been thoroughly studied.China,Children,Homes,Health(CCHH),Phase I,was a cross-sectional questionnaire survey of 48219 children 1–8 years old in 10 Chinese cities during 2010–2012.The questionnaire includes the International Study of Asthma and Allergies in Childhood(ISAAC)core health questions and additional questions regarding housing,life habits and outdoor environment.In health analyses,children aged 3–6 years old were included.The prevalences of doctor diagnosed asthma varied from 1.7%to 9.8%(mean 6.8%),a large increase from 0.91%in 1999 and 1.50%in2000.The prevalence of wheeze,rhinitis and atopic eczema(last 12 months)varied from 13.9%to 23.7%,24.0%to 50.8%and4.8%to 15.8%,respectively.Taiyuan had the lowest prevalences of all illnesses and Shanghai the highest,except for wheezewhere the highest value was for Urumqi.We found(1)no obvious association between disease prevalences and ambient PM10concentrations and(2)higher prevalences of disease in humid climates with hot summers and cold winters,but with no centrally heated buildings.Associations between the diseases and economic status as indexed by Gross Domestic Product(GDP)requires further study. | ZHANG YinPing LI BaiZhan HUANG Chen YANG Xu QIAN Hua DENG QiHong ZHAO ZhuoHui LI AnGui ZHAO JiaNing ZHANG Xin QU Fang HU Yu YANG Qin WANG Juan ZHANG Ming WANG Fang ZHENG XiaoHong LU Chan LIU ZhiJian SUN YueXia MO JinHan ZHAO YiLi LIU Wei WANG TingTing NORBCK Dan BORNEHAG Carl-Gustaf SUNDELL Jan | 2013 | Chinese Science Bulletin2013，58，34： | 22 |
| 7 | Changed clinical aspects of primary liver cancer in China during the past 30 years显示文摘BACKGROUND: Primary liver cancer (PLC) is one of the most frequently seen tumors in China. Thirty years ago, patients with PLC were often detected at relatively late stage, with a palpable mass or marked clinical symptoms and poor prognosis. In the past 30 years, the diagnosis and treatment of PLC have been greatly improved with better prognosis. METHODS: In order to study the changes of PLC during the 30 years, the clinical data of 3250 patients with PLC from 10 medical institutions of China were collected, ana- lyzed , and compared with those of 3254 PLC patients be- fore the 30 years. RESULTS: In the 3250 patients aged 1-80 years, with an average age of 49.1 years, the male to female ratio (2.3:1) was lower than that before the 30 years. 73.5% of the 3250 patients sought medical advice within 3 months after the onset of the disease in contrast to 63.8% before the 30 years. Compared with those patients before the 30 years the symptoms and signs were alleviated generally. The HBsAg positive rate was 81.0%, but the HCV-Ab positive rate was 13.2%. The AFP level in 75% of patients was elevated, but in the remaining 25% was normal. 1912 patients (58.8%) were confirmed pathologically. Among them 1755 patients (91.8%) had hepatocellular carcinoma. The overall resec- tion rate was 46.3%. Those who had early, middle, late stage carcinoma accounted for 29.9%, 51.5%, and 18.6%respectively in contrast to 0.4%, 47.0%, and 52.6% repor- ted before the 30 years. The 1-, 3-, 5-year survival rates of the patients were 66.1%, 39.7%, and 32.5% respectively, whereas 93.5%, 70.1%, and 59.1% for the early stage pa- tients, and 65.3%, 30.5%, and 23.5% for the middle stage patients. The half and 1-year survival rates of the late stage patients were 52.5%, and 14.7%, respectively. CONCLUSION: Comparison with the clinical data before and after the 30 years show that PLC can be diagnosed ear- ly. More PLC patients tend to undergo resection while re- ceiving a better conservative treatment, which ensures a prognosis. | Bing-Hui Yang, Jing-Lin Xia, Li-Wen Huang, Zhao-You Tang, Ming-Shan Chen, Jin-Qing Li, An-Min Liang, Qin-Guo Mo, Hui-Shan Lu, Chao-Liu Dai, Lu-Nan Yan, Zhi-Jian Yu, Rong-Sheng Rao, Le-Qun Li, Zhi-Xiong Su, Zhuang-Wei Fang Shanghai, China Liver Cancer Institute & Zhongshan