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| 1 | Mycophenolate mofetil for maintenance of remission in steroid-dependent autoimmune pancreatitis显示文摘Systemic corticosteroids represent the standard treatment for autoimmune pancreatitis with IgG4-associated cholangitis.For steroid-dependent disease,azathioprine has been used for maintenance of remission.Mycophenolate mofetil has been used for transplant immunosuppression and more recently for autoimmune hepatitis;however,there are no case reports to date on the use of mycophenolate mofetil in adult patients with autoimmune pancreatitis.A patient with IgG4-mediated autoimmune pancreatitis and IgG4-associated cholangitis refractory to steroids and intolerant of azathioprine was treated with mycophenolate mofetil,which inhibits de novo guanosine synthesis and blockade of both B and T lymphocyte production.Introduction of mycophenolate mofetil and uptitration to 1000 mg by mouth twice daily over a treatment period of 4 mo was associated with improvement in the patient's energy level and blood glucose control and was not associated with any adverse events.The patient was managed without a biliary stent.However,there was a return of symptoms,jaundice,increase in transaminases,and hyperbilirubinemia when the prednisone dose reached 11 mg per day.In the first report of mycophenolate mofetil use in an adult patient with IgG4-associated autoimmune pancreatitis and IgG4-associated cholangitis,the introduction of mycophenolate mofetil was safe and well-tolerated without adverse events,but it did not enable discontinuation of the steroids.Mycophenolate mofetil and other immunomodulatory therapies should continue to be studied for maintenance of remission in the large subset of patients with refractory or recurrent autoimmune pancreatitis. | Jamie B Sodikoff Steven A Keilin Sheila J Bharmal Melinda M Lewis Gottumukkala S Raju Field F Willingham | 2012 | World Journal of Gastroenterology2012，18，18： | 6 |
| 2 | Pancreatic enzymes and abdominal adipose tissue distribution in new-onset prediabetes/diabetes after acute pancreatitis显示文摘BACKGROUND New-onset prediabetes/diabetes after acute pancreatitis(NODAP)is the most common sequela of pancreatitis,and it differs from type 2 prediabetes/diabetes mellitus(T2DM).AIM To study the associations between circulating levels of pancreatic amylase,pancreatic lipase,chymotrypsin and fat phenotypes in NODAP,T2DM,and health.METHODS Individuals with NODAP(n=30),T2DM(n=30),and sex-matched healthy individuals(n=30)were included.Five fat phenotypes(intra-pancreatic fat,liver fat,skeletal muscle fat,visceral fat,and subcutaneous fat)were determined using the same magnetic resonance imaging protocol and scanner magnet strength for all participants.One-way analysis of covariance,linear regression analysis,and relative importance analysis were conducted.RESULTS Intra-pancreatic fat deposition(IPFD)was higher in NODAP(9.4%±1.8%)and T2DM(9.8%±1.1%)compared with healthy controls(7.8%±1.9%)after adjusting for covariates(P=0.003).Similar findings were observed in regards to visceral fat volume(P=0.005),but not subcutaneous fat volume,liver fat,or skeletal muscle fat.Both IPFD(β=-2.201,P=0.023)and visceral fat volume(β=-0.004,P=0.028)were significantly associated with circulating levels of pancreatic amylase in NODAP,but not in T2DM or healthy individuals.Of the five fat phenotypes,IPFD explained the highest amount of variance in pancreatic amylase concentration(R2=15.3%out of 41.2%).None of the phenotypes contributed meaningfully to the variance in pancreatic lipase or chymotrypsin.CONCLUSION Both NODAP and T2DM are characterized by increased IPFD and visceral fat volume.However,only NODAP is characterized by significant inverse associations between the two fat phenotypes and pancreatic amylase. | Juyeon Ko Loren Skudder-Hill Jaelim Cho Sakina H Bharmal Maxim S Petrov | 2021 | World Journal of Gastroenterology2021，27，23： | 5 |
