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您的检索式：作者名="Benjamin Gutierrez"
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| 1 | A key‘foxy’aroma gene is regulated by homologyinduced promoter indels in the iconic juice grape‘Concord’显示文摘‘Concord’,the most well-known juice grape with a parentage of the North American grape species Vitis labrusca L.,possesses a special‘foxy’aroma predominantly resulted from the accumulation of methyl anthranilate(MA)in berries.This aroma,however,is often perceived as an undesirable attribute by wine consumers and rarely noticeable in the common table and wine grape species V.vinifera.Here we discovered homology-induced promoter indels as a major genetic mechanism for species-specific regulation of a key‘foxy’aroma gene,anthraniloyl-CoA:methanol acyltransferase(AMAT),that is responsible for MA biosynthesis.We found the absence of a 426-bp and/or a 42-bp sequence in AMAT promoters highly associated with high levels of AMAT expression and MA accumulation in‘Concord’and other V.labrusca-derived grapes.These promoter variants,all with direct and inverted repeats,were further confirmed in more than 1,300 Vitis germplasm.Moreover,functional impact of these indels was validated in transgenic Arabidopsis.Superimposed on the promoter regulation,large structural changes including exonic insertion of a retrotransposon were present at the AMAT locus in some V.vinifera grapes.Elucidation of the AMAT genetic regulation advances our understanding of the‘foxy’aroma trait and makes it genetically trackable and amenable in grapevine breeding. | Yingzhen Yang JoséCuenca Nian Wang Zhenchang Liang Honghe Sun Benjamin Gutierrez Xiaojun Xi Jie Arro YiWang Peige Fan Jason Londo Peter Cousins Shaohua Li Zhangjun Fei Gan-Yuan Zhong | 2020 | Horticulture Research2020，7，1： | 3 |
| 2 | Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia显示文摘 | Gutierrez Alejandro Pan Li Groen Richard W J Baleydier Frederic Kentsis Alex Marineau Jason Grebliunaite Ruta Kozakewich Elena Reed Casie Pflumio Francoise Poglio Sandrine Uzan Benjamin Clemons Paul VerPlank Lynn An Frank Burbank Jason Nor | 2014 | Journal of Clinical Investigation2014，，2： | 1 |
| 3 | Tricyclic Antidepressants for Management of Residual Symptoms in Inflammatory Bowel Disease显示文摘 | Heba N. Iskandar Benjamin Cassell Navya Kanuri C. Prakash Gyawali Alexandra Gutierrez Themistocles Dassopoulos Matthew A. Ciorba Gregory S. Sayuk | 2014 | Journal of Clinical Gastroenterology2014，，： | 1 |
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