Hospital, Fudan University, Shanghai 200032, China Tumor Hospital, Zhongshan University, Guangzhou 510000, China Tumor Hospital, Guangxi Medical Universi- ty, Nanning 530000, China Xiehe Hospital, Fujian Medical University, Fuzhou 350000, China Second Hos- pital, Chinese Medical University, Shenyang 110000, China Huaxi Hospital, Sichuan University, Chengdu 610041, China Hospital Affiliated to Nantong Medical University, Nantong 226000 , China Second Hospital, Jiangxi Medical University, Nanchang 330000 , China First Hospital Affiliated to Guangxi Medical University, Nanning 530000 , China People’s Hospital of Hainan Province, Haikou 570000, China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，2： | 20 |
| 8 | A New Capillary Electrophoresis Apparatus with Piezoelectric Ceramics High Voltage Source and Amperometric Detector显示文摘IntroductionHighperformancecapiliar}'electrophoresis(HPCE)isanewanalyticaltechnology'rapidly'developedinrecentyears.Withtheadvantagesofsmallsample.highsensitivity,highresolution.rapidanalysisandverycheaprunning,ithasbeenappliedinchemistry'.lifescienc... | Chen, ZG Mo, JYM Yang, XY Wang, LS Mei, XT Zhang, MS | 1999 | Chinese Chemical Letters1999，10，3： | 19 |
| 9 | Patients Aged 80 Years or Older are Encountered More Potentially Inappropriate Medication Use显示文摘 | Li Mo Ding Ding Shi-Yun Pu Qin-Hui Liu Hong Li Bi-Rong Dong Xiao-Yan Yang Jin-Han He | 2016 | Chinese Medical Journal2016，，1： | 16 |
| 10 | Evolution of Circum-Pacific Basins andVolcanic Belts in East China and Their Geodynamic Background显示文摘Evolution of Circum-Pacific Basins andVolcanic Belts in East China andTheir Geodynamic Background￥LiSitian(FacultyofEarthReso... | Li Sitian(Faculty of Earth Resources, China University of Geosciences, Wuhan 430074)Mo Xuanxue(Department of Geology and Mineral Resources, China University of Geosciences, Beijing 100083 )Yang Shigong(Faculty of Earth Resources, China University of Geosc | 1995 | Journal of Earth Science1995，14，1： | 15 |
| 11 | Some constructions of projectively flat Finsler metrics显示文摘In this paper, we find some solutions to a system of partial differential equations that characterize the projectively flat Finsler metrics. Further, we discover that some of these metrics actually have the zero flag curvature. | MO Xiaohuan, SHEN Zhongmin & YANG Chunhong LMAM, School of Mathematical Sciences, Peking University, Beijing 100871, China Department of Mathematical Sciences, Indiana University-Purdue University, Indianapolis, IN 46202-3216, USA Department of Mathematics, Inner Mongolia University, Hohhot 010021, China | 2006 | Science China Mathematics2006，49，5： | 15 |
| 12 | Phosphate Solubilizing Ability and Phylogenetic Diversity of Bacteria from P-Rich Soils Around Dianchi Lake Drainage Area of China显示文摘The phylogenetic diversity of phosphate solubilizing bacteria (PSB) distributed in P-rich soils in the Dianchi Lake drainage area of China was characterized, and the tricalcium phosphate (TCP) solubilizing activities of isolated PSB were determined. Among 1328 bacteria isolated from 100 P-rich soil samples, 377 isolates (28.39% of the total) that exhibited TCP solubilization activity were taken as PSB. These PSB showed different abilities to solubilize TCP, with the concentrations of solubilized P in bacterial cultures varying from 33.48 to 69.63 mg L-1. A total of 123 PSB isolates, with relatively high TCP solubilization activity (> 54.00 mg L-1), were submitted for restriction fragment length polymorphism (RFLP) analysis, which revealed 32 unique RFLP patterns. Based on these patterns, 62 representative isolates, one to three from each RFLP pattern, were selected for 16S rRNA sequencing. Phylogenetic analysis placed the 123 PSB into three bacterial phyla, namely Proteobacteria, Actinobacteria and Firmicutes. Members of Proteobacteria were the dominant PSB, where 107 isolates represented by 26 RFLP patterns were