| 3 | Cardiac Troponins I and T: Molecular Markers for Early Diagnosis, Prognosis, and Accurate Triaging of Patients with Acute Myocardial Infarction显示文摘 | Ram P. Tiwari Anubhav Jain Zakir Khan Veena Kohli R. N. Bharmal S. Kartikeyan Prakash S. Bisen | 2012 | Molecular Diagnosis & Therapy2012，，6： | 3 |
| 4 | Pre‐ and post‐training session evaluation for interobserver agreement and diagnostic accuracy of probe‐based confocal laser endomicroscopy for biliary strictures显示文摘 | Jayant P. Talreja Brian G. Turner Frank G. Gress Sammy Ho Savreet Sarkaria Naveen Paddu Nikola Natov Sheila Bharmal Monica Gaidhane Amrita Sethi Michel Kahaleh | 2014 | Digestive Endoscopy2014，，4： | 2 |
| 5 | Open-book pelvic frac- tures with perineal open wounds:a significant morbid combination 显示文摘 | Duchesne JC Bharmal HM Dini AA | 2009 | Am Surg2009，75，12： | 1 |
| 6 | Incremental direct expenditure of trea ring asthma in the United States 显示文摘 | Kamble S Bharmal M | 2009 | J Asthma2009，46，1： | 1 |
| 7 | Modern approaches to a rapid diagnosis of tuberculosis:promises and challenges ahead显示文摘 | Tiwari RP Hattikudur NS Bharmal RN | | 0，，： | 1 |
| 8 | Cardiac troponins I and T: molecular markers for early diagnosis, prognosis, and accurate triaging of patients with acute myocardial infarction显示文摘 | Tiwari R P Jain A Khan Z Kohli V Bharmal R N Kartikeyan S | 2012 | Mol Diagn Ther2012，16，： | 1 |
| 9 | Andro Similar:Robust signature for detecting variants of Android malware显示文摘 | Faruki P Laxmi V Bharmal A | 2014 | Journal of Information Security and Applications2014，，38： | 1 |
| 10 | Incremental direct expenditure of treating asthma in the United States显示文摘 | Kamble S Bharmal M | 2009 | J Asthma2009，46，1： | 1 |
| 11 | Encryption and decryption of data using twofish algorithm 显示文摘 | Landge I Bharmal T Narwankar P | 2012 | World Journal of Science and Technology2012，2，3： | 1 |
| 12 | Incremental direct expenditure of treating asthma in the United States 显示文摘 | Kamble S Bharmal M | 2009 | J Asthma2009，46，1： | 1 |
| 13 | Increased diagnostic yield of endoscopic ultrasound‐guided fine needle aspirates with flow cytometry and immunohistochemistry显示文摘 | Jamie B. Sodikoff Hunter L. Johnson Melinda M. Lewis Sagar S. Garud Sheila J. Bharmal Steven A. Keilin Momin T. Siddiqui Qiang Cai Field F. Willingham | 2013 | Cytopathol2013，，12： | 1 |
| 14 | Mod- em approaches to a rapid diagnosis of tuberculosis: prom- ises and challenges ahead 显示文摘 | Tiwari R P Hattikudur N S Bharmal R N | 2007 | Tuberculosis (Edinb)2007，87，3： | 1 |
| 15 | Cardiac Troponins I and T: Molecular Markers for Early Diagnosis, Prognosis, and Accurate Triaging of Patients with Acute Myocardial Infarction显示文摘 | Ram P. Tiwari Anubhav Jain Zakir Khan Veena Kohli R. N. Bharmal S. Kartikeyan Prakash S. Bisen | 2012 | Molecular Diagnosis & Therapy2012，，6： | 1 |
| 16 | Application of the Orthoplastic Reconstructive Ladder to Preserve Lower Extremity Amputation Length显示文摘 | Mark E. Fleming Anthony O’Daniel Husain Bharmal Ian Valerio | 2014 | Annals of Plastic Surgery2014，，2： | 1 |
| 17 | Modem approaches to a rapid diag- nosis of and challenges ahead显示文摘 | Tiwari RP Hattikudar NS Bharmal RN | 2007 | Tuberculosis2007，87，： | 1 |
| 18 | Open-book pelvic fractures with perineal open wounds:a significant morbid combination显示文摘 | Duchesne JC Bharmal HM Dini AA | | 0，，12： | 1 |
| 19 | Prevalence and correlates of potentially inappropriate prescribing among ambulatory older patients in the year 2001: Comparison of three explicit criteria显示文摘 | Hema Viswanathan Murtuza Bharmal Joseph Thomas | 2005 | Clinical Therapeutics2005，，1： | 1 |
| 20 | Open-book pel- vic fractures with perineal open wounds: a significant mor- bid combination 显示文摘 | Duchesne JC Bharmal HM Dini AA | 2009 | Am Surg2009，75，12： | 1 |
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