associated with the genera of Burkholderia, Pseudomonas, Acinetobacter, Enterobacter, Pantoea, Serratia, Klebsiella, Leclercia, Raoultella and Cedecea. Firmicutes were the subdominant group, in which 13 isolates were affliated with the genera of Bacillus and Brevibacterium. The remaining 3 isolates were identified as three species of the genus Arthrobacter. This research extends the knowledge on PSB in P-rich soils and broadens the spectrum of PSB for the development of environmentally friendly biophosphate fertilizers. | YANG Pei-Xiang MA Li CHEN Ming-Hui XI Jia-Qin HE Feng DUAN Chang-Qun MO Ming-He FANG Dun-Huang DUAN Yan-Qing YANG Fa-Xiang | 2012 | Pedosphere2012，22，5： | 13 |
| 13 | A smart safe rechargeable zinc ion battery based on sol-gel transition electrolytes显示文摘Thermal runaway has been a long-standing safety issue impeding the development of high-energydensity batteries. Physical safety designs such as employing circuit-breakers and fuses to batteries are limited by small operating voltage windows and no resumption of original working condition when it is cooled down. Here we report a smart thermoresponsive polymer electrolyte that can be incorporated inside batteries to prevent thermal runaway via a fast and reversible sol-gel transition, and successfully combine this smart electrolyte with a rechargeable Zn/a-MnO_2 battery system. At high temperature, battery operation is inhibited as a result of the increased internal resistance caused by the gelation of liquid electrolyte. After cooling down, the electrolyte is spontaneously reversed to sol state and the electrochemical performance of the battery is restored. More importantly, sol-gel transition enables the smart battery to experience different charge-discharge rates under various temperature levels, providing a smart and active strategy to achieve dynamic and reversible self-protection. | Funian Mo Hongfei Li Zengxia Pei Guojin Liang Longtao Ma Qi Yang Donghong Wang Yan Huang Chunyi Zhi | 2018 | Science Bulletin2018，63，16： | 13 |
| 14 | Recent progress in CFD for naval architecture and ocean engineering显示文摘An overview is provided of CFDShip-Iowa modeling, numerical methods and high performance computing(HPC), including both current V4.5 and V5.5 and next generation V6. Examples for naval architecture highlight capability and needs. High fidelity V6 simulations for ocean engineering and fundamental physics describe increased resolution for analysis of physics of fluids. Uncertainty quantification research is overviewed as the first step towards development stochastic optimization. | STERN Frederick WANG Zhaoyuan YANG Jianming SADAT-HOSSEINI Hamid MOUSAVIRAAD Maysam BHUSHAN Shanti DIEZ Matteo YOON Sung-Hwan WU Ping-Chen YEON Seong Mo DOGAN Timur KIM Dong-Hwan VOLPI Silvia CONGER Michael MICHAEL Thad XING Tao THODAL Robert S. GRENESTEDT Joachim L. | 2015 | Journal of Hydrodynamics2015，27，1： | 12 |
| 15 | Role of NLRP3 and NLRP1 inflammasomes signaling pathways in pathogenesis of rheumatoid arthritis显示文摘Objective:To investigate the role of NLRP3 and NLRP1 inflammasomes signaling pathways in rheumatoid arthritis(RA).Methods:A total of 36 patients with RA were selected,peripheral blood mononuclear cell(PBMC)and granulocyte were separated from venous blood.RT-qPCR method was used to detect the expression level and diversity of NLRP3 and NLRP1 in PBMC and granulocyte mRNA in patieuts with RA.and detect the mRNA expression of downstream factor IL-1β.The correlation between RA and the expression of NLRP3 aud NLRP1 was analyzed.Normal 30 cases were set as control group.Results:Expression levels of NLRP1.and caspase-1mRNA in PBMC of RA group were significautly lower than those of control group(P<0.05).while there was no significant differeuee in expression levels of NLRP3,ASC.IL-1βmRNA between these two groups(P>0.05);NLRP3,caspase-1,and ASC mRNA expression in granulocyte of RA patients were significantly lower than those in control group(P<0.05).There was no currelation between rheumatoid factor and expression levels of NLRP3.ASC.caspase-1 mRNA in RA group(P>0.05);NLRP1,IL-1βmRNA expression level had a negative corrlation with anti-rheunatoid factor antibody(P=0.0332,0.0340).Conclusions:NLRP3 and NLRP1 inflammasomes signaling pathways are involved in RA inflammatory reaction process as protective factors,and play an important role in RA inflammatory mechanisms. | Tao Wang Chang-Liang Zhu Shuai Wang Li-Wen Mo Guo-Dong Yang Jun Hu Fan Zhang | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，10： | 11 |
| 16 | Tanshinol alleviates impaired bone formation by inhibiting adipogenesis via KLF15/PPARγ2 signaling in GIO rats显示文摘Glucocorticoid (GC ) 导致了骨质疏松症(GIO ) 被损害骨头形成描绘,它能被 tanshinol 减轻,从鼠尾草植物 miltiorrhiza Bunge 孤立的水的多酚。在这研究,我们调查了位于成骨以及使用 tanshinol 防碍 GIO 的可能性的导致 GC 的调整下面的分子的机制。4 个月的女 SD 老鼠是口头上地管理的提取的水(反对) ,泼尼松(GC, 5 | Ya-jun YANG Zhu ZHU Dong-tao WANG Xin-le ZHANG Yu-yu LIU Wen-xiu LAI Yu-lin MO Jin LI Yan-long LIANG Zhuo-qing HU Yong-jie YU Liao CUI | 2018 | Acta Pharmacologica Sinica2018，39，4： | 11 |
| 17 | One-stop strategy for treatment of atrial fibrillation:feasibility and safety of combining catheter ablation and left atrial appendage closure in a single procedure显示文摘Background:Catheter ablation is effective in restoring sinus rhythm and left atrial appendage closure(LAAC)is increasingly used for stroke prevention in patients with atrial fibrillation(AF).We aimed to observe the feasibility and safety of performing AF ablation and LAAC in a single(one-stop)procedure.Methods:Consecutive AF patients who underwent the combined procedure of AF ablation and LAAC with WATCHMAN device between March 2017 and September 2018 were prospectively enrolled.Baseline and intra-procedural parameters were evaluated.Three-month and subsequent 1-year follow-up were performed in all and earlier-enrolled subjects,respectively.Results:A total of 178 AF patients(94 males,68.9±8.1 years)underwent the one-stop procedure with CHA2DS2-VASc score 3.3±1.5 and HAS-BLED score 1.6±1.0,respectively.Pulmonary vein isolation was achieved in all patients while additional linear ablation was applied if the operator deemed necessary,yielding immediate ablation success rate of 98.9%(176/178).In the subsequent LAAC,satisfactory seal(residual leak<5 mm)was achieved in all patients.One stroke and four cardiac perforations occurred peri-operatively.At 3-month follow-up,sinus rhythm and satisfactory seal were maintained in 153/178(86.0%)and 178/178(100%)patients,respectively.One stroke and one delayed cardiac tamponade occurred,while no device-related thrombus or device migration was observed.During the 1-year follow-up for the earlier enrolled subjects,52/72(72.2%)of the patients maintained sinus rhythm.There was no stroke or systemic embolism observed.Conclusion:Combining catheter ablation and LAAC in a single procedure can be successfully and safely performed in non-valvular AF patients of Chinese population. | Mu Chen Zhi-Quan Wang Qun-Shan Wang Jian Sun Peng-Pai Zhang Xiang-Fei Feng Wei Li Ying Yu Bo Liu Bin-Feng Mo Rui Zhang Mei Yang Chang-Qi Gong Ming-Zhe Zhao Yi-Chi Yu Yan Zhao Qiu-Fen Lu Yi-Gang Li | 2020 | Chinese Medical Journal2020，，12： | 11 |
| 18 | Preoperative surgical planning and simulation of complex cranial base tumors in virtual reality显示文摘 | YI Zhi-qiang LI Liang MO Da-peng ZHANG Jia-yong ZHANG Yang BAO Sheng-de | 2008 | Chinese Medical Journal2008，，12： | 11 |
| 19 | Major advances in studies of the physical geography and living environment of China during the past 70 years and future prospects显示文摘The natural environment provides material essentials for human survival and development. The characteristics,processes, regional differentiation and forcing mechanisms of the elements of the natural environment(e.g. geomorphology,climate, hydrology, soil, etc.) are the main objects of research in physical geography. China has a complex natural environment and huge regional differentiation and therefore it provides outstanding reserach opportunities in physical geography. This review summarizes the most important developments and the main contributions of research in the physical geography and human living environment in China during the past 70 years. The major topics addressed are the uplift of the Tibetan Plateau and the evolution of its cryosphere, the development of fluvial systems, the acidification of the vast arid region of the Asian interior, variations in the monsoon and westerly climate systems on multiple timescales, the development of lakes and wetlands, the watershed system model, soil erosion, past human-environment interactions, biogeography, and physical geographic zonality. After briefly introducing international research developments, we review the history of research in physical geography in China, focusing on the major achievements and major academic debates, and finally we summarize the status of current research and the future prospects. We propose that in the context of the national demand for the construction of an ecological civilization, we should make full use of the research findings of physical geography, and determine the patterns and mechanisms of natural environmental processes in order to continue to promote the continued contribution of physical geography to national development strategies, and to further contribute to the theory of physical geography from a global perspective. | Fahu CHEN Bojie FU Jun XIA Duo WU Shaohong WU Yili ZHANG Hang SUN Yu LIU Xiaomin FANG Boqiang QIN Xin LI Tingjun ZHANG Baoyuan LIU Zhibao DONG Shugui HOU Lide TIAN Baiqing XU Guanghui DONG Jingyun ZHENG Wei YANG Xin WANG Zaijun LI Fei Wang Zhenbo HU Jie WANG Jianbao LIU Jianhui CHEN Wei HUANG Juzhi HOU Qiufang CAI Hao LONG Ming JIANG Yaxian HU Xiaoming FENG Xingguo MO Xiaoyan YANG Dongju ZHANG Xiuhong WANG Yunhe YIN Xiaochen LIU | 2019 | Science China Earth Sciences2019，62，11： | 11 |
| 20 | Analysis of the Dynamic Response of a Shield Tunnel in Soft Soil Under a Metro-Train Vibrating Load显示文摘This paper concerns the impact of an operating metro train on the structure of a shield tunnel lining and its soft foundation. An elastoplastic 3D dynamic finite difference model was established by using the FLAC3D numerical soft- ware. By fully considering the joints, the A-B-K segments and the soft stratum, the dynamic response of the shield tunnel buried in thick, soft soil under the vibrating load induced by a metro train was numerically simulated. The simulation result, for which the joint was considered, was compared with the result when the joint was not considered. The results show that an operating metro train induces a significant dynamic response in the structure of the lining of the shield tunnel and its soft foundation. The severe dynamic response zones of the lining structure are largely distributed in the range of the lower half of the segment-ring and the nearer to the bottom of the segment-ring, the more severe the response. Of two horizontally symmetric, corresponding places on the segment lining, the one near the joint is more severe in its dynamic response than that of the one far from the joint; the nearer the zone of the foundation soil to the lower half of the seg- ment-ring, the more severe the dynamic response. The maximum shear strain of the foundation soil takes place near the joint between two normal segments at the bottom. The dynamic response influenced by joints is more severe than the response not influenced by joints, showing that the non-joint assumption is somewhat impractical. | DENG Fei-huang MO Hai-hong ZENG Qing-jun YANG Xiao-jie | 2006 | Journal of China University of Mining and Technology2006，16，4： | 10 